Article
Nutrition & Dietetics
Chuanqi Chu, Leilei Yu, Yiwen Li, Hang Guo, Qixiao Zhai, Wei Chen, Fengwei Tian
Summary: Recent studies suggest that disturbances in gut microbiota and microbiota-derived metabolites are associated with the development of Parkinson's disease (PD), and probiotic treatments that restore them might delay disease progression. This study investigated the potential neuroprotective effects of L. plantarum CCFM405 in mice with rotenone-induced PD. The results showed that L. plantarum CCFM405 improved motor deficits, reduced neuronal death, inflammation, and increased dopamine levels in the brains of PD mice. Sequencing of fecal microbiota revealed that L. plantarum CCFM405 normalized the gut bacterial composition and enhanced the biosynthesis of branched-chain amino acids (BCAAs), which played a dominant role in neuroprotection. Overall, L. plantarum CCFM405 could be a potential food supplement for managing PD.
Article
Cell & Tissue Engineering
So-Young Lee, Hyun-Ju An, Jin Man Kim, Min-Ji Sung, Do Kyung Kim, Hyung Kyung Kim, Jongbeom Oh, Hye Yun Jeong, Yu Ho Lee, Taeyoung Yang, Jun Han Kim, Ha Jeong Lim, Soonchul Lee
Summary: PINK1 is critical for mitochondrial quality control and decreasing reactive oxygen species production during osteoblast differentiation. Inhibition of PINK1 leads to impaired osteoblast differentiation and defects in mitochondrial homeostasis, while activation of PINK1 may be a potential treatment target for bone diseases.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Chi-Jing Choong, Hideki Mochizuki, Cesar Borlongan
Summary: Mitochondrial dysregulation is strongly associated with the pathogenesis of Parkinson's disease (PD), with mutated genes affecting mitochondrial features. Disruption of mitochondrial quality control and abnormal secretion of mitochondrial contents play a role in PD, and circulating mitochondrial DNAs can elicit inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Arum Darmastuti, Pratama N. Hasan, Rachma Wikandari, Tyas Utami, Endang S. Rahayu, Dian Anggraini Suroto
Summary: The adhesion properties of Lactobacillus plantarum Dad-13 and Mut-7 to the intestinal mucosa of Sprague Dawley rats were studied, showing their ability to adhere to the surface of the rat intestine. Genomic analysis revealed genes related to adhesion properties in both strains, suggesting their potential role in increasing probiotics' adherence to the intestinal mucosa.
Article
Food Science & Technology
Sendeku Takele Alemneh, Shimelis Admassu Emire, Bernd Hitzmann
Summary: This study evaluated the suitability of a teff-based substrate for developing probiotic functional beverages, finding that both Lactobacillus rhamnosus GG (LGG) and Lactobacillus plantarum A6 (LA6) could grow and produce desired products in the substrate. The combination of the two evaluated lactobacilli strains reduced fermentation time, indicating the potential for producing functional probiotic beverages using teff flour as a substrate without any supplements.
Article
Chemistry, Multidisciplinary
Guy Mann, Gandhesiri Satish, Prasad Sulkshane, Shaswati Mandal, Michael H. Glickman, Ashraf Brik
Summary: Protein post-translational modifications play a crucial role in cellular signaling, but their study in human cells is limited. This study presents the first synthesis, delivery, and cellular study of a stable phosphoubiquitin probe, allowing for direct visualization of Parkin's substrate preference during mitophagy.
CHEMICAL COMMUNICATIONS
(2021)
Article
Cell Biology
Lisa Schwarz, Julia C. Fitzgerald
Summary: The Miro1 S156A mutation leads to a significant depletion of Miro1 protein levels, a slight increase in mitochondrial mass, and slightly lengthened mitochondria. This mutation also causes a significant reduction in mitochondrial oxygen consumption, accompanied by a depletion of OXPHOS complexes III and V.
Article
Food Science & Technology
Yuhan Xu, Qiaoling Xie, Wei Zhang, Meizhen Zhu, Xiaoxuan Chen, Dongbei Guo, Lili Pan, Junru Li, Hui Lan, Hongwei Li
Summary: The effects of probiotics Lp662 and Lp299v on severe inflammatory bowel disease induced by dextran sodium sulfate were evaluated. The results showed that these probiotics can reduce weight loss caused by colitis, decrease tissue injury, and lower inflammatory factor levels. Additionally, probiotics can also increase bone density. Therefore, probiotics have the potential to be a treatment option for inflammatory bowel disease.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Brad Ebanks, Thomas L. Ingram, Gunjan Katyal, John R. Ingram, Nicoleta Moisoi, Lisa Chakrabarti
Summary: Exercise has therapeutic potential in alleviating Parkinson's disease symptoms by enhancing synaptic plasticity, protecting against neuro-inflammation, and modulating signaling pathways. Proteomic profiles of Pink1 deficient fruit flies showed alterations after exercise, but exercising them brought their profiles closer to those of wild-type fruit flies.
Article
Toxicology
Beom Hee Kim, Hyun Chul Koh
Summary: CK2 regulates receptor-mediated mitophagy and is involved in PINK1/Parkin-dependent mitophagy. Whether CK2 regulates PINK1/Parkin-dependent mitophagy in response to stress is not yet clear.
TOXICOLOGY LETTERS
(2023)
Article
Food Science & Technology
Angel Urbina, Fernando Calderon, Santiago Benito
Summary: The study proposes a novel alternative for winemaking by using a combination of different microorganisms to improve wine quality and reduce risks associated with the traditional fermentation process.
Article
Biochemistry & Molecular Biology
Marta Vranas, Yang Lu, Shafqat Rasool, Nathalie Croteau, Jonathan D. Krett, Veronique Sauve, Kalle Gehring, Edward A. Fon, Thomas M. Durcan, Jean-Francois Trempe
Summary: Mutations in Parkin and PINK1 cause early-onset familial Parkinson's disease. The study found that His433 contributes to the catalysis of Parkin and its mutation impairs mitophagy. Mfn2 is a kinetically preferred substrate for Parkin, co-localizing with PINK1 and phospho-ubiquitin upon mitochondrial depolarization.
Article
Pharmacology & Pharmacy
Renato Kovacs, Lorand Erdelyi, Ferenc Fenyvesi, Noemi Balla, Fruzsina Kovacs, Gyoergy Vamosi, Agnes Klusoczki, Alexandra Gyoengyoesi, Ildiko Bacskay, Miklos Vecsernyes, Judit Varadi
Summary: The antimicrobial effect of chitosan and its derivatives has been confirmed on various bacteria and fungi. The tests conducted on pathogenic microorganisms revealed the inhibitory effect mechanism and concentration dependence of chitosan. By adding commercially available chitosan derivatives to a probiotic strain, it was determined that chitosan has a viabilty decreasing effect at concentrations above the minimum inhibitory concentration (MIC). The study also identified increased cell membrane permeability and irreversible interaction between low molecular weight chitosan and bacterial cells.
Article
Food Science & Technology
Liliana Luca, Mircea Oroian
Summary: This study examined the testing of three prebiotics and their effects on the properties and survival rates of microcapsules under different conditions. The extrusion encapsulation technique was found to be effective in producing microcapsules that meet the requirements of the food industry. Using prebiotic encapsulation matrix can increase cell viability and protection, indicating its potential use in probiotic microcapsule production for the food industry.
Review
Biochemistry & Molecular Biology
Chunling Huang, Ji Bian, Qinghua Cao, Xin-Ming Chen, Carol A. Pollock
Summary: Research shows that PINK1 plays a crucial role in regulating mitochondrial function, not only in neuronal diseases but also closely linked to various diseases including kidney diseases. In diabetic kidney disease, PINK1 plays an important physiological role in multiple key cells, making it a promising target for the treatment of diabetic kidney disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Yi Xu, Ting Wang, Jian Kong, Hui-Li Wang
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2015)
Article
Psychiatry
Yi Xu, Xiang-Tao Chen, Man Luo, Yuqing Tang, Guangxiang Zhang, De Wu, Bin Yang, Di-Yun Ruan, Hui-Li Wang
JOURNAL OF PSYCHIATRIC RESEARCH
(2015)
Article
Toxicology
Yulan Wu, Yi Xu, Xiyao Huang, Danlei Ye, Miaomiao Han, Hui-Li Wang
TOXICOLOGICAL SCIENCES
(2018)
Article
Biotechnology & Applied Microbiology
Yi Xu, Jian Kong
JOURNAL OF FOOD PROTECTION
(2013)
Article
Biotechnology & Applied Microbiology
Yan Niu, Jian Kong, Longyun Fu, Jing Yang, Yi Xu
MARINE BIOTECHNOLOGY
(2009)
Article
Microbiology
Yi Xu, Jian Kong, Wentao Kong
Article
Toxicology
Man Luo, Yi Xu, Rong Cai, Yuqing Tang, Meng-Meng Ge, Zhi-Hua Liu, Li Xu, Fan Hu, Di-Yun Ruan, Hui-Li Wang
TOXICOLOGY LETTERS
(2014)
Article
Cell Biology
Xiaozhen Gu, Yi Xu, Wei-Zhen Xue, Yulan Wu, Zi Ye, Guiran Xiao, Hui-Li Wang
CELL DEATH & DISEASE
(2019)
Article
Psychiatry
Jie Xiao, Tian Wang, Yi Xu, Xiaozhen Gu, Danyang Li, Kang Niu, Tiandong Wang, Jing Zhao, Ruiqing Zhou, Hui-Li Wang
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Biotechnology & Applied Microbiology
Yali Li, Yi Xu, Qiaoming Liao, Mengmeng Xie, Han Tao, Hui-Li Wang
Summary: This study demonstrated that the photodynamic efficacy of hypocrellin B can be potentiated by joint action with curcumin, leading to a synergistic activity in controlling the growth of Staphylococcal aureus. The synergistic action may be attributed to the increased type I/type II ratio of reactive oxygen species (ROS). The use of dual photosensitizers reduced microbial contamination of tested apple while maintaining its quality, providing a novel approach to food safety.
MICROBIAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Danyang Li, Hui-Li Wang, Xiyao Huang, Xiaozhen Gu, Weizhen Xue, Yi Xu
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2019)