Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer

Novel compound heterozygous LIAS mutations cause glycine encephalopathy

(2015) Yoshinori Tsurusaki et al.   JOURNAL OF HUMAN GENETICS

Identification of potential mitochondrial CLPXP protease interactors and substrates suggests its central role in energy metabolism

(2015) Fabian Fischer et al.   Scientific Reports

Polymerase  -Interacting Protein 2 Promotes Postischemic Neovascularization of the Mouse Hindlimb

(2014) A. M. Amanso et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TPpred2: improving the prediction of mitochondrial targeting peptide cleavage sites by exploiting sequence motifs

(2014) Castrense Savojardo et al.   BIOINFORMATICS

Poldip2 Knockout Results in Perinatal Lethality, Reduced Cellular Growth and Increased Autophagy of Mouse Embryonic Fibroblasts

(2014) David I. Brown et al.   PLoS One

Polymerase Delta Interacting Protein 2 Sustains Vascular Structure and Function

(2013) Roy L. Sutliff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The prediction of organelle-targeting peptides in eukaryotic proteins with Grammatical-Restrained Hidden Conditional Random Fields

(2013) Valentina Indio et al.   BIOINFORMATICS

Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5

(2013) Peter R. Baker et al.   BRAIN

Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes

(2013) Frederic Tort et al.   HUMAN MOLECULAR GENETICS

Mitochondrial matrix proteases as novel therapeutic targets in malignancy

(2013) C A Goard et al.   ONCOGENE

Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase

(2013) Yohan Soreze et al.   Orphanet Journal of Rare Diseases

Lipoic Acid Synthetase Deficiency Causes Neonatal-Onset Epilepsy, Defective Mitochondrial Energy Metabolism, and Glycine Elevation

(2011) Johannes A. Mayr et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ClpXP, an ATP-powered unfolding and protein-degradation machine

(2011) Tania A. Baker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Assessing bioenergetic function in response to oxidative stress by metabolic profiling

(2011) Brian P. Dranka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis

(2011) Yi-Fen Lo et al.   KIDNEY INTERNATIONAL

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH