The renaissance of anti-neoplastic immunity from tumor cell demise

Long-term use of antibiotics and risk of colorectal adenoma

(2017) Yin Cao et al.   GUT

The in vivo evidence for regulated necrosis

(2017) Wulf Tonnus et al.   IMMUNOLOGICAL REVIEWS

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

High-Intensity Focused Ultrasound– and Radiation Therapy–Induced Immuno-Modulation: Comparison and Potential Opportunities

(2017) Roberta Cirincione et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Talimogene Laherparepvec (T-VEC) and Other Oncolytic Viruses for the Treatment of Melanoma

(2016) Praveen K. Bommareddy et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma

(2016) Irina V. Tiper et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

(2016) Emeric Limagne et al.   CANCER RESEARCH

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

(2016) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

Radiopharmaceuticals for metastatic bone pain palliation: available options in the clinical domain and their comparisons

(2016) Tapas Das et al.   CLINICAL & EXPERIMENTAL METASTASIS

PD-1 Blockade Boosts Radiofrequency Ablation-Elicited Adaptive Immune Responses against Tumor

(2016) L. Shi et al.   CLINICAL CANCER RESEARCH

HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma

(2016) Hong Zheng et al.   CLINICAL CANCER RESEARCH

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF

(2016) Tsuguhide Takeshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGE2 induced in and released by dying cells functions as an inhibitory DAMP

(2016) Sho Hangai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Chemotherapy-induced uridine diphosphate release promotes breast cancer metastasis through P2Y6 activation

(2016) Xiaobin Ma et al.   Oncotarget

Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

(2016) Heng Yang et al.   OncoImmunology

Immune infiltrate in cancer

(2015) Gautier Stoll et al.   Aging-US

STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells

(2015) Heng Yang et al.   CANCER RESEARCH

Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor- B to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer

(2015) J. Peng et al.   CANCER RESEARCH

The Role of TLR4 in Chemotherapy-Driven Metastasis

(2015) S. Ran   CANCER RESEARCH

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14

(2015) J. J. Fong et al.   EMBO JOURNAL

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

(2015) Robert H.I. Andtbacka et al.   JOURNAL OF CLINICAL ONCOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Therapy-induced tumour secretomes promote resistance and tumour progression

(2015) Anna C. Obenauf et al.   NATURE

Natural and therapy-induced immunosurveillance in breast cancer

(2015) Guido Kroemer et al.   NATURE MEDICINE

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity

(2015) K Cao et al.   ONCOGENE

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death

(2015) K Moriwaki et al.   Cell Death & Disease

Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies

(2015) Gautier Stoll et al.   Oncotarget

CD8+/FOXP3+-ratio in osteosarcoma microenvironment separates survivors from non-survivors: a multicenter validated retrospective study

(2015) Benedikt Fritzsching et al.   OncoImmunology

Immunosuppressive Myeloid Cells Induced by Chemotherapy Attenuate Antitumor CD4+ T-Cell Responses through the PD-1-PD-L1 Axis

(2014) Z.-C. Ding et al.   CANCER RESEARCH

IL-17A Produced by    T Cells Promotes Tumor Growth in Hepatocellular Carcinoma

(2014) S. Ma et al.   CANCER RESEARCH

Tumor-infiltrating dendritic cells exhibit defective cross-presentation of tumor antigens, but is reversed by chemotherapy

(2014) Alison M. McDonnell et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death

(2014) Konstantin Neumann et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Harnessing the potential of epigenetic therapy to target solid tumors

(2014) Nita Ahuja et al.   JOURNAL OF CLINICAL INVESTIGATION

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

(2014) Xiaqiong Wang et al.   NATURE IMMUNOLOGY

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Targeting heat shock proteins in metastatic castration-resistant prostate cancer

(2014) Arun A. Azad et al.   Nature Reviews Urology

 1 Integrin Inhibition Elicits a Prometastatic Switch Through the TGF -miR-200-ZEB Network in E-Cadherin-Positive Triple-Negative Breast Cancer

(2014) H. H. Truong et al.   Science Signaling

Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy

(2014) D. Zamarin et al.   Science Translational Medicine

Activation-induced necroptosis contributes to B-cell lymphopenia in active systemic lupus erythematosus

(2014) H Fan et al.   Cell Death & Disease

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Targeting Cancer-Derived Adenosine:New Therapeutic Approaches

(2014) A. Young et al.   Cancer Discovery

Immune-related gene signatures predict the outcome of neoadjuvant chemotherapy

(2014) Gautier Stoll et al.   OncoImmunology

Autophagy-dependent ATP release from dying cells via lysosomal exocytosis

(2013) Yidan Wang et al.   Autophagy

CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

(2013) Yuting Ma et al.   CANCER RESEARCH

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Dendritic cell c-kit signaling and adaptive immunity

(2013) Timothy B. Oriss et al.   Current Opinion in Allergy and Clinical Immunology

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

Cancer immunotherapy using tumor cryoablation

(2013) Abhinav Sidana   Immunotherapy

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

(2013) John R. Lukens et al.   NATURE

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

(2013) S. Viaud et al.   SCIENCE

Molecularly targeted cancer therapy: some lessons from the past decade

(2013) Min Huang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tumor necrosis factor is dispensable for the success of immunogenic anticancer chemotherapy

(2013) Yuting Ma et al.   OncoImmunology

Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-tumor T cell immunity in vivo

(2012) Miki Tongu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Inflammation-mediated genomic instability: roles of activation-induced cytidine deaminase in carcinogenesis

(2012) Takahiro Shimizu et al.   CANCER SCIENCE

Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer

(2012) Ivan Shevchenko et al.   INTERNATIONAL JOURNAL OF CANCER

Cyclophosphamide Promotes Chronic Inflammation–Dependent Immunosuppression and Prevents Antitumor Response in Melanoma

(2012) Alexandra Sevko et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

In Vivo Evaluation of a Cancer Therapy Strategy Combining HSV1716-Mediated Oncolysis with Gene Transfer and Targeted Radiotherapy

(2012) A. Sorensen et al.   JOURNAL OF NUCLEAR MEDICINE

Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

(2012) Axel Hauschild et al.   LANCET

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

(2012) L. Senovilla et al.   SCIENCE

Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors

(2011) S. R. Mattarollo et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

(2011) Yuting Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-Term Results of Radiofrequency Ablation Treatment of Stage I Non-small Cell Lung Cancer: A Prospective Intention-to-Treat Study

(2011) Marcello Carlo Ambrogi et al.   Journal of Thoracic Oncology

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum Amyloid A Protein in Clinical Cancer Diagnosis

(2011) Chibo Liu   PATHOLOGY & ONCOLOGY RESEARCH

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Management of febrile neutropenia: ESMO Clinical Practice Guidelines

(2010) J. de Naurois et al.   ANNALS OF ONCOLOGY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Heat shock protein 70 is acute phase reactant: response elicited by tumor treatment with photodynamic therapy

(2010) Soroush Merchant et al.   CELL STRESS & CHAPERONES

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

(2010) Michael A. Kohanski et al.   MOLECULAR CELL

Metronomic chemotherapy: new rationale for new directions

(2010) Eddy Pasquier et al.   Nature Reviews Clinical Oncology

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis

(2010) S. L. Osborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFN-γ-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancer

(2010) Matteo Martini et al.   VACCINE

Lymphopenia as a Prognostic Factor for Overall Survival in Advanced Carcinomas, Sarcomas, and Lymphomas

(2009) Isabelle Ray-Coquard et al.   CANCER RESEARCH

Tumor-mediated down-regulation of MHC class II in DC development is attributable to the epigenetic control of the CIITA type I promoter

(2009) Young-Eun Choi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Administration of Cyclophosphamide Changes the Immune Profile of Tumor-bearing Mice

(2009) Pu Liu et al.   JOURNAL OF IMMUNOTHERAPY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Myeloablative chemotherapy with autologous hematopoietic progenitor cell rescue for childhood central nervous system tumors

(2008) A Marachelian et al.   BONE MARROW TRANSPLANTATION

Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3+ Regulatory T Cells

(2008) S. Ladoire et al.   CLINICAL CANCER RESEARCH

A strategy for systemic delivery of the oncolytic herpes virus HSV1716: redirected tropism by antibody-binding sites incorporated on the virion surface as a glycoprotein D fusion protein

(2008) J Conner et al.   GENE THERAPY

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY