Article
Cell Biology
Yonghua Zheng, Huaxia Ji, Wulin Yi, Zhanjun Chen, Xiaobiao Hu, Jie Zhou, Yang Wang, Xiao Zheng
Summary: PRMT5 is overexpressed in lung cancer cells and tissues, and its expression is induced by hypoxia. Inhibiting or silencing PRMT5 disrupts the phosphorylation of the VEGFR/Akt/eNOS angiogenic signaling pathway, NOS activity, and NO production. Additionally, inhibiting PRMT5 activity reduces HIF-1a expression and stability, resulting in the down-regulation of the VEGF/VEGFR signaling pathway. Our study provides compelling evidence of the close association between PRMT5 and angiogenesis/EMT and highlights the potential of targeting PRMT5 activity as a promising therapeutic approach for treating lung cancer with abnormal angiogenesis.
Article
Oncology
Catarina Nascimento, Andreia Gameiro, Joao Ferreira, Jorge Correia, Fernando Ferreira
Summary: Feline mammary carcinoma is the third most common neoplasia in cats, with highly malignant behavior. The study suggests that VEGF-A and its serum receptors assessment may have potential in the diagnosis and treatment of feline mammary carcinoma.
Article
Medicine, Research & Experimental
Mariko Miyashita-Ishiwata, Malak El Sabeh, Lauren D. Reschke, Sadia Afrin, Mostafa A. Borahay
Summary: This study reveals an aberrant response of leiomyoma cells to hypoxia, characterized by increased cell proliferation and secretion of angiogenic factors. This abnormal response may contribute to the development and growth of leiomyoma.
Article
Biotechnology & Applied Microbiology
Ling Sun
Summary: Silencing FBXW7 upregulates the HIF-1α/VEGF signaling pathway, promoting angiogenesis in neonatal rats with hypoxic-ischemic brain damage (HIBD) after brain injury, reducing infarct volume and improving recovery of nerve function in HIBD rats.
Article
Oncology
Ali Abdalla, Chandraprabha Murali, Amr Amin
Summary: This study reveals for the first time the antiangiogenic potential of safranal and proposes its possible underlying mechanism in the treatment of hepatocellular carcinoma (HCC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Yang Li, Tingting Ma, Xiaoyu Zhu, Mingqi Zhang, Liang Zhao, Peng Wang, Jia Liang
Summary: This study found that zinc improves neurological function recovery during the cerebral ischemia repair stage by promoting astrocyte induced angiogenesis. Zinc alleviates brain atrophy and enhances neurological function recovery. Furthermore, zinc increases the protein levels of HIF-1 alpha, VEGF-A, and VEGF-R2 in astrocytes, thereby promoting angiogenesis during cerebral ischemic repair.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Balaji Kyathegowdanadoddi Srinivas, Madhu Chakkere Shivamadhu, Shankar Jayarama
Summary: This study aimed to purify lectin from the sap of Musa acuminate pseudostem and investigate its apoptotic and angiogenic mechanisms in both in-vitro and in-vivo models. The findings suggest that the lectin possesses significant anticancer potential by inducing apoptosis and suppressing neoangiogenesis in cancer cells and animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Nurina Febriyanti Ayuningtyas, Chanbora Chea, Toshinori Ando, Karina Erda Saninggar, Keiji Tanimoto, Toshihiro Inubushi, Nako Maishi, Kyoko Hida, Masanobu Shindoh, Mutsumi Miyauchi, Takashi Takata
Summary: This study evaluated the inhibitory effects of bovine lactoferrin (bLF) on tumor angiogenesis in vivo and in vitro. The results showed that bLF inhibited proliferation, migration, and tube formation in tumor endothelial cells (TECs) while promoting apoptosis. This effect was achieved through the inhibition of p-p65 via binding with TNF receptor-associated factor 6 (TRAF6), leading to the down-regulation of hypoxia inducible factor-alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF), specifically in TECs.
Article
Oncology
Yueyang Mou, Yaqin Hu, Guolian Xue, Wenjian Zhao, Yang Jiao, Chen Li, Haiyan Cao, Min Chao, Jianping Deng, Penggao Dai, Hongli Zhu, Liang Wang
Summary: ELK3 plays a crucial role in glioma angiogenesis by activating the HIF-1 alpha/VEGF-A signaling axis. It may serve as a prognostic marker for glioma angiogenesis and targeting ELK3 may improve the efficacy of anti-angiogenic therapies.
Review
Chemistry, Medicinal
Die Jiang, Ting Xu, Lei Zhong, Qi Liang, Yonghe Hu, Wenjing Xiao, Jianyou Shi
Summary: Angiogenesis is a vital biological process for body growth and development, wound healing, and tissue formation. Dysregulation of VEGFR signaling can lead to diseases, making it a crucial research area for disease treatment. Currently, anti-VEGF drugs used in ophthalmology have limitations, and there is a need to develop small molecule inhibitors of VEGFR for the targeted treatment of ocular neovascularization diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Ivan Guryanov, Tatiana Tennikova, Arto Urtti
Summary: VEGFs play crucial roles in angiogenesis, but dysregulation can lead to pathological angiogenesis in various diseases. Monoclonal antibodies and decoy receptors are commonly used to neutralize VEGFA in anti-angiogenic therapies. Short peptides are promising alternatives to full-length VEGFA inhibitors, overcoming some limitations of existing therapies.
Article
Biochemistry & Molecular Biology
Min Jeong Kim, Jin Mo Ku, Yu-Jeong Choi, Seo Yeon Lee, Se Hyang Hong, Hyo In Kim, Yong Cheol Shin, Seong-Gyu Ko
Summary: Lung cancer is the leading cause of cancer-related death worldwide, and metastasis remains a major challenge in its treatment. Solid tumors, including lung, prostate, and colon cancer, are often characterized by a hypoxic environment, which is associated with poor prognosis. This study investigates the anticancer mechanism of heat shock protein 90 (HSP90) in stabilizing HIF-1α, a key transcription factor involved in oxygen homeostasis and cancer progression. The findings demonstrate that 6-gingerol inhibits lung cancer metastasis by suppressing cell proliferation and blocking the nuclear translocation of HIF-1α, offering a potential antimetastatic treatment for lung cancer.
Review
Biochemistry & Molecular Biology
Peace Mabeta, Vanessa Steenkamp
Summary: The VEGF/VEGFR axis plays a crucial role in angiogenesis and tumor vascularization. Current therapies targeting VEGF and its receptors have shown limited effectiveness and undesirable off-target effects. Recent studies have identified VEGF splice variants that modulate angiogenesis, and their expression is regulated by cues within the tumor microenvironment. These variants challenge the established norm of VEGF signaling and their aberrant expression has been observed in several cancers, highlighting the need for further research on their role in cancer and their impact on antiangiogenic therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yan Li, Meng-Zhao Zhang, Shu-Jing Zhang, Xin Sun, Can Zhou, Juan Li, Jie Liu, Jun Feng, Shao-Ying Lu, Liu Pei-Jun, Ji-Chang Wang
Summary: Triple negative breast cancer (TNBC) is a subtype of breast cancer with limited treatment options. In this study, it was found that an HIF-1 alpha inhibitor called YC-1 could inhibit TNBC growth by inducing apoptosis and reducing blood vessel density. Further experiments revealed that YC-1 could shift the polarization of tumor-associated macrophages (TAMs) from the M2 phenotype to the M1 phenotype, thereby suppressing TNBC angiogenesis and growth. These findings provide a potential treatment option for TNBC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Lorenzo Fornaro, Gianna Musettini, Paola Orlandi, Irene Pecora, Caterina Vivaldi, Marta Banchi, Francesca Salani, Elisabetta Fini, Valentina Massa, Silvia Catanese, Federico Cucchiara, Monica Lencioni, Gianluca Masi, Enrico Vasile, Guido Bocci
Summary: Ramucirumab plus paclitaxel is considered standard treatment for second-line gastric carcinoma (GC) patients. This study evaluated plasma VEGF-A, VEGF-D, and sVEGFR-2 as potential markers of resistance or response to this treatment. Results showed significant increases in VEGF-A and VEGF-D levels during treatment, and early increase in sVEGFR-2 levels was associated with longer progression-free survival and overall survival.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)