Hallmarks of the aging T‐cell system

Immunometabolism in the development of rheumatoid arthritis

(2020) Cornelia M. Weyand et al.   IMMUNOLOGICAL REVIEWS

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

Influence of immune aging on vaccine responses

(2020) Claire E. Gustafson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation

(2020) Wenqiang Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA methylation disruption reshapes the hematopoietic differentiation landscape

(2020) Franco Izzo et al.   NATURE GENETICS

Sestrins induce natural killer function in senescent-like CD8+ T cells

(2020) Branca I. Pereira et al.   NATURE IMMUNOLOGY

The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

(2020) Peter C de Greef et al.   eLife

FOXO1 deficiency impairs proteostasis in aged T cells

(2020) Jun Jin et al.   Science Advances

The Aging of γδ T Cells

(2020) Weili Xu et al.   Cells

The Transcription Factor TCF1 in T Cell Differentiation and Aging

(2020) Chulwoo Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The coronavirus is most deadly if you are older and male — new data reveal the risks

(2020) Smriti Mallapaty   NATURE

Genetic and environmental determinants of human TCR repertoire diversity

(2020) Chirag Krishna et al.   Immunity & Ageing

A Cell for the Ages: Human γδ T Cells across the Lifespan

(2020) Brandi L. Clark et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The immunology of rheumatoid arthritis

(2020) Cornelia M. Weyand et al.   NATURE IMMUNOLOGY

Immune responses to zoster vaccines

(2019) Myron J Levin et al.   Human Vaccines & Immunotherapeutics

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

(2019) Ayelet Alpert et al.   NATURE MEDICINE

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

(2019) Zhenke Wen et al.   NATURE IMMUNOLOGY

Assessment of Lymph Node Stromal Cells as an Underlying Factor in Age-Related Immune Impairment

(2019) April R Masters et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

(2019) Lei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic reprogramming in memory CD4 T cell responses of old adults

(2019) Rolando E. Yanes et al.   CLINICAL IMMUNOLOGY

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

Roles of circular RNAs in immune regulation and autoimmune diseases

(2019) Zheng Zhou et al.   Cell Death & Disease

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

(2019) Arsun Bektas et al.   Aging-US

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

(2019) Chulwoo Kim et al.   Cell Reports

Somatic mutations and T-cell clonality in patients with immunodeficiency

(2019) Paula Savola et al.   HAEMATOLOGICA

Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins

(2019) Hidetaka Tanno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An epigenetic biomarker of aging for lifespan and healthspan

(2018) Morgan E. Levine et al.   Aging-US

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

Signaling and Function of Interleukin-2 in T Lymphocytes

(2018) Sarah H. Ross et al.   Annual Review of Immunology

Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging

(2018) Peggie Cheung et al.   CELL

Understanding Subset Diversity in T Cell Memory

(2018) Stephen C. Jameson et al.   IMMUNITY

Lymphoid tissue fibrosis is associated with impaired vaccine responses

(2018) Cissy Kityo et al.   JOURNAL OF CLINICAL INVESTIGATION

TCR Signaling: Mechanisms of Initiation and Propagation

(2018) Adam H. Courtney et al.   TRENDS IN BIOCHEMICAL SCIENCES

Age-Related Decline in Primary CD8 + T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8 + T Cells

(2018) Kylie M. Quinn et al.   Cell Reports

Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness

(2018) Pedro Costa del Amo et al.   PLOS BIOLOGY

The natural history of naive T cells from birth to maturity

(2018) Benedict Seddon et al.   IMMUNOLOGICAL REVIEWS

Current best estimates for the average lifespans of mouse and human leukocytes: reviewing two decades of deuterium-labeling experiments

(2018) José A. M. Borghans et al.   IMMUNOLOGICAL REVIEWS

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

(2018) Joseph A. Fraietta et al.   NATURE

Population dynamics of normal human blood inferred from somatic mutations

(2018) Henry Lee-Six et al.   NATURE

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

(2018) Heather L. Thompson et al.   AGING CELL

Functional pathways regulated by microRNA networks in CD8 T-cell aging

(2018) Claire E. Gustafson et al.   AGING CELL

Short telomere syndromes cause a primary T cell immunodeficiency

(2018) Christa L. Wagner et al.   JOURNAL OF CLINICAL INVESTIGATION

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

(2018) Judith Feucht et al.   NATURE MEDICINE

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice

(2018) Noga Ron-Harel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells

(2018) Chulwoo Kim et al.   Cell Reports

Successful and Maladaptive T Cell Aging

(2017) Jörg J. Goronzy et al.   IMMUNITY

The chromatin accessibility signature of human immune aging stems from CD8+T cells

(2017) Duygu Ucar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic reprogramming of human CD8+memory T cells through loss of SIRT1

(2017) Mark Y. Jeng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reduced generation of lung tissue–resident memory T cells during infancy

(2017) Kyra D. Zens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis

(2017) Hossam A. Abdelsamed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transporters Involved in Metformin Pharmacokinetics and Treatment Response

(2017) Xiaomin Liang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Origin and differentiation of human memory CD8 T cells after vaccination

(2017) Rama S. Akondy et al.   NATURE

Age-associated DNA methylation changes in naive CD4+ T cells suggest an evolving autoimmune epigenotype in aging T cells

(2017) Mikhail G Dozmorov et al.   Epigenomics

Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis

(2017) P. Savola et al.   Nature Communications

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Immune senescence: significance of the stromal microenvironment

(2016) A. R. Masters et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

(2016) Yinyin Li et al.   IMMUNITY

Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians

(2016) Olga V. Britanova et al.   JOURNAL OF IMMUNOLOGY

CMV induces expansion of highly polyfunctional CD4 + T cell subset coexpressing CD57 and CD154

(2016) Alejandra Pera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing

(2016) Margaret L. Hoang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

(2016) Andrew L. Young et al.   Nature Communications

Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals

(2016) Fengqin Fang et al.   Cell Reports

Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals

(2016) Qian Qi et al.   PLoS Pathogens

Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans

(2016) Shai S. Shen-Orr et al.   Cell Systems

Age-associated changes in basal NF-κB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase

(2016) Arsun Bektas et al.   Aging-US

The aged lymphoid tissue environment fails to support naïve T cell homeostasis

(2016) Bryan R. Becklund et al.   Scientific Reports

Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover

(2015) Liset Westera et al.   AGING CELL

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD

(2015) A. C. Alho et al.   BLOOD

Defining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation

(2015) H. Kiyomi Komori et al.   JOURNAL OF IMMUNOLOGY

Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation

(2015) Guangjin Li et al.   JOURNAL OF IMMUNOLOGY

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging

(2015) Chan C. Whiting et al.   PLoS One

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

Immuno-miRs: critical regulators of T-cell development, function and ageing

(2014) Bart-Jan Kroesen et al.   IMMUNOLOGY

Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA

(2014) A. Agrawal et al.   JOURNAL OF IMMUNOLOGY

Rapid Proliferation and Differentiation Impairs the Development of Memory CD8+ T Cells in Early Life

(2014) N. L. Smith et al.   JOURNAL OF IMMUNOLOGY

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related variations in the methylome associated with gene expression in human monocytes and T cells

(2014) Lindsay M. Reynolds et al.   Nature Communications

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Postthymic Expansion in Human CD4 Naive T Cells Defined by Expression of Functional High-Affinity IL-2 Receptors

(2013) M. L. Pekalski et al.   JOURNAL OF IMMUNOLOGY

Human Neonatal Naive CD4+ T Cells Have Enhanced Activation-Dependent Signaling Regulated by the MicroRNA miR-181a

(2013) A. C. Palin et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells

(2013) B.-C. Chiu et al.   JOURNAL OF IMMUNOLOGY

Dual Role of miR-21 in CD4+ T-Cells: Activation-Induced miR-21 Supports Survival of Memory T-Cells and Regulates CCR7 Expression in Naive T-Cells

(2013) Katarzyna Smigielska-Czepiel et al.   PLoS One

Acute Neonatal Infections ‘Lock-In’ a Suboptimal CD8+ T Cell Repertoire with Impaired Recall Responses

(2013) Brian D. Rudd et al.   PLoS Pathogens

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8+ T cells sensitizing them to apoptotic cell death

(2012) Stefan Brunner et al.   AGING CELL

Immune aging and autoimmunity

(2012) Jörg J. Goronzy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

Single-Cell Network Profiling of Peripheral Blood Mononuclear Cells from Healthy Donors Reveals Age- and Race-Associated Differences in Immune Signaling Pathway Activation

(2012) D. M. Longo et al.   JOURNAL OF IMMUNOLOGY

Lymphopenia-Driven Homeostatic Regulation of Naive T Cells in Elderly and Thymectomized Young Adults

(2012) D. Sauce et al.   JOURNAL OF IMMUNOLOGY

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia

(2012) Hanna L.M. Koskela et al.   NEW ENGLAND JOURNAL OF MEDICINE

TET2andDNMT3AMutations in Human T-Cell Lymphoma

(2012) Lucile Couronné et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age

(2012) P. L. F. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age

(2012) M. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects

(2012) Laura Haynes et al.   SEMINARS IN IMMUNOLOGY

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

(2011) Cyril Quivoron et al.   CANCER CELL

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

(2011) Jonathan Sprent et al.   NATURE IMMUNOLOGY

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging

(2010) Matthias Hackl et al.   AGING CELL

Epigenomics of T cell activation, differentiation, and memory

(2010) Suresh Cuddapah et al.   CURRENT OPINION IN IMMUNOLOGY

DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis

(2010) Lan Shao et al.   EMBO Molecular Medicine

Quantifying the development of the peripheral naive CD4+ T-cell pool in humans

(2009) I. Bains et al.   BLOOD

Comprehensive assessment of T-cell receptor  -chain diversity in    T cells

(2009) H. S. Robins et al.   BLOOD

Diversity in T Cell Memory: An Embarrassment of Riches

(2009) Stephen C. Jameson et al.   IMMUNITY

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

(2009) Lan Shao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ERK-Dependent T Cell Receptor Threshold Calibration in Rheumatoid Arthritis

(2009) K. Singh et al.   JOURNAL OF IMMUNOLOGY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Telomerase insufficiency in rheumatoid arthritis

(2009) H. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

T-cell immunosenescence: lessons learned from mouse models of aging

(2009) Alexander C. Maue et al.   TRENDS IN IMMUNOLOGY

Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets

(2008) S. Kohler et al.   BLOOD

T cell subset-specific susceptibility to aging

(2008) Marta Czesnikiewicz-Guzik et al.   CLINICAL IMMUNOLOGY

Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people

(2008) Sven Koch et al.   Immunity & Ageing