The landscape of the mesenchymal signature in brain tumours

Multiclonal tumor origin: Evidence and implications

(2018) Barbara L. Parsons   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

(2018) Ana C. deCarvalho et al.   NATURE GENETICS

An anatomic transcriptional atlas of human glioblastoma

(2018) Ralph B. Puchalski et al.   SCIENCE

Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas

(2017) C. J. Herting et al.   GLIA

Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression

(2017) Vita Fedele et al.   MOLECULAR CANCER RESEARCH

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

(2017) Jin-Ku Lee et al.   NATURE GENETICS

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

(2017) Xun Jin et al.   NATURE MEDICINE

Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma

(2017) James R. Perry et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and characterization of a new source of adult human neural progenitors

(2017) Jinan Behnan et al.   Cell Death & Disease

Blocking epithelial-to-mesenchymal transition in glioblastoma with a sextet of repurposed drugs: the EIS regimen

(2017) Richard E. Kast et al.   Oncotarget

Identification of a Druggable Pathway Controlling Glioblastoma Invasiveness

(2017) Nora Pencheva et al.   Cell Reports

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples

(2016) Frank Szulzewsky et al.   GLIA

Divergent clonal selection dominates medulloblastoma at recurrence

(2016) A. Sorana Morrissy et al.   NATURE

Clonal evolution of glioblastoma under therapy

(2016) Jiguang Wang et al.   NATURE GENETICS

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide

(2016) Ralf S. Schmid et al.   NEURO-ONCOLOGY

Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency

(2016) J Behnan et al.   ONCOGENE

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

(2016) Anna Segerman et al.   Cell Reports

Ultrasonic Surgical Aspirate is a Reliable Source For Culturing Glioblastoma Stem Cells

(2016) Jinan Behnan et al.   Scientific Reports

DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors

(2015) Tali Mazor et al.   CANCER CELL

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes

(2015) Sheila R. Alcantara Llaguno et al.   CANCER CELL

STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma

(2015) J. Lau et al.   CANCER RESEARCH

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

(2015) Hoon Kim et al.   GENOME RESEARCH

Stromal contribution to the colorectal cancer transcriptome

(2015) Claudio Isella et al.   NATURE GENETICS

Changes in the EGFR amplification and EGFRvIII expression between paired primary and recurrent glioblastomas

(2015) Martin J. van den Bent et al.   NEURO-ONCOLOGY

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

(2015) Jeanette E. Eckel-Passow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Precursor States of Brain Tumor Initiating Cell Lines Are Predictive of Survival in Xenografts and Associated with Glioblastoma Subtypes

(2015) Carlo Cusulin et al.   Stem Cell Reports

Endogenous Brain Pericytes Are Widely Activated and Contribute to Mouse Glioma Microvasculature

(2015) Andreas Svensson et al.   PLoS One

Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1

(2015) Kiran Kumar Velpula et al.   Oncotarget

Most Human Non-GCIMP Glioblastoma Subtypes Evolve from a Common Proneural-like Precursor Glioma

(2014) Tatsuya Ozawa et al.   CANCER CELL

Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy

(2014) B Auffinger et al.   CELL DEATH AND DIFFERENTIATION

Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial

(2014) Walter Taal et al.   LANCET ONCOLOGY

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

(2014) Olivier L. Chinot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of gene expression patterns across 12 tumor types identifies a cancer supercluster characterized by TP53 mutations and cell cycle defects

(2014) E Martínez et al.   ONCOGENE

Molecular Subtypes of Glioblastoma Are Relevant to Lower Grade Glioma

(2014) Xiaowei Guan et al.   PLoS One

In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift

(2014) J. Halliday et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma

(2014) B. J. Gill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Modeling Adult Gliomas Using RCAS/t-va Technology

(2014) Dolores Hambardzumyan et al.   Translational Oncology

Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression

(2014) J. P. Sullivan et al.   Cancer Discovery

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Phase II Study of Bevacizumab in Combination with Sorafenib in Recurrent Glioblastoma (N0776): A North Central Cancer Treatment Group Trial

(2013) E. Galanis et al.   CLINICAL CANCER RESEARCH

Tumor-Infiltrating Lymphocytes in Glioblastoma Are Associated with Specific Genomic Alterations and Related to Transcriptional Class

(2013) W. C. Rutledge et al.   CLINICAL CANCER RESEARCH

Acquired Resistance to Anti-VEGF Therapy in Glioblastoma Is Associated with a Mesenchymal Transition

(2013) Y. Piao et al.   CLINICAL CANCER RESEARCH

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

(2013) Florian A. Siebzehnrubl et al.   EMBO Molecular Medicine

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

(2013) B. E. Johnson et al.   SCIENCE

Recruited Brain Tumor-Derived Mesenchymal Stem Cells Contribute to Brain Tumor Progression

(2013) Jinan Behnan et al.   STEM CELLS

Patient-Specific Orthotopic Glioblastoma Xenograft Models Recapitulate the Histopathology and Biology of Human Glioblastomas In Situ

(2013) Kyeung Min Joo et al.   Cell Reports

The Tumor Microenvironment Strongly Impacts Master Transcriptional Regulators and Gene Expression Class of Glioblastoma

(2012) Lee A.D. Cooper et al.   AMERICAN JOURNAL OF PATHOLOGY

VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex

(2012) Kan V. Lu et al.   CANCER CELL

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Studying a Complex Tumor

(2012) Siyuan Zheng et al.   CANCER JOURNAL

Stem-like Tumor-Initiating Cells Isolated from IL13R 2 Expressing Gliomas Are Targeted and Killed by IL13-Zetakine-Redirected T Cells

(2012) C. E. Brown et al.   CLINICAL CANCER RESEARCH

Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF- 1 Signaling Pathway

(2012) X.-z. Ye et al.   JOURNAL OF IMMUNOLOGY

Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial

(2012) Wolfgang Wick et al.   LANCET ONCOLOGY

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype

(2012) Y. Piao et al.   NEURO-ONCOLOGY

The molecular profile of microglia under the influence of glioma

(2012) W. Li et al.   NEURO-ONCOLOGY

A Multi-Cancer Mesenchymal Transition Gene Expression Signature Is Associated with Prolonged Time to Recurrence in Glioblastoma

(2012) Wei-Yi Cheng et al.   PLoS One

Increased Microglia/Macrophage Gene Expression in a Subset of Adult and Pediatric Astrocytomas

(2012) Jane R. Engler et al.   PLoS One

Genetics of adult glioma

(2012) McKinsey L. Goodenberger et al.   Cancer Genetics

Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma

(2011) Chong Liu et al.   CELL

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma

(2011) K. P. L. Bhat et al.   GENES & DEVELOPMENT

Molecular subclassification of diffuse gliomas: Seeing order in the chaos

(2011) Jason T. Huse et al.   GLIA

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Integration and analysis of genome-scale data from gliomas

(2011) Gregory Riddick et al.   Nature Reviews Neurology

Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice

(2011) J. F. de Groot et al.   NEURO-ONCOLOGY

The Temporal Order of Genetic and Pathway Alterations in Tumorigenesis

(2011) Moritz Gerstung et al.   PLoS One

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interobserver variation of the histopathological diagnosis in clinical trials on glioma: a clinician’s perspective

(2010) Martin J. van den Bent   ACTA NEUROPATHOLOGICA

Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA, THBS2 and COL11A1

(2010) Hoon Kim et al.   BMC Medical Genomics

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin

(2010) C. Lottaz et al.   CANCER RESEARCH

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Phase II Study of Bevacizumab Plus Temozolomide During and After Radiation Therapy for Patients With Newly Diagnosed Glioblastoma Multiforme

(2010) Albert Lai et al.   JOURNAL OF CLINICAL ONCOLOGY

BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery

(2010) S. Facchino et al.   JOURNAL OF NEUROSCIENCE

Bevacizumab salvage therapy following progression in high-grade glioma patients treated with VEGF receptor tyrosine kinase inhibitors

(2010) B. J. Scott et al.   NEURO-ONCOLOGY

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

Role of a second chemotherapy in recurrent malignant glioma patients who progress on bevacizumab

(2009) Eudocia C. Quant et al.   NEURO-ONCOLOGY

Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts

(2009) J. Graeme Hodgson et al.   NEURO-ONCOLOGY

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma

(2008) Anastasia Murat et al.   JOURNAL OF CLINICAL ONCOLOGY

Gliomas in Neurofibromatosis Type 1: A Clinicopathologic Study of 100 Patients

(2008) Fausto J. Rodriguez et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE