Group X Secreted Phospholipase A2Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility

The role of group IIF-secreted phospholipase A2in epidermal homeostasis and hyperplasia

(2015) Kei Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical role of phospholipase A2group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection

(2015) Rahul Vijay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Group V Secreted Phospholipase A2Is Upregulated by IL-4 in Human Macrophages and Mediates Phagocytosis via Hydrolysis of Ethanolamine Phospholipids

(2015) Julio M. Rubio et al.   JOURNAL OF IMMUNOLOGY

A new era of secreted phospholipase A2

(2015) Makoto Murakami et al.   JOURNAL OF LIPID RESEARCH

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut

(2015) Jun Kunisawa et al.   Scientific Reports

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

(2014) L. H. Boudreau et al.   BLOOD

The Adipocyte-Inducible Secreted Phospholipases PLA2G5 and PLA2G2E Play Distinct Roles in Obesity

(2014) Hiroyasu Sato et al.   Cell Metabolism

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Lack of group X secreted phospholipase A2 increases survival following pandemic H1N1 influenza infection

(2014) Alyson A. Kelvin et al.   VIROLOGY

Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity

(2014) Erwan Pernet et al.   Nature Communications

Regulation and Function of Epithelial Secreted Phospholipase A2Group X in Asthma

(2013) Teal S. Hallstrand et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Group X Secreted Phospholipase A2 Limits the Development of Atherosclerosis in LDL Receptor–Null Mice

(2013) Hafid Ait-Oufella et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

The Immune System as a Sensor of the Metabolic State

(2013) Justin I. Odegaard et al.   IMMUNITY

Lymphoid tissue phospholipase A2group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators

(2013) Yoshimi Miki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Group V Secretory Phospholipase A2 Is Involved in Macrophage Activation and Is Sufficient for Macrophage Effector Functions in Allergic Pulmonary Inflammation

(2013) S. Ohta et al.   JOURNAL OF IMMUNOLOGY

Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2–DP1 receptor paracrine axis

(2013) Yoshitaka Taketomi et al.   NATURE IMMUNOLOGY

Specialized Proresolving Mediators Enhance Human B Cell Differentiation to Antibody-Secreting Cells

(2012) S. Ramon et al.   JOURNAL OF IMMUNOLOGY

Group X secretory PLA2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice

(2011) Kazuhiro Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation

(2011) Ryan G. Holzer et al.   CELL

Experimental Inflammatory Bowel Disease: Insights into the Host-Microbiota Dialog

(2011) Maya Saleh et al.   IMMUNITY

Physiological Roles of Group X-secreted Phospholipase A2in Reproduction, Gastrointestinal Phospholipid Digestion, and Neuronal Function

(2011) Hiroyasu Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hair Follicular Expression and Function of Group X Secreted Phospholipase A2in Mouse Skin

(2011) Kei Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

Omega-3 Fatty Acid-Derived Mediators 17(R)-Hydroxy Docosahexaenoic Acid, Aspirin-Triggered Resolvin D1 and Resolvin D2 Prevent Experimental Colitis in Mice

(2011) A. F. Bento et al.   JOURNAL OF IMMUNOLOGY

Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models

(2010) Shuntaro Hara et al.   BIOCHIMIE

CCR7/CCR9: knockin' on the thymus door

(2010) N. Taylor   BLOOD

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

A novel anti-inflammatory role for secretory phospholipase A2in immune complex-mediated arthritis

(2010) Eric Boilard et al.   EMBO Molecular Medicine

Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models

(2010) Xia Li et al.   FASEB JOURNAL

Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis

(2010) Yoshiko Iizuka et al.   FASEB JOURNAL

Eosinophil Cysteinyl Leukotriene Synthesis Mediated by Exogenous Secreted Phospholipase A2Group X

(2010) Ying Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response

(2010) Hiroyuki Ariyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice

(2010) Jessica Escoffier et al.   JOURNAL OF CLINICAL INVESTIGATION

Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice

(2010) Hiroyasu Sato et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory activity of polyunsaturated fatty acids in T-cell signaling

(2010) Wooki Kim et al.   PROGRESS IN LIPID RESEARCH

Docosapentaenoic acid (22:5n-3): A review of its biological effects

(2010) Gunveen Kaur et al.   PROGRESS IN LIPID RESEARCH

Recent progress in phospholipase A2 research: From cells to animals to humans

(2010) Makoto Murakami et al.   PROGRESS IN LIPID RESEARCH

Settling the thymus: immigration requirements

(2009) Jason G. Cyster   JOURNAL OF EXPERIMENTAL MEDICINE

Group V Secretory Phospholipase A2 Modulates Phagosome Maturation and Regulates the Innate Immune Response against Candida albicans

(2009) B. Balestrieri et al.   JOURNAL OF IMMUNOLOGY

Group X Phospholipase A2 Stimulates the Proliferation of Colon Cancer Cells by Producing Various Lipid Mediators

(2009) F. Surrel et al.   MOLECULAR PHARMACOLOGY

Biochemistry and Physiology of Mammalian Secreted Phospholipases A2

(2008) Gérard Lambeau et al.   Annual Review of Biochemistry

Reduced Colitis-Associated Colon Cancer in Fat-1 (n-3 Fatty Acid Desaturase) Transgenic Mice

(2008) Q. Jia et al.   CANCER RESEARCH

Reduction in Myocardial Ischemia/Reperfusion Injury in Group X Secretory Phospholipase A 2 –Deficient Mice

(2008) Daisuke Fujioka et al.   CIRCULATION

Analyses of Group III Secreted Phospholipase A2Transgenic Mice Reveal Potential Participation of This Enzyme in Plasma Lipoprotein Modification, Macrophage Foam Cell Formation, and Atherosclerosis

(2008) Hiroyasu Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Secretory Phospholipase A2Group X Enhances Anti-inflammatory Responses, Promotes Lipid Accumulation, and Contributes to Aberrant Lung Pathology

(2008) Daniëlle M. J. Curfs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroaxonal Dystrophy Caused by Group VIA Phospholipase A2 Deficiency in Mice: A Model of Human Neurodegenerative Disease

(2008) K. Shinzawa et al.   JOURNAL OF NEUROSCIENCE