Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer

Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting

(2019) Ellen M. Langer et al.   Cell Reports

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

(2018) Amelie Griveau et al.   CANCER CELL

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

(2018) Marat S. Pavlyukov et al.   CANCER CELL

Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

(2018) Xiuxing Wang et al.   Cell Stem Cell

Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells

(2018) Jianghong Man et al.   Cell Stem Cell

LncRNA MALAT1/miR-129 axis promotes glioma tumorigenesis by targeting SOX2

(2018) Zhiyong Xiong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis

(2018) Yajuan Zhang et al.   MOLECULAR CELL

Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B

(2018) Mikkel Staberg et al.   Molecular Oncology

AMP kinase promotes glioblastoma bioenergetics and tumour growth

(2018) Rishi Raj Chhipa et al.   NATURE CELL BIOLOGY

Genetically engineered cerebral organoids model brain tumor formation

(2018) Shan Bian et al.   NATURE METHODS

A brave new world of RNA-binding proteins

(2018) Matthias W. Hentze et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncolytic virotherapy in glioblastoma patients induces a tumor macrophage phenotypic shift leading to an altered glioblastoma microenvironment

(2018) Wouter B L van den Bossche et al.   NEURO-ONCOLOGY

Recurrent Glioblastoma Treated with Recombinant Poliovirus

(2018) Annick Desjardins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

(2018) Mariella G. Filbin et al.   SCIENCE

An anatomic transcriptional atlas of human glioblastoma

(2018) Ralph B. Puchalski et al.   SCIENCE

Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance

(2018) Yu Shi et al.   Science Translational Medicine

Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling

(2018) Barbara Oldrini et al.   Nature Communications

Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival

(2018) Jiri Sana et al.   Scientific Reports

The Generation and Application of Patient-Derived Xenograft Model for Cancer Research

(2018) Jaeyun Jung et al.   Cancer Research and Treatment

Glioblastoma Model Using Human Cerebral Organoids

(2018) Junko Ogawa et al.   Cell Reports

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

(2018) Franz L. Ricklefs et al.   Science Advances

Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner

(2018) Andrew Mancini et al.   CANCER CELL

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

(2018) Samuel K. McBrayer et al.   CELL

A metabolic function of FGFR3-TACC3 gene fusions in cancer

(2018) Véronique Frattini et al.   NATURE

Human glioblastoma arises from subventricular zone cells with low-level driver mutations

(2018) Joo Ho Lee et al.   NATURE

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence

(2018) Gabriele Sulli et al.   NATURE

A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma

(2018) J. Matthew Barnes et al.   NATURE CELL BIOLOGY

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

(2018) Johanna Klughammer et al.   NATURE MEDICINE

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

(2018) Pakawat Chongsathidkiet et al.   NATURE MEDICINE

Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor

(2018) Huimin Hu et al.   CELL

N-methyladenine DNA Modification in Glioblastoma

(2018) Qi Xie et al.   CELL

Infiltrative and drug‐resistant slow‐cycling cells support metabolic heterogeneity in glioblastoma

(2018) Lan B Hoang‐Minh et al.   EMBO JOURNAL

Actively personalized vaccination trial for newly diagnosed glioblastoma

(2018) Norbert Hilf et al.   NATURE

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop

(2018) Jun Wang et al.   NATURE NEUROSCIENCE

Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators

(2017) Harry Bulstrode et al.   GENES & DEVELOPMENT

Mutant IDH1 regulates the tumor-associated immune system in gliomas

(2017) Nduka M. Amankulor et al.   GENES & DEVELOPMENT

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma

(2017) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Zika virus has oncolytic activity against glioblastoma stem cells

(2017) Zhe Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Current trends in mouse models of glioblastoma

(2017) Masafumi Miyai et al.   JOURNAL OF NEURO-ONCOLOGY

Serum microRNA profiling in patients with glioblastoma: a survival analysis

(2017) Hua Zhao et al.   Molecular Cancer

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

(2017) Xinjian Li et al.   MOLECULAR CELL

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

(2017) Tyler E. Miller et al.   NATURE

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

(2017) Stephen C. Mack et al.   NATURE

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

(2017) Xiaoyang Lan et al.   NATURE

Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence

(2017) Sevin Turcan et al.   NATURE GENETICS

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

(2017) Xun Jin et al.   NATURE MEDICINE

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

(2017) Xiuxing Wang et al.   NATURE NEUROSCIENCE

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

(2017) Ryan D Chow et al.   NATURE NEUROSCIENCE

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

(2017) Andrew S. Venteicher et al.   SCIENCE

Tumor-homing cytotoxic human induced neural stem cells for cancer therapy

(2017) Juli R. Bagó et al.   Science Translational Medicine

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

(2017) Donald M. O’Rourke et al.   Science Translational Medicine

PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3

(2017) Jorge A. Benitez et al.   Nature Communications

Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth

(2017) Yu Shi et al.   Nature Communications

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma

(2017) Dinesh K. Singh et al.   Cell Reports

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

Systemic T Cells Immunosuppression of Glioma Stem Cell-Derived Exosomes Is Mediated by Monocytic Myeloid-Derived Suppressor Cells

(2017) Rossana Domenis et al.   PLoS One

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells

(2016) Sonam Dolma et al.   CANCER CELL

Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis

(2016) Chiara Bardella et al.   CANCER CELL

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers

(2016) Genaro R. Villa et al.   CANCER CELL

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

(2016) Baoli Hu et al.   CELL

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability

(2016) Kamalakannan Palanichamy et al.   CLINICAL CANCER RESEARCH

Neural Stem Cell–Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients

(2016) Jana Portnow et al.   CLINICAL CANCER RESEARCH

Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic

(2016) N. M. Teplyuk et al.   EMBO Molecular Medicine

RBPJ maintains brain tumor–initiating cells through CDK9-mediated transcriptional elongation

(2016) Qi Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

An ID2-dependent mechanism for VHL inactivation in cancer

(2016) Sang Bae Lee et al.   NATURE

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

(2016) Itay Tirosh et al.   NATURE

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation

(2016) Takashi Shingu et al.   NATURE GENETICS

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

(2016) Christine E. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

(2016) D. F. Quail et al.   SCIENCE

Origin of the U87MG glioma cell line: Good news and bad news

(2016) Marie Allen et al.   Science Translational Medicine

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion

(2016) Balint Otvos et al.   STEM CELLS

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

(2016) Xue Gao et al.   Nature Communications

EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells

(2016) Benjamin Krusche et al.   eLife

Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells

(2016) Yuki Yasumoto et al.   PLoS One

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

(2015) David L. Schonberg et al.   CANCER CELL

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

(2015) Chunming Cheng et al.   CANCER CELL

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

(2015) Marco Gallo et al.   CANCER CELL

Spatiotemporal Evolution of the Primary Glioblastoma Genome

(2015) Jinkuk Kim et al.   CANCER CELL

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes

(2015) Sheila R. Alcantara Llaguno et al.   CANCER CELL

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Molecular Identity of Human Outer Radial Glia during Cortical Development

(2015) Alex A. Pollen et al.   CELL

miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma

(2015) Fotini M. Kouri et al.   GENES & DEVELOPMENT

Convection-enhanced delivery of an anti-miR is well-tolerated, preserves anti-miR stability and causes efficient target de-repression: a proof of concept

(2015) Bo Halle et al.   JOURNAL OF NEURO-ONCOLOGY

EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling

(2015) Feng Liu et al.   MOLECULAR CELL

Comprehensive analysis of microRNA expression profile in malignant glioma tissues

(2015) Monika Piwecka et al.   Molecular Oncology

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

(2015) Duane A. Mitchell et al.   NATURE

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

(2015) Dohoon Kim et al.   NATURE

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Serum exosomes and cytokines promote a T-helper cell type 2 environment in the peripheral blood of glioblastoma patients

(2015) Larry A. Harshyne et al.   NEURO-ONCOLOGY

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012

(2015) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway

(2015) Anwar Hossain et al.   STEM CELLS

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

(2015) Shunlei Duan et al.   Nature Communications

Differential Connexin Function Enhances Self-Renewal in Glioblastoma

(2015) Masahiro Hitomi et al.   Cell Reports

CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells

(2015) Jianfeng Han et al.   Scientific Reports

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Modeling Adult Gliomas Using RCAS/t-va Technology

(2014) Dolores Hambardzumyan et al.   Translational Oncology

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

(2013) Lin Cheng et al.   CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Glioma Grade Is Associated with the Accumulation and Activity of Cells Bearing M2 Monocyte Markers

(2013) M. Prosniak et al.   CLINICAL CANCER RESEARCH

Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A

(2013) C. G. Hubert et al.   GENES & DEVELOPMENT

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

(2013) Olesya A Ulanovskaya et al.   Nature Chemical Biology

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequency of TERT promoter mutations in human cancers

(2013) João Vinagre et al.   Nature Communications

VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex

(2012) Kan V. Lu et al.   CANCER CELL

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

A Radial Glia Gene Marker, Fatty Acid Binding Protein 7 (FABP7), Is Involved in Proliferation and Invasion of Glioblastoma Cells

(2012) Antonella De Rosa et al.   PLoS One

Current Strategies for Identification of Glioma Stem Cells: Adequate or Unsatisfactory?

(2012) Paola Brescia et al.   Journal of Oncology

MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10

(2011) Lihua Sun et al.   BRAIN RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells

(2011) Erika Pastrana et al.   Cell Stem Cell

The Utility and Limitations of Neurosphere Assay, CD133 Immunophenotyping and Side Population Assay in Glioma Stem Cell Research

(2010) Feng Wan et al.   BRAIN PATHOLOGY

Yin and yang: Cancer-implicated miRNAs that have it both ways

(2010) Jason T. Huse et al.   CELL CYCLE

Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy

(2010) Robert M. Prins et al.   CLINICAL CANCER RESEARCH

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

Human Glioblastoma-Derived Cancer Stem Cells: Establishment of Invasive Glioma Models and Treatment with Oncolytic Herpes Simplex Virus Vectors

(2009) H. Wakimoto et al.   CANCER RESEARCH

SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma

(2009) Myung Jin Son et al.   Cell Stem Cell

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

Cancer stem cells: Cell culture, markers, and targets for new therapies

(2009) Candace A. Gilbert et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells

(2008) Scott Bidlingmaier et al.   JOURNAL OF MOLECULAR MEDICINE-JMM