Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

(2019) Cheng-cheng Zhang et al.   APOPTOSIS

Hypoxia promotes colorectal cancer cell migration and invasion in a SIRT1-dependent manner

(2019) Shentong Yu et al.   Cancer Cell International

S-nitrosylation of the Peroxiredoxin-2 promotes S-nitrosoglutathione-mediated lung cancer cells apoptosis via AMPK-SIRT1 pathway

(2019) Yihan Zhang et al.   Cell Death & Disease

Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways

(2019) José Esparza-López et al.   BMC CANCER

The role of an anti-diabetic drug metformin in the treatment of endocrine tumors

(2019) Shilpa Thakur et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Programmed necrosis and its role in management of breast cancer

(2019) Banita Thakur et al.   PATHOLOGY RESEARCH AND PRACTICE

Identification and functional characterization of the transcription factor NF-κB subunit p65 in common carp (Cyprinus carpio L.)

(2019) Shijuan Shan et al.   FISH & SHELLFISH IMMUNOLOGY

Metformin attenuates hepatoma cell proliferation by decreasing glycolytic flux through the HIF-1α/PFKFB3/PFK1 pathway

(2019) La Hu et al.   LIFE SCIENCES

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

(2018) Yubin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells

(2018) Shuhua Ji et al.   EXPERIMENTAL CELL RESEARCH

SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells

(2018) Yao Wu et al.   EXPERIMENTAL CELL RESEARCH

Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri

(2018) Shan Liu et al.   FISH & SHELLFISH IMMUNOLOGY

Apoptosis as a Prognostic Factor in Colorectal Carcinoma

(2018) Nenad Kunac et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells

(2018) Yu Tai et al.   Acta Pharmaceutica Sinica B

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Oogenesis, vitellogenin-mediated ovarian degeneration and immune response in the annual fish Nothobranchius guentheri

(2017) Tingting Liu et al.   FISH & SHELLFISH IMMUNOLOGY

Live-cell visualization of gasdermin D-driven pyroptotic cell death

(2017) Joseph K. Rathkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

FOXQ1 regulates senescence-associated inflammation via activation of SIRT1 expression

(2017) Pan Wang et al.   Cell Death & Disease

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Resveratrol Regulates Colorectal Cancer Cell Invasion by Modulation of Focal Adhesion Molecules

(2017) Constanze Buhrmann et al.   Nutrients

Racial differences in the expression of inhibitors of apoptosis (IAP) proteins in extracellular vesicles (EV) from prostate cancer patients

(2017) Salma Khan et al.   PLoS One

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability

(2016) Hui Wang et al.   AGING CELL

Mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone induces vasorelaxation without involving KATPchannel activation in smooth muscle cells of arteries

(2016) Yan-Qiu Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency

(2016) Reza Yazdani et al.   MOLECULAR IMMUNOLOGY

Inhibitory effect of metformin combined with gemcitabine on pancreatic cancer cells in vitro and in vivo

(2016) Yuqi Shi et al.   Molecular Medicine Reports

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metformin as a new anti-cancer drug in adrenocortical carcinoma

(2016) Giada Poli et al.   Oncotarget

Sirtuins Link Inflammation and Metabolism

(2016) Vidula T. Vachharajani et al.   Journal of Immunology Research

Serum-dependent processing of late apoptotic cells and their immunogenicity

(2015) Ying Yu Liang et al.   APOPTOSIS

Premature aging/senescence in cancer cells facing therapy: good or bad?

(2015) Llilians Calvo Gonzalez et al.   BIOGERONTOLOGY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Optimal chemotherapy for advanced gastric cancer: is there a global consensus?

(2013) Florian Lordick et al.   Gastric Cancer

Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway

(2013) GAO YI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Metabolic roles of AMPK and metformin in cancer cells

(2013) Yeon Kyung Choi et al.   MOLECULES AND CELLS

Low Concentrations of Metformin Selectively Inhibit CD133+ Cell Proliferation in Pancreatic Cancer and Have Anticancer Action

(2013) Shanmiao Gou et al.   PLoS One

Mitochondrial dysfunction in breast cancer cells prevents tumor growth

(2012) Rosa Sanchez-Alvarez et al.   CELL CYCLE

Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects

(2012) M A Pierotti et al.   ONCOGENE

Acetaminophen Induces Human Neuroblastoma Cell Death through NFKB Activation

(2012) Inmaculada Posadas et al.   PLoS One

Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression

(2011) Carina Roth et al.   BMC CANCER

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Metformin, diet and breast cancer: An avenue for chemoprevention

(2011) Paola Muti et al.   CELL CYCLE

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma

(2008) M S Kim et al.   ONCOGENE

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY