Emerging roles of aerobic glycolysis in breast cancer

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

(2019) Dongya Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer

(2019) Jianan Chen et al.   Molecular Cancer

JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors

(2019) Emily A. Irey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation

(2019) Elise S. Hibdon et al.   NEOPLASIA

Transcriptional Regulation of the Warburg Effect in Cancer by SIX1

(2018) Ling Li et al.   CANCER CELL

Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007

(2018) Naoise C. Synnott et al.   CANCER LETTERS

AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation

(2018) Manipa Saha et al.   CANCER RESEARCH

HSPC159 promotes proliferation and metastasis by inducing epithelial-mesenchymal transition and activating the PI3K/Akt pathway in breast cancer

(2018) Jie Zheng et al.   CANCER SCIENCE

A Glycolysis Outsider Steps into the Cancer Spotlight

(2018) Marcus D. Goncalves et al.   Cell Metabolism

PFKFB3 is involved in breast cancer proliferation, migration, invasion and angiogenesis

(2018) Fang Peng et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade

(2018) Cheng-fu Cai et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation

(2018) Jong-Ho Lee et al.   MOLECULAR CELL

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer

(2018) Tingting Yang et al.   ONCOGENE

Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2

(2018) Mani Shankar Babu et al.   PLoS One

Lapatinib Inhibits Breast Cancer Cell Proliferation by Influencing PKM2 Expression

(2018) Mingxiu Guan et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis

(2018) Meysam Yousefi et al.   CELLULAR ONCOLOGY

Narciclasine induces autophagy-dependent apoptosis in triple-negative breast cancer cells by regulating the AMPK-ULK1 axis

(2018) Chuan Cao et al.   CELL PROLIFERATION

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

(2018) Subhamoy Dasgupta et al.   NATURE

Akt1 inhibition promotes breast cancer metastasis through EGFR-mediated β-catenin nuclear accumulation

(2018) Wei Li et al.   Cell Communication and Signaling

PKM2 promotes glucose metabolism through a let-7a-5p/Stat3/hnRNP-A1 regulatory feedback loop in breast cancer cells

(2018) Ao Yao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

(2018) Fei Han et al.   Nature Communications

Targeting the Hippo Pathway for Breast Cancer Therapy

(2018) Liqing Wu et al.   Cancers

Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity

(2017) Victor Castro et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells

(2017) L Poulain et al.   LEUKEMIA

PI3K-AKT-mTOR inhibitors in breast cancers: From tumor cell signaling to clinical trials

(2017) Nandini Dey et al.   PHARMACOLOGY & THERAPEUTICS

P53-miR-191- SOX4 regulatory loop affects apoptosis in breast cancer

(2017) Shivani Sharma et al.   RNA

MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer

(2017) Nana Li et al.   Cell Death & Disease

The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway

(2017) Yazhuo Liu et al.   Oncology Letters

IGF-1-mediated PKM2/β-catenin/miR-152 regulatory circuit in breast cancer

(2017) Yi-Yang Wen et al.   Scientific Reports

Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

(2017) Muheeb Beg et al.   eLife

SHARPIN Facilitates p53 Degradation in Breast Cancer Cells

(2017) Huijie Yang et al.   NEOPLASIA

Taming Tumor Glycolysis and Potential Implications for Immunotherapy

(2017) Shanmugasundaram Ganapathy-Kanniappan   Frontiers in Oncology

MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway

(2017) Yuan Miao et al.   Scientific Reports

High expressions of LDHA and AMPK as prognostic biomarkers for breast cancer

(2016) Xiaojia Huang et al.   BREAST

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer

(2016) Julie O’Neal et al.   BREAST CANCER RESEARCH AND TREATMENT

PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment

(2016) Angel Guerrero-Zotano et al.   CANCER AND METASTASIS REVIEWS

Hormone Receptor/Human Epidermal Growth Factor Receptor 2-positive breast cancer: Where we are now and where we are going

(2016) Francesco Schettini et al.   CANCER TREATMENT REVIEWS

Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer

(2016) Yuan Tang et al.   Clinical Breast Cancer

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

Cation-selective transporters are critical to the AMPK-mediated antiproliferative effects of metformin in human breast cancer cells

(2016) Hao Cai et al.   INTERNATIONAL JOURNAL OF CANCER

Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment

(2016) Carly C. Barron et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Narciclasine – an Amaryllidaceae Alkaloid with Potent Antitumor and Anti-Inflammatory Properties

(2016) Robert Fürst   PLANTA MEDICA

Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer

(2016) Liangqian Huang et al.   Scientific Reports

HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection

(2015) Valerie P Tan et al.   Autophagy

Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

(2015) Xin Ge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer

(2015) S. Jain et al.   CANCER RESEARCH

Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation

(2015) Alex J. Bott et al.   Cell Metabolism

Glucose promotes cell proliferation, glucose uptake and invasion in endometrial cancer cells via AMPK/mTOR/S6 and MAPK signaling

(2015) Jianjun Han et al.   GYNECOLOGIC ONCOLOGY

PIK3CA Mutations Are Associated With Decreased Benefit to Neoadjuvant Human Epidermal Growth Factor Receptor 2–Targeted Therapies in Breast Cancer

(2015) Ian J. Majewski et al.   JOURNAL OF CLINICAL ONCOLOGY

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells

(2015) Amélie Fouqué et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulatory circuit of PKM2/NF-κB/miR-148a/152-modulated tumor angiogenesis and cancer progression

(2015) Q Xu et al.   ONCOGENE

The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc

(2015) Xiao-Xin Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

(2015) Huimin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer

(2015) Jun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HER2-mTOR signaling–driven breast cancer cells require ER-associated degradation to survive

(2015) Navneet Singh et al.   Science Signaling

MYC and metabolism on the path to cancer

(2015) Annie L. Hsieh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The prognostic value of phosphorylated Akt in breast cancer: a systematic review

(2015) Zu-Yao Yang et al.   Scientific Reports

Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy

(2015) Xue-bing Li et al.   Thoracic Cancer

High Expression of Pyruvate Kinase M2 is Associated with Chemosensitivity to Epirubicin and 5-Fluorouracil in Breast Cancer

(2015) Yang Lin et al.   Journal of Cancer

HER2-mTOR signaling–driven breast cancer cells require ER-associated degradation to survive

(2015) Navneet Singh et al.   Science Signaling

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells

(2015) Yu Mi Woo et al.   PLoS One

mTORC2 dictates Warburg effect and drug resistance

(2014) Kenta Masui et al.   CELL CYCLE

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells

(2014) Pablo Garrido et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms associated with resistance to tamoxifen in estrogen receptor-positive breast cancer (Review)

(2014) RUBÍ VIEDMA-RODRÍGUEZ et al.   ONCOLOGY REPORTS

The structural basis for mTOR function

(2014) Domagoj Baretić et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27

(2014) A Yalcin et al.   Cell Death & Disease

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

(2014) Lei Wang et al.   Cell Reports

MYC Degradation

(2014) A. S. Farrell et al.   Cold Spring Harbor Perspectives in Medicine

Hormone Resistance in Two MCF-7 Breast Cancer Cell Lines is Associated with Reduced mTOR Signaling, Decreased Glycolysis, and Increased Sensitivity to Cytotoxic Drugs

(2014) Euphemia Yee Leung et al.   Frontiers in Oncology

Hexokinase II in breast carcinoma: A potent prognostic factor associated with hypoxia-inducible factor-1α and Ki-67

(2013) Akiko Sato-Tadano et al.   CANCER SCIENCE

Beta-naphthoflavone (DB06732) mediates estrogen receptor-positive breast cancer cell cycle arrest through AhR-dependent regulation of PI3K/AKT and MAPK/ERK signaling

(2013) Chun Wang et al.   CARCINOGENESIS

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

17β-Estradiol Activates Glucose Uptake via GLUT4 Translocation and PI3K/Akt Signaling Pathway in MCF-7 Cells

(2013) Pablo Garrido et al.   ENDOCRINOLOGY

Akt-dependent Activation of the Heart 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase (PFKFB2) Isoenzyme by Amino Acids

(2013) Laura Novellasdemunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SLC2 (GLUT) family of membrane transporters

(2013) Mike Mueckler et al.   MOLECULAR ASPECTS OF MEDICINE

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

(2013) Pengda Liu et al.   NATURE CELL BIOLOGY

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

A novel imidazopyridine derivative, HS-106, induces apoptosis of breast cancer cells and represses angiogenesis by targeting the PI3K/mTOR pathway

(2012) Guang-Yong Li et al.   CANCER LETTERS

A novel miR-155/miR-143 cascade controls glycolysis by regulatinghexokinase 2in breast cancer cells

(2012) Shuai Jiang et al.   EMBO JOURNAL

p53, a Target of Estrogen Receptor (ER) α, Modulates DNA Damage-induced Growth Suppression in ER-positive Breast Cancer Cells

(2012) Crystal E. Berger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer

(2012) J C Montero et al.   ONCOGENE

Estrogen receptor prevents p53-dependent apoptosis in breast cancer

(2012) S. T. Bailey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARγ contributes to PKM2 and HK2 expression in fatty liver

(2012) Ganna Panasyuk et al.   Nature Communications

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis

(2011) T L Ng et al.   CELL DEATH AND DIFFERENTIATION

PKM2: A gatekeeper between growth and survival

(2011) Isaac Harris et al.   CELL RESEARCH

“Overcoming breast cancer drug resistance with mTOR inhibitors”. Could it be a myth or a real possibility in the short-term future?

(2010) Nadia Margariti et al.   BREAST CANCER RESEARCH AND TREATMENT

The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

(2010) Carlos A. Castaneda et al.   CANCER AND METASTASIS REVIEWS

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

(2010) C. V. Clower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

BRCA1 tumours correlate with a HIF-1α phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression

(2009) M Yan et al.   BRITISH JOURNAL OF CANCER

Transcriptional Repression of Epithelial Cell Adhesion Molecule Contributes to p53 Control of Breast Cancer Invasion

(2009) N. V. Sankpal et al.   CANCER RESEARCH

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality

(2009) Elena López-Knowles et al.   INTERNATIONAL JOURNAL OF CANCER

Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases

(2009) Abdullah Yalcin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TOR complex 2: a signaling pathway of its own

(2009) Nadine Cybulski et al.   TRENDS IN BIOCHEMICAL SCIENCES

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Phosphoinositide 3-kinases in cell migration

(2008) Robert J. Cain et al.   BIOLOGY OF THE CELL

Disruption of estrogen receptor α-p53 interaction in breast tumors: a novel mechanism underlying the anti-tumor effect of radiation therapy

(2008) Wensheng Liu et al.   BREAST CANCER RESEARCH AND TREATMENT

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

Glucose Metabolism Attenuates p53 and Puma-dependent Cell Death upon Growth Factor Deprivation

(2008) Yuxing Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Apigenin Inhibits the GLUT-1 Glucose Transporter and the Phosphoinositide 3-Kinase/Akt Pathway in Human Pancreatic Cancer Cells

(2008) Laleh G. Melstrom et al.   PANCREAS

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

(2007) Jungwoon Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY