Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype

Myeloid Biomarkers Associated with Glioblastoma Response to Anti-VEGF Therapy with Aflibercept

(2011) J. F. de Groot et al.   CLINICAL CANCER RESEARCH

Bevacizumab and Irinotecan in the Treatment of Recurrent Malignant Gliomas

(2010) John F. de Groot et al.   CANCER JOURNAL

Vascular Endothelial Growth Factor--A Positive and Negative Regulator of Tumor Growth

(2010) L. M. Vecchiarelli-Federico et al.   CANCER RESEARCH

Complementary Actions of Inhibitors of Angiopoietin-2 and VEGF on Tumor Angiogenesis and Growth

(2010) H. Hashizume et al.   CANCER RESEARCH

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development

(2010) Muh-Hwa Yang et al.   CELL CYCLE

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

(2010) X. Lu et al.   CLINICAL CANCER RESEARCH

Phase II study of sunitinib malate in patients with recurrent high-grade glioma

(2010) B. Neyns et al.   JOURNAL OF NEURO-ONCOLOGY

Reversible Epithelial to Mesenchymal Transition and Acquired Resistance to Sunitinib in Patients with Renal Cell Carcinoma: Evidence from a Xenograft Study

(2010) H. J. Hammers et al.   MOLECULAR CANCER THERAPEUTICS

Ongoing Clinical Trials

(2010) J. L. Clarke et al.   NEURO-ONCOLOGY

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Mediators of Glioblastoma Resistance and Invasion during Antivascular Endothelial Growth Factor Therapy

(2009) A. K. Lucio-Eterovic et al.   CLINICAL CANCER RESEARCH

"Antimyeloangiogenic" Therapy for Cancer by Inhibiting PlGF

(2009) S. Loges et al.   CLINICAL CANCER RESEARCH

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

(2009) William Y. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

VEGFR1-activity-independent metastasis formation

(2009) Michelle R. Dawson et al.   NATURE

VEGFR1 Activity Modulates Myeloid Cell Infiltration in Growing Lung Metastases but Is Not Required for Spontaneous Metastasis Formation

(2009) Michelle R. Dawson et al.   PLoS One

G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models

(2009) F. Shojaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Flt-1 Signaling in Macrophages Promotes Glioma Growth In vivo

(2008) M. Kerber et al.   CANCER RESEARCH

Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model

(2008) Qingyu Zhou et al.   NEURO-ONCOLOGY