Immunometabolism in the development of rheumatoid arthritis

The metabolic signature of T cells in rheumatoid arthritis

(2020) Cornelia M. Weyand et al.   CURRENT OPINION IN RHEUMATOLOGY

Ataxia‐telangiectasia: A review of clinical features and molecular pathology

(2019) Parisa Amirifar et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

(2019) Zhenke Wen et al.   NATURE IMMUNOLOGY

N-myristoylation of AMPK controls T cell inflammatory function

(2019) David K. Finlay   NATURE IMMUNOLOGY

The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation

(2019) Yinyin Li et al.   Cell Metabolism

And three’s a party: lysosomes, lipid droplets, and the ER in lipid trafficking and cell homeostasis

(2019) Mike Henne   CURRENT OPINION IN CELL BIOLOGY

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

(2019) Marc Foretz et al.   Nature Reviews Endocrinology

How to investigate: Pre-clinical rheumatoid arthritis

(2019) Patrícia Martins et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Pyruvate kinase M2: A simple molecule with complex functions

(2019) Mohammed Alquraishi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation

(2018) Markus Zeisbrich et al.   ANNALS OF THE RHEUMATIC DISEASES

The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair

(2018) Aleem Syed et al.   Annual Review of Biochemistry

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Matrix Metalloprotease-9 (MMP-9)-Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis

(2018) Ryu Watanabe et al.   CIRCULATION RESEARCH

DNA damage, metabolism and aging in pro-inflammatory T cells

(2018) Yinyin Li et al.   EXPERIMENTAL GERONTOLOGY

The potential utility of PFKFB3 as a therapeutic target

(2018) Ramon Bartrons et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

NADPH-dependent and -independent disulfide reductase systems

(2018) Colin G. Miller et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox-sensitive signaling in inflammatory T cells and in autoimmune disease

(2018) Cornelia M. Weyand et al.   FREE RADICAL BIOLOGY AND MEDICINE

Monocytes M( MP )aking Way for T-Cell Vascular Infiltration

(2018) Ryszard Nosalski et al.   CIRCULATION RESEARCH

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

(2018) Georges Abboud et al.   Frontiers in Immunology

Autoimmunity, inflammation, and dysbiosis mutually govern the transition from the preclinical to the clinical stage of rheumatoid arthritis

(2018) Alexander Kalinkovich et al.   IMMUNOLOGIC RESEARCH

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

Lysosome: The metabolic signaling hub

(2018) Dudley W. Lamming et al.   TRAFFIC

Role of the Mre11 Complex in Preserving Genome Integrity

(2018) Julyun Oh et al.   Genes

Variations on the theme of podosomes: A matter of context

(2018) Florian Alonso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Development of autoantibodies precedes clinical manifestations of autoimmune diseases: A comprehensive review

(2017) Wen-Tao Ma et al.   JOURNAL OF AUTOIMMUNITY

HIV as a Cause of Immune Activation and Immunosenescence

(2017) T. Sokoya et al.   MEDIATORS OF INFLAMMATION

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immunometabolism in early and late stages of rheumatoid arthritis

(2017) Cornelia M. Weyand et al.   Nature Reviews Rheumatology

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

(2017) Robert J. Eddy et al.   TRENDS IN CELL BIOLOGY

The life cycle of a T cell after vaccination - where does immune ageing strike?

(2016) C. Kim et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration

(2016) Laurel E. Hind et al.   DEVELOPMENTAL CELL

What has passed is prolog: new cellular and physiological roles of G6PD

(2016) Hung-Chi Yang et al.   FREE RADICAL RESEARCH

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

(2016) Yinyin Li et al.   IMMUNITY

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Metabolic control of arthritis: Switch pathways to treat

(2016) George C. Tsokos   Science Translational Medicine

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

(2016) Zhen Yang et al.   Science Translational Medicine

Assessing immune aging in HIV-infected patients

(2016) Victor Appay et al.   Virulence

T Cell Interstitial Migration: Motility Cues from the Inflamed Tissue for Micro- and Macro-Positioning

(2016) Alison Gaylo et al.   Frontiers in Immunology

Senescence from G2 arrest, revisited

(2015) Véronique Gire et al.   CELL CYCLE

Autophagy in autoimmune disease

(2015) Zhen Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sustained biologic-free and drug-free remission in rheumatoid arthritis, where are we now?

(2015) György Nagy et al.   ARTHRITIS RESEARCH & THERAPY

Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules

(2015) Kang Liang et al.   Nature Communications

The glycolytic enzyme PFKFB3/phosphofructokinase regulates autophagy

(2014) Zhen Yang et al.   Autophagy

T-cell aging in rheumatoid arthritis

(2013) Cornelia M. Weyand et al.   CURRENT OPINION IN RHEUMATOLOGY

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

(2013) T. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell migration and invasion in human disease: the Tks adaptor proteins

(2012) Sara A. Courtneidge   BIOCHEMICAL SOCIETY TRANSACTIONS

Emerging Roles for Lipid Droplets in Immunity and Host-Pathogen Interactions

(2011) Hector Alex Saka et al.   Annual Review of Cell and Developmental Biology

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

ATM Is a Redox Sensor Linking Genome Stability and Carbon Metabolism

(2011) A. Kruger et al.   Science Signaling

Atm-Deficient Mice Exhibit Increased Sensitivity to Dextran Sulfate Sodium-Induced Colitis Characterized by Elevated DNA Damage and Persistent Immune Activation

(2010) A. M. Westbrook et al.   CANCER RESEARCH

 -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

(2010) J. S. Oakhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Aging and Rheumatoid Arthritis

(2010) Jorg J. Goronzy et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Role of the extracellular matrix in lymphocyte migration

(2009) Eva Korpos et al.   CELL AND TISSUE RESEARCH

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer

(2009) Abdullah Yalcin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

(2009) Lan Shao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Telomerase insufficiency in rheumatoid arthritis

(2009) H. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle

(2008) Sharon Biton et al.   DNA REPAIR