Pathogenetic Features and Current Management of Glioblastoma

CTLA-4 correlates with immune and clinical characteristics of glioma

(2020) Fangkun Liu et al.   Cancer Cell International

Potential of Glioblastoma-Targeted Chimeric Antigen Receptor (CAR) T-Cell Therapy

(2020) Ryan D. Salinas et al.   CNS DRUGS

Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma

(2020) Antje Wick et al.   INVESTIGATIONAL NEW DRUGS

Nanomedicine and Immunotherapy: A Step Further towards Precision Medicine for Glioblastoma

(2020) Neja Šamec et al.   MOLECULES

EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma

(2020) Nina Struve et al.   ONCOGENE

Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma

(2020) Marion Rabé et al.   Cell Death & Disease

Extracellular Vesicles in Glioblastoma Tumor Microenvironment

(2020) Anuroop Yekula et al.   Frontiers in Immunology

Oncolytic Virus Encoding a Master Pro-Inflammatory Cytokine Interleukin 12 in Cancer Immunotherapy

(2020) Hong-My Nguyen et al.   Cells

Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma

(2020) Jingyu Wang et al.   Frontiers in Oncology

Resistance Mechanisms to Anti-angiogenic Therapies in Cancer

(2020) Yolla Haibe et al.   Frontiers in Oncology

Using Light for Therapy of Glioblastoma Multiforme (GBM)

(2020) Alex Vasilev et al.   Brain Sciences

Immunotherapy for glioma: Current management and future application

(2020) Shengchao Xu et al.   CANCER LETTERS

The Roles of miRNA in Glioblastoma Tumor Cell Communication: Diplomatic and Aggressive Negotiations

(2020) Andrei Buruiană et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Depatuxizumab mafodotin (ABT-414)-induced glioblastoma cell death requires EGFR overexpression, but not EGFRY1068 phosphorylation

(2020) Caroline von Achenbach et al.   MOLECULAR CANCER THERAPEUTICS

Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma

(2020) Bhavesh K. Ahir et al.   MOLECULAR NEUROBIOLOGY

Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions

(2020) Patrick Y Wen et al.   NEURO-ONCOLOGY

Breaking through the glioblastoma micro-environment via extracellular vesicles

(2020) Thomas Simon et al.   ONCOGENE

Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses

(2020) Quazim A. Alayo et al.   Scientific Reports

Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling

(2020) Evan K. Day et al.   Cell Reports

Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma

(2020) Hélène Grégoire et al.   Frontiers in Pharmacology

Advances in the Knowledge of the Molecular Biology of Glioblastoma and Its Impact in Patient Diagnosis, Stratification, and Treatment

(2020) Belén Delgado‐Martín et al.   Advanced Science

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages

(2020) Marta Di Martile et al.   Journal for ImmunoTherapy of Cancer

Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma

(2020) Dipongkor Saha et al.   Journal for ImmunoTherapy of Cancer

Immunotherapy in Glioblastoma: Current Shortcomings and Future Perspectives

(2020) Bas Weenink et al.   Cancers

Oncolytic Herpes Simplex Virus Encoding IL12 Controls Triple-Negative Breast Cancer Growth and Metastasis

(2020) Shanawaz M. Ghouse et al.   Frontiers in Oncology

Concurrent Tumor Treating Fields (TTFields) and Radiation Therapy for Newly Diagnosed Glioblastoma: A Prospective Safety and Feasibility Study

(2020) Felix Bokstein et al.   Frontiers in Oncology

Effective Treatment of Glioblastoma Multiforme With Oncolytic Virotherapy: A Case-Series

(2020) Benjamin Gesundheit et al.   Frontiers in Oncology

Proteasome inhibition for the treatment of glioblastoma

(2020) Patrick Roth et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Targeting the DNA Damage Response to Overcome Cancer Drug Resistance in Glioblastoma

(2020) Alessandra Ferri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

(2019) Wei Yang et al.   Science Translational Medicine

Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target

(2019) Delphine Garnier et al.   Frontiers in Oncology

Treatment of Glioblastoma (GBM) with the Addition of Tumor-Treating Fields (TTF): A Review

(2019) Denise Fabian et al.   Cancers

The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesion

(2019) Laura Pinton et al.   Journal for ImmunoTherapy of Cancer

Triple combination immunotherapy with GVAX, anti-PD-1 monoclonal antibody, and agonist anti-OX40 monoclonal antibody is highly effective against murine intracranial glioma

(2019) Nusrat Jahan et al.   OncoImmunology

Dexamethasone in Glioblastoma Multiforme Therapy: Mechanisms and Controversies

(2019) Marta Cenciarini et al.   Frontiers in Molecular Neuroscience

Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies

(2019) Chrysovalantis Voutouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3

(2019) Maria Paz Ventero et al.   PLoS One

Eradication of glioblastoma by immuno-virotherapy with a retargeted oncolytic HSV in a preclinical model

(2019) Francesco Alessandrini et al.   ONCOGENE

Vessel co-option in cancer

(2019) Elizabeth A. Kuczynski et al.   Nature Reviews Clinical Oncology

Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction

(2019) Sheila Alcantara Llaguno et al.   NATURE NEUROSCIENCE

Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

(2019) Junfei Zhao et al.   NATURE MEDICINE

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

(2019) Timothy F. Cloughesy et al.   NATURE MEDICINE

The Role of Brain Vasculature in Glioblastoma

(2019) J. Robert Kane   MOLECULAR NEUROBIOLOGY

Targeting PI3K in cancer: mechanisms and advances in clinical trials

(2019) Jing Yang et al.   Molecular Cancer

Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice

(2019) Minjee Kim et al.   DRUG METABOLISM AND DISPOSITION

PD-1/PD-L1 immune-checkpoint inhibitors in glioblastoma: A concise review

(2019) Mario Caccese et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

The landscape of the mesenchymal signature in brain tumours

(2019) Jinan Behnan et al.   BRAIN

Phase I/IIa study of concomitant radiotherapy with olaparib and temozolomide in unresectable or partially resectable glioblastoma: OLA-TMZ-RTE-01 trial protocol

(2019) Paul Lesueur et al.   BMC CANCER

Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells

(2019) Cholpon S. Djuzenova et al.   BMC CANCER

Glioma stem cells-derived exosomal miR-26a promotes angiogenesis of microvessel endothelial cells in glioma

(2019) Zhi-Fei Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The third-generation EGFR inhibitor AZD9291 overcomes primary resistance by continuously blocking ERK signaling in glioblastoma

(2019) Xuejiao Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

(2019) Anne Dirkse et al.   Nature Communications

The efficacy and toxicity of ATM inhibition in glioblastoma initiating cells-driven tumor models

(2019) Guido Frosina et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer

(2019) Ryan C. Gimple et al.   GENES & DEVELOPMENT

The Evolving Role of CD8+CD28− Immunosenescent T Cells in Cancer Immunology

(2019) Wei X. Huff et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors

(2019) Danny N. Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

Nanobody-Targeted Photodynamic Therapy Selectively Kills Viral GPCR-Expressing Glioblastoma Cells

(2019) Timo W. M. De Groof et al.   MOLECULAR PHARMACEUTICS

Increased Antiangiogenic Effect by Blocking CCL2-dependent Macrophages in a Rodent Glioblastoma Model: Correlation Study with Dynamic Susceptibility Contrast Perfusion MRI

(2019) Hye Rim Cho et al.   Scientific Reports

Chemotherapeutic Stress Induces Transdifferentiation of Glioblastoma Cells to Endothelial Cells and Promotes Vascular Mimicry

(2019) Shivani Baisiwala et al.   Stem Cells International

Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect

(2019) Nathan Suek et al.   Frontiers in Immunology

Oncolytic Viruses and Immune Checkpoint Inhibition: The Best of Both Worlds

(2019) Venkatesh Sivanandam et al.   Molecular Therapy-Oncolytics

ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells

(2019) Ana Jimenez-Pascual et al.   Cancer Discovery

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

(2019) Erik R. Abels et al.   Cell Reports

Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications

(2019) Esperanza R. Matarredona et al.   Frontiers in Oncology

Vessel co-option in glioblastoma: emerging insights and opportunities

(2019) Giorgio Seano et al.   ANGIOGENESIS

PD-L1/PD-1 Axis in Glioblastoma Multiforme

(2019) Jakub Litak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATIM-14. RESULTS OF PHASE II CLINICAL TRIAL OF ONCOLYTIC HERPES VIRUS G47Δ IN PATIENTS WITH GLIOBLASTOMA

(2019) Tomoki Todo   NEURO-ONCOLOGY

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012–2016

(2019) Quinn T Ostrom et al.   NEURO-ONCOLOGY

Phospho-mTOR expression in human glioblastoma microglia-macrophage cells

(2019) Lucia Lisi et al.   NEUROCHEMISTRY INTERNATIONAL

Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway

(2019) Pauline Deshors et al.   Cell Death & Disease

Engineering dendritic cell vaccines to improve cancer immunotherapy

(2019) Caleb R. Perez et al.   Nature Communications

CAR-Engineered NK Cells for the Treatment of Glioblastoma: Turning Innate Effectors Into Precision Tools for Cancer Immunotherapy

(2019) Michael C. Burger et al.   Frontiers in Immunology

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

(2018) Amelie Griveau et al.   CANCER CELL

Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas

(2018) Sharmistha Pal et al.   CANCER RESEARCH

Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

(2018) Xiuxing Wang et al.   Cell Stem Cell

Cellular origin of glioblastoma and its implication in precision therapy

(2018) Maojin Yao et al.   Cellular & Molecular Immunology

IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma

(2018) Erik Ladomersky et al.   CLINICAL CANCER RESEARCH

Combinatorial Effects of VEGFR Kinase Inhibitor Axitinib and Oncolytic Virotherapy in Mouse and Human Glioblastoma Stem-Like Cell Models

(2018) Dipongkor Saha et al.   CLINICAL CANCER RESEARCH

T-cell Dysfunction in Glioblastoma: Applying a New Framework

(2018) Karolina I. Woroniecka et al.   CLINICAL CANCER RESEARCH

Oncolytic herpes simplex virus immunovirotherapy in combination with immune checkpoint blockade to treat glioblastoma

(2018) Dipongkor Saha et al.   Immunotherapy

Differential Expression and Clinical Significance of Transforming Growth Factor-Beta Isoforms in GBM Tumors

(2018) Laurent-Olivier Roy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

(2018) Linda M. Liau et al.   Journal of Translational Medicine

Restriction of Replication of Oncolytic Herpes Simplex Virus with a Deletion of γ34.5 in Glioblastoma Stem-Like Cells

(2018) Cole Peters et al.   JOURNAL OF VIROLOGY

Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities

(2018) Yazhuo Zhang et al.   Molecular Cancer

Nanomedicines in the treatment of brain tumors

(2018) Funmilola A Fisusi et al.   Nanomedicine

INtraoperative photoDYnamic Therapy for GliOblastomas: Study Protocol for a Phase I Clinical Trial

(2018) Clément Dupont et al.   NEUROSURGERY

Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies

(2018) Zhenyi An et al.   ONCOGENE

Current Challenges and Opportunities in Treating Glioblastoma

(2018) Andrea Shergalis et al.   PHARMACOLOGICAL REVIEWS

Prognostic significance of epidermal growth factor receptor expression in glioma patients

(2018) Junhong Li et al.   OncoTargets and Therapy

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

(2018) Fred C. Lam et al.   Nature Communications

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

(2018) Xia Liu et al.   Nature Communications

Enhanced proteasomal activity is essential for long term survival and recurrence of innately radiation resistant residual glioblastoma cells

(2018) Jacinth Rajendra et al.   Oncotarget

Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival

(2018) Jiri Sana et al.   Scientific Reports

Association of Glioblastoma Multiforme Stem Cell Characteristics, Differentiation, and Microglia Marker Genes with Patient Survival

(2018) Sandra Bien-Möller et al.   Stem Cells International

Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma

(2018) David C. Binder et al.   Translational Cancer Research

Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro

(2018) Rodolfo Garza-Morales et al.   Cancers

Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target

(2018) Ramona Schulz-Heddergott et al.   Cancers

Influence of Hyaluronic Acid Transitions in Tumor Microenvironment on Glioblastoma Malignancy and Invasive Behavior

(2018) Jee-Wei E. Chen et al.   Frontiers in Materials

Oncolytic Virotherapy for Breast Cancer Treatment

(2018) Samia M. O’Bryan et al.   CURRENT GENE THERAPY

Interactions between tumor-associated macrophages and tumor cells in glioblastoma: unraveling promising targeted therapies

(2018) Mony Chenda Morisse et al.   Expert Review of Neurotherapeutics

Phase-2 trial of palbociclib in adult patients with recurrent RB1-positive glioblastoma

(2018) Jennie W. Taylor et al.   JOURNAL OF NEURO-ONCOLOGY

Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma

(2018) Thomas Simon et al.   Molecular Cancer

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Human glioblastoma arises from subventricular zone cells with low-level driver mutations

(2018) Joo Ho Lee et al.   NATURE

Subtype-specific signaling pathways and genomic aberrations associated with prognosis of glioblastoma

(2018) Ae Kyung Park et al.   NEURO-ONCOLOGY

Potential Strategies Overcoming the Temozolomide Resistance for Glioblastoma

(2018) Shabierjiang JIAPAER et al.   NEUROLOGIA MEDICO-CHIRURGICA

Newcastle disease virus enhances the growth-inhibiting and proapoptotic effects of temozolomide on glioblastoma cells in vitro and in vivo

(2018) Yang Bai et al.   Scientific Reports

Aberrant neuronal differentiation is common in glioma but is associated neither with epileptic seizures nor with better survival

(2018) Christoph Patrick Beier et al.   Scientific Reports

Challenges in the Treatment of Glioblastoma: Multisystem Mechanisms of Therapeutic Resistance

(2018) Evan K. Noch et al.   World Neurosurgery

CXCR2-Expressing Tumor Cells Drive Vascular Mimicry in Antiangiogenic Therapy–Resistant Glioblastoma

(2018) Kartik Angara et al.   NEOPLASIA

The p53 Pathway in Glioblastoma

(2018) Ying Zhang et al.   Cancers

The Current Status and Future Prospects of Oncolytic Viruses in Clinical Trials against Melanoma, Glioma, Pancreatic, and Breast Cancers

(2018) Ibrahim Eissa et al.   Cancers

Mutant p53 as a guardian of the cancer cell

(2018) Fiamma Mantovani et al.   CELL DEATH AND DIFFERENTIATION

­­­­Immunotherapy for Glioblastoma: Adoptive T-cell Strategies

(2018) Bryan D. Choi et al.   CLINICAL CANCER RESEARCH

Expression of PD-1 by T cells in malignant glioma patients reflects exhaustion and activation

(2018) Tom B Davidson et al.   CLINICAL CANCER RESEARCH

Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients

(2018) Daniela Osti et al.   CLINICAL CANCER RESEARCH

Targeting mTOR in Glioblastoma: Rationale and Preclinical/Clinical Evidence

(2018) Carmen Mecca et al.   DISEASE MARKERS

TGF-β1 secreted by M2 phenotype macrophages enhances the stemness and migration of glioma�cells via the SMAD2/3 signalling pathway

(2018) Zhengzheng Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways

(2018) S. Hallal et al.   MOLECULAR NEUROBIOLOGY

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

Anti-vascular endothelial growth factor in glioblastoma: a systematic review and meta-analysis

(2018) Qiuxiang Xiao et al.   NEUROLOGICAL SCIENCES

Extracellular matrix differences in glioblastoma patients with different prognoses

(2018) J�zsef Virga et al.   Oncology Letters

Selective Effects of mTOR Inhibitor Sirolimus on Naïve and CMV-Specific T Cells Extending Its Applicable Range Beyond Immunosuppression

(2018) Szilvia Bak et al.   Frontiers in Immunology

A Critical Overview of Targeted Therapies for Glioblastoma

(2018) Kewal K. Jain   Frontiers in Oncology

A systematic review: differentiation of stem cells into functional pericytes

(2017) Jianguang Xu et al.   FASEB JOURNAL

Overcoming therapeutic resistance in glioblastoma: the way forward

(2017) Satoru Osuka et al.   JOURNAL OF CLINICAL INVESTIGATION

Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Study of Onartuzumab Plus Bevacizumab Versus Placebo Plus Bevacizumab in Patients With Recurrent Glioblastoma: Efficacy, Safety, and Hepatocyte Growth Factor and O6-Methylguanine–DNA Methyltransferase Biomarker Analyses

(2017) Timothy Cloughesy et al.   JOURNAL OF CLINICAL ONCOLOGY

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

(2017) Michael Weller et al.   LANCET ONCOLOGY

Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development

(2017) Hua-fu Zhao et al.   Molecular Cancer

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

(2017) Beatrice S Melin et al.   NATURE GENETICS

Glioblastoma on a microfluidic chip: Generating pseudopalisades and enhancing aggressiveness through blood vessel obstruction events

(2017) Jose M. Ayuso et al.   NEURO-ONCOLOGY

Glioblastoma stem cell differentiation into endothelial cells evidenced through live-cell imaging

(2017) Xin Mei et al.   NEURO-ONCOLOGY

EGFR heterogeneity and implications for therapeutic intervention in glioblastoma

(2017) Eskil Eskilsson et al.   NEURO-ONCOLOGY

Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

(2017) Jann N Sarkaria et al.   NEURO-ONCOLOGY

Type I and Type II Photosensitized Oxidation Reactions: Guidelines and Mechanistic Pathways

(2017) Maurício S. Baptista et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

(2017) Donald M. O’Rourke et al.   Science Translational Medicine

Delivery of Exogenous miR-124 to Glioblastoma Multiform Cells by Wharton’s Jelly Mesenchymal Stem Cells Decreases Cell Proliferation and Migration, and Confers Chemosensitivity

(2017) S. Sharif et al.   Stem Cell Reviews and Reports

Bevacizumab in Colorectal Cancer: Current Role in Treatment and the Potential of Biosimilars

(2017) Lee S. Rosen et al.   Targeted Oncology

The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection

(2017) Andrea M. Muscat et al.   Oncotarget

Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update

(2017) Laure Malric et al.   Oncotarget

Glioma stem cells-derived exosomes promote the angiogenic ability of endothelial cells through miR-21/VEGF signal

(2017) Xu Sun et al.   Oncotarget

Advances in epigenetic glioblastoma therapy

(2017) Dong Hoon Lee et al.   Oncotarget

Recurrent glioma clinical trial, CheckMate-143: the game is not over yet

(2017) Anna C. Filley et al.   Oncotarget

PDGF Family Expression in Glioblastoma Multiforme: Data Compilation from Ivy Glioblastoma Atlas Project Database

(2017) Isabella Gomes Cantanhede et al.   Scientific Reports

Vaccination in the immunotherapy of glioblastoma

(2017) Ziren Kong et al.   Human Vaccines & Immunotherapeutics

Delivery of Exogenous miR-124 to Glioblastoma Multiform Cells by Wharton’s Jelly Mesenchymal Stem Cells Decreases Cell Proliferation and Migration, and Confers Chemosensitivity

(2017) S. Sharif et al.   Stem Cell Reviews and Reports

Advances in Immunotherapy for Glioblastoma Multiforme

(2017) Boyuan Huang et al.   Journal of Immunology Research

Tumor-infiltrating lymphocytes (TILs) from patients with glioma

(2017) Zhenjiang Liu et al.   OncoImmunology

The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8 + T Cell Anti-tumor Activity

(2017) Anne Kleijn et al.   Molecular Therapy-Oncolytics

PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies

(2017) Anne Perdrix et al.   Cancers

The prognostic value of cytotoxic T-lymphocyte antigen 4 in cancers: a systematic review and meta-analysis

(2017) Pingping Hu et al.   Scientific Reports

New photosensitizers for photodynamic therapy

(2016) H. Abrahamse et al.   BIOCHEMICAL JOURNAL

Survival in glioblastoma: a review on the impact of treatment modalities

(2016) P. D. Delgado-López et al.   Clinical & Translational Oncology

Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

(2016) Jennifer E. Kim et al.   CLINICAL CANCER RESEARCH

Ipilimumab and Bevacizumab in Glioblastoma

(2016) T. Carter et al.   CLINICAL ONCOLOGY

Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic

(2016) N. M. Teplyuk et al.   EMBO Molecular Medicine

T-Cell Therapy Enabling Adenoviruses Coding for IL2 and TNFα Induce Systemic Immunomodulation in Mice With Spontaneous Melanoma

(2016) Siri Tähtinen et al.   JOURNAL OF IMMUNOTHERAPY

Advances in immunotherapy for the treatment of glioblastoma

(2016) Amanda Tivnan et al.   JOURNAL OF NEURO-ONCOLOGY

Inhibition of glioblastoma cell proliferation, migration and invasion by the proteasome antagonist carfilzomib

(2016) Zammam Areeb et al.   MEDICAL ONCOLOGY

Adenoviral Delivery of Tumor Necrosis Factor-α and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma

(2016) Mikko Siurala et al.   MOLECULAR THERAPY

Vascular endothelial growth factor: a neurovascular target in neurological diseases

(2016) Christian Lange et al.   Nature Reviews Neurology

M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma

(2016) Alexandra Pisklakova et al.   NEURO-ONCOLOGY

CXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone

(2016) Nicolas Goffart et al.   NEURO-ONCOLOGY

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

(2016) Christine E. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined therapy of oncolytic adenovirus and temozolomide enhances lung cancer virotherapy in vitro and in vivo

(2016) Jorge G. Gomez-Gutierrez et al.   VIROLOGY

Crossing the barrier: treatment of brain tumors using nanochain particles

(2016) Efstathios Karathanasis et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways

(2016) Kunxin Luo   Cold Spring Harbor Perspectives in Biology

Inhibition of histone deacetylases sensitizes glioblastoma cells to lomustine

(2016) Mikkel Staberg et al.   CELLULAR ONCOLOGY

IL-10 secreted by M2 macrophage promoted tumorigenesis through interaction with JAK2 in glioma

(2016) Ling Qi et al.   Oncotarget

Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status

(2016) Mariia Patyka et al.   Oncotarget

CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study

(2016) Viveka Nand Yadav et al.   Oncotarget

Inhibition of miR-21 in glioma cells using catalytic nucleic acids

(2016) Agnieszka Belter et al.   Scientific Reports

Oncolytic herpes simplex virus interactions with the host immune system

(2016) Dipongkor Saha et al.   Current Opinion in Virology

Vascular Transdifferentiation in the CNS: A Focus on Neural and Glioblastoma Stem-Like Cells

(2016) Sophie Guelfi et al.   Stem Cells International

Prognostic value of preoperative von Willebrand factor plasma levels in patients with Glioblastoma

(2016) Giovanni Marfia et al.   Cancer Medicine

Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain

(2015) Se Jeong Lee et al.   BMC CANCER

Exploring the antitumor effect of virus in malignant glioma

(2015)   DRUGS OF THE FUTURE

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High levels of c-Met is associated with poor prognosis in glioblastoma

(2015) Stine Asferg Petterson et al.   JOURNAL OF NEURO-ONCOLOGY

The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

(2015) J. Canon et al.   MOLECULAR CANCER THERAPEUTICS

Comprehensive analysis of microRNA expression profile in malignant glioma tissues

(2015) Monika Piwecka et al.   Molecular Oncology

Nanoparticle-Delivered Antisense MicroRNA-21 Enhances the Effects of Temozolomide on Glioblastoma Cells

(2015) Jeyarama S. Ananta et al.   MOLECULAR PHARMACEUTICS

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Prospects of immune checkpoint modulators in the treatment of glioblastoma

(2015) Matthias Preusser et al.   Nature Reviews Neurology

Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma

(2015) Melissa M. Singh et al.   NEURO-ONCOLOGY

Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation

(2015) Shuli Xia et al.   NEURO-ONCOLOGY

Immunosuppressive mechanisms in glioblastoma: Fig. 1.

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

Histone Deacetylase Inhibitors Resensitize EGFR/EGFRvIII-Overexpressing, Erlotinib-Resistant Glioblastoma Cells to Tyrosine Kinase Inhibition

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Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

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