Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection

Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance

(2020) Kelsey J. Yamada et al.   PLoS Pathogens

HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2

(2019) Ji Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research

(2019) Nicholas A. Turner et al.   NATURE REVIEWS MICROBIOLOGY

STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion

(2019) Chuan-xia Zhang et al.   CELL DEATH AND DIFFERENTIATION

IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation

(2019) Wenjun Ouyang et al.   IMMUNITY

Performance of synovial fluid D-lactate for the diagnosis of periprosthetic joint infection: A prospective observational study

(2019) Katsiaryna Yermak et al.   JOURNAL OF INFECTION

Definitions and guidelines for research on antibiotic persistence

(2019) Nathalie Q. Balaban et al.   NATURE REVIEWS MICROBIOLOGY

Resistance to leukocytes ties benefits of quorum sensing dysfunctionality to biofilm infection

(2019) Lei He et al.   Nature Microbiology

Perforin and Granzyme B Expressed by Murine Myeloid-Derived Suppressor Cells: A Study on Their Role in Outgrowth of Cancer Cells

(2019) Inès Dufait et al.   Cancers

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Histone Deacetylase 11 Is a Fatty-Acid Deacylase

(2018) Zsofia Kutil et al.   ACS Chemical Biology

Interleukin-10 Directly Inhibits CD8 + T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity

(2018) Logan K. Smith et al.   IMMUNITY

Arginase-1 Expression in Myeloid Cells Regulates Staphylococcus aureus Planktonic but Not Biofilm Infection

(2018) Kelsey J. Yamada et al.   INFECTION AND IMMUNITY

A genetic determinant of persister cell formation in bacterial pathogens

(2018) David R. Cameron et al.   JOURNAL OF BACTERIOLOGY

Implant infections: adhesion, biofilm formation and immune evasion

(2018) Carla Renata Arciola et al.   NATURE REVIEWS MICROBIOLOGY

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

(2018) Cyril Corbet et al.   Nature Communications

Immune Evasion Mechanisms of Staphylococcus epidermidis Biofilm Infection

(2018) Katherine Y. Le et al.   Frontiers in Microbiology

Metformin blocks myeloid-derived suppressor cell accumulation through AMPK-DACH1-CXCL1 axis

(2018) Guohui Qin et al.   OncoImmunology

Heterogeneity of Ly6G+Ly6C+ myeloid-derived suppressor cell (MDSC) infiltrates during S. aureus biofilm infection

(2018) Cortney E. Heim et al.   INFECTION AND IMMUNITY

In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes

(2018) Jacqueline M. Ratter et al.   Frontiers in Immunology

IL-10 Plays Opposing Roles duringStaphylococcus aureusSystemic and Localized Infections

(2017) John M. Leech et al.   JOURNAL OF IMMUNOLOGY

Human prosthetic joint infections are associated with myeloid-derived suppressor cells (MDSCs): Implications for infection persistence

(2017) Cortney E. Heim et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

(2017) Maria Ouzounova et al.   Nature Communications

Targeting Metabolic Remodeling in Triple Negative Breast Cancer in a Murine Model

(2017) Verónica García-Castillo et al.   Journal of Cancer

Cyclic di-AMP Released from Staphylococcus aureus Biofilm Induces a Macrophage Type I Interferon Response

(2016) Casey M. Gries et al.   INFECTION AND IMMUNITY

Staphylococcus aureuslactate- and malate-quinone oxidoreductases contribute to nitric oxide resistance and virulence

(2016) Nicole A. Spahich et al.   MOLECULAR MICROBIOLOGY

Biofilms: an emergent form of bacterial life

(2016) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Expanded Glucose Import Capability Affords Staphylococcus aureus Optimized Glycolytic Flux during Infection

(2016) Nicholas P. Vitko et al.   mBio

Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants

(2016) Dennis Hanzelmann et al.   Nature Communications

IκBζ Regulates Human Monocyte Pro-Inflammatory Responses Induced by Streptococcus pneumoniae

(2016) Kruthika Sundaram et al.   PLoS One

Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt–mTOR signaling pathway

(2015) Zhi Zhao et al.   CANCER LETTERS

L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation

(2015) Waldemar Wagner et al.   Cell Communication and Signaling

IL-12 Promotes Myeloid-Derived Suppressor Cell Recruitment and Bacterial Persistence duringStaphylococcus aureusOrthopedic Implant Infection

(2015) Cortney E. Heim et al.   JOURNAL OF IMMUNOLOGY

Interleukin-10 production by myeloid-derived suppressor cells contributes to bacterial persistence during Staphylococcus aureus orthopedic biofilm infection

(2015) Cortney E. Heim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control

(2015) S. L. Percival et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function

(2015) Eva Sahakian et al.   MOLECULAR IMMUNOLOGY

Glycolytic Dependency of High-Level Nitric Oxide Resistance and Virulence in Staphylococcus aureus

(2015) Nicholas P. Vitko et al.   mBio

Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin

(2015) Tyler D. Scherr et al.   mBio

Detecting differential peaks in ChIP-seq signals with ODIN

(2014) Manuel Allhoff et al.   BIOINFORMATICS

Lactate Dehydrogenase Is the Key Enzyme for Pneumococcal Pyruvate Metabolism and Pneumococcal Survival in Blood

(2014) Paula Gaspar et al.   INFECTION AND IMMUNITY

Myeloid-Derived Suppressor Cells Contribute to Staphylococcus aureus Orthopedic Biofilm Infection

(2014) C. E. Heim et al.   JOURNAL OF IMMUNOLOGY

A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression duringStaphylococcus aureusInfection

(2014) Christina Tebartz et al.   JOURNAL OF IMMUNOLOGY

The Janus Face of a-Toxin: A Potent Mediator of Cytoprotection in Staphylococci-Infected Macrophages

(2014) Joanna Koziel et al.   Journal of Innate Immunity

Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors

(2014) Daniel W. Beury et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport

(2014) B. M. Bola et al.   MOLECULAR CANCER THERAPEUTICS

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells

(2014) Fengdong Cheng et al.   MOLECULAR IMMUNOLOGY

deepTools: a flexible platform for exploring deep-sequencing data

(2014) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Vancomycin-Rifampin Combination Therapy Has Enhanced Efficacy against an Experimental Staphylococcus aureus Prosthetic Joint Infection

(2013) Jared A. Niska et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis

(2013) Hiroshi Katoh et al.   CANCER CELL

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

(2013) R. Polanski et al.   CLINICAL CANCER RESEARCH

Staphopains Modulate Staphylococcus aureus Biofilm Integrity

(2013) Joe M. Mootz et al.   INFECTION AND IMMUNITY

Regulation of the Activity of Lactate Dehydrogenases from Four Lactic Acid Bacteria

(2013) Anna Feldman-Salit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer

(2013) Je-In Youn et al.   NATURE IMMUNOLOGY

Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells

(2013) XIAOMING ZHAI et al.   ONCOLOGY REPORTS

A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

(2013) H. A. Eskandarian et al.   SCIENCE

Cyclooxygenase 2 promoted the tumorigenecity of pancreatic cancer cells

(2013) Wenjun Li et al.   TUMOR BIOLOGY

A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential Staphylococcus aureus Genes

(2013) P. D. Fey et al.   mBio

Myeloid-Derived Suppressor Cells Function as Novel Osteoclast Progenitors Enhancing Bone Loss in Breast Cancer

(2012) A. Sawant et al.   CANCER RESEARCH

Influence of epigenetic modifications of the interleukin-10 promoter on IL10 gene expression

(2012) Lena Larsson et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

(2012) Tom Latham et al.   NUCLEIC ACIDS RESEARCH

Monitoring Bacterial Burden, Inflammation and Bone Damage Longitudinally Using Optical and μCT Imaging in an Orthopaedic Implant Infection in Mice

(2012) Jared A. Niska et al.   PLoS One

Key role of the positive feedback between PGE2and COX2 in the biology of myeloid-derived suppressor cells

(2012) Nataša Obermajer et al.   OncoImmunology

Antigen-Presenting Cell Production of IL-10 Inhibits T-Helper 1 and 17 Cell Responses and Suppresses Colitis in Mice

(2011) Bo Liu et al.   GASTROENTEROLOGY

Staphylococcus epidermidis Uses Distinct Mechanisms of Biofilm Formation To Interfere with Phagocytosis and Activation of Mouse Macrophage-Like Cells 774A.1

(2011) Nina N. Schommer et al.   INFECTION AND IMMUNITY

Staphylococcus aureus Biofilms Prevent Macrophage Phagocytosis and Attenuate Inflammation In Vivo

(2011) L. R. Thurlow et al.   JOURNAL OF IMMUNOLOGY

Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo

(2011) Brian R. Rosborough et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Protective role of IL-1β against post-arthroplasty Staphylococcus aureus infection

(2011) Nicholas M. Bernthal et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mouse model of chronic post-arthroplasty infection: Noninvasive in vivo bioluminescence imaging to monitor bacterial burden for long-term study

(2011) Jonathan R. Pribaz et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Histone deacetylases as regulators of inflammation and immunity

(2011) Melanie R. Shakespear et al.   TRENDS IN IMMUNOLOGY

Identification of a Lactate-Quinone Oxidoreductase in Staphylococcus aureus that is Essential for Virulence

(2011) James R. Fuller et al.   Frontiers in Cellular and Infection Microbiology

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection

(2010) Galit Alter et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

(2010) B. Korkmaz et al.   PHARMACOLOGICAL REVIEWS

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Periprosthetic Joint Infection: The Incidence, Timing, and Predisposing Factors

(2008) Luis Pulido et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

(2008) Alejandro Villagra et al.   NATURE IMMUNOLOGY