DAMPening Inflammation by Modulating TLR Signalling

Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A

(2014) N. Cheng et al.   JOURNAL OF IMMUNOLOGY

Low Molecular Weight Hyaluronic Acid Increases the Self-Defense of Skin Epithelium by Induction of  -Defensin 2 via TLR2 and TLR4

(2014) S. Gariboldi et al.   JOURNAL OF IMMUNOLOGY

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-  Production in Human Monocytes

(2014) J. H. Youn et al.   JOURNAL OF IMMUNOLOGY

Recent Advances in Hsp90 Inhibitors as Antitumor Agents

(2012) S. Messaoudi et al.   Anti-Cancer Agents in Medicinal Chemistry

ORIGINAL ARTICLE: Antiphospholipid Antibodies Induce a Pro-Inflammatory Response in First Trimester Trophoblast Via the TLR4/MyD88 Pathway

(2009) Melissa J. Mulla et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Expression and Role of Myeloid-related Protein-14 in Clinical and Experimental Sepsis

(2009) Marieke A. D. van Zoelen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Experimental Therapeutic Strategies for Severe Sepsis

(2009) William R. Parrish et al.   Annals of the New York Academy of Sciences

Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

(2009) Clett Erridge et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia

(2009) Gina Ziegler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Heat shock protein 60 causes osteoclastic bone resorption via toll-like receptor-2 in estrogen deficiency

(2009) Jung-Min Koh et al.   BONE

The biological role and regulation of versican levels in cancer

(2009) Carmela Ricciardelli et al.   CANCER AND METASTASIS REVIEWS

Potent Triazolothione Inhibitor of Heat-Shock Protein-90

(2009) Richard I. Feldman et al.   Chemical Biology & Drug Design

Myeloid-Related Protein-8/14 Is Critical for the Biological Response to Vascular Injury

(2009) Kevin Croce et al.   CIRCULATION

Targeting Toll-like Receptors in Autoimmunity

(2009) K. Midwood et al.   CURRENT DRUG TARGETS

Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes

(2009) S. Devaraj et al.   DIABETOLOGIA

TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1β and caspase-1 in monocytes and dendritic cells

(2009) Julia Hurst et al.   IMMUNOBIOLOGY

Human antiphospholipid antibodies induce TNFα in monocytes via Toll-like receptor 8

(2009) Yvonne Döring et al.   IMMUNOBIOLOGY

Partial role of TLR4 as a receptor responding to damage-associated molecular pattern

(2009) Kyung-Mi Lee et al.   IMMUNOLOGY LETTERS

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DAMPs ramp up drug toxicity

(2009) Jacquelyn J. Maher   JOURNAL OF CLINICAL INVESTIGATION

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome

(2009) Avlin B. Imaeda et al.   JOURNAL OF CLINICAL INVESTIGATION

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering

(2009) A.-C. Raby et al.   JOURNAL OF IMMUNOLOGY

Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis

(2009) Shaival H. Davé et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Low-dose cisplatin administration in murine cecal ligation and puncture prevents the systemic release of HMGB1 and attenuates lethality

(2009) P. Pan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Heat shock proteins and immune system

(2009) Min-Fu Tsan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The inhibition of neutrophil elastase ameliorates mouse liver damage due to ischemia and reperfusion

(2009) Yoichiro Uchida et al.   LIVER TRANSPLANTATION

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

Inflaming metastasis

(2009) Alberto Mantovani   NATURE

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses

(2009) G. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

SIVELESTAT (SELECTIVE NEUTROPHIL ELASTASE INHIBITOR) IMPROVES THE MORTALITY RATE OF SEPSIS ASSOCIATED WITH BOTH ACUTE RESPIRATORY DISTRESS SYNDROME AND DISSEMINATED INTRAVASCULAR COAGULATION PATIENTS

(2009) Mineji Hayakawa et al.   SHOCK

CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns

(2009) Yang Liu et al.   TRENDS IN IMMUNOLOGY

MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis

(2009) Dawn M. E. Bowdish et al.   PLoS Pathogens

Neuropeptides Rescue Mice from Lethal Sepsis by Down-regulating Secretion of the Late-Acting Inflammatory Mediator High Mobility Group Box 1

(2008) Alejo Chorny et al.   AMERICAN JOURNAL OF PATHOLOGY

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

(2008) John W. Rice et al.   ARTHRITIS AND RHEUMATISM

Construction and characterization of the HMGB1 mutant as a competitive antagonist to HMGB1 induced cytokines release

(2008) Zhiqiang Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2

(2008) R. L. He et al.   BLOOD

Requirements for a lead compound to become a clinical candidate

(2008) Franz F Hefti   BMC NEUROSCIENCE

Heparanase is overexpressed in lung cancer and correlates inversely with patient survival

(2008) Esti Cohen et al.   CANCER

Expression of heat shock protein 90 at the cell surface in human neuroblastoma cells

(2008) Cristina Cid et al.   CELL STRESS & CHAPERONES

Toll-Like Receptor 2 Mediates Apolipoprotein CIII–Induced Monocyte Activation: Retracted

(2008) Akio Kawakami et al.   CIRCULATION RESEARCH

Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

(2008) Yun Soo Bae et al.   CIRCULATION RESEARCH

Hyperelongated biglycan: the surreptitious initiator of atherosclerosis

(2008) Peter J Little et al.   CURRENT OPINION IN LIPIDOLOGY

Signalling adaptors used by Toll-like receptors: An update

(2008) Elaine F. Kenny et al.   CYTOKINE

When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction

(2008) Luke A.J. O'Neill   IMMUNITY

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY

Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity

(2008) Andreas Schaeffler et al.   IMMUNOLOGY

A Neutrophil Elastase Inhibitor, Sivelestat, Reduces Lung Injury Following Endotoxin-Induced Shock in Rats by Inhibiting HMGB1

(2008) Satoshi Hagiwara et al.   INFLAMMATION

Human neutrophil elastase: Mediator and therapeutic target in atherosclerosis

(2008) P HENRIKSEN et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculaturein vivo

(2008) Alessandra Villa et al.   INTERNATIONAL JOURNAL OF CANCER

Genetic variation in heat shock protein 70 is associated with septic shock: narrowing the association to a specific haplotype

(2008) C. Kee et al.   International Journal of Immunogenetics

Clinical Significance of Serum HMGB-1 and sRAGE Levels in Systemic Sclerosis: Association with Disease Severity

(2008) Ayumi Yoshizaki et al.   JOURNAL OF CLINICAL IMMUNOLOGY

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

(2008) Karen A. Cavassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

(2008) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma

(2008) Ryuhei Nishino et al.   JOURNAL OF HEPATOLOGY

Pivotal Advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis

(2008) Åsa Andersson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Is serum amyloid A an endogenous TLR4 agonist?

(2008) Silvana Sandri et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics

(2008) Elissa J. Chesler et al.   MAMMALIAN GENOME

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(2008) John Klune et al.   MOLECULAR MEDICINE

Patients with multiple sclerosis resisted to glucocorticoid therapy: abnormal expression of heat-shock protein 90 in glucocorticoid receptor complex

(2008) M Matysiak et al.   Multiple Sclerosis Journal

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

(2008) Aurelien Trompette et al.   NATURE

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE

ROLE OF NEUTROPHIL ELASTASE IN DEVELOPMENT OF PULMONARY VASCULAR INJURY AND SEPTIC SHOCK IN RATS

(2008) Naoaki Harada et al.   SHOCK

Functional Toll-like receptor 4 mutations modulate the response to fibrinogen

(2008) Kunal Patel et al.   THROMBOSIS AND HAEMOSTASIS

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

(2008) David S Pisetsky et al.   ARTHRITIS RESEARCH & THERAPY

The role of high-mobility group box 1 protein in the pathogenesis of autoimmune diseases

(2008) Reinhard E. Voll et al.   Current Rheumatology Reports

Extracellular Superoxide Dismutase Protects Against Matrix Degradation of Heparan Sulfate in the Lung

(2007) Corrine R. Kliment et al.   ANTIOXIDANTS & REDOX SIGNALING