Mitochondrial DNA Integrity: Role in Health and Disease

Mechanisms of Mitochondrial DNA Repair in Mammals

(2018) L. A. Zinovkina   BIOCHEMISTRY-MOSCOW

The C-terminal tail of the NEIL1 DNA glycosylase interacts with the human mitochondrial single-stranded DNA binding protein

(2018) Nidhi Sharma et al.   DNA REPAIR

8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis

(2018) Katja Scheffler et al.   DNA REPAIR

An overview of mammalian mitochondrial DNA replication mechanisms

(2018) Takehiro Yasukawa et al.   JOURNAL OF BIOCHEMISTRY

Mitochondrial maintenance under oxidative stress depends on mitochondrially localised α-OGG1

(2018) Debora Lia et al.   JOURNAL OF CELL SCIENCE

Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA

(2018) Thomas J. Nicholls et al.   MOLECULAR CELL

Mitochondrial DNA Transcription and Its Regulation: An Evolutionary Perspective

(2018) Gilad Barshad et al.   TRENDS IN GENETICS

Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet

(2018) Dolores Corella et al.   Journal of the Academy of Nutrition and Dietetics

Structural basis of mitochondrial transcription

(2018) Hauke S. Hillen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DNA Repair Protein OGG1 Protects Against Obesity by Altering Mitochondrial Energetics in White Adipose Tissue

(2018) Sai Santosh Babu Komakula et al.   Scientific Reports

Biparental Inheritance of Mitochondrial DNA in Humans

(2018) Shiyu Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole sequence of the mitochondrial DNA genome of Kearns Sayre Syndrome patients: Identification of deletions and variants

(2018) Angélica Saldaña-Martínez et al.   GENE

Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease

(2018) E. Sandra Chocron et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?

(2017) Yusaku Nakabeppu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial transcription in mammalian cells

(2017) Mikhail F Alexeyev   Frontiers in Bioscience-Landmark

Mitochondrial DNA repair and damage tolerance

(2017) Elaine A Sia   Frontiers in Bioscience-Landmark

The little big genome the organization of mitochondrial DNA

(2017) Robert Gilkerson   Frontiers in Bioscience-Landmark

Re-imagining Alzheimer's disease - the diminishing importance of amyloid and a glimpse of what lies ahead

(2017) Kai-Hei Tse et al.   JOURNAL OF NEUROCHEMISTRY

Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion

(2017) Aaron F. Phillips et al.   MOLECULAR CELL

Editor’s Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinson’s Disease Risk

(2017) Laurie H. Sanders et al.   TOXICOLOGICAL SCIENCES

The Mitochondrial Basis of Aging and Age-Related Disorders

(2017) Sarika Srivastava   Genes

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

(2017) Vladimir Vartanian et al.   PLoS One

Associations between DNA Damage, DNA Base Excision Repair Gene Variability and Alzheimer's Disease Risk

(2016) Dominik Kwiatkowski et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Aging of hematopoietic stem cells: DNA damage and mutations?

(2016) Bettina M. Moehrle et al.   EXPERIMENTAL HEMATOLOGY

The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

(2016) Narciso Couto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial DNA damage induced autophagy cell death and disease

(2016) Bennett Van Houten   Frontiers in Bioscience-Landmark

Uncoupling proteins of invertebrates: A review

(2016) Malgorzata Slocinska et al.   IUBMB LIFE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions

(2016) Julio Leon et al.   Scientific Reports

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice

(2016) Tonje Skarpengland et al.   Scientific Reports

Oxidative DNA damage stalls the human mitochondrial replisome

(2016) Gorazd Stojkovič et al.   Scientific Reports

Biochemical abnormalities in Pearson syndrome

(2015) Beatrice Letizia Crippa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Leigh syndrome: One disorder, more than 75 monogenic causes

(2015) Nicole J. Lake et al.   ANNALS OF NEUROLOGY

The role of mitochondrial dysfunction in age-related diseases

(2015) Rebecca K. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Base Excision Repair in the Mitochondria

(2015) Aishwarya Prakash et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A mitochondrial superoxide theory for oxidative stress diseases and aging

(2015) Hiroko P. Indo et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Redefining phenotypes associated with mitochondrial DNA single deletion

(2015) Michelangelo Mancuso et al.   JOURNAL OF NEUROLOGY

MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options

(2015) Ayman W. El-Hattab et al.   MOLECULAR GENETICS AND METABOLISM

Gene mutations in the D-loop region of mitochondrial DNA in oral squamous cell carcinoma

(2015) RONG-TAO YUAN et al.   Molecular Medicine Reports

TEFM is a potent stimulator of mitochondrial transcription elongation in vitro

(2015) Viktor Posse et al.   NUCLEIC ACIDS RESEARCH

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain

(2015) Jian Jiang et al.   TOXICOLOGY LETTERS

Mitochondrial epigenetics: an overlooked layer of regulation?

(2015) Monique G.P. van der Wijst et al.   TRENDS IN GENETICS

DNA Damage, DNA Repair, Aging, and Neurodegeneration

(2015) Scott Maynard et al.   Cold Spring Harbor Perspectives in Medicine

Oxidative DNA damage in disease-Insights gained from base excision repair glycosylase-deficient mouse models

(2014) Harini Sampath   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Treatment strategies for inherited optic neuropathies: past, present and future

(2014) P Yu-Wai-Man et al.   EYE

Defects of Mitochondrial DNA Replication

(2014) William C. Copeland   JOURNAL OF CHILD NEUROLOGY

Associations Between hOGG1 Ser326Cys Polymorphism and Increased Body Mass Index and Fasting Glucose Level in the Japanese General Population

(2014) Megumi Hara et al.   JOURNAL OF EPIDEMIOLOGY

Comparative analysis of human mitochondrial methylomes shows distinct patterns of epigenetic regulation in mitochondria

(2014) Sourav Ghosh et al.   MITOCHONDRION

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication

(2014) Javier Miralles Fusté et al.   PLoS Genetics

Epidemiological, Clinical, and Molecular Study of a Cohort of Italian Parkinson Disease Patients: Association with Glutathione-S-Transferase and DNA Repair Gene Polymorphisms

(2013) Tommaso Cornetta et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern

(2013) D. Bellizzi et al.   DNA RESEARCH

Alteration of Mitochondrial Function and Insulin Sensitivity in Primary Mouse Skeletal Muscle Cells Isolated From Transgenic and Knockout Mice: Role of OGG1

(2013) Larysa V. Yuzefovych et al.   ENDOCRINOLOGY

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

(2013) Sara García-Gómez et al.   MOLECULAR CELL

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

(2013) Larysa V. Yuzefovych et al.   PLoS One

Accessorizing the human mitochondrial transcription machinery

(2013) Megan L. Bestwick et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Regulation of DNA glycosylases and their role in limiting disease

(2012) Harini Sampath et al.   FREE RADICAL RESEARCH

Mitochondrial Protein Synthesis, Import, and Assembly

(2012) Thomas D. Fox   GENETICS

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

(2012) Zijing Sheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase: implications for bypass RNA synthesis on oxidative DNA lesions

(2012) Nozomi Nakanishi et al.   MUTAGENESIS

Minimizing the damage: repair pathways keep mitochondrial DNA intact

(2012) Lawrence Kazak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

(2012) Harini Sampath et al.   PLoS One

Human Mitochondrial DNA Replication

(2012) I. J. Holt et al.   Cold Spring Harbor Perspectives in Biology

Obesity and Hepatosteatosis in Mice with Enhanced Oxidative DNA Damage Processing in Mitochondria

(2011) Haihong Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice

(2011) Harini Sampath et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hitting the brakes: Termination of mitochondrial transcription

(2011) Kip E. Guja et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells

(2011) Heini Ruhanen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Human Mitochondrial Transcriptome

(2011) Tim R. Mercer et al.   CELL

DNA ligase III

(2011) Deniz Simsek et al.   CELL CYCLE

RNA processing in human mitochondria

(2011) Maria I.G. Lopez Sanchez et al.   CELL CYCLE

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

Protection from Palmitate-Induced Mitochondrial DNA Damage Prevents from Mitochondrial Oxidative Stress, Mitochondrial Dysfunction, Apoptosis, and Impaired Insulin Signaling in Rat L6 Skeletal Muscle Cells

(2011) Larysa V. Yuzefovych et al.   ENDOCRINOLOGY

Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome

(2011) Santi M. Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial DNA transcription regulation and nucleoid organization

(2011) Adriana P. Rebelo et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mitochondrial DNA Damage Level Determines Neural Stem Cell Differentiation Fate

(2011) W. Wang et al.   JOURNAL OF NEUROSCIENCE

Repair of persistent strand breaks in the mitochondrial genome

(2011) Peter Sykora et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial Ribosomal Protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription

(2011) Y. V. Surovtseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

(2011) M. Sato et al.   SCIENCE

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

(2011) S. Al Rawi et al.   SCIENCE

Overview of Base Excision Repair Biochemistry

(2011) Yun-Jeong Kim et al.   Current Molecular Pharmacology

The Ser(326)Cys Polymorphism of 8-Oxoguanine Glycosylase 1 (OGG1) Is Associated with Type 2 Diabetes in Mexican Americans

(2010) Farook Thameem et al.   HUMAN HEREDITY

Human Mitochondrial Transcription Revisited

(2010) Dmitry Litonin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease

(2010) Fabio Coppedè et al.   NEUROSCIENCE LETTERS

Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease

(2010) Aurelia Santoro et al.   PLoS One

Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations

(2009) Young-Sam Lee et al.   CELL

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Oxidative stress induces degradation of mitochondrial DNA

(2009) Inna Shokolenko et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial DNA, base excision repair and neurodegeneration

(2008) Nadja C. de Souza-Pinto et al.   DNA REPAIR

Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains

(2008) Veslemøy Rolseth et al.   DNA REPAIR

Mitochondrial Transcription Factor B2 Is Essential for Metabolic Function inDrosophila melanogasterDevelopment

(2008) Cristina Adán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tandem duplication/triplication correlated with poly-cytosine stretch variation in human mitochondrial DNA D-loop region

(2008) W.-Y. Hung et al.   MUTAGENESIS

Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions

(2008) Ricardo Gredilla et al.   NEUROBIOLOGY OF AGING

Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro

(2008) S. Wanrooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA