Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation

Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation

(2020) Johannes Westman et al.   Frontiers in Immunology

A Pro-resolving Role for Galectin-1 in Acute Inflammation

(2020) Hannah L. Law et al.   Frontiers in Pharmacology

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

(2020) Ioannis Kourtzelis et al.   Frontiers in Immunology

Transcriptomic Analysis of Monocyte-Derived Non-Phagocytic Macrophages Favors a Role in Limiting Tissue Repair and Fibrosis

(2020) Sergei Butenko et al.   Frontiers in Immunology

Untangling “NETosis” from NETs

(2019) Shida Yousefi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study

(2019) Ravi Lokwani et al.   BMJ Open

Mediators of the Resolution of the Inflammatory Response

(2019) Michelle A. Sugimoto et al.   TRENDS IN IMMUNOLOGY

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation

(2019) Saroj Nepal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells

(2019) Beatrice Lazzaretto et al.   JOURNAL OF IMMUNOLOGY

Characterization of the Dynamic Behavior of Neutrophils Following Influenza Vaccination

(2019) Diego Ulisse Pizzagalli et al.   Frontiers in Immunology

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of macrophage activation by proteins expressed on apoptotic neutrophils: subversion towards autoimmunity by proteinase 3

(2018) Nathalie Thieblemont et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

(2018) Ioannis Kourtzelis et al.   NATURE IMMUNOLOGY

CCL5 Promotes Resolution-Phase Macrophage Reprogramming in Concert with the Atypical Chemokine Receptor D6 and Apoptotic Polymorphonuclear Cells

(2017) Miran Aswad et al.   JOURNAL OF IMMUNOLOGY

Mild acidosis delays neutrophil apoptosis via multiple signaling pathways and acts in concert with inflammatory mediators

(2017) Driss El Kebir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil extracellular traps contribute to the pathogenesis of acid-aspiration-induced ALI/ARDS

(2017) Haitao Li et al.   Oncotarget

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming

(2017) Eduardo Reátegui et al.   Nature Biomedical Engineering

Neutrophil heterogeneity: implications for homeostasis and pathogenesis

(2016) C. Silvestre-Roig et al.   BLOOD

Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives

(2016) Julio Lahoz-Beneytez et al.   BLOOD

Aged neutrophils contribute to the first line of defense in the acute inflammatory response

(2016) B. Uhl et al.   BLOOD

Tumor-Associated Neutrophils Show Phenotypic and Functional Divergence in Human Lung Cancer

(2016) Shilpi Saha et al.   CANCER CELL

Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis

(2016) Spencer A. Freeman et al.   CELL

Phagocytosis: An Immunobiologic Process

(2016) Siamon Gordon   IMMUNITY

Neutrophil swarming: an essential process of the neutrophil tissue response

(2016) Korbinian Kienle et al.   IMMUNOLOGICAL REVIEWS

Neutrophil extracellular traps — the dark side of neutrophils

(2016) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1

(2016) Juliana P. Vago et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming

(2016) Xiaoliang Wang et al.   JOURNAL OF IMMUNOLOGY

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human neutrophils: Their role in cancer and relation to myeloid-derived suppressor cells

(2016) Katrin Moses et al.   SEMINARS IN IMMUNOLOGY

Reverse Migration of Neutrophils: Where, When, How, and Why?

(2016) Sussan Nourshargh et al.   TRENDS IN IMMUNOLOGY

Proton pump inhibitors protect mice from acute systemic inflammation and induce long-term cross-tolerance

(2016) E Balza et al.   Cell Death & Disease

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo

(2015) Bartomeu Colom et al.   IMMUNITY

Platelet-derived HMGB1 is a critical mediator of thrombosis

(2015) Sebastian Vogel et al.   JOURNAL OF CLINICAL INVESTIGATION

Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation

(2015) Simon McArthur et al.   JOURNAL OF IMMUNOLOGY

Mature Cystic Fibrosis Airway Neutrophils Suppress T Cell Function: Evidence for a Role of Arginase 1 but Not Programmed Death-Ligand 1

(2015) Sarah A. Ingersoll et al.   JOURNAL OF IMMUNOLOGY

Neutrophils rapidly transit inflamed lymphatic vessel endothelium via integrin-dependent proteolysis and lipoxin-induced junctional retraction

(2015) David A. Rigby et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In the eye of the neutrophil swarm-navigation signals that bring neutrophils together in inflamed and infected tissues

(2015) Tim Lämmermann   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil plasticity: acquisition of phenotype and functionality of antigen-presenting cell

(2015) A. Takashima et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

MET is required for the recruitment of anti-tumoural neutrophils

(2015) Veronica Finisguerra et al.   NATURE

Neutrophil Recruitment to Lymph Nodes Limits Local Humoral Response to Staphylococcus aureus

(2015) Olena Kamenyeva et al.   PLoS Pathogens

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

(2015) Philipp Kruger et al.   PLoS Pathogens

Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T-cell responses

(2014) Natascha Köstlin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung Diseases

(2014) D. Hartl et al.   JOURNAL OF IMMUNOLOGY

Phagocytosis of Staphylococcus aureus by Human Neutrophils Prevents Macrophage Efferocytosis and Induces Programmed Necrosis

(2014) M. C. Greenlee-Wacker et al.   JOURNAL OF IMMUNOLOGY

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Differential Expression of Granulopoiesis Related Genes in Neutrophil Subsets Distinguished by Membrane Expression of CD177

(2014) Nan Hu et al.   PLoS One

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

Characterization of a novel mouse model with genetic deletion of CD177

(2014) Qing Xie et al.   Protein & Cell

The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

(2013) Masayuki Morita et al.   CELL

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Whatˈs your age again? Determination of human neutrophil half-lives revisited

(2013) Tamar Tak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Activation of neutrophils by autocrine IL-17A–IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2

(2013) Patricia R Taylor et al.   NATURE IMMUNOLOGY

The Human Neutrophil Subsets Defined by the Presence or Absence of OLFM4 Both Transmigrate into Tissue In Vivo and Give Rise to Distinct NETs In Vitro

(2013) Amanda Welin et al.   PLoS One

Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity

(2013) Carmelo Carmona-Rivera et al.   Seminars in Immunopathology

A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread

(2012) Wolfgang Kastenmüller et al.   CELL

The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation

(2012) Ester Pashover-Schallinger et al.   FASEB JOURNAL

Neutrophils Transport Antigen from the Dermis to the Bone Marrow, Initiating a Source of Memory CD8+ T Cells

(2012) Darragh Duffy et al.   IMMUNITY

Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis

(2012) Baptiste N. Jaeger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Olfactomedin 4 Inhibits Cathepsin C-Mediated Protease Activities, Thereby Modulating Neutrophil Killing of Staphylococcus aureus and Escherichia coli in Mice

(2012) W. Liu et al.   JOURNAL OF IMMUNOLOGY

Proteinase 3 Contributes to Transendothelial Migration of NB1-Positive Neutrophils

(2012) C. J. Kuckleburg et al.   JOURNAL OF IMMUNOLOGY

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

(2012) Mehmet A Eskan et al.   NATURE IMMUNOLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils

(2012) Zvi G. Fridlender et al.   PLoS One

Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

(2012) S. Bozinovski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy

(2012) Chin-Chih Lin et al.   Scientific Reports

Inflammatory Gout: Observations over a Half-Century

(2011) Stephen E. Malawista et al.   FASEB JOURNAL

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

(2011) Daeho Park et al.   NATURE

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

(2011) Abigail Woodfin et al.   NATURE IMMUNOLOGY

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival

(2011) Andrew Oberst et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature

(2010) M. Pederzoli-Ribeil et al.   BLOOD

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model

(2010) Jadwiga Jablonska et al.   JOURNAL OF CLINICAL INVESTIGATION

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or Roscovitine: Evidence for an Innate Neutrophil Disturbance

(2010) Sandra Moriceau et al.   Journal of Innate Immunity

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Junctional Adhesion Molecule-C Mediates Leukocyte Infiltration in Response to Ischemia Reperfusion Injury

(2009) Christoph Scheiermann et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophils phagocytose activated platelets in vivo: a phosphatidylserine, P-selectin, and  2 integrin-dependent cell clearance program

(2009) N. Maugeri et al.   BLOOD

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

Dynamics of Neutrophil Migration in Lymph Nodes during Infection

(2008) Tatyana Chtanova et al.   IMMUNITY

Integrin-dependent phagocytosis - spreading from microadhesion to new concepts

(2008) A. G. Dupuy et al.   JOURNAL OF CELL SCIENCE

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

(2008) N. C. Peters et al.   SCIENCE