Role of the mitochondrial stress response in human cancer progression

Signaling and Regulation of the Mitochondrial Unfolded Protein Response

(2019) Nandhitha Uma Naresh et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment

(2019) Dongki Yang et al.   Cells

Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells

(2019) Maria Kalli et al.   Scientific Reports

MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction

(2019) Huanyu Lu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancer

(2019) Jui-Chih Chang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome

(2019) Ruud P. H. Raijmakers et al.   Journal of Translational Medicine

Regulation of succinate dehydrogenase and role of succinate in cancer

(2019) Elisa Dalla Pozza et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer

(2019) Hong-En Yu et al.   Cell Death & Disease

Mitohormesis Primes Tumor Invasion and Metastasis

(2019) Timothy C. Kenny et al.   Cell Reports

Mitophagy in Cancer: A Tale of Adaptation

(2019) Vara-Perez et al.   Cells

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

(2019) Feven Tameire et al.   NATURE CELL BIOLOGY

Mitochondrial DNA Variants and Common Diseases: A Mathematical Model for the Diversity of Age-Related mtDNA Mutations

(2019) Huanzheng Li et al.   Cells

A Clinicopathologic and Molecular Analysis of Fumarate Hydratase-Deficient Renal Cell Carcinoma in 32 Patients

(2019) Hubert D. Lau et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma

(2019) Yu-Yu Kao et al.   CANCER LETTERS

Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

(2019) Saara Forsström et al.   Cell Metabolism

Association between Circulating Fibroblast Growth Factor 21 and Aggressiveness in Thyroid Cancer

(2019) Yea Eun Kang et al.   Cancers

Mitochondrial plasticity in cell fate regulation

(2019) Amir Bahat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitocellular communication: Shaping health and disease

(2019) Adrienne Mottis et al.   SCIENCE

Involvement of mitophagy in cisplatin-induced cell death regulation

(2018) Alibek Abdrakhmanov et al.   BIOLOGICAL CHEMISTRY

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress

(2018) Kyung Hwa Kim et al.   Cell Metabolism

Mitochondrial dynamics: overview of molecular mechanisms

(2018) Lisa Tilokani et al.   Essays in Biochemistry

GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2

(2018) Shan Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Esophageal squamous cell carcinoma with low mitochondrial copy number has mesenchymal and stem-like characteristics, and contributes to poor prognosis

(2018) Yasunori Masuike et al.   PLoS One

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

(2018) Angelika S. Rambold et al.   TRENDS IN IMMUNOLOGY

Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets

(2018) Ádám Nagy et al.   Scientific Reports

EZH2-Mediated Epigenetic Suppression of GDF15 Predicts a Poor Prognosis and Regulates Cell Proliferation in Non-Small-Cell Lung Cancer

(2018) Xiyi Lu et al.   Molecular Therapy-Nucleic Acids

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

Role of Signaling Molecules in Mitochondrial Stress Response

(2018) Shauna Hill et al.   Frontiers in Genetics

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Targeting Toll-Like Receptors for Cancer Therapy

(2018) Marc J. Braunstein et al.   Targeted Oncology

Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases

(2018) Camila Florencia Zuccato et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis

(2018) Sheng-Fan Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GDF15 and Growth Control

(2018) Paul J. Emmerson et al.   Frontiers in Physiology

Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation

(2017) Takeo Goji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Nutrient acquisition strategies of mammalian cells

(2017) Wilhelm Palm et al.   NATURE

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Low SIRT3 expression contributes to tumor progression, development and poor prognosis in human pancreatic carcinoma

(2017) Shanshan Huang et al.   PATHOLOGY RESEARCH AND PRACTICE

SGK3 sustains ERα signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis

(2017) Yuanzhong Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

(2017) Inge M.N. Wortel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility

(2017) Chun-Shik Shin et al.   Nature Communications

Succinate: An initiator in tumorigenesis and progression

(2017) Ting Zhao et al.   Oncotarget

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway

(2017) Meng-Shian Chen et al.   Oncotarget

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

(2017) Elodie Villa et al.   Cell Reports

The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond

(2017) Timothy C. Kenny et al.   Frontiers in Oncology

The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities

(2017) Kate L. Hertweck et al.   Frontiers in Oncology

Transcriptomic analysis of mitochondrial TFAM depletion changing cell morphology and proliferation

(2017) Woo Rin Lee et al.   Scientific Reports

IDH mutations in cancer and progress toward development of targeted therapeutics

(2016) L. Dang et al.   ANNALS OF ONCOLOGY

Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype

(2016) Xianghui Zou et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Fumarate drives EMT in renal cancer

(2016) Marco Sciacovelli et al.   CELL DEATH AND DIFFERENTIATION

A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers

(2016) G. Karpel-Massler et al.   CLINICAL CANCER RESEARCH

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Role of mitochondrial dysfunction in cancer progression

(2016) Chia-Chi Hsu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Nuclear respiratory factor-1 and bioenergetics in tamoxifen-resistant breast cancer cells

(2016) Brandie N. Radde et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond

(2016) Song Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Isocitrate dehydrogenase mutations in myeloid malignancies

(2016) B C Medeiros et al.   LEUKEMIA

Gemcitabine-Induced Autophagy Protects Human Lung Cancer Cells from Apoptotic Death

(2016) Hui-Mei Wu et al.   LUNG

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis

(2016) Ulrike Topf et al.   TRENDS IN CELL BIOLOGY

MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features

(2016) Xiaoran Li et al.   Oncotarget

Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway

(2016) Sheng-Fan Wang et al.   Oncotarget

Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study

(2016) Ishrat Mahjabeen et al.   PLoS One

Combined Secretomics and Transcriptomics Revealed Cancer-Derived GDF15 is Involved in Diffuse-Type Gastric Cancer Progression and Fibroblast Activation

(2016) Takayuki Ishige et al.   Scientific Reports

Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders

(2015) Shuichi Yatsuga et al.   ANNALS OF NEUROLOGY

Mitochondrial dysfunction and risk of cancer

(2015) M Lund et al.   BRITISH JOURNAL OF CANCER

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2015) Alicia Cole et al.   CANCER CELL

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

(2015) Changhan Lee et al.   Cell Metabolism

ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2-deoxyglucose in the same cells

(2015) Clara Lucía León-Annicchiarico et al.   FEBS Journal

Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma

(2015) Kristine M. Cornejo et al.   HUMAN PATHOLOGY

Mitochondria Retrograde Signaling and the UPRmt: Where Are We in Mammals?

(2015) Thierry Arnould et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

(2015) Souvik Dey et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAF V600E Melanoma

(2015) Shira Y. Wieder et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases

(2015) Yasunori Fujita et al.   MITOCHONDRION

Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors

(2015) Madhavika N. Serasinghe et al.   MOLECULAR CELL

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

The molecular era of the mitochondrial calcium uniporter

(2015) Kimberli J. Kamer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis

(2015) Zhipeng Wang et al.   Scientific Reports

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

(2015) Norman Moullan et al.   Cell Reports

Mitochondrial Dynamics Protein Drp1 Is Overexpressed in Oncocytic Thyroid Tumors and Regulates Cancer Cell Migration

(2015) André Ferreira-da-Silva et al.   PLoS One

Mitochondrial dysfunction in cancer chemoresistance

(2014) Nicoletta Guaragnella et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial DNA copy number is associated with diagnosis and prognosis of head and neck cancer

(2014) Frank Cheau-Feng Lin et al.   BIOMARKERS

ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use

(2014) Rebeca Acín-Pérez et al.   Cell Metabolism

p53 Is Required for Cisplatin-induced Processing of the Mitochondrial Fusion Protein L-Opa1 That Is Mediated by the Mitochondrial Metallopeptidase Oma1 in Gynecologic Cancers

(2014) Bao Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Genetics and Disease

(2014) Estela Area-Gomez et al.   JOURNAL OF CHILD NEUROLOGY

The Expression of Genes Involved in Hepatocellular Carcinoma Chemoresistance Is Affected by Mitochondrial Genome Depletion

(2014) Ester Gonzalez-Sanchez et al.   MOLECULAR PHARMACEUTICS

Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition

(2014) L Jiang et al.   ONCOGENE

Isocitrate Dehydrogenase 1 (IDH1) Mutation in Breast Adenocarcinoma Is Associated With Elevated Levels of Serum and Urine 2-Hydroxyglutarate

(2014) A. T. Fathi et al.   ONCOLOGIST

Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression

(2014) Hsin-Chen Lee   WORLD JOURNAL OF GASTROENTEROLOGY

Genome expression analysis by suppression subtractive hybridization identified overexpression of Humanin, a target gene in gastric cancer chemoresistance

(2014) Negar Mottaghi-Dastjerdi et al.   DARU-Journal of Pharmaceutical Sciences

Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells

(2013) Chia-Chi Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The broadening spectrum of mitochondrial disease: Shifts in the diagnostic paradigm

(2013) Christina Liang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress

(2013) Chaofeng Yang et al.   BMC GASTROENTEROLOGY

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation

(2013) T. Kelly Rainbolt et al.   Cell Metabolism

The role of dynamin-related protein 1 in cancer growth: a promising therapeutic target?

(2013) Wei Qian et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

(2013) Antonio F. Santidrian et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

(2013) V. Jovaisaite et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics

(2013) Manti Guha et al.   MITOCHONDRION

SirT3 Regulates the Mitochondrial Unfolded Protein Response

(2013) L. Papa et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Sirt3 is a tumor suppressor in lung adenocarcinoma cells

(2013) KUI XIAO et al.   ONCOLOGY REPORTS

A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways

(2013) S. Chae et al.   Science Signaling

Blocking mtDNA Replication Upregulates the Expression of Stemness-related Genes in Prostate Cancer Cell Lines

(2013) Yishan Liu et al.   ULTRASTRUCTURAL PATHOLOGY

SIRT3 Expression as a Biomarker for Better Prognosis in Gastric Cancer

(2013) Kuo-Hung Huang et al.   WORLD JOURNAL OF SURGERY

Oncogenic Isocitrate Dehydrogenase Mutations: Mechanisms, Models, and Clinical Opportunities

(2013) R. A. Cairns et al.   Cancer Discovery

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

AMPK and GCN2–ATF4 signal the repression of mitochondria in colon cancer cells

(2012) Inmaculada Martínez-Reyes et al.   BIOCHEMICAL JOURNAL

Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells

(2012) Wen-Yi Hung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The retrograde response: When mitochondrial quality control is not enough

(2012) S. Michal Jazwinski   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

(2012) Ralph J. DeBerardinis et al.   CELL

Mitochondrial dynamics is affected by 17β-estradiol in the MCF-7 breast cancer cell line. Effects on fusion and fission related genes

(2012) Jorge Sastre-Serra et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Glioma derived isocitrate dehydrogenase-2 mutations induced up-regulation of HIF-1α and β-catenin signaling: Possible impact on glioma cell metastasis and chemo-resistance

(2012) Yuejun Fu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

(2012) Laura Formentini et al.   MOLECULAR CELL

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

When more is less

(2012) Lei Jiang et al.   NATURE

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial dynamics regulates migration and invasion of breast cancer cells

(2012) J Zhao et al.   ONCOGENE

Low SIRT3 Expression Correlates with Poor Differentiation and Unfavorable Prognosis in Primary Hepatocellular Carcinoma

(2012) Chris Zhiyi Zhang et al.   PLoS One

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

SDH mutations in cancer

(2011) Chiara Bardella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The awakening of an advanced malignant cancer: An insult to the mitochondrial genome

(2011) Cody C. Cook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Somatic mutations of the mitochondrial genome in human breast cancers

(2011) Ling-Ming Tseng et al.   GENES CHROMOSOMES & CANCER

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

(2011) Anu Suomalainen et al.   LANCET NEUROLOGY

Novel Role of Androgens in Mitochondrial Fission and Apoptosis

(2011) V. Choudhary et al.   MOLECULAR CANCER RESEARCH

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Mediates HIF-2α Accumulation and Promotes Migration and Invasion

(2011) Sunil Sudarshan et al.   PLoS One

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Mitochondrial energy metabolism and ageing

(2010) Ivana Bratic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial DNA Content as a Potential Marker to Predict Response to Anthracycline in Breast Cancer Patients

(2010) Chih-Wei Hsu et al.   Breast Journal

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer

(2010) Turki Y. Alhazzazi et al.   CANCER

Obtusilactone A and (−)-sesamin induce apoptosis in human lung cancer cells by inhibiting mitochondrial Lon protease and activating DNA damage checkpoints

(2010) Hui-Min Wang et al.   CANCER SCIENCE

How do tumours adapt to nutrient stress?

(2010) Ronald C Wek et al.   EMBO JOURNAL

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4-CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

(2010) Z. Galehdar et al.   JOURNAL OF NEUROSCIENCE

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer

(2009) Wen-Yi Hung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial dysfunction-induced amphiregulin upregulation mediates chemo-resistance and cell migration in HepG2 cells

(2009) C.-J. Chang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial DNA Instability and Metabolic Shift in Human Cancers

(2009) Hsin-Chen Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in mitochondrial DNA polymerase-γ promote breast tumorigenesis

(2009) Keshav K Singh et al.   JOURNAL OF HUMAN GENETICS

The role of mitochondrial DNA alterations in esophageal squamous cell carcinomas

(2009) Chen-Sung Lin et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Somatic mutations of mitochondrial genome in hepatocellular carcinoma

(2009) Pen-Hui Yin et al.   MITOCHONDRION

Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia

(2009) Jillian M. Silva et al.   NEUROBIOLOGY OF DISEASE

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma

(2008) Q. Lan et al.   BLOOD

The xc− cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance

(2008) M Lo et al.   BRITISH JOURNAL OF CANCER

Coupling of Endoplasmic Reticulum Stress to CDDO-Me-Induced Up-regulation of Death Receptor 5 via a CHOP-Dependent Mechanism Involving JNK Activation

(2008) W. Zou et al.   CANCER RESEARCH

Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells

(2008) Akihiro Naito et al.   CANCER SCIENCE

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Resistance of mtDNA-depleted cells to apoptosis

(2008) Roberta Ferraresi et al.   CYTOMETRY PART A

Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability

(2008) Wan Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Hormesis and disease resistance: activation of cellular stress response pathways

(2008) Mark P Mattson   HUMAN & EXPERIMENTAL TOXICOLOGY

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA

(2008) Philippe A. Parone et al.   PLoS One

Mitochondria in cancer cells: what is so special about them?

(2008) Vladimir Gogvadze et al.   TRENDS IN CELL BIOLOGY

Hormesis defined

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS