Alternative Splicing in Angiogenesis

FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells

(2019) Ming Zhao et al.   Oncotarget

A VEGF-A/SOX2/SRSF2 network controls VEGFR1 pre-mRNA alternative splicing in lung carcinoma cells

(2019) Cherine Abou Faycal et al.   Scientific Reports

Fibroblast Growth Factor Receptor 4 Targeting in Cancer: New Insights into Mechanisms and Therapeutic Strategies

(2019) Liwei Lang et al.   Cells

Splicing and cancer: Challenges and opportunities

(2019) Patricia P. Coltri et al.   Wiley Interdisciplinary Reviews-RNA

A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

(2019) Yoo Hyung Kim et al.   Nature Communications

Regulation of angiogenesis by microRNAs in cardiovascular diseases

(2018) Devika Kir et al.   ANGIOGENESIS

Modulation of Angiopoietin 2 release from endothelial cells and angiogenesis by the synaptic protein Neuroligin 2

(2018) Margherita Pergolizzi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of fibroblast growth factor receptor-2 splicing in normal and cancer cells

(2018) Toshiyuki Ishiwata   Frontiers in Bioscience-Landmark

Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2

(2018) Chloe Peach et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Positive and Negative Regulation of Angiogenesis by Soluble Vascular Endothelial Growth Factor Receptor-1

(2018) Cristina Failla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ang-2 promotes lung cancer metastasis by increasing epithelial-mesenchymal transition

(2018) Zhizhen Dong et al.   Oncotarget

Open questions: How many genes do we have?

(2018) Steven L. Salzberg   BMC BIOLOGY

TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency

(2018) Takashi Yamazaki et al.   GENES & DEVELOPMENT

The Different Effects of VEGFA121 and VEGFA165 on Regulating Angiogenesis Depend on Phosphorylation Sites of VEGFR2

(2017) Wang Shiying et al.   INFLAMMATORY BOWEL DISEASES

Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion

(2017) Danilo Ranieri et al.   MOLECULAR CARCINOGENESIS

Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis

(2017) Peng Yao et al.   NUCLEIC ACIDS RESEARCH

Cervical cancer cell–derived angiopoietins promote tumor progression

(2017) Ping Yang et al.   TUMOR BIOLOGY

FDA Approves Eteplirsen for Duchenne Muscular Dystrophy: The Next Chapter in the Eteplirsen Saga

(2017) Annemieke Aartsma-Rus et al.   Nucleic Acid Therapeutics

Distinctive role of vasohibin-1A and its splicing variant vasohibin-1B in tumor angiogenesis

(2016) S Horie et al.   CANCER GENE THERAPY

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

Directional Phosphorylation and Nuclear Transport of the Splicing Factor SRSF1 Is Regulated by an RNA Recognition Motif

(2016) Pedro Serrano et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation

(2016) Takayuki Ikeda et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Novel Physiological Glycosaminoglycan-Deficient Splice Variant of Neuropilin-1 Is Anti-Tumorigenic In Vitro and In Vivo

(2016) Céline Hendricks et al.   PLoS One

NRP1 function and targeting in neurovascular development and eye disease

(2016) Claudio Raimondi et al.   PROGRESS IN RETINAL AND EYE RESEARCH

VEGFR-2 conformational switch in response to ligand binding

(2016) Sarvenaz Sarabipour et al.   eLife

The Size of the Human Proteome: The Width and Depth

(2016) Elena A. Ponomarenko et al.   International Journal of Analytical Chemistry

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis

(2016) Gareth W. Fearnley et al.   Biology Open

Angiopoietin-2: marker or mediator of angiogenesis in continuous-flow left ventricular assist device patients?

(2016) Lauren K. Truby et al.   Journal of Thoracic Disease

Angiogenesis as a Therapeutic Target in Endometriosis

(2016) Dusan Djokovic et al.   Acta Medica Portuguesa

The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis

(2015) G. A. Smith et al.   BIOSCIENCE REPORTS

A pharmacokinetic binding model for bevacizumab and VEGF165 in colorectal cancer patients

(2015) Eirini Panoilia et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Hypoxia promotes apoptosis of neuronal cells through hypoxia-inducible factor-1α-microRNA-204-B-cell lymphoma-2 pathway

(2015) Xiuwen Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The action of HIF-3α variants on HIF-2α–HIF-1β heterodimer formation is directly probed in live cells

(2015) Seong Ho Kim et al.   EXPERIMENTAL CELL RESEARCH

SRSF1-Regulated Alternative Splicing in Breast Cancer

(2015) Olga Anczuków et al.   MOLECULAR CELL

Splicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage

(2015) Daniel F. Comiskey et al.   NUCLEIC ACIDS RESEARCH

Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form

(2015) Matthew W. Parker et al.   STRUCTURE

Splicing and Proteolytic Processing in VEGF Signaling: Now It Is the Coreceptor’s Turn

(2015) Xiaolan Yao et al.   STRUCTURE

The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells

(2015) Yu-Chih Liang et al.   Oncotarget

Allosteric regulation of pathologic angiogenesis: potential application for angiogenesis-related blindness

(2014) Dong Hyun Jo et al.   ARCHIVES OF PHARMACAL RESEARCH

Angiogenic factors as potential drug target: Efficacy and limitations of anti-angiogenic therapy

(2014) Rajesh N. Gacche et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma

(2014) M V Gammons et al.   BRITISH JOURNAL OF CANCER

Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis

(2014) Sung-Hee Chang et al.   CURRENT OPINION IN HEMATOLOGY

Isoforms of Receptors of Fibroblast Growth Factors

(2014) Siew-Ging Gong   JOURNAL OF CELLULAR PHYSIOLOGY

VEGF-A isoforms differentially regulate ATF-2–dependent VCAM-1 gene expression and endothelial–leukocyte interactions

(2014) Gareth W. Fearnley et al.   MOLECULAR BIOLOGY OF THE CELL

An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease

(2014) Ryosuke Kikuchi et al.   NATURE MEDICINE

A day in the life of the spliceosome

(2014) A. Gregory Matera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Serine–arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer

(2014) A Mavrou et al.   ONCOGENE

NOTCH Decoys That Selectively Block DLL/NOTCH or JAG/NOTCH Disrupt Angiogenesis by Unique Mechanisms to Inhibit Tumor Growth

(2014) Thaned Kangsamaksin et al.   Cancer Discovery

The RNAissance family: SR proteins as multifaceted regulators of gene expression

(2014) Jonathan M. Howard et al.   Wiley Interdisciplinary Reviews-RNA

GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2

(2013) Silvia Coma et al.   ANGIOGENESIS

A hypoxia-inducible factor (HIF)-3α splicing variant, HIF-3α4 impairs angiogenesis in hypervascular malignant meningiomas with epigenetically silenced HIF-3α4

(2013) Hitoshi Ando et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Alternative Splicing Events Regulated by the Oncogenic Factor SRSF1 in Lung Cancer

(2013) F. J. de Miguel et al.   CANCER RESEARCH

AUF1-RGG peptides up-regulate the VEGF antagonist, soluble VEGF receptor-1 (sFlt-1)

(2013) Abigail Fellows et al.   CYTOKINE

Detection of VEGF-Axxxb Isoforms in Human Tissues

(2013) David O. Bates et al.   PLoS One

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

SRPK1 inhibitionin vivo: modulation of VEGF splicing and potential treatment for multiple diseases: Figure 1

(2012) Sebastian Oltean et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Neuropilin-1Stimulates Tumor Growth by Increasing Fibronectin Fibril Assembly in the Tumor Microenvironment

(2012) Usman Yaqoob et al.   CANCER RESEARCH

Vasohibin induces prolyl hydroxylase-mediated degradation of hypoxia-inducible factor-1α in human umbilical vein endothelial cells

(2012) Tomohiro Kozako et al.   FEBS LETTERS

The vasohibin family: a novel family for angiogenesis regulation

(2012) Y. Sato   JOURNAL OF BIOCHEMISTRY

Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

(2012) Matthew W. Parker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vasohibin-2 Expressed in Human Serous Ovarian Adenocarcinoma Accelerates Tumor Growth by Promoting Angiogenesis

(2012) Y. Takahashi et al.   MOLECULAR CANCER RESEARCH

Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F

(2012) Erming Wang et al.   PLoS One

Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing

(2011) Takayuki Ikeda et al.   BIOCHEMICAL JOURNAL

CAPER-α alternative splicing regulates the expression of vascular endothelial growth factor165 in Ewing sarcoma cells

(2011) Gangxiong Huang et al.   CANCER

WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing

(2011) Elianna M. Amin et al.   CANCER CELL

Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L

(2011) Faegheh Jafarifar et al.   EMBO JOURNAL

VEGF gene alternative splicing: pro- and anti-angiogenic isoforms in cancer

(2011) P. M. Biselli-Chicote et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation

(2011) Birger Herzog et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Using positional distribution to identify splicing elements and predict pre-mRNA processing defects in human genes

(2011) K. H. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1

(2011) J.-N. Boeckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble VEGFR-2: an antilymphangiogenic variant of VEGF receptors

(2010) Helena Pavlakovic et al.   Annals of the New York Academy of Sciences

Protein Kinase Cδ Deficiency Accelerates Neointimal Lesions of Mouse Injured Artery Involving Delayed Reendothelialization and Vasohibin-1 Accumulation

(2010) Xue Bai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins)

(2010) J. L. Manley et al.   GENES & DEVELOPMENT

The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo

(2010) G Merdzhanova et al.   ONCOGENE

The role of the Angiopoietins in vascular morphogenesis

(2009) Markus Thomas et al.   ANGIOGENESIS

VEGF121b, a new member of the VEGF xxx b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo

(2009) E S Rennel et al.   BRITISH JOURNAL OF CANCER

Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms

(2009) Dawid G. Nowak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A systems biology perspective on sVEGFR1: its biological function, pathogenic role & therapeutic use

(2009) Florence T.H. Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth

(2009) Romulo J C Albuquerque et al.   NATURE MEDICINE

Novel Splice Variants of sFlt1 are Upregulated in Preeclampsia

(2009) M. Heydarian et al.   PLACENTA

Alternative Splicing of Vasohibin-1 Generates an Inhibitor of Endothelial Cell Proliferation, Migration, and Capillary Tube Formation

(2008) Johann Kern et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

(2008) Maresa Caunt et al.   CANCER CELL

Vascular Endothelial Growth Factor (VEGF)-A165b Is a Weak In vitro Agonist for VEGF Receptor-2 Due to Lack of Coreceptor Binding and Deficient Regulation of Kinase Activity

(2008) H. Kawamura et al.   CANCER RESEARCH

Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway

(2008) Paul Frankel et al.   EMBO REPORTS

Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1α in activated human T lymphocytes

(2008) Dmitriy Lukashev et al.   HUMAN IMMUNOLOGY

Aberrant Receptor Internalization and Enhanced FRS2-dependent Signaling Contribute to the Transforming Activity of the Fibroblast Growth Factor Receptor 2 IIIb C3 Isoform

(2008) Jiyoung Y. Cha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors

(2008) D. G. Nowak et al.   JOURNAL OF CELL SCIENCE

A stress-responsive RNA switch regulates VEGFA expression

(2008) Partho Sarothi Ray et al.   NATURE

5-Aza-2′-deoxycytidine increases the expression of anti-angiogenic vascular endothelial growth factor 189b variant in human lung microvascular endothelial cells

(2007) E. Miller-Kasprzak et al.   BIOMEDICINE & PHARMACOTHERAPY