HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response

Mitochondrial Dysfunction in Huntington’s Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors

(2019) Taylor A. Intihar et al.   Frontiers in Cellular Neuroscience

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

PARP1 promotes the human heat shock response by facilitating HSF1 binding to DNA

(2018) Mitsuaki Fujimoto et al.   MOLECULAR AND CELLULAR BIOLOGY

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Regulation of heat shock transcription factors and their roles in physiology and disease

(2017) Rocio Gomez-Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation

(2016) Christian Münch et al.   NATURE

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity

(2015) Ke Tan et al.   Nature Communications

Differential Scales of Protein Quality Control

(2014) Suzanne Wolff et al.   CELL

Mitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila

(2014) Rehan M. Baqri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ATF1 Modulates the Heat Shock Response by Regulating the Stress-Inducible Heat Shock Factor 1 Transcription Complex

(2014) Ryosuke Takii et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Hallmarks of a new era in mitochondrial biochemistry

(2013) D. J. Pagliarini et al.   GENES & DEVELOPMENT

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

(2013) Eva D. Runkel et al.   PLoS Genetics

The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives

(2012) S. H. Bernstein et al.   BLOOD

RPA Assists HSF1 Access to Nucleosomal DNA by Recruiting Histone Chaperone FACT

(2012) Mitsuaki Fujimoto et al.   MOLECULAR CELL

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells

(2011) Markus D. Siegelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Lack of maternal Heat Shock Factor 1 results in multiple cellular and developmental defects, including mitochondrial damage and altered redox homeostasis, and leads to reduced survival of mammalian oocytes and embryos

(2010) Christiane Bierkamp et al.   DEVELOPMENTAL BIOLOGY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Mammalian Heat Shock Factor 1 Is Essential for Oocyte Meiosis and Directly Regulates Hsp90α Expression

(2009) Aïcha Metchat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

(2009) Byoung Heon Kang et al.   JOURNAL OF CLINICAL INVESTIGATION