Lysophosphatidic acid receptor 1 (LPA1) plays critical roles in microglial activation and brain damage after transient focal cerebral ischemia

Involvement of LPA-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain

(2018) Hiroshi Ueda et al.   PAIN

Identifying lysophosphatidic acid receptor subtype 1 (LPA1) as a novel factor to modulate microglial activation and their TNF-α production by activating ERK1/2

(2018) Jin Hyun Kwon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization

(2018) Bhakta Prasad Gaire et al.   Journal of Neuroinflammation

Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

(2017) I. Plastira et al.   Journal of Neuroinflammation

Identification of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1) as a Pathogenic Factor in Transient Focal Cerebral Ischemia

(2017) Bhakta Prasad Gaire et al.   MOLECULAR NEUROBIOLOGY

Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey

(2017) Eli Shobin et al.   GeroScience

1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype

(2016) Ioanna Plastira et al.   Journal of Neuroinflammation

Promising Pharmacological Directions in the World of Lysophosphatidic Acid Signaling

(2015) Nicole C. Stoddard et al.   Biomolecules & Therapeutics

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inflammatory Responses in Brain Ischemia

(2015) Masahito Kawabori et al.   CURRENT MEDICINAL CHEMISTRY

Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury

(2015) E. Santos-Nogueira et al.   JOURNAL OF NEUROSCIENCE

Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling

(2015) Eunjung Moon et al.   MEDIATORS OF INFLAMMATION

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

(2015) Ruey-Horng Shih et al.   Frontiers in Molecular Neuroscience

Neuroprotective Effect of 6-Paradol in Focal Cerebral Ischemia Involves the Attenuation of Neuroinflammatory Responses in Activated Microglia

(2015) Bhakta Prasad Gaire et al.   PLoS One

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage

(2013) Roslyn A. Taylor et al.   Clinical & Developmental Immunology

LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

(2013) Norihiko Sakai et al.   FASEB JOURNAL

Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi

(2013) LiZe Gu et al.   Journal of Neuroinflammation

Involvement of LPA1 receptor signaling in cerebral ischemia-induced neuropathic pain

(2013) S.K. Halder et al.   NEUROSCIENCE

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Lysophospholipids and their receptors in the central nervous system

(2012) Ji Woong Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

An Automated Method to Quantify Microglia Morphology and Application to Monitor Activation State Longitudinally In Vivo

(2012) Cleopatra Kozlowski et al.   PLoS One

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma

(2011) Flavia V. Castelino et al.   ARTHRITIS AND RHEUMATISM

NF-κB and innate immunity in ischemic stroke

(2010) Olivier A. Harari et al.   Annals of the New York Academy of Sciences

Lysophosphatidic Acid Level and the Incidence of Silent Brain Infarction in Patients with Nonvalvular Atrial Fibrillation

(2010) Zhen-Guang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microglial activation mediates de novo lysophosphatidic acid production in a model of neuropathic pain

(2010) Lin Ma et al.   JOURNAL OF NEUROCHEMISTRY

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture

(2009) Eva Bernhart et al.   PROTEOMICS

NCX1 Expression and Functional Activity Increase in Microglia Invading the Infarct Core

(2009) Francesca Boscia et al.   STROKE

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications

(2008) T Weichhart et al.   ANNALS OF THE RHEUMATIC DISEASES

Astrocytes and Ischemic Injury

(2008) T. Takano et al.   STROKE

Lysophosphatidic acid stimulates astrocyte proliferation through LPA1

(2007) Shinya Shano et al.   NEUROCHEMISTRY INTERNATIONAL