Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

Induction of Oxidative Stress via Inhibition of Thioredoxin Reductase 1 is an Effective Therapeutic Approach for Hepatocellular Carcinoma

(2018) Derek Lee et al.   HEPATOLOGY

Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma

(2017) Derek Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

(2017) Anthony B El-Khoueiry et al.   LANCET

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

(2016) S. Agnihotri et al.   CANCER RESEARCH

NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma

(2016) R. K.-H. Lai et al.   CLINICAL CANCER RESEARCH

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

(2016) Kenneth R. Pryde et al.   JOURNAL OF CELL BIOLOGY

Transketolase counteracts oxidative stress to drive cancer development

(2016) Iris Ming-Jing Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling

(2016) Eunice Yuen Ting Lau et al.   Cell Reports

Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers

(2016) Zhixin Qiu et al.   Scientific Reports

PI3K isoform-selective inhibitors: next-generation targeted cancer therapies

(2015) Xiang Wang et al.   ACTA PHARMACOLOGICA SINICA

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Novel Basic Helix–Loop–Helix Transcription Factor Hes4 Antagonizes the Function of Twist-1 to Regulate Lineage Commitment of Bone Marrow Stromal/Stem Cells

(2015) Dimitrios Cakouros et al.   STEM CELLS AND DEVELOPMENT

PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402

(2014) Liesbeth Aerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease

(2014) Roberta Tufi et al.   NATURE CELL BIOLOGY

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

(2014) V. A. Morais et al.   SCIENCE

PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1

(2014) Raquel Requejo-Aguilar et al.   Nature Communications

PINK1-mediated Phosphorylation of Miro Inhibits Synaptic Growth and Protects Dopaminergic Neurons in Drosophila

(2014) Pei-I Tsai et al.   Scientific Reports

PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage

(2013) G Arena et al.   CELL DEATH AND DIFFERENTIATION

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

The impact of hypoxia in hepatocellular carcinoma metastasis

(2013) Carmen Chak-Lui Wong et al.   Frontiers of Medicine

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Target Gene Analysis by Microarrays and Chromatin Immunoprecipitation Identifies HEY Proteins as Highly Redundant bHLH Repressors

(2012) Julia Heisig et al.   PLoS Genetics

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

(2011) Olga Corti et al.   PHYSIOLOGICAL REVIEWS

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

(2011) C. C.-L. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation

(2009) Y. Mei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Quest for the 1p36 Tumor Suppressor

(2008) A. Bagchi et al.   CANCER RESEARCH

PINK1heterozygous rare variants: prevalence, significance and phenotypic spectrum

(2008) Roberta Marongiu et al.   HUMAN MUTATION

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

(2008) Ann-Lii Cheng et al.   LANCET ONCOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE