Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment

The future of immune checkpoint cancer therapy after PD-1 and CTLA-4

(2017) Andrew W Hahn et al.   Immunotherapy

TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action

(2017) Wenwen Du et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression

(2017) Canan Kasikara et al.   MOLECULAR CANCER RESEARCH

Antitumor Synergism and Enhanced Survival with a Tumor Vasculature–Targeted Enzyme Prodrug System, Rapamycin, and Cyclophosphamide

(2017) John J. Krais et al.   MOLECULAR CANCER THERAPEUTICS

Characterization of the scrambling domain of the TMEM16 family

(2017) Sayuri Gyobu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands

(2017) Greg Lemke   TRENDS IN BIOCHEMICAL SCIENCES

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

(2016) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

Programmed Cell Death During Caenorhabditis elegans Development

(2016) Barbara Conradt et al.   GENETICS

Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo

(2016) Chang Sup Lee et al.   IMMUNITY

The C-Terminal Acidic Region of Calreticulin Mediates Phosphatidylserine Binding and Apoptotic Cell Phagocytosis

(2016) Sanjeeva Joseph Wijeyesakere et al.   JOURNAL OF IMMUNOLOGY

Detection of cancer cells using SapC-DOPS nanovesicles

(2016) Harold W. Davis et al.   Molecular Cancer

Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation

(2016) Claudia Z. Han et al.   NATURE

Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation

(2016) Thomas Welte et al.   NATURE CELL BIOLOGY

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure

(2016) Jun Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Programmed Cell Death During Caenorhabditis elegans Development

(2016) Barbara Conradt et al.   GENETICS

Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma

(2016) B. D. Freimark et al.   Cancer Immunology Research

Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells

(2016) E. J. Brea et al.   Cancer Immunology Research

Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response

(2016) Viralkumar Davra et al.   Cancers

Unbiased Selection of Peptide–Peptoid Hybrids Specific for Lung Cancer Compared to Normal Lung Epithelial Cells

(2015) Jaya M. Matharage et al.   ACS Chemical Biology

TAM Receptor Signaling in Immune Homeostasis

(2015) Carla V. Rothlin et al.   Annual Review of Immunology

Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer

(2015) Kristin J. Lastwika et al.   CANCER RESEARCH

Induction of PD-L1 Expression by the EML4-ALK Oncoprotein and Downstream Signaling Pathways in Non-Small Cell Lung Cancer

(2015) K. Ota et al.   CLINICAL CANCER RESEARCH

Atomic structure of the apoptosome: mechanism of cytochromec- and dATP-mediated activation of Apaf-1

(2015) Mengying Zhou et al.   GENES & DEVELOPMENT

Apoptotic cell recognition receptors and scavenger receptors

(2015) Kristen K. Penberthy et al.   IMMUNOLOGICAL REVIEWS

Upregulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-Driven NSCLC: Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation

(2015) Nan Chen et al.   Journal of Thoracic Oncology

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets

(2015) Toshihiro Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure

(2015) Katsumori Segawa et al.   TRENDS IN CELL BIOLOGY

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

(2015) W. Peng et al.   Cancer Discovery

Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells

(2015) Mikaella Vouri et al.   Oncotarget

The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs

(2015) Yanna Tang et al.   Oncotarget

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic ‘eat-me’ signals: cleavage and inhibition of phagocytosis by Lp-PLA2

(2014) V A Tyurin et al.   CELL DEATH AND DIFFERENTIATION

Exposure of Phosphatidylserine by Xk-related Protein Family Members during Apoptosis

(2014) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo

(2014) Manikandan Subramanian et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphatidylserine-targeted bimodal liposomal nanoparticles for in vivo imaging of breast cancer in mice

(2014) Liang Zhang et al.   JOURNAL OF CONTROLLED RELEASE

High Mobility Group Protein-1 Inhibits Phagocytosis of Apoptotic Neutrophils through Binding to Phosphatidylserine

(2014) G. Liu et al.   JOURNAL OF IMMUNOLOGY

Tim4- and MerTK-Mediated Engulfment of Apoptotic Cells by Mouse Resident Peritoneal Macrophages

(2014) C. Nishi et al.   MOLECULAR AND CELLULAR BIOLOGY

The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis

(2014) Ronald S. Flannagan et al.   MOLECULAR BIOLOGY OF THE CELL

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Diversification of TAM receptor tyrosine kinase function

(2014) Anna Zagórska et al.   NATURE IMMUNOLOGY

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia

(2014) Fargol Mazaheri et al.   Nature Communications

PD-L1 Expression in Triple-Negative Breast Cancer

(2014) E. A. Mittendorf et al.   Cancer Immunology Research

Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity

(2014) Stanley Gititu Kimani et al.   Frontiers in Immunology

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

PD-L1 on Tumor Cells Is Induced in Ascites and Promotes Peritoneal Dissemination of Ovarian Cancer through CTL Dysfunction

(2013) K. Abiko et al.   CLINICAL CANCER RESEARCH

Inducers of immunogenic cancer cell death

(2013) Aleksandra M. Dudek et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Crosstalk between ER stress and immunogenic cell death

(2013) Oliver Kepp et al.   CYTOKINE & GROWTH FACTOR REVIEWS

T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response

(2013) Eugenio A. Carrera Silva et al.   IMMUNITY

Phosphatidylserine recognition and induction of apoptotic cell clearance by Drosophila engulfment receptor Draper

(2013) Tran Thanh Tung et al.   JOURNAL OF BIOCHEMISTRY

Integrin αPS3/βν-mediated Phagocytosis of Apoptotic Cells and Bacteria inDrosophila

(2013) Saori Nonaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

(2013) Rebecca S. Cook et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

PTEN functions as a melanoma tumor suppressor by promoting host immune response

(2013) Y Dong et al.   ONCOGENE

Surface code—biophysical signals for apoptotic cell clearance

(2013) Mona Biermann et al.   PHYSICAL BIOLOGY

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Biology of the TAM Receptors

(2013) G. Lemke   Cold Spring Harbor Perspectives in Biology

Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization

(2013) Yu-Zen Chen et al.   Nature Communications

Phosphatidylserine-Targeting Antibody Induces M1 Macrophage Polarization and Promotes Myeloid-Derived Suppressor Cell Differentiation

(2013) Y. Yin et al.   Cancer Immunology Research

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

C. elegans Secreted Lipid-Binding Protein NRF-5 Mediates PS Appearance on Phagocytes for Cell Corpse Engulfment

(2012) Yan Zhang et al.   CURRENT BIOLOGY

CED-1, CED-7, and TTR-52 Regulate Surface Phosphatidylserine Expression on Apoptotic and Phagocytic Cells

(2012) James Mapes et al.   CURRENT BIOLOGY

Complement Component C1q Regulates Macrophage Expression of Mer Tyrosine Kinase To Promote Clearance of Apoptotic Cells

(2012) M. D. Galvan et al.   JOURNAL OF IMMUNOLOGY

Jedi-1 and MEGF10 Signal Engulfment of Apoptotic Neurons through the Tyrosine Kinase Syk

(2012) J. L. Scheib et al.   JOURNAL OF NEUROSCIENCE

Cross Talk between Engulfment Receptors Stabilin-2 and Integrin  v 5 Orchestrates Engulfment of Phosphatidylserine-Exposed Erythrocytes

(2012) S. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

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(2012) Kasey Davis et al.   MOLECULAR MEDICINE

The emergence of phox-ER stress induced immunogenic apoptosis

(2012) Abhishek D. Garg et al.   OncoImmunology

Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA

(2011) Mark Mackiewicz et al.   BREAST CANCER RESEARCH AND TREATMENT

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Development of bavituximab, a vascular targeting agent with immune-modulating properties, for lung cancer treatment

(2011) Paul DeRose et al.   Immunotherapy

Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways

(2011) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Constitutive exposure of phosphatidylserine on viable cells

(2011) K. Segawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malignant transformation in melanocytes is associated with increased production of procoagulant microvesicles

(2011) Luize Lima et al.   THROMBOSIS AND HAEMOSTASIS

Disturbances of apoptotic cell clearance in systemic lupus erythematosus

(2011) Wen-Hai Shao et al.   ARTHRITIS RESEARCH & THERAPY

Desirable cell death during anticancer chemotherapy

(2010) Clara Locher et al.   Annals of the New York Academy of Sciences

Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

(2010) L. Aymeric et al.   CANCER RESEARCH

Engulfment of Apoptotic Cells in C. elegans Is Mediated by Integrin α/SRC Signaling

(2010) Tsung-Yuan Hsu et al.   CURRENT BIOLOGY

Clearance of apoptotic cells: implications in health and disease

(2010) Michael R. Elliott et al.   JOURNAL OF CELL BIOLOGY

Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce β-chemokines

(2010) M. Anthony Moody et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor

(2010) Xiaochen Wang et al.   NATURE CELL BIOLOGY

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner

(2009) Luize G. Lima et al.   CANCER LETTERS

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Antiphosphatidylserine Antibody Combined with Irradiation Damages Tumor Blood Vessels and Induces Tumor Immunity in a Rat Model of Glioblastoma

(2009) J. He et al.   CLINICAL CANCER RESEARCH

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

AnnexinA5 renders dead tumor cells immunogenic—implications for multimodal cancer therapies

(2009) Benjamin Frey et al.   Journal of Immunotoxicology

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor

(2009) Hsiao-Huei Wu et al.   NATURE NEUROSCIENCE

Innate apoptotic immunity: the calming touch of death

(2008) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

The immunogenicity of tumor cell death

(2008) Oliver Kepp et al.   CURRENT OPINION IN ONCOLOGY

Phagocytic Receptor CED-1 Initiates a Signaling Pathway for Degrading Engulfed Apoptotic Cells

(2008) Xiaomeng Yu et al.   PLOS BIOLOGY