The Aging of γδ T Cells

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates

(2019) Ling Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-1/PD-L1 pathway: Basic biology and role in cancer immunotherapy

(2019) Arash Salmaninejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

(2019) Toufic Mayassi et al.   CELL

Intestinal iNKT Cells Migrate to Liver and Contribute to Hepatocyte Apoptosis During Alcoholic Liver Disease

(2019) Kuei-Chuan Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Difference in Long-Term Trends in COPD Mortality between China and the U.S., 1992–2017: An Age–Period–Cohort Analysis

(2019) Haoyu Wen et al.   International Journal of Environmental Research and Public Health

IL ‐7‐dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti‐tumour response

(2019) Hung‐Chang Chen et al.   EMBO REPORTS

Five-Year Survival and Correlates Among Patients With Advanced Melanoma, Renal Cell Carcinoma, or Non–Small Cell Lung Cancer Treated With Nivolumab

(2019) Suzanne L. Topalian et al.   JAMA Oncology

Immune checkpoint modulators in cancer immunotherapy: Recent advances and combination rationales

(2019) Li Fan et al.   CANCER LETTERS

TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells

(2019) Maria Papadopoulou et al.   JOURNAL OF IMMUNOLOGY

The human fetal thymus generates invariant effector γδ T cells

(2019) Paola Tieppo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer

(2019) Elena Bruni et al.   Journal for ImmunoTherapy of Cancer

Rapid Advances in Immunotherapy to Treat Cancer

(2018) Jeannine S. McCune   CLINICAL PHARMACOLOGY & THERAPEUTICS

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

Human Vδ3 + γδ T cells induce maturation and IgM secretion by B cells

(2018) Andreea Petrasca et al.   IMMUNOLOGY LETTERS

Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations

(2018) Stuart Hunter et al.   JOURNAL OF HEPATOLOGY

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

(2018) A Danielle Iuliano et al.   LANCET

γδ T cell responses: How many ligands will it take till we know?

(2018) David Vermijlen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Prognostic factors for mortality due to pneumonia among adults from different age groups in Singapore and mortality predictions based on PSI and CURB-65

(2018) ZX Zhang et al.   SINGAPORE MEDICAL JOURNAL

The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets

(2018) Martin S. Davey et al.   Nature Communications

Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application

(2018) Yueshui Zhao et al.   Journal of Immunology Research

Next-Generation Sequencing Analysis of the Human TCRγδ+ T-Cell Repertoire Reveals Shifts in Vγ- and Vδ-Usage in Memory Populations upon Aging

(2018) Martine J. Kallemeijn et al.   Frontiers in Immunology

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells

(2018) Camille Khairallah et al.   Frontiers in Immunology

Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence

(2018) Weili Xu et al.   EBioMedicine

Introduction to checkpoint inhibitors and cancer immunotherapy

(2017) Arlene H. Sharpe   IMMUNOLOGICAL REVIEWS

Markers of T Cell Senescence in Humans

(2017) Weili Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lymphocyte generation and population homeostasis throughout life

(2017) Rolando E. Yanes et al.   SEMINARS IN HEMATOLOGY

Innate and adaptive immune traits are differentially affected by genetic and environmental factors

(2017) Massimo Mangino et al.   Nature Communications

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

(2017) Martin S. Davey et al.   Nature Communications

The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks

(2017) Jan R. Aunan et al.   Aging and Disease

γδ T Cell-Mediated Immunity to Cytomegalovirus Infection

(2017) Camille Khairallah et al.   Frontiers in Immunology

Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly

(2017) Anshu Agrawal et al.   Frontiers in Immunology

Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications

(2017) Myriam Lawand et al.   Frontiers in Immunology

Epigenetics and Trained Immunity

(2017) Charlotte D.C.C. van der Heijden et al.   ANTIOXIDANTS & REDOX SIGNALING

Age dependent differences in the kinetics of γδ T cells after influenza vaccination

(2017) Ulrik Stervbo et al.   PLoS One

Ageing and latent CMV infection impact on maturation, differentiation and exhaustion profiles of T-cell receptor gammadelta T-cells

(2017) Martine J. Kallemeijn et al.   Scientific Reports

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

(2016) A. R. Almeida et al.   CLINICAL CANCER RESEARCH

Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection

(2016) Mahboob Salim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotaxis and Immunoregulatory Function of Cardiac γδ T Cells in Dystrophin-Deficient Mice

(2016) Cynthia Machado Cascabulho et al.   JOURNAL OF IMMUNOLOGY

Heterogeneous yet stable Vδ2(+)T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals

(2016) Paul L. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation

(2015) T. Fulop et al.   BIOGERONTOLOGY

Human gamma delta T cells: Evolution and ligand recognition

(2015) Erin J. Adams et al.   CELLULAR IMMUNOLOGY

The burgeoning family of unconventional T cells

(2015) Dale I Godfrey et al.   NATURE IMMUNOLOGY

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Dynamics of Circulating γδ T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma

(2015) Benjamin H. Beck et al.   PLoS One

Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire

(2015) Tanya Dimova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A clonotypic Vγ4Jγ1/Vδ5Dδ2Jδ1 innate γδ T-cell population restricted to the CCR6+CD27− subset

(2015) Elham Kashani et al.   Nature Communications

Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation

(2015) Sérgio T. Ribeiro et al.   Frontiers in Immunology

γδ T Lymphocytes in the Diagnosis of Human T Cell Receptor Immunodeficiencies

(2015) Beatriz Garcillán et al.   Frontiers in Immunology

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life

(2014) Joseph J.C. Thome et al.   CELL

T cells and their cytokines in persistent stimulation of the immune system

(2014) Hassen Kared et al.   CURRENT OPINION IN IMMUNOLOGY

Cellular signaling in the aging immune system

(2014) Tamas Fulop et al.   CURRENT OPINION IN IMMUNOLOGY

IL-17A Produced by    T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver

(2014) S. Hamada et al.   JOURNAL OF IMMUNOLOGY

γ/δ T cell subsets in human aging using the classical α/β T cell model

(2014) Anusha Vasudev et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of Non-conventional T Lymphocytes in Respiratory Infections: The Case of the Pneumococcus

(2014) Stoyan Ivanov et al.   PLoS Pathogens

Human Vγ9Vδ2-T cells efficiently kill influenza virus-infected lung alveolar epithelial cells

(2013) Hong Li et al.   Cellular & Molecular Immunology

Current development in isoprenoid precursor biosynthesis and regulation

(2013) Wei-chen Chang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

From “truly naïve” to “exhausted senescent” T cells: When markers predict functionality

(2013) Anis Larbi et al.   CYTOMETRY PART A

The Th17/Treg balance is disturbed during aging

(2013) Vanessa Schmitt et al.   EXPERIMENTAL GERONTOLOGY

γδ T Cells Exhibit Multifunctional and Protective Memory in Intestinal Tissues

(2013) Brian S. Sheridan et al.   IMMUNITY

Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human V 3 T Cells

(2013) B. A. Mangan et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of the Antitumor Activity of Human Vγ9Vδ2 T Cells in Combination With Zoledronic Acid in a Preclinical Model of Neuroblastoma

(2013) Emma Di Carlo et al.   MOLECULAR THERAPY

Evolutionary implications of a third lymphocyte lineage in lampreys

(2013) Masayuki Hirano et al.   NATURE

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

CD1d-lipid antigen recognition by the γδ TCR

(2013) Adam P Uldrich et al.   NATURE IMMUNOLOGY

The effect of aging of the immune system on vaccination responses

(2013) Janet M. Lord   Human Vaccines & Immunotherapeutics

Comparative Biology of γδ T Cell Function in Humans, Mice, and Domestic Animals

(2013) Jeff Holderness et al.   Annual Review of Animal Biosciences

Human T Cell Aging and the Impact of Persistent Viral Infections

(2013) T. Fülöp et al.   Frontiers in Immunology

The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR

(2012) Li Bai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Understanding the complexity of γδ T-cell subsets in mouse and human

(2012) Dick J. Pang et al.   IMMUNOLOGY

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

Distribution of γδ and other T-lymphocyte subsets in patients with chronic obstructive pulmonary disease and asthma

(2012) Daiva Urboniene et al.   RESPIRATORY MEDICINE

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

(2012) Jörg J. Goronzy et al.   SEMINARS IN IMMUNOLOGY

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

(2012) Rafael Solana et al.   SEMINARS IN IMMUNOLOGY

Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence

(2012) Pierre-Olivier Lang et al.   Clinical Interventions in Aging

Age-associated alteration of γδ T-cell repertoire and different profiles of activation-induced death of Vδ1 and Vδ2 T cells

(2011) Yoshihiro Michishita et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a γδ T cell population in humanized mice

(2011) Wenwei Tu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted    T Cells in the Normal Murine Repertoire

(2011) M. Dieude et al.   JOURNAL OF IMMUNOLOGY

Skint-1 is a highly specific, unique selecting component for epidermal T cells

(2011) S. D. Barbee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of a    T-cell receptor specific for the human MHC class I homolog MICA

(2011) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate control of B cell responses

(2011) Andrea Cerutti et al.   TRENDS IN IMMUNOLOGY

Aging and Immune Function: Molecular Mechanisms to Interventions

(2010) Subramaniam Ponnappan et al.   ANTIOXIDANTS & REDOX SIGNALING

A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human γδ T lymphocytes

(2010) Julie M. Jameson et al.   CELLULAR IMMUNOLOGY

Analysis of    T Cell Functions in the Mouse

(2010) W. K. Born et al.   JOURNAL OF IMMUNOLOGY

γδ T Cells and the Lymphoid Stress-Surveillance Response

(2009) Adrian C. Hayday   IMMUNITY

Thymic involution and immune reconstitution

(2009) Heather E. Lynch et al.   TRENDS IN IMMUNOLOGY

Natural killer and γδ T cells in haematological malignancies: enhancing the immune effectors

(2009) Jérôme Rey et al.   TRENDS IN MOLECULAR MEDICINE

An autonomous CDR3δ is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by γδ T cells

(2008) Erin J Adams et al.   NATURE IMMUNOLOGY