LPA receptor signaling: pharmacology, physiology, and pathophysiology

Autotaxin Production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation

(2013) Gye Young Park et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lysophosphatidic Acid Receptor–2 Deficiency Confers Protection against Bleomycin-Induced Lung Injury and Fibrosis in Mice

(2013) Long Shuang Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis

(2013) Beatriz Orosa et al.   ANNALS OF THE RHEUMATIC DISEASES

Necessity of Lysophosphatidic Acid Receptor 1 for Development of Arthritis

(2013) Yoshishige Miyabe et al.   ARTHRITIS AND RHEUMATISM

Involvement of autotaxin/lysophosphatidic acid signaling in obesity and impaired glucose homeostasis

(2013) Chloé Rancoule et al.   BIOCHIMIE

Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays

(2013) Semjon Willier et al.   BIOLOGY OF THE CELL

Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): Metabolically stabilized LPA receptor agonists

(2013) Guowei Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fear extinction and acute stress reactivity reveal a role of LPA1 receptor in regulating emotional-like behaviors

(2013) C. Pedraza et al.   Brain Structure & Function

The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells

(2013) Hui Cai et al.   Cell Communication and Signaling

Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice

(2013) C. Rancoule et al.   DIABETOLOGIA

Targeting the epithelial cells in fibrosis: a new concept for an old disease

(2013) Solange Moll et al.   DRUG DISCOVERY TODAY

LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

(2013) Norihiko Sakai et al.   FASEB JOURNAL

Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase

(2013) Éva Ruisanchez et al.   FASEB JOURNAL

Regulation Of Angiogenesis By Phospholipid Lysophosphatidic Acid

(2013) Bin Ren   Frontiers in Bioscience-Landmark

Lysophosphatidic acid (LPA) and its receptor, LPA1, influence embryonic schwann cell migration, myelination, and cell-to-axon segregation

(2013) Brigitte Anliker et al.   GLIA

Structural Characterization of an LPA1 Second Extracellular Loop Mimetic with a Self-Assembling Coiled-Coil Folding Constraint

(2013) John Young et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simultaneous profiling of polar lipids by supercritical fluid chromatography/tandem mass spectrometry with methylation

(2013) Jae Won Lee et al.   JOURNAL OF CHROMATOGRAPHY A

Constitutive Lymphocyte Transmigration across the Basal Lamina of High Endothelial Venules Is Regulated by the Autotaxin/Lysophosphatidic Acid Axis

(2013) Z. Bai et al.   JOURNAL OF IMMUNOLOGY

Lysophosphatidic Acid Produced by Hen Egg White Lysophospholipase D Induces Vascular Development on Extraembryonic Membranes

(2013) Junichi Morishige et al.   LIPIDS

Distinct Phospholipase C-  Isozymes Mediate Lysophosphatidic Acid Receptor 1 Effects on Intestinal Epithelial Homeostasis and Wound Closure

(2013) S.-J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

An LPA Species (18:1 LPA) Plays Key Roles in the Self-Amplification of Spinal LPA Production in the Peripheral Neuropathic Pain Model

(2013) Lin Ma et al.   Molecular Pain

A Metabolically-Stabilized Phosphonate Analog of Lysophosphatidic Acid Attenuates Collagen-Induced Arthritis

(2013) Ioanna Nikitopoulou et al.   PLoS One

Lysophosphatidic Acid Increases Proximal Tubule Cell Secretion of Profibrotic Cytokines PDGF-B and CTGF through LPA2- and Gαq-Mediated Rho and αvβ6 Integrin-Dependent Activation of TGF-β

(2012) Hui Geng et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysophosphatidic acid: A potential mediator of osteoblast–osteoclast signaling in bone

(2012) Stephen M. Sims et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Synthesis and biological evaluation of optically active Ki16425

(2012) Takanao Sato et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo

(2012) Mayumi Komachi et al.   CANCER SCIENCE

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Unlike Two Peas in a Pod: Lipid Phosphate Phosphatases and Phosphatidate Phosphatases

(2012) Bernard P. C. Kok et al.   CHEMICAL REVIEWS

Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right asymmetry in zebrafish

(2012) S.-L. Lai et al.   DEVELOPMENT

Plasma lysophosphatidic acid levels and hepatocellular carcinoma

(2012) Hitoshi Ikeda et al.   HEPATOLOGY

Elevated Serum Levels of Arachidonoyl-lysophosphatidic Acid and Sphingosine 1-Phosphate in Systemic Sclerosis

(2012) Akira Tokumura et al.   International Journal of Medical Sciences

Targeted Deletion of LPA5Identifies Novel Roles for Lysophosphatidic Acid Signaling in Development of Neuropathic Pain

(2012) Mu-En Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lpa2 Is a Negative Regulator of Both Dendritic Cell Activation and Murine Models of Allergic Lung Inflammation

(2012) J. Emo et al.   JOURNAL OF IMMUNOLOGY

Effect of Inhibition of the Lysophosphatidic Acid Receptor 1 on Metastasis and Metastatic Dormancy in Breast Cancer

(2012) Jean-Claude A. Marshall et al.   JNCI-Journal of the National Cancer Institute

Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes

(2012) Melissa N. Barber et al.   PLoS One

The PDZ Protein GIPC Regulates Trafficking of the LPA1 Receptor from APPL Signaling Endosomes and Attenuates the Cell’s Response to LPA

(2012) Tal Varsano et al.   PLoS One

Lysophospholipids and lysophospholipase D in rabbit aqueous humor following corneal injury

(2012) Akira Tokumura et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradation

(2012) Niina Aaltonen et al.   BMC Pharmacology & Toxicology

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma

(2011) Flavia V. Castelino et al.   ARTHRITIS AND RHEUMATISM

Blockade of lysophosphatidic acid receptors LPAR1/3 ameliorates lung fibrosis induced by irradiation

(2011) Lu Gan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass

(2011) Isabelle Gennero et al.   BONE

The emerging role of lysophosphatidic acid (LPA) in skeletal biology

(2011) Julia Blackburn et al.   BONE

Insights into the pharmacological relevance of lysophospholipid receptors

(2011) Tetsuji Mutoh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autotaxin and LPA receptor signaling in cancer

(2011) Anna J. S. Houben et al.   CANCER AND METASTASIS REVIEWS

Serum autotaxin measurements in pregnant women: Application for the differentiation of normal pregnancy and pregnancy-induced hypertension

(2011) Akiko Masuda et al.   CLINICA CHIMICA ACTA

Increased circulating plasma lysophosphatidic acid in patients with acute coronary syndrome

(2011) Tomotaka Dohi et al.   CLINICA CHIMICA ACTA

Lysophosphatidic acid receptors in ovine uterus during estrous cycle and early pregnancy and their regulation by progesterone

(2011) E. Liszewska et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

LPA-producing enzyme PA-PLA1α regulates hair follicle development by modulating EGFR signalling

(2011) Asuka Inoue et al.   EMBO JOURNAL

Clinical significance of enzymatic lysophosphatidylcholine (LPC) assay data in patients with sepsis

(2011) W. H. Cho et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

The NF-κB pathway mediates lysophosphatidic acid (LPA)-induced VEGF signaling and cell invasion in epithelial ovarian cancer (EOC)

(2011) Sonia Dutta et al.   GYNECOLOGIC ONCOLOGY

Unmasking of LPA1 receptor-mediated migration response to lysophosphatidic acid by interleukin-1β-induced attenuation of Rho signaling pathways in rat astrocytes

(2011) Koichi Sato et al.   JOURNAL OF NEUROCHEMISTRY

Astrocytes treated by lysophosphatidic acid induce axonal outgrowth of cortical progenitors through extracellular matrix protein and epidermal growth factor signaling pathway

(2011) Tania Cristina Leite de Sampaio e Spohr et al.   JOURNAL OF NEUROCHEMISTRY

Antinociceptive Effect of Cyclic Phosphatidic Acid and Its Derivative on Animal Models of Acute and Chronic Pain

(2011) Yasutaka Kakiuchi et al.   Molecular Pain

LPA5 Is Abundantly Expressed by Human Mast Cells and Important for Lysophosphatidic Acid Induced MIP-1β Release

(2011) Anders Lundequist et al.   PLoS One

Aggravation of Chronic Stress Effects on Hippocampal Neurogenesis and Spatial Memory in LPA1 Receptor Knockout Mice

(2011) Estela Castilla-Ortega et al.   PLoS One

Autotaxin and LPA Receptors Represent Potential Molecular Targets for the Radiosensitization of Murine Glioma through Effects on Tumor Vasculature

(2011) Stephen M. Schleicher et al.   PLoS One

LPA Is a Chemorepellent for B16 Melanoma Cells: Action through the cAMP-Elevating LPA5 Receptor

(2011) Maikel Jongsma et al.   PLoS One

Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA1) signaling

(2011) K. J. Herr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus

(2011) Y. C. Yung et al.   Science Translational Medicine

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

(2011) Graciana Diez-Roux et al.   PLOS BIOLOGY

Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors

(2010) Dong-Soon Im   ACTA PHARMACOLOGICA SINICA

LPA Receptors: Subtypes and Biological Actions

(2010) Ji Woong Choi et al.   Annual Review of Pharmacology and Toxicology

Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway

(2010) Seiichi Koike et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biological roles of lysophosphatidic acid signaling through its production by autotaxin

(2010) Shinichi Okudaira et al.   BIOCHIMIE

LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis

(2010) H. Sumida et al.   BLOOD

A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model

(2010) JS Swaney et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aiming drug discovery at lysophosphatidic acid targets

(2010) Gabor Tigyi   BRITISH JOURNAL OF PHARMACOLOGY

Lysophosphatidic Acid Receptors LPA 1 and LPA 3 Promote CXCL12-Mediated Smooth Muscle Progenitor Cell Recruitment in Neointima Formation

(2010) Pallavi Subramanian et al.   CIRCULATION RESEARCH

A novel mutation in LPAR6 causes autosomal recessive hypotrichosis of the scalp

(2010) S. Nahum et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Effects of lysophosphatidic acid on the in vitro proliferation and differentiation of a novel porcine preadipocyte cell line

(2010) Hiroyuki Nobusue et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Involvement of Cytosolic Phospholipase A2, Calcium Independent Phospholipase A2 and Plasmalogen Selective Phospholipase A2 in Neurodegenerative and Neuropsychiatric Conditions

(2010) W.-Y. Ong et al.   CURRENT MEDICINAL CHEMISTRY

Ovarian cancer-derived lysophosphatidic acid stimulates secretion of VEGF and stromal cell-derived factor-1α from human mesenchymal stem cells

(2010) Eun Su Jeon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes

(2010) Therese E. Holmström et al.   EXPERIMENTAL CELL RESEARCH

Colorectal cancer cells – Proliferation, survival and invasion by lysophosphatidic acid

(2010) Sei-Jung Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Abnormalities in α/β-CaMKII and related mechanisms suggest synaptic dysfunction in hippocampus of LPA1 receptor knockout mice

(2010) Laura Musazzi et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review

(2010) J J Reilly et al.   INTERNATIONAL JOURNAL OF OBESITY

Lysophosphatidic Acid Signals through Multiple Receptors in Osteoclasts to Elevate Cytosolic Calcium Concentration, Evoke Retraction, and Promote Cell Survival

(2010) Danielle M. Lapierre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4

(2010) Yao-Bin Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography–electrospray tandem mass spectrometry

(2010) Niina Aaltonen et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Diversity of Lysophosphatidic Acid Receptor-Mediated Intracellular Calcium Signaling in Early Cortical Neurogenesis

(2010) A. E. Dubin et al.   JOURNAL OF NEUROSCIENCE

Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-Induced Neuropathic Pain

(2010) L. Ma et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacokinetic and Pharmacodynamic Characterization of an Oral Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist

(2010) J. S. Swaney et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Altered food consumption in mice lacking lysophosphatidic acid receptor-1

(2010) R. Dusaulcy et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Regulation of Cerebromicrovascular Permeability by Lysophosphatidic Acid

(2010) MOSHARRAF H. SARKER et al.   MICROCIRCULATION

Autotaxin expression and its connection with the TNF-alpha-NF-κB axis in human hepatocellular carcinoma

(2010) Jian-Min Wu et al.   Molecular Cancer

Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor

(2010) Estela Castilla-Ortega et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Mutations of Lysophosphatidic Acid Receptor Genes in Human Osteosarcoma Cells

(2010) Kyoko Okabe et al.   PATHOBIOLOGY

Systematic generation of in vivo G protein-coupled receptor mutants in the rat

(2010) R van Boxtel et al.   PHARMACOGENOMICS JOURNAL

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature

(2010) J. Chun et al.   PHARMACOLOGICAL REVIEWS

Cancer Cell Expression of Autotaxin Controls Bone Metastasis Formation in Mouse through Lysophosphatidic Acid-Dependent Activation of Osteoclasts

(2010) Marion David et al.   PLoS One

Lysophosphatidic acid-activated Cl- current activity in human systemic sclerosis skin fibroblasts

(2010) Z. Yin et al.   RHEUMATOLOGY

Lysophosphatidic acid (LPA)—a perspective marker in ovarian cancer

(2010) Iva Sedláková et al.   TUMOR BIOLOGY

P2Y5 is a Gαi, Gα12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion

(2009) Mike Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

ORIGINAL ARTICLE: Expression of Autotaxin, an Ectoenzyme that Produces Lysophosphatidic Acid, in Human Placenta

(2009) Yuki Iwasawa et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces

(2009) Jason P. Mansell et al.   BIOMATERIALS

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

(2009) Shuying Liu et al.   CANCER CELL

Mammary Tumorigenesis through LPA Receptor Signaling

(2009) Jos Jonkers et al.   CANCER CELL

Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

(2009) Honglu Zhang et al.   CANCER RESEARCH

Expression of Autotaxin and Acylglycerol kinase in prostate cancer: Association with cancer development and progression

(2009) Mohammed Ahmed Abdel Muneem Nouh et al.   CANCER SCIENCE

LPA 1 receptors mediate stimulation, whereas LPA 2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites

(2009) Mayumi Komachi et al.   CARCINOGENESIS

Synaptic PRG-1 Modulates Excitatory Transmission via Lipid Phosphate-Mediated Signaling

(2009) Thorsten Trimbuch et al.   CELL

Autotaxin enzyme immunoassay in human cerebrospinal fluid samples

(2009) Kazuhiro Nakamura et al.   CLINICA CHIMICA ACTA

High-Throughput Analysis of Sphingosine 1-Phosphate, Sphinganine 1-Phosphate, and Lysophosphatidic Acid in Plasma Samples by Liquid Chromatography-Tandem Mass Spectrometry

(2009) M. Scherer et al.   CLINICAL CHEMISTRY

Impaired Preadipocyte Differentiation in Human Abdominal Obesity: Role of Wnt, Tumor Necrosis Factor- , and Inflammation

(2009) P. Isakson et al.   DIABETES

Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells

(2009) Kang Jin Jeong et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Lysophosphatidic Acid Stimulates Prostaglandin E2 Production in Cultured Stromal Endometrial Cells Through LPA1 Receptor

(2009) Izabela Woclawek-Potocka et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Lysophosphatidic Acid Stimulates the Intestinal Brush Border Na+/H+ Exchanger 3 and Fluid Absorption via LPA5 and NHERF2

(2009) Songbai Lin et al.   GASTROENTEROLOGY

Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits

(2009) L. J. Santin et al.   GENES BRAIN AND BEHAVIOR

Lysophosphatidic acid in vascular development and disease

(2009) Siew T. Teo et al.   IUBMB LIFE

Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6

(2009) Keisuke Yanagida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Ligand Selectivity of the GPR92/LPA5Lysophosphatidate Receptor Indicates Role in Human Platelet Activation

(2009) Jesica R. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vitro Analysis of LIPH Mutations Causing Hypotrichosis Simplex: Evidence Confirming the Role of Lipase H and Lysophosphatidic Acid in Hair Growth

(2009) Sandra M. Pasternack et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

 -Arrestin/Ral Signaling Regulates Lysophosphatidic Acid-Mediated Migration and Invasion of Human Breast Tumor Cells

(2009) T. T. Li et al.   MOLECULAR CANCER RESEARCH

Lysophosphatidic Acid-3 Receptor-Mediated Feed-Forward Production of Lysophosphatidic Acid: an Initiator of Nerve Injury-Induced Neuropathic Pain

(2009) Lin Ma et al.   Molecular Pain

Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol

(2009) Kumiko Makide et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Lysophosphatidic acid (LPA) receptors: Signaling properties and disease relevance

(2009) Mu-En Lin et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Lysophosphatidic acid (LPA) signaling in vertebrate reproduction

(2009) Xiaoqin Ye et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Involvement of the Lysophosphatidic Acid-Generating Enzyme Autotaxin in Lymphocyte-Endothelial Cell Interactions

(2008) Tae Nakasaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Roles of lysophosphatidic acid in cardiovascular physiology and disease

(2008) S SMYTH   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulation of the LPA2 receptor signaling through the carboxyl-terminal tail-mediated protein–protein interactions

(2008) F LIN   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Two pathways for lysophosphatidic acid production

(2008) J AOKI   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Age-Dependent Loss of Sperm Production in Mice via Impaired Lysophosphatidic Acid Signaling1

(2008) Xiaoqin Ye et al.   BIOLOGY OF REPRODUCTION

Identification of non-lipid LPA3 antagonists by virtual screening

(2008) James I. Fells et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cross-talk between LPA1 and Epidermal Growth Factor Receptors Mediates Up-regulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion

(2008) D. Shida et al.   CANCER RESEARCH

Lysophosphatidic acid upregulates vascular endothelial growth factor-C and tube formation in human endothelial cells through LPA1/3, COX-2, and NF-κB activation- and EGFR transactivation-dependent mechanisms

(2008) Chi-Iou Lin et al.   CELLULAR SIGNALLING

Lysophosphatidic Acid Receptors 1 and 2 Play Roles in Regulation of Vascular Injury Responses but Not Blood Pressure

(2008) Manikandan Panchatcharam et al.   CIRCULATION RESEARCH

Inhibition of Lysophosphatidic Acid Receptor-2 Expression by RNA Interference Decreases Lysophosphatidic Acid-induced Urokinase Plasminogen Activator Activation, Cell Invasion, and Migration in Ovarian Cancer SKOV-3 Cells

(2008) Gui-li Wang et al.   CROATIAN MEDICAL JOURNAL

LPA and its Analogs-Attractive Tools for Elucidation of LPA Biology and Drug Development

(2008) Kuniyuki Kano et al.   CURRENT MEDICINAL CHEMISTRY

Lysophosphatidic acid (LPA) and its receptors

(2008) Kyoko Noguchi et al.   CURRENT OPINION IN PHARMACOLOGY

Expression patterns of the lysophospholipid receptor genes during mouse early development

(2008) Hideyo Ohuchi et al.   DEVELOPMENTAL DYNAMICS

Autosomal recessive woolly hair with hypotrichosis caused by a novel homozygous mutation in theP2RY5gene

(2008) Yutaka Shimomura et al.   EXPERIMENTAL DERMATOLOGY

LPA receptor 2 mediates LPA-induced endometrial cancer invasion

(2008) Joanie Mayer Hope et al.   GYNECOLOGIC ONCOLOGY

A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese

(2008) Hideyuki Mototani et al.   HUMAN MOLECULAR GENETICS

Lysophospholipid signaling in the function and pathology of the reproductive system

(2008) X. Ye   HUMAN REPRODUCTION UPDATE

Subtype-specific Residues Involved in Ligand Activation of the Endothelial Differentiation Gene Family Lysophosphatidic Acid Receptors

(2008) William J. Valentine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Farnesyl Pyrophosphate andN-Arachidonylglycine as Endogenous Ligands for GPR92

(2008) Da Young Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysophosphatidic Acid Receptor-dependent Secondary Effects via Astrocytes Promote Neuronal Differentiation

(2008) Tânia Cristina de Sampaio e Spohr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysophosphatidic acid signaling through LPA receptor subtype 1 induces colony scattering of gastrointestinal cancer cells

(2008) Kum-Joo Shin et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Lipid phosphate phosphatases and signaling

(2008) David N. Brindley et al.   JOURNAL OF LIPID RESEARCH

Lysophosphatidic Acid Receptors Determine Tumorigenicity and Aggressiveness of Ovarian Cancer Cells

(2008) Shuangxing Yu et al.   JNCI-Journal of the National Cancer Institute

Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus

(2008) Elisa Matas-Rico et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Role of LPA4/p2y9/GPR23 in Negative Regulation of Cell Motility

(2008) Zendra Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Autotaxin, a Synthetic Enzyme of Lysophosphatidic Acid (LPA), Mediates the Induction of Nerve-Injured Neuropathic Pain

(2008) Makoto Inoue et al.   Molecular Pain

Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors

(2008) Yumi Obo et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

(2008) Sandra M Pasternack et al.   NATURE GENETICS

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

(2008) Hidenobu Kanda et al.   NATURE IMMUNOLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysophosphatidic Acid can Support the Formation of Membranous Structures and an Increase in MBP mRNA Levels in Differentiating Oligodendrocytes

(2008) Luciana Nogaroli et al.   NEUROCHEMICAL RESEARCH

Influence of acetylsalicylate on plasma lysophosphatidic acid level in patients with ischemic cerebral vascular diseases

(2008) Zhen-Guang Li et al.   NEUROLOGICAL RESEARCH

Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid

(2008) M. Inoue et al.   NEUROSCIENCE

Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis

(2008) N Samadi et al.   ONCOGENE

Synthesis, Pharmacology, and Cell Biology ofsn-2-Aminooxy Analogues of Lysophosphatidic Acid

(2008) Joanna Gajewiak et al.   ORGANIC LETTERS

Lysophosphatidic acid-induced oxidized low-density lipoprotein uptake is class A scavenger receptor-dependent in macrophages

(2008) Chi-Lun Chang et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: Relevance to prostate cancer and benign hyperplasia

(2008) Yu Zeng et al.   PROSTATE

Lysophosphatic acid modulates prostaglandin secretion in the bovine uterus

(2008) Izabela Woclawek-Potocka et al.   REPRODUCTION

Measurement of plasma lysophosphatidic acid concentration in healthy subjects: strong correlation with lysophospholipase D activity

(2008) S. Hosogaya et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents

(2007) Hilary P. Beck et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lysophosphatidic acid stimulates astrocyte proliferation through LPA1

(2007) Shinya Shano et al.   NEUROCHEMISTRY INTERNATIONAL

Lysophosphatidic Acid Protects Mesenchymal Stem Cells Against Hypoxia and Serum Deprivation-Induced Apoptosis

(2007) Jinghai Chen et al.   STEM CELLS

Gene expression profiling for the identification of G-protein coupled receptors in human platelets

(2007) Stefan Amisten et al.   THROMBOSIS RESEARCH