Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA–dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis

Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis

(2017) Joseph A. Karam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Concerted actions of distinct nonmuscle myosin II isoforms drive intracellular membrane remodeling in live animals

(2017) Oleg Milberg et al.   JOURNAL OF CELL BIOLOGY

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

(2017) Yu-Hsiu Wang et al.   Nature Communications

Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120

(2017) Rebecca C. Allsopp et al.   Scientific Reports

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML

(2016) Mohammed Dany et al.   BLOOD

Pre-assembled Nuclear Pores Insert into the Nuclear Envelope during Early Development

(2016) Bernhard Hampoelz et al.   CELL

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4

(2016) Malek Najjar et al.   IMMUNITY

CerS6Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress

(2016) Baharan Fekry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

(2016) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

(2016) Giovanni Quarato et al.   MOLECULAR CELL

Piwi maintains germline stem cells and oogenesis in Drosophila through negative regulation of Polycomb group proteins

(2016) Jamy C Peng et al.   NATURE GENETICS

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Active diffusion and microtubule-based transport oppose myosin forces to position organelles in cells

(2016) Congping Lin et al.   Nature Communications

Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila

(2016) Hsueh-Yen Ku et al.   PLoS Genetics

Nanotubes mediate niche–stem-cell signalling in the Drosophila testis

(2015) Mayu Inaba et al.   NATURE

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

(2015) Shanmugam Panneer Selvam et al.   Science Signaling

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1

(2015) Gilles Vanwalleghem et al.   Nature Communications

Structural basis for self-assembly of a cytolytic pore lined by protein and lipid

(2015) Koji Tanaka et al.   Nature Communications

Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo

(2015) Duy T. Tran et al.   Nature Communications

Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1

(2015) Malek Najjar et al.   Cell Reports

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

(2015) Shanmugam Panneer Selvam et al.   Science Signaling

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

The dynein inhibitor Ciliobrevin D inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches

(2014) Rajiv Sainath et al.   Developmental Neurobiology

Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond

(2014) Christopher S. Garris et al.   IMMUNOLOGY

Coupling between endocytosis and sphingosine kinase 1 recruitment

(2014) Hongying Shen et al.   NATURE CELL BIOLOGY

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

(2014) Nitai C Hait et al.   NATURE NEUROSCIENCE

miR-200a-mediated suppression of non-muscle heavy chain IIb inhibits meningioma cell migration and tumor growth in vivo

(2014) O Senol et al.   ONCOGENE

Direct in Vivo RNAi Screen Unveils Myosin IIa as a Tumor Suppressor of Squamous Cell Carcinomas

(2014) D. Schramek et al.   SCIENCE

The Nuclear Lamina Regulates Germline Stem Cell Niche Organization via Modulation of EGFR Signaling

(2013) Haiyang Chen et al.   Cell Stem Cell

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

(2013) Paolo Neviani et al.   JOURNAL OF CLINICAL INVESTIGATION

Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse

(2013) Joseph C. Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

(2013) Philip A. Harris et al.   ACS Medicinal Chemistry Letters

Dual role of myosin II during Drosophila imaginal disc metamorphosis

(2013) Silvia Aldaz et al.   Nature Communications

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

Modulation of Ceramide Synthase Activity via Dimerization

(2012) Elad L. Laviad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

(2012) Robert E Sorge et al.   NATURE MEDICINE

Elucidating membrane structure and protein behavior using giant plasma membrane vesicles

(2012) Erdinc Sezgin et al.   Nature Protocols

Fingolimod for Multiple Sclerosis

(2012) Daniel Pelletier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Poly(ADP-ribose) controls DE-cadherin-dependent stem cell maintenance and oocyte localization

(2012) Yingbiao Ji et al.   Nature Communications

Ecdysteroids affectDrosophilaovarian stem cell niche formation and early germline differentiation

(2011) Annekatrin König et al.   EMBO JOURNAL

Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma

(2011) Hany A. Omar et al.   HEPATOLOGY

Loss of ceramide synthase 3 causes lethal skin barrier disruption

(2011) Richard Jennemann et al.   HUMAN MOLECULAR GENETICS

Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+and ER/Golgi Membrane Network

(2011) Can E. Senkal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wolbachia Enhance Drosophila Stem Cell Proliferation and Target the Germline Stem Cell Niche

(2011) E. M. Fast et al.   SCIENCE

Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights

(2010) Xiongpeng Zhu et al.   Journal of Hematology & Oncology

Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation

(2010) Vamsi K Gangaraju et al.   NATURE GENETICS

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

(2010) Guangwei Liu et al.   NATURE IMMUNOLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase

(2010) Kazuhiro Maeshima et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Achieving reliability and high accuracy in automated protein docking: Cluspro, PIPER, SDU, and stability analysis in CAPRI rounds 13-19

(2010) Dima Kozakov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells

(2009) R. Nakai et al.   CANCER RESEARCH

Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-de pend ent Manner

(2009) Sujoy Lahiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells

(2009) Evgeny V. Berdyshev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Medicinal Chemistry and the Molecular Operating Environment (MOE): Application of QSAR and Molecular Docking to Drug Discovery

(2008) Santiago Vilar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Male Germ Cells Require Polyenoic Sphingolipids with Complex Glycosylation for Completion of Meiosis

(2008) Mariona Rabionet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels

(2008) Leah J. Siskind et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lasp anchors the Drosophila male stem cell niche and mediates spermatid individualization

(2008) Soojin Lee et al.   MECHANISMS OF DEVELOPMENT