Cellular origin of glioblastoma and its implication in precision therapy

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

(2017) Xiaoyang Lan et al.   NATURE

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

(2017) Yiwen Jiang et al.   Cell Reports

Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype

(2016) Smitha Sreedharan et al.   CANCER RESEARCH

Culture conditions tailored to the cell of origin are critical for maintaining native properties and tumorigenicity of glioma cells

(2016) Pítia F. Ledur et al.   NEURO-ONCOLOGY

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes

(2015) Sheila R. Alcantara Llaguno et al.   CANCER CELL

MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment

(2015) Hua He et al.   Cellular & Molecular Immunology

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Cell of Origin Determines Tumor Phenotype in an Oncogenic Ras/p53 Knockout Transgenic Model of High-Grade Glioma

(2012) Sabah O. Ghazi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cooperativity within and among Pten, p53, and Rb Pathways Induces High-Grade Astrocytoma in Adult Brain

(2011) Lionel M.L. Chow et al.   CANCER CELL

Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma

(2011) Chong Liu et al.   CELL

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE