Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages

Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis

(2018) Tamara Muliaditan et al.   Nature Communications

Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb

(2018) Simona D’Aguanno et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

(2018) Irena Kaplanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1 and IL-1 regulatory pathways in cancer progression and therapy

(2017) Alberto Mantovani et al.   IMMUNOLOGICAL REVIEWS

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor

(2017) Xiaofeng Wu et al.   NATURE CELL BIOLOGY

Molecular characterisation of cutaneous melanoma: creating a framework for targeted and immune therapies

(2016) Shivshankari Rajkumar et al.   BRITISH JOURNAL OF CANCER

NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis

(2016) E. Shoshan et al.   CANCER RESEARCH

A novel liposomal Clodronate depletes tumor-associated macrophages in primary and metastatic melanoma: Anti-angiogenic and anti-tumor effects

(2016) F. Piaggio et al.   JOURNAL OF CONTROLLED RELEASE

Affinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein

(2016) D Trisciuoglio et al.   Cell Death & Disease

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Alternative Treatments For Melanoma: Targeting BCL-2 Family Members to De-Bulk and Kill Cancer Stem Cells

(2015) Nabanita Mukherjee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

miR-211 and MITF modulation by Bcl-2 protein in melanoma cells

(2015) Teresa De Luca et al.   MOLECULAR CARCINOGENESIS

Macrophage-Tumor Cell Fusions from Peripheral Blood of Melanoma Patients

(2015) Gary A. Clawson et al.   PLoS One

Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis

(2014) Ole Helm et al.   INTERNATIONAL JOURNAL OF CANCER

Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1)-mediated Bcl-2 Induction Prolongs Macrophage Survival

(2014) Zhihong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dacarbazine with or without oblimersen (a Bcl-2 antisense oligonucleotide) in chemotherapy-naive patients with advanced melanoma and low–normal serum lactate dehydrogenase

(2014) Agop Y. Bedikian et al.   MELANOMA RESEARCH

Tumor-Derived Interleukin-1 Promotes Lymphangiogenesis and Lymph Node Metastasis through M2-Type Macrophages

(2014) Kosuke Watari et al.   PLoS One

BH4 domain of bcl-2 protein is required for its proangiogenic function under hypoxic condition

(2013) Chiara Gabellini et al.   CARCINOGENESIS

Overcoming stroma-mediated treatment resistance in chronic lymphocytic leukemia through BCL-2 inhibition

(2013) Matthew S. Davids et al.   LEUKEMIA & LYMPHOMA

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

PGE2-Driven Induction and Maintenance of Cancer-Associated Myeloid-Derived Suppressor Cells

(2012) Nataša Obermajer et al.   IMMUNOLOGICAL INVESTIGATIONS

Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells

(2011) N. Obermajer et al.   BLOOD

Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells

(2011) D Trisciuoglio et al.   CELL DEATH AND DIFFERENTIATION

Constitutive Aberrant Endogenous Interleukin-1 Facilitates Inflammation and Growth in Human Melanoma

(2011) Y. Qin et al.   MOLECULAR CANCER RESEARCH

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY

bcl-2 expression is not associated with survival in metastatic cutaneous melanoma: A historical cohort study

(2008) Marília B Espíndola et al.   World Journal of Surgical Oncology