Bioactive Lipid Mediators in the Initiation and Resolution of Inflammation after Spinal Cord Injury

Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria

(2020) Yi-Zhi Ren et al.   JOURNAL OF NEUROCHEMISTRY

Immune cell regulation of glia during CNS injury and disease

(2020) Andrew D. Greenhalgh et al.   NATURE REVIEWS NEUROSCIENCE

Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation

(2020) János G Filep et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain

(2020) Xueshu Tao et al.   Neurotherapeutics

Lysophosphatidic Acid Receptor 5 Plays a Pathogenic Role in Brain Damage after Focal Cerebral Ischemia by Modulating Neuroinflammatory Responses

(2020) Arjun Sapkota et al.   Cells

Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases

(2020) Lun Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Specialized pro-resolving mediator network: an update on production and actions

(2020) Nan Chiang et al.   Essays in Biochemistry

Resolvin D3 Promotes Inflammatory Resolution, Neuroprotection, and Functional Recovery After Spinal Cord Injury

(2020) Juri Kim et al.   MOLECULAR NEUROBIOLOGY

Microglia-organized scar-free spinal cord repair in neonatal mice

(2020) Yi Li et al.   NATURE

A new neutrophil subset promotes CNS neuron survival and axon regeneration

(2020) Andrew R. Sas et al.   NATURE IMMUNOLOGY

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

(2020) C. Madore et al.   Nature Communications

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

(2019) Victor Bellver-Landete et al.   Nature Communications

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

(2019) Yong-Hyun Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage migration inhibitory factor facilitates prostaglandin E2 production of astrocytes to tune inflammatory milieu following spinal cord injury

(2019) Yuxin Zhang et al.   Journal of Neuroinflammation

The Healing Power of Neutrophils

(2019) Mia Phillipson et al.   TRENDS IN IMMUNOLOGY

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

(2019) Joel Zindel et al.   Annual Review of Pathology-Mechanisms of Disease

Extracellular ADP augments microglial inflammasome and NF‐κB activation via the P2Y12 receptor

(2019) Tomonori Suzuki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

(2019) Nan Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysophosphatidic acid receptor 1 (LPA1) plays critical roles in microglial activation and brain damage after transient focal cerebral ischemia

(2019) Bhakta Prasad Gaire et al.   Journal of Neuroinflammation

Quantitative Mass Spectrometry Imaging of Prostaglandins as Silver Ion Adducts with Nanospray Desorption Electrospray Ionization

(2018) Kyle D. Duncan et al.   ANALYTICAL CHEMISTRY

Lipoxin A4 protects against spinal cord injury via regulating Akt/nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 signaling

(2018) Tan Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology

(2018) Jesmond Dalli et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

(2018) Sangsu Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid cell responses after spinal cord injury

(2018) Samuel David et al.   JOURNAL OF NEUROIMMUNOLOGY

Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke

(2018) Ludmila Belayev et al.   MOLECULAR NEUROBIOLOGY

Resolvin D1 Halts Remote Neuroinflammation and Improves Functional Recovery after Focal Brain Damage Via ALX/FPR2 Receptor-Regulated MicroRNAs

(2018) Elisa Bisicchia et al.   MOLECULAR NEUROBIOLOGY

Traumatic Spinal Injury: Global Epidemiology and Worldwide Volume

(2018) Ramesh Kumar et al.   World Neurosurgery

Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice

(2018) Linlin Zhang et al.   Frontiers in Pharmacology

Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2

(2018) Aikaterini Nikolaou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cytosolic phospholipase A2 and lysophospholipid acyltransferases

(2018) Yoshihiro Kita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Group IID, IIE, IIF and III secreted phospholipase A2s

(2018) Makoto Murakami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lysophosphatidic acid receptor type 2 activation contributes to secondary damage after spinal cord injury in mice

(2018) Clara López-Serrano et al.   BRAIN BEHAVIOR AND IMMUNITY

The Leptomeninges Produce Prostaglandin D2 Involved in Sleep Regulation in Mice

(2018) Yoan Cherasse et al.   Frontiers in Cellular Neuroscience

Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury

(2018) Andrew D. Greenhalgh et al.   PLOS BIOLOGY

Mechanisms of lysophosphatidylcholine-induced demyelination: A primary lipid disrupting myelinopathy

(2017) Jason R. Plemel et al.   GLIA

Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury

(2017) Isaac Francos-Quijorna et al.   JOURNAL OF NEUROSCIENCE

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

Physiological and Pathological Roles of 15-Deoxy-Δ12,14-Prostaglandin J2 in the Central Nervous System and Neurological Diseases

(2017) Tatsurou Yagami et al.   MOLECULAR NEUROBIOLOGY

Gut Microbiota Are Disease-Modifying Factors After Traumatic Spinal Cord Injury

(2017) Kristina A. Kigerl et al.   Neurotherapeutics

Aging with Spinal Cord Injury

(2017) Joel E. Frontera et al.   Physical Medicine and Rehabilitation Clinics of North America

Arachidonic acid containing phosphatidylcholine increases due to microglial activation in ipsilateral spinal dorsal horn following spared sciatic nerve injury

(2017) Tomohiro Banno et al.   PLoS One

Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury

(2017) Kathren L. Fink et al.   Cell Reports

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis

(2017) K. Schmitz et al.   Acta Neuropathologica Communications

The pro-resolving lipid mediator Maresin 1 protects against cerebral ischemia/reperfusion injury by attenuating the pro-inflammatory response

(2016) Wenjing Xian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury

(2016) Rae L. Russell et al.   BMC NEUROSCIENCE

Arginase-1 is expressed exclusively by infiltrating myeloid cells in CNS injury and disease

(2016) Andrew D. Greenhalgh et al.   BRAIN BEHAVIOR AND IMMUNITY

Modulation of Hexadecyl-LPA-Mediated Activation of Mast Cells and Microglia by a Chemical Probe for LPA5

(2016) Detlef H. Kozian et al.   CHEMBIOCHEM

IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury

(2016) Isaac Francos-Quijorna et al.   GLIA

Group X Secreted Phospholipase A2Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility

(2016) Remi Murase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gut dysbiosis impairs recovery after spinal cord injury

(2016) Kristina A. Kigerl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

(2016) Alessandra Cadete Martini et al.   Journal of Neuroinflammation

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury

(2016) Athanasios Didangelos et al.   Scientific Reports

Increased arachidonic acid-containing phosphatidylcholine is associated with reactive microglia and astrocytes in the spinal cord after peripheral nerve injury

(2016) Dongmin Xu et al.   Scientific Reports

Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse

(2015) Jordan L. Harrison et al.   BRAIN BEHAVIOR AND IMMUNITY

How microglia kill neurons

(2015) Guy C. Brown et al.   BRAIN RESEARCH

Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats

(2015) Mushfiquddin Khan et al.   Journal of Neuroinflammation

A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury

(2015) Z.-H. Liu et al.   JOURNAL OF NEUROSCIENCE

Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury

(2015) E. Santos-Nogueira et al.   JOURNAL OF NEUROSCIENCE

Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury

(2015) Y. Zhu et al.   NEUROBIOLOGY OF DISEASE

Lysophosphatidic Acid Signaling in the Nervous System

(2015) Yun C. Yung et al.   NEURON

Macrophage and microglial plasticity in the injured spinal cord

(2015) S. David et al.   NEUROSCIENCE

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

Treatments for erectile dysfunction in spinal cord patients: alternatives to phosphodiesterase type 5 inhibitors? A review study

(2015) G Lombardi et al.   SPINAL CORD

The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life

(2015) Aggeliki Katsifa et al.   PLoS One

Cytosolic phospholipase A2protein as a novel therapeutic target for spinal cord injury

(2014) Nai-Kui Liu et al.   ANNALS OF NEUROLOGY

Toll-like receptors in central nervous system injury and disease: A focus on the spinal cord

(2014) Adee Heiman et al.   BRAIN BEHAVIOR AND IMMUNITY

Incidence of traumatic spinal cord injury worldwide: a systematic review

(2014) Seyed Behzad Jazayeri et al.   EUROPEAN SPINE JOURNAL

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies

(2014) Irene Paterniti et al.   Journal of Neuroinflammation

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

(2014) Peter J Crack et al.   Journal of Neuroinflammation

Differences in the Phagocytic Response of Microglia and Peripheral Macrophages after Spinal Cord Injury and Its Effects on Cell Death

(2014) A. D. Greenhalgh et al.   JOURNAL OF NEUROSCIENCE

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Role of the Prostaglandin E2 EP1 Receptor in Traumatic Brain Injury

(2014) Alexander V. Glushakov et al.   PLoS One

Fatty Acid Receptor Gpr40 Mediates Neuromicrovascular Degeneration Induced by Transarachidonic Acids in Rodents

(2013) Jean-Claude Honoré et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Temporal changes in monocyte and macrophage subsets and microglial macrophages following spinal cord injury in the lys-egfp-ki mouse model

(2013) Sakina G. Thawer et al.   JOURNAL OF NEUROIMMUNOLOGY

Licofelone Modulates Neuroinflammation and Attenuates Mechanical Hypersensitivity in the Chronic Phase of Spinal Cord Injury

(2013) J. N. Dulin et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Therapy for Acute Spinal Cord Injury

(2013) R. John Hurlbert et al.   NEUROSURGERY

Role of PGE2 EP1 Receptor in Intracerebral Hemorrhage-Induced Brain Injury

(2013) Nilendra Singh et al.   NEUROTOXICITY RESEARCH

Proresolution Lipid Mediators in Multiple Sclerosis — Differential, Disease Severity-Dependent Synthesis — A Clinical Pilot Trial

(2013) Harald Prüss et al.   PLoS One

Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity?

(2013) Adina T. Michael-Titus et al.   TRENDS IN NEUROSCIENCES

Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes

(2012) Yona Goldshmit et al.   AMERICAN JOURNAL OF PATHOLOGY

Spatiotemporal alteration of phospholipids and prostaglandins in a rat model of spinal cord injury

(2012) Mitsuru Hanada et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid

(2012) Siew-Na Lim et al.   EXPERIMENTAL NEUROLOGY

Differential Detection and Distribution of Microglial and Hematogenous Macrophage Populations in the Injured Spinal Cord oflys-EGFP-kiTransgenic Mice

(2012) Leah A. Mawhinney et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Transgenic mice with high endogenous omega-3 fatty acids are protected from spinal cord injury

(2012) Siew-Na Lim et al.   NEUROBIOLOGY OF DISEASE

Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury

(2012) Mehmet Erşahin et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial

(2012) Lai Kuan Lee et al.   PSYCHOPHARMACOLOGY

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Phospholipase A2 superfamily members play divergent roles after spinal cord injury

(2011) Rubèn López-Vales et al.   FASEB JOURNAL

Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury

(2011) Adriana Redensek et al.   GLIA

Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages

(2011) D. J. Donnelly et al.   JOURNAL OF NEUROSCIENCE

Lipocalin 2 Plays an Immunomodulatory Role and Has Detrimental Effects after Spinal Cord Injury

(2011) K. I. Rathore et al.   JOURNAL OF NEUROSCIENCE

Prevention of Both Neutrophil and Monocyte Recruitment Promotes Recovery after Spinal Cord Injury

(2011) Sang Mi Lee et al.   JOURNAL OF NEUROTRAUMA

The LTB4-BLT1 Axis Mediates Neutrophil Infiltration and Secondary Injury in Experimental Spinal Cord Injury

(2010) Hirokazu Saiwai et al.   AMERICAN JOURNAL OF PATHOLOGY

Mapping Lipid Alterations in Traumatically Injured Rat Spinal Cord by Desorption Electrospray Ionization Imaging Mass Spectrometry

(2010) Marion Girod et al.   ANALYTICAL CHEMISTRY

Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment

(2010) Kevin D. Beck et al.   BRAIN

Prostaglandin E 2 reduces amyloid β-induced phagocytosis in cultured rat microglia

(2010) Takayuki Nagano et al.   BRAIN RESEARCH

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

A novel role of prostaglandin E2 in neuropathic pain

(2010) Shunji Kunori et al.   GLIA

NO mediates microglial response to acute spinal cord injury under ATP control in vivo

(2010) Payam Dibaj et al.   GLIA

Nano PGE1 promoted the recovery from spinal cord injury-induced motor dysfunction through its accumulation and sustained release

(2010) Mitsuko Takenaga et al.   JOURNAL OF CONTROLLED RELEASE

Fenretinide Promotes Functional Recovery and Tissue Protection after Spinal Cord Contusion Injury in Mice

(2010) R. Lopez-Vales et al.   JOURNAL OF NEUROSCIENCE

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) Contributes to Secondary Damage after Spinal Cord Injury

(2010) N. Ghasemlou et al.   JOURNAL OF NEUROSCIENCE

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Limaprost reduces motor disturbances by increasing the production of insulin-like growth factor I in rats subjected to spinal cord injury

(2010) Takehiro Umemura et al.   Translational Research

Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis

(2009) Athena Kalyvas et al.   BRAIN

Microglia processes block the spread of damage in the brain and require functional chloride channels

(2009) Dustin J. Hines et al.   GLIA

B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice

(2009) Daniel P. Ankeny et al.   JOURNAL OF CLINICAL INVESTIGATION

Depletion of Ly6G/Gr-1 Leukocytes after Spinal Cord Injury in Mice Alters Wound Healing and Worsens Neurological Outcome

(2009) D. P. Stirling et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Protective role of hematopoietic prostaglandin D synthase in transient focal cerebral ischemia in mice

(2009) M. Liu et al.   NEUROSCIENCE

Prostaglandin E1 analog increases spinal cord blood flow at the point of compression during and after experimental spinal cord injury

(2009) Y Hamamoto et al.   SPINAL CORD

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury

(2008) Rubèn López-Vales et al.   BRAIN

α4β1 integrin blockade after spinal cord injury decreases damage and improves neurological function

(2008) Jennifer C. Fleming et al.   EXPERIMENTAL NEUROLOGY

The protective effects of 15-deoxy-Δ-12,14-prostaglandin J2 in spinal cord injury

(2008) Bradley J. Kerr et al.   GLIA

Intrathecal Rosiglitazone Acts at Peroxisome Proliferator–Activated Receptor-γ to Rapidly Inhibit Neuropathic Pain in Rats

(2008) Sajay B. Churi et al.   JOURNAL OF PAIN

Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus

(2008) Elisa Matas-Rico et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Effects of zileuton and montelukast in mouse experimental spinal cord injury

(2007) T Genovese et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

(2007) Dustin J. Donnelly et al.   EXPERIMENTAL NEUROLOGY

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark