Lysophosphatidic Acid Receptor 5 Plays a Pathogenic Role in Brain Damage after Focal Cerebral Ischemia by Modulating Neuroinflammatory Responses

Neuroinflammation: friend and foe for ischemic stroke

(2019) Richard L. Jayaraj et al.   Journal of Neuroinflammation

Lysophosphatidic acid receptor 1 (LPA1) plays critical roles in microglial activation and brain damage after transient focal cerebral ischemia

(2019) Bhakta Prasad Gaire et al.   Journal of Neuroinflammation

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

(2019) Ioanna Plastira et al.   Frontiers in Cellular Neuroscience

S1P2 contributes to microglial activation and M1 polarization following cerebral ischemia through ERK1/2 and JNK

(2019) Arjun Sapkota et al.   Scientific Reports

Ischaemic stroke

(2019) Bruce C. V. Campbell et al.   Nature Reviews Disease Primers

Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells

(2018) Kaori Fukushima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches

(2018) Shashank Shekhar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lysophosphatidic acid induces neuronal cell death via activation of asparagine endopeptidase in cerebral ischemia-reperfusion injury

(2018) Chao Wang et al.   EXPERIMENTAL NEUROLOGY

LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model

(2018) Ryoko Tsukahara et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neurotransmitters in the mediation of cerebral ischemic injury

(2018) Diana Mayor et al.   NEUROPHARMACOLOGY

2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

(2018) William J. Powers et al.   STROKE

Identifying lysophosphatidic acid receptor subtype 1 (LPA1) as a novel factor to modulate microglial activation and their TNF-α production by activating ERK1/2

(2018) Jin Hyun Kwon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway

(2018) Fengchen Zhang et al.   Journal of Neuroinflammation

Lysophosphatidic acid receptor type 2 activation contributes to secondary damage after spinal cord injury in mice

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The Impact of Tumor Necrosis Factor-α and Interleukin-1β Levels and Polymorphisms on Long-Term Stroke Outcomes

(2017) Ju-Wan Kim et al.   EUROPEAN NEUROLOGY

Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

(2017) I. Plastira et al.   Journal of Neuroinflammation

Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1

(2017) Hiroki Kittaka et al.   JOURNAL OF PHYSIOLOGY-LONDON

Stroke

(2017) Graeme J Hankey   LANCET

Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents

(2017) Nobuhito Murai et al.   NEUROPHARMACOLOGY

1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype

(2016) Ioanna Plastira et al.   Journal of Neuroinflammation

Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

(2016) Xiangrong Liu et al.   STROKE

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inflammatory Responses in Brain Ischemia

(2015) Masahito Kawabori et al.   CURRENT MEDICINAL CHEMISTRY

Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury

(2015) E. Santos-Nogueira et al.   JOURNAL OF NEUROSCIENCE

Oxymatrine attenuated hypoxic-ischemic brain damage in neonatal rats via improving antioxidant enzyme activities and inhibiting cell death

(2015) Peng Zhao et al.   NEUROCHEMISTRY INTERNATIONAL

Lysophosphatidic Acid Signaling in the Nervous System

(2015) Yun C. Yung et al.   NEURON

The Ischemic Environment Drives Microglia and Macrophage Function

(2015) Stefano Fumagalli et al.   Frontiers in Neurology

Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke

(2014) Qin Jin et al.   BRAIN BEHAVIOR AND IMMUNITY

Innate Inflammatory Responses in Stroke: Mechanisms and Potential Therapeutic Targets

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Bipolar/rod-shaped microglia are proliferating microglia with distinct M1/M2 phenotypes

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Involvement of LPA1 receptor signaling in cerebral ischemia-induced neuropathic pain

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Lysophospholipids and their receptors in the central nervous system

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Lysophosphatidic acid: Chemical signature of neuropathic pain

(2012) Hiroshi Ueda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

LPA5receptor plays a role in pain sensitivity, emotional exploration and reversal learning

(2012) Z. Callaerts-Vegh et al.   GENES BRAIN AND BEHAVIOR

Targeted Deletion of LPA5Identifies Novel Roles for Lysophosphatidic Acid Signaling in Development of Neuropathic Pain

(2012) Mu-En Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory Cytokines in Experimental and Human Stroke

(2012) Kate Lykke Lambertsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus

(2011) Y. C. Yung et al.   Science Translational Medicine

Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection

(2010) Hai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics

Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke

(2009) Junying Yuan   APOPTOSIS

Unique Ligand Selectivity of the GPR92/LPA5Lysophosphatidate Receptor Indicates Role in Human Platelet Activation

(2009) Jesica R. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Biological roles of lysophospholipid receptors revealed by genetic null mice: An update

(2008) J CHOI   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Identification of Farnesyl Pyrophosphate andN-Arachidonylglycine as Endogenous Ligands for GPR92

(2008) Da Young Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of acetylsalicylate on plasma lysophosphatidic acid level in patients with ischemic cerebral vascular diseases

(2008) Zhen-Guang Li et al.   NEUROLOGICAL RESEARCH