The crosstalk between HIFs and mitochondrial dysfunctions in cancer development

A transgenic mouse expressing miR‐210 in proximal tubule cells shows mitochondrial alteration: possible association of miR‐210 with a shift in energy metabolism

(2020) Chisato Nakada et al.   JOURNAL OF PATHOLOGY

Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK2

(2020) Lili Cao et al.   Cell Death & Disease

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth

(2020) Hao Nie et al.   Nature Communications

Energy Metabolism in Cancer: The Roles of STAT3 and STAT5 in the Regulation of Metabolism-Related Genes

(2020) Arturo Valle-Mendiola et al.   Cancers

Targeting Glucose Transporters for Breast Cancer Therapy: The Effect of Natural and Synthetic Compounds

(2020) Ana M. Barbosa et al.   Cancers

Mitoepigenetics and Its Emerging Roles in Cancer

(2020) Zhen Dong et al.   Frontiers in Cell and Developmental Biology

NUDT21 suppresses the growth of small cell lung cancer by modulating GLS1 splicing

(2020) Chuan-Cheng Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ginsenoside 20(S)‐Rg3 upregulates HIF‐1α‐targeting miR‐519a‐5p to inhibit the Warburg effect in ovarian cancer cells

(2020) Jiaojiao Lu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Cross talk between oxidative stress and hypoxia via thioredoxin and HIF‐2α drives metastasis of hepatocellular carcinoma

(2020) Man‐Qing Cao et al.   FASEB JOURNAL

PLAGL2‐EGFR‐HIF‐1/2α signaling loop promotes HCC progression and Erlotinib insensitivity

(2020) Weiwei Hu et al.   HEPATOLOGY

VHL-HIF-2α axis-induced SMYD3 upregulation drives renal cell carcinoma progression via direct trans-activation of EGFR

(2020) Cheng Liu et al.   ONCOGENE

Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK

(2020) Nurbubu T. Moldogazieva et al.   Cancers

Metformin as an Adjuvant to Photodynamic Therapy in Resistant Basal Cell Carcinoma Cells

(2020) Marta Mascaraque et al.   Cancers

CDCA2 Inhibits Apoptosis and Promotes Cell Proliferation in Prostate Cancer and Is Directly Regulated by HIF-1α Pathway

(2020) Yixiang Zhang et al.   Frontiers in Oncology

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

(2020) Guo Chen et al.   Frontiers in Cell and Developmental Biology

Regulators of glucose uptake in thyroid cancer cell lines

(2020) Shabnam Heydarzadeh et al.   Cell Communication and Signaling

Deregulated Mitochondrial DNA in Diseases

(2020) Ngoc Ngo Yen Nguyen et al.   DNA AND CELL BIOLOGY

Multifaceted Roles of Mitochondrial Components and Metabolites in Metabolic Diseases and Cancer

(2020) Jean Nakhle et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of mitochondrial-related nuclear genes in age-related common disease

(2020) Huanzheng Li et al.   MITOCHONDRION

Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer

(2020) Lisa M. Becker et al.   Cell Reports

Protein Kinase CK2 in Cancer Energetics

(2020) Eduardo Silva-Pavez et al.   Frontiers in Oncology

hCINAP is a potential direct HIF-1 target gene and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells

(2020) yong zhang et al.   Biochemistry and Cell Biology

HIF-1a regulates hypoxia-induced autophagy via translocation of ANKRD37 in colon cancer

(2020) Minzi Deng et al.   EXPERIMENTAL CELL RESEARCH

Autonomous glucose metabolic reprogramming of tumour cells under hypoxia: opportunities for targeted therapy

(2020) Mingyao Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers

(2020) Kuo Chen et al.   SEMINARS IN CANCER BIOLOGY

A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1α and p53 activity in triple-negative breast cancer

(2020) Ye Du et al.   Cell Death & Disease

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon

(2020) Anindya Roy Chowdhury et al.   Redox Biology

Mitochondrial DNA Integrity: Role in Health and Disease

(2019) Priyanka Sharma et al.   Cells

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

(2019) Ivana Kurelac et al.   Nature Communications

HIF Inhibitors: Status of Current Clinical Development

(2019) Jaleh Fallah et al.   Current Oncology Reports

Tricarboxylic acid cycle metabolites in the control of macrophage activation and effector phenotypes

(2019) Jordan T. Noe et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical, radiological, and genetic characteristics of 16 patients with ACO2 gene defects: Delineation of an emerging neurometabolic syndrome

(2019) Rajech Sharkia et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Inhibition of HSP90 overcomes resistance to chemotherapy and radiotherapy in pancreatic cancer

(2019) Ganji Purnachandra Nagaraju et al.   INTERNATIONAL JOURNAL OF CANCER

Hypoxia/pseudohypoxia‐mediated activation of hypoxia‐inducible factor‐1α in cancer

(2019) Yoshihiro Hayashi et al.   CANCER SCIENCE

UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer

(2019) Qiangsheng Hu et al.   CANCER LETTERS

The roles and signaling pathways of prolyl-4-hydroxylase 2 in the tumor microenvironment

(2019) Anqi Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Alternative Splicing in Angiogenesis

(2019) Elizabeth Bowler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging roles of aerobic glycolysis in breast cancer

(2019) Z. Wu et al.   Clinical & Translational Oncology

Changes in the Turnover of the Cellular Proteome during Metabolic Reprogramming: A Role for mtROS in Proteostasis

(2019) Ana García-Aguilar et al.   JOURNAL OF PROTEOME RESEARCH

Activation of hypoxia-inducible factor -1α via succinate dehydrogenase pathway during acute lung injury induced by trauma/hemorrhagic shock

(2019) Mengya Li et al.   SHOCK

Impairment of HIF-1α-mediated metabolic adaption by NRF2-silencing in breast cancer cells

(2019) Sujin Lee et al.   Redox Biology

The enhancement of glycolysis regulates pancreatic cancer metastasis

(2019) Jinshou Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α–regulated pseudohypoxic state

(2019) Yuan Wang et al.   FASEB JOURNAL

Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming

(2019) Jinmei Jin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mitochondrial fission causes cisplatin resistance under hypoxic conditions via ROS in ovarian cancer cells

(2019) Youngjin Han et al.   ONCOGENE

Hypoxia-Inducible Factors as an Alternative Source of Treatment Strategy for Cancer

(2019) Musbau Adewumi Akanji et al.   Oxidative Medicine and Cellular Longevity

Small molecules targeting HIF-1α pathway for cancer therapy in recent years

(2019) Wendi Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A novel LncRNA HITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth

(2019) Xingwen Wang et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms

(2019) Julian Baumeister et al.   LEUKEMIA

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

(2019) Xinming Jing et al.   Molecular Cancer

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

(2019) Milica Momcilovic et al.   NATURE

Mitochondrial Dysfunction Pathway Networks and Mitochondrial Dynamics in the Pathogenesis of Pituitary Adenomas

(2019) Na Li et al.   Frontiers in Endocrinology

Hydrogen sulfide modulates epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via HIF-1α activation

(2019) Mingqi Wang et al.   BIOCHEMICAL PHARMACOLOGY

AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1α/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo

(2019) Peng-Chao Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Aberrant mitochondrial function in ageing and cancer

(2019) Julia C. Whitehall et al.   BIOGERONTOLOGY

DKC1 enhances angiogenesis by promoting HIF-1α transcription and facilitates metastasis in colorectal cancer

(2019) Pingfu Hou et al.   BRITISH JOURNAL OF CANCER

SIK2 promotes reprogramming of glucose metabolism through PI3K/AKT/HIF-1α pathway and Drp1-mediated mitochondrial fission in ovarian cancer

(2019) Tian Gao et al.   CANCER LETTERS

Circadian clock gene NPAS2 promotes reprogramming of glucose metabolism in hepatocellular carcinoma cells

(2019) Peng Yuan et al.   CANCER LETTERS

A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

(2019) Hee Chan Yoo et al.   Cell Metabolism

Biological and Clinical Relevance of microRNAs in Mitochondrial Diseases/Dysfunctions

(2019) Durairaj Sekar et al.   DNA AND CELL BIOLOGY

Mitochondria-targeting nanomedicine self-assembled from GSH-responsive paclitaxel-ss-berberine conjugate for synergetic cancer treatment with enhanced cytotoxicity

(2019) Yu Cheng et al.   JOURNAL OF CONTROLLED RELEASE

Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells

(2019) Marie-Ange Djeungoue-Petga et al.   Cell Death & Disease

Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

(2019) David Kung-Chun Chiu et al.   Cell Death & Disease

Analysis of apoptosis related genes in nurses exposed to anti-neoplastic drugs

(2019) Maral Ramazani et al.   BMC Pharmacology & Toxicology

Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the α-Ketoglutarate Signaling Pathway

(2018) Chien-Wei Tseng et al.   CANCER RESEARCH

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress

(2018) Maya Barben et al.   CELL DEATH AND DIFFERENTIATION

Vosaroxin induces mitochondrial dysfunction and apoptosis in cervical cancer HeLa cells: Involvement of AMPK/Sirt3/HIF-1 pathway

(2018) Xian-Li Zhao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Combinatorial treatment of Rhizoma Paridis saponins and sorafenib overcomes the intolerance of sorafenib

(2018) Jingwen Yao et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate

(2018) Chun-Peng Liao et al.   ONCOGENE

MicroRNA-519d-3p inhibits proliferation and promotes apoptosis by targeting HIF-2α in cervical cancer under hypoxic conditions

(2018) Lixia Jiang et al.   ONCOLOGY RESEARCH

Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer

(2018) Felipe Paredes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Autonomous Metabolic Reprogramming in Hypoxia

(2018) Luana Schito et al.   TRENDS IN CELL BIOLOGY

The role of HIF-1α in chemo-/radioresistant tumors

(2018) Yu Xia et al.   OncoTargets and Therapy

Hypoxic-induced truncation of voltage-dependent anion channel 1 is mediated by both asparagine endopeptidase and calpain 1 activities

(2018) Hadas Pahima et al.   Oncotarget

Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States

(2018) Dongya Jia et al.   Cells

Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1α and Slug signaling pathways

(2018) Jing Ying Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma

(2018) Xinqun Li et al.   CELL DEATH AND DIFFERENTIATION

The role of mitochondria in angiogenesis

(2018) Andrew Reichard et al.   MOLECULAR BIOLOGY REPORTS

Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia

(2018) Jan Ježek et al.   Frontiers in Endocrinology

VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function

(2018) Thomas Briston et al.   Frontiers in Oncology

Mitochondrial complex II regulates a distinct oxygen sensing mechanism in monocytes

(2017) Shraddha Sharma et al.   HUMAN MOLECULAR GENETICS

Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism

(2017) Ravi Naik et al.   JOURNAL OF MEDICINAL CHEMISTRY

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

(2017) Andrew M Intlekofer et al.   Nature Chemical Biology

A novel HIF-1α/VMP1-autophagic pathway induces resistance to photodynamic therapy in colon cancer cells

(2017) M. E. Rodríguez et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR

(2017) Pan Deng et al.   SEMINARS IN CANCER BIOLOGY

Brusatol-Mediated Inhibition of c-Myc Increases HIF-1α Degradation and Causes Cell Death in Colorectal Cancer under Hypoxia

(2017) Eun-Taex Oh et al.   Theranostics

HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia

(2016) Nana Zhe et al.   CANCER BIOLOGY & THERAPY

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis

(2016) D. Samanta et al.   CANCER RESEARCH

The prospect of precision therapy for renal cell carcinoma

(2016) Chiara Ciccarese et al.   CANCER TREATMENT REVIEWS

NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma

(2016) R. K.-H. Lai et al.   CLINICAL CANCER RESEARCH

Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase

(2016) Adam Kinnaird et al.   EUROPEAN UROLOGY

Bortezomib sensitizes esophageal squamous cancer cells to radiotherapy by suppressing the expression of HIF-1α and apoptosis proteins

(2016) Di Wang et al.   Journal of X-Ray Science and Technology

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondrial dysfunctions in cancer: Genetic defects and oncogenic signaling impinging on TCA cycle activity

(2015) Enrico Desideri et al.   CANCER LETTERS

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells

(2015) Jhudit Pérez-Escuredo et al.   CELL CYCLE

Enigmas of IDH mutations in hematology/oncology

(2015) Michael Heuser et al.   EXPERIMENTAL HEMATOLOGY

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

(2015) Tuomas Laukka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?

(2015) Hemant Kumar et al.   MEDIATORS OF INFLAMMATION

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1α/BNIP3 signaling pathway

(2015) HAIWEI WU et al.   Molecular Medicine Reports

Structural integration in hypoxia-inducible factors

(2015) Dalei Wu et al.   NATURE

Pheochromocytoma: Gasping for Air

(2015) Ivana Jochmanová et al.   Hormones & Cancer

PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation

(2014) Y Qi et al.   CELL DEATH AND DIFFERENTIATION

Apoptotic Cell Death Under Hypoxia

(2014) Ataman Sendoel et al.   PHYSIOLOGY

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

(2014) J. Ye et al.   Cancer Discovery