Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups

(2017) A Burns et al.   LEUKEMIA

Accurate identification of single-nucleotide variants in whole-genome-amplified single cells

(2017) Xiao Dong et al.   NATURE METHODS

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)

(2017) Chongyi Chen et al.   SCIENCE

Aging increases cell-to-cell transcriptional variability upon immune stimulation

(2017) Celia Pilar Martinez-Jimenez et al.   SCIENCE

Aging and neurodegeneration are associated with increased mutations in single human neurons

(2017) Michael A. Lodato et al.   SCIENCE

Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis

(2017) Taejeong Bae et al.   SCIENCE

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

SomaticSignatures: inferring mutational signatures from single-nucleotide variants: Fig. 1.

(2015) Julian S. Gehring et al.   BIOINFORMATICS

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes

(2015) Leng-Siew Yeap et al.   CELL

Clock-like mutational processes in human somatic cells

(2015) Ludmil B Alexandrov et al.   NATURE GENETICS

Targeted single molecule mutation detection with massively parallel sequencing

(2015) Mark T. Gregory et al.   NUCLEIC ACIDS RESEARCH

Somatic mutation in cancer and normal cells

(2015) I. Martincorena et al.   SCIENCE

B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity

(2014) Jason Qian et al.   CELL

B cell function and influenza vaccine responses in healthy aging and disease

(2014) Daniela Frasca et al.   CURRENT OPINION IN IMMUNOLOGY

Genome Instability and Aging

(2013) Jan Vijg et al.   Annual Review of Physiology

Fibronectin coating of oxygenator membranes enhances endothelial cell attachment

(2013) Christian G Cornelissen et al.   Biomedical Engineering Online

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia

(2012) A J Ramsay et al.   LEUKEMIA

Architecture of the human regulatory network derived from ENCODE data

(2012) Mark B. Gerstein et al.   NATURE

Predicting the Functional Effect of Amino Acid Substitutions and Indels

(2012) Yongwook Choi et al.   PLoS One

Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes

(2012) L. Kato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct mutation analysis by high-throughput sequencing: From germline to low-abundant, somatic variants

(2011) Michael Gundry et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Chronic lymphocytic leukemia: planning for an aging population

(2010) John G Gribben   Expert Review of Anticancer Therapy

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

(2010) Arito Yamane et al.   NATURE IMMUNOLOGY

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols