Advances in the Knowledge of the Molecular Biology of Glioblastoma and Its Impact in Patient Diagnosis, Stratification, and Treatment

PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity

(2019) Shiv K. Gupta et al.   Frontiers in Oncology

Virus-Based Immunotherapy of Glioblastoma

(2019) Miika Martikainen et al.   Cancers

Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies

(2019) Chrysovalantis Voutouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nano-mediated delivery of double-stranded RNA for gene therapy of glioblastoma multiforme

(2019) Małgorzata Grabowska et al.   PLoS One

PD-1/PD-L1 immune-checkpoint inhibitors in glioblastoma: A concise review

(2019) Mario Caccese et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Nanocarriers and nonviral methods for delivering antiangiogenic factors for glioblastoma therapy: the story so far

(2019) Anne Clavreul et al.   International Journal of Nanomedicine

Transcriptome profiling-based identification of prognostic subtypes and multi-omics signatures of glioblastoma

(2019) Junseong Park et al.   Scientific Reports

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes

(2019) Hong Wang et al.   Nature Communications

Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

(2019) Anna Galstyan et al.   Nature Communications

Immune landscapes associated with different glioblastoma molecular subtypes

(2019) Maria Martinez-Lage et al.   Acta Neuropathologica Communications

MicroRNAs as biomarkers for human glioblastoma: progress and potential

(2018) Shi-wei Huang et al.   ACTA PHARMACOLOGICA SINICA

Drug delivery challenges and future of chemotherapeutic nanomedicine for glioblastoma treatment

(2018) Lakshmi Pallavi Ganipineni et al.   JOURNAL OF CONTROLLED RELEASE

Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic target

(2018) Ma Carmen Ocaña et al.   MEDICINAL RESEARCH REVIEWS

OUP accepted manuscript

(2018)   NEURO-ONCOLOGY

Comparison of glioblastoma (GBM) molecular classification methods

(2018) Eunjee Lee et al.   SEMINARS IN CANCER BIOLOGY

Focused Ultrasound-enabled Brain Tumor Liquid Biopsy

(2018) Lifei Zhu et al.   Scientific Reports

Advances in Glioblastoma Multiforme Treatment: New Models for Nanoparticle Therapy

(2018) Elif Ozdemir-Kaynak et al.   Frontiers in Physiology

Phase-2 trial of palbociclib in adult patients with recurrent RB1-positive glioblastoma

(2018) Jennie W. Taylor et al.   JOURNAL OF NEURO-ONCOLOGY

An Experimenter’s Guide to Glioblastoma Invasion Pathways

(2018) Mark C. de Gooijer et al.   TRENDS IN MOLECULAR MEDICINE

­­­­Immunotherapy for Glioblastoma: Adoptive T-cell Strategies

(2018) Bryan D. Choi et al.   CLINICAL CANCER RESEARCH

Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma

(2018) Francesco Marampon et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma

(2018) Wei Meng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Assessment of efficacy of dendritic cell therapy and viral therapy in high grade glioma clinical trials. A meta-analytic review

(2018) Bogdan Ionel Vatu et al.   JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY

Immune Checkpoints and Innovative Therapies in Glioblastoma

(2018) Massimo Romani et al.   Frontiers in Oncology

Angiogenesis inhibitors in tackling recurrent glioblastoma

(2017) Thomas Hundsberger et al.   Expert Review of Anticancer Therapy

Phase I/II trial of vorinostat, bevacizumab, and daily temozolomide for recurrent malignant gliomas

(2017) Katherine B. Peters et al.   JOURNAL OF NEURO-ONCOLOGY

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

(2017) Michael Weller et al.   LANCET ONCOLOGY

Diagnostic and Therapeutic Biomarkers in Glioblastoma: Current Status and Future Perspectives

(2017) Wojciech Szopa et al.   Biomed Research International

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models

(2016) David M. Irvin et al.   BRAIN PATHOLOGY

Identification of Patients with Recurrent Glioblastoma Who May Benefit from Combined Bevacizumab and CCNU Therapy: A Report from the BELOB Trial

(2016) L. Erdem-Eraslan et al.   CANCER RESEARCH

The Role of Molecular Diagnostics in the Management of Patients with Gliomas

(2016) Hans-Georg Wirsching et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope

(2016) A. C. Phillips et al.   MOLECULAR CANCER THERAPEUTICS

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Glioblastoma: pathology, molecular mechanisms and markers

(2015) Kenneth Aldape et al.   ACTA NEUROPATHOLOGICA

Molecular and Genomic Alterations in Glioblastoma Multiforme

(2015) Ines Crespo et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Current status and future directions of anti-angiogenic therapy for gliomas

(2015) Wolfgang Wick et al.   NEURO-ONCOLOGY

Vaccination strategies for neuro-oncology: Table 1.

(2015) John H. Sampson et al.   NEURO-ONCOLOGY

Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627)

(2015) Andrew B. Lassman et al.   NEURO-ONCOLOGY

Glutamate as chemotactic fuel for diffuse glioma cells: Are they glutamate suckers?

(2014) Sanne A.M. van Lith et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Molecular Genetics of Gliomas

(2014) Christina L. Appin et al.   CANCER JOURNAL

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The epidemiology of glioma in adults: a "state of the science" review

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

(2014) Mark R. Gilbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

(2014) Olivier L. Chinot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe

(2014) M Cornago et al.   Cell Death & Disease

EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing

(2014) J. M. Francis et al.   Cancer Discovery

Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes

(2013) Daniel Stieber et al.   ACTA NEUROPATHOLOGICA

Invasion as target for therapy of glioblastoma multiforme

(2013) Anne Vehlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Snail depletes the tumorigenic potential of glioblastoma

(2013) K Savary et al.   ONCOGENE

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

(2013) B. E. Johnson et al.   SCIENCE

Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment?

(2013) Tom Donnem et al.   Cancer Medicine

Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression

(2013) Shannon Patricia Fortin Ensign et al.   Frontiers in Oncology

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

The Definition of Primary and Secondary Glioblastoma

(2012) H. Ohgaki et al.   CLINICAL CANCER RESEARCH

Emerging insights into the molecular and cellular basis of glioblastoma

(2012) G. P. Dunn et al.   GENES & DEVELOPMENT

Identification of Function for CD44 Intracytoplasmic Domain (CD44-ICD)

(2012) Karl E. Miletti-González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma

(2012) D Kesanakurti et al.   Cell Death & Disease

Angiogenesis and invasion in glioma

(2011) Manabu Onishi et al.   Brain Tumor Pathology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

MMP-9 induces CD44 cleavage and CD44 mediated cell migration in glioblastoma xenograft cells

(2011) Chandramu Chetty et al.   CELLULAR SIGNALLING

Extracellular matrix and perineuronal nets in CNS repair

(2011) Jessica C.F. Kwok et al.   Developmental Neurobiology

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

ATP-Binding Cassette Transporters and Their Roles in Protecting the Brain

(2011) Ayman ElAli et al.   NEUROSCIENTIST

Patient-oriented gene set analysis for cancer mutation data

(2011) Simina M Boca et al.   GENOME BIOLOGY

In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma

(2010) Shahryar E. Mir et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

FoxM1B Regulates NEDD4-1 Expression, Leading to Cellular Transformation and Full Malignant Phenotype in Immortalized Human Astrocytes

(2010) Bingbing Dai et al.   CANCER RESEARCH

Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin

(2010) C. Lottaz et al.   CANCER RESEARCH

RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53

(2010) Sindy Sohr et al.   CELL CYCLE

Bevacizumab and Recurrent Malignant Gliomas: A European Perspective

(2010) Wolfgang Wick et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease

(2010) Barbara S. Paugh et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

(2009) H. Song et al.   CANCER RESEARCH

Imaging glioma cell invasionin vivoreveals mechanisms of dissemination and peritumoral angiogenesis

(2009) Frank Winkler et al.   GLIA

Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors

(2009) Qinghai Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Intratumoral patterns of clonal evolution in gliomas

(2009) Ana Luísa Vital et al.   NEUROGENETICS

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression

(2008) Samuel Godar et al.   CELL

Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas

(2008) Kyeung Min Joo et al.   LABORATORY INVESTIGATION

The Role of Myosin II in Glioma Invasion of the Brain

(2008) Christopher Beadle et al.   MOLECULAR BIOLOGY OF THE CELL

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

(2008) A Jeanes et al.   ONCOGENE

CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells

(2007) Jian Wang et al.   INTERNATIONAL JOURNAL OF CANCER