HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

(2015) S. Sriskanthadevan et al.   BLOOD

Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy

(2015) B.-S. Cho et al.   BLOOD

Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML

(2015) C E Forristal et al.   LEUKEMIA

Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway

(2015) Xiaojing Lin et al.   LEUKEMIA RESEARCH

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

2ME2 inhibits the activated hypoxia-inducible pathways by cabozantinib and enhances its efficacy against medullary thyroid carcinoma

(2015) Han Lin et al.   TUMOR BIOLOGY

Role of Microenvironment in Resistance to Therapy in AML

(2015) Yoko Tabe et al.   Current Hematologic Malignancy Reports

Targeting the Microenvironment in Acute Myeloid Leukemia

(2015) Armin Rashidi et al.   Current Hematologic Malignancy Reports

HIF-1α and GLUT1 Gene Expression is Associated with Chemoresistance of Acute Myeloid Leukemia

(2014) Kui Song et al.   Asian Pacific Journal of Cancer Prevention

Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells

(2014) Y. Wang et al.   BLOOD

HIF-1  can act as a tumor suppressor gene in murine acute myeloid leukemia

(2014) T. Velasco-Hernandez et al.   BLOOD

Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia

(2014) Nana Zhe et al.   Hematology

CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia

(2014) P M Korthuis et al.   LEUKEMIA

Outcome of children treated for relapsed acute myeloid leukemia in Central America

(2014) Stacey Marjerrison et al.   PEDIATRIC BLOOD & CANCER

The Histone Deacetylase Inhibitor, Vorinostat, Represses Hypoxia Inducible Factor 1 Alpha Expression through Translational Inhibition

(2014) Darren M. Hutt et al.   PLoS One

Reactive oxygen species, glutathione, and thioredoxin influence suberoyl bishydroxamic acid-induced apoptosis in A549 lung cancer cells

(2014) Bo Ra You et al.   TUMOR BIOLOGY

Anticancer Drug 2-Methoxyestradiol Protects against Renal Ischemia/Reperfusion Injury by Reducing Inflammatory Cytokines Expression

(2014) Ying-Yin Chen et al.   Biomed Research International

Citrate induces apoptosis of the acute monocytic leukemia U937 cell line through regulation of HIF-1α signaling

(2013) XIAOWEI XU et al.   Molecular Medicine Reports

The Contributions of HIF-Target Genes to Tumor Growth in RCC

(2013) Ting Zhang et al.   PLoS One

Cited2 Is Required for the Maintenance of Glycolytic Metabolism in Adult Hematopoietic Stem Cells

(2013) Jinwei Du et al.   STEM CELLS AND DEVELOPMENT

HIF-1  deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency

(2012) J. Du et al.   BLOOD

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment

(2012) Y. Chen et al.   BLOOD

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines

(2011) Peter Spégel et al.   BIOCHEMICAL JOURNAL

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Downregulation of c-Myc determines sensitivity to 2-methoxyestradiol–induced apoptosis in human acute myeloid leukemia

(2008) Jyh-Ming Chow et al.   EXPERIMENTAL HEMATOLOGY