The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

Genesis of the αβ T-cell receptor

(2019) Thomas Dupic et al.   PLoS Computational Biology

Fate mapping reveals the age structure of the peripheral T cell compartment

(2019) Arnold Reynaldi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins

(2019) Hidetaka Tanno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination

(2018) Yuval Elhanati et al.   IMMUNOLOGICAL REVIEWS

High-throughput immune repertoire analysis with IGoR

(2018) Quentin Marcou et al.   Nature Communications

Age is not just a number: Naive T cells increase their ability to persist in the circulation over time

(2018) Sanket Rane et al.   PLOS BIOLOGY

A new mechanism shapes the naïve CD8 + T cell repertoire: the selection for full diversity

(2017) Pedro Gonçalves et al.   MOLECULAR IMMUNOLOGY

Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire

(2017) Ryan O Emerson et al.   NATURE GENETICS

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

(2017) Mikhail Shugay et al.   NUCLEIC ACIDS RESEARCH

Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires

(2017) Mikhail V. Pogorelyy et al.   PLoS Computational Biology

Quantitative Characterization of the T Cell Receptor Repertoire of Naïve and Memory Subsets Using an Integrated Experimental and Computational Pipeline Which Is Robust, Economical, and Versatile

(2017) Theres Oakes et al.   Frontiers in Immunology

RTCR: a pipeline for complete and accurate recovery of T cell repertoires from high throughput sequencing data

(2016) Bram Gerritsen et al.   BIOINFORMATICS

How many TCR clonotypes does a body maintain?

(2016) Grant Lythe et al.   JOURNAL OF THEORETICAL BIOLOGY

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

(2016) Vesna Pulko et al.   NATURE IMMUNOLOGY

Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover

(2015) Liset Westera et al.   AGING CELL

Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection

(2015) Benjamin D. McDonald et al.   IMMUNITY

Fluctuating fitness shapes the clone-size distribution of immune repertoires

(2015) Jonathan Desponds et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal fate mapping reveals age-linked heterogeneity in naive T lymphocytes in mice

(2015) Thea Hogan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-lasting stem cell–like memory CD8 + T cells with a naïve-like profile upon yellow fever vaccination

(2015) Silvia A. Fuertes Marraco et al.   Science Translational Medicine

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Quantifying selection in immune receptor repertoires

(2014) Yuval Elhanati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

(2014) Marco Lepore et al.   Nature Communications

Decombinator: a tool for fast, efficient gene assignment in T-cell receptor sequences using a finite state machine

(2013) N. Thomas et al.   BIOINFORMATICS

Superior T memory stem cell persistence supports long-lived T cell memory

(2013) Enrico Lugli et al.   JOURNAL OF CLINICAL INVESTIGATION

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Mechanistic Model for Naive CD4 T Cell Homeostasis in Healthy Adults and Children

(2013) Tharindi Hapuarachchi et al.   Frontiers in Immunology

Estimating the Diversity, Completeness, and Cross-Reactivity of the T Cell Repertoire

(2013) Veronika I. Zarnitsyna et al.   Frontiers in Immunology

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells

(2012) Enrico Lugli et al.   Nature Protocols

Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age

(2012) P. L. F. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Statistical inference of the generation probability of T-cell receptors from sequence repertoires

(2012) A. Murugan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mechanism for TCR Sharing between T Cell Subsets and Individuals Revealed by Pyrosequencing

(2011) Vanessa Venturi et al.   JOURNAL OF IMMUNOLOGY

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions

(2011) B. D. Rudd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the Composition of the Preimmune Repertoire of T Cells Specific for Peptide–Major Histocompatibility Complex Ligands

(2010) Marc K. Jenkins et al.   Annual Review of Immunology

Stochastic competitive exclusion in the maintenance of the naïve T cell repertoire

(2010) Emily R. Stirk et al.   JOURNAL OF THEORETICAL BIOLOGY

Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoire

(2010) M. F. Quigley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overlap and Effective Size of the Human CD8+ T Cell Receptor Repertoire

(2010) H. S. Robins et al.   Science Translational Medicine

Comprehensive assessment of T-cell receptor  -chain diversity in    T cells

(2009) H. S. Robins et al.   BLOOD

Modelling naive T-cell homeostasis: consequences of heritable cellular lifespan during ageing

(2009) Mark R Dowling et al.   IMMUNOLOGY AND CELL BIOLOGY

Stochastic niche structure and diversity maintenance in the T cell repertoire

(2008) Emily R. Stirk et al.   JOURNAL OF THEORETICAL BIOLOGY