Pancreatic islet inflammation: an emerging role for chemokines

Pancreatic β-Cell production of CXCR3 ligands precedes diabetes onset

(2016) Susan J. Burke et al.   BIOFACTORS

Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes

(2016) Christine Bender et al.   DIABETES

Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes

(2016) Marcus Lundberg et al.   DIABETES

“Prediabetes”: Are There Problems With This Label? No, We Need Heightened Awareness of This Condition!

(2016) William T. Cefalu   DIABETES CARE

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation, Signaling, and Physiological Functions of G-Proteins

(2016) Viktoriya Syrovatkina et al.   JOURNAL OF MOLECULAR BIOLOGY

Immune and Pancreatic β Cell Interactions in Type 1 Diabetes

(2016) Joanne Boldison et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

IL-1β reciprocally regulates chemokine and insulin secretion in pancreatic β-cells via NF-κB

(2015) Susan J. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CCL20 is elevated during obesity and differentially regulated by NF-κB subunits in pancreatic β-cells

(2015) Susan J. Burke et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Stress-induced dissociations between intracellular calcium signaling and insulin secretion in pancreatic islets

(2015) Farhan M. Qureshi et al.   CELL CALCIUM

Transitioning Safely from Intravenous to Subcutaneous Insulin

(2015) Kathryn Evans Kreider et al.   Current Diabetes Reports

CXCR3 ligands in disease and therapy

(2015) Katrien Van Raemdonck et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Anti-CD3/Anti-CXCL10 Antibody Combination Therapy Induces a Persistent Remission of Type 1 Diabetes in Two Mouse Models

(2015) Stanley Lasch et al.   DIABETES

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice

(2015) Ronald G. Gill et al.   DIABETES

Insulin resistance in patients with type 1 diabetes assessed by glucose clamp studies: systematic review and meta-analysis

(2015) E. Donga et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The diet-induced metabolic syndrome is accompanied by whole-genome epigenetic changes

(2015) Irais Sánchez et al.   Genes and Nutrition

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets

(2015) Nathan Karin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets

(2015) Changyun Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity, inflammation, and the gut microbiota

(2015) Amanda J Cox et al.   Lancet Diabetes & Endocrinology

The diet-induced metabolic syndrome is accompanied by whole-genome epigenetic changes

(2015) Irais Sánchez et al.   Genes and Nutrition

Testing Pancreatic Islet Function at the Single Cell Level by Calcium Influx with Associated Marker Expression

(2015) Jennifer H. R. Kenty et al.   PLoS One

Acylcarnitines activate proinflammatory signaling pathways

(2014) Jennifer M. Rutkowsky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CXCR3, CXCL10 and type 1 diabetes

(2014) Alessandro Antonelli et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CXCR1/2 Inhibition Blocks and Reverses Type 1 Diabetes in Mice

(2014) Antonio Citro et al.   DIABETES

The Alarming and Rising Costs of Diabetes and Prediabetes: A Call for Action!

(2014) William T. Cefalu et al.   DIABETES CARE

Insulin Therapy in People With Type 2 Diabetes: Opportunities and Challenges?

(2014) Philip Home et al.   DIABETES CARE

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells

(2014) Oanh H. Do et al.   DIABETOLOGIA

Macrophages and  -cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes

(2014) J. Diana et al.   EMBO Molecular Medicine

Temporal profiling of cytokine-induced genes in pancreatic β-cells by meta-analysis and network inference

(2014) Miguel Lopes et al.   GENOMICS

Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function

(2014) Craig S Nunemaker et al.   JOURNAL OF ENDOCRINOLOGY

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Adaptor Protein2 (AP2) Orchestrates CXCR2-Mediated Cell Migration

(2014) Dayanidhi Raman et al.   TRAFFIC

Bias in chemokine receptor signalling

(2014) Annelien J.M. Zweemer et al.   TRENDS IN IMMUNOLOGY

NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription

(2013) Susan J. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Fractalkine/CX3CR1 System Regulates β Cell Function and Insulin Secretion

(2013) Yun Sok Lee et al.   CELL

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Plasma Levels of CXCL1 (GRO-α) and CXCL10 (IP-10) are Elevated in Type 2 Diabetic Patients: Evidence for the Involvement of Inflammation and Angiogenesis / Angiostasis in this Disease State

(2013) Seyyed Sajadi et al.   Clinical Laboratory

Recent developments in biased agonism

(2013) James W Wisler et al.   CURRENT OPINION IN CELL BIOLOGY

Functional Redundancy of CXCR3/CXCL10 Signaling in the Recruitment of Diabetogenic Cytotoxic T Lymphocytes to Pancreatic Islets in a Virally Induced Autoimmune Diabetes Model

(2013) K. T. Coppieters et al.   DIABETES

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

(2013) Sudarshan Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse novel functions of neutrophils in immunity, inflammation, and beyond

(2013) Attila Mócsai   JOURNAL OF EXPERIMENTAL MEDICINE

Synergistic Expression of the CXCL10 Gene in Response to IL-1  and IFN-  Involves NF- B, Phosphorylation of STAT1 at Tyr701, and Acetylation of Histones H3 and H4

(2013) S. J. Burke et al.   JOURNAL OF IMMUNOLOGY

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

(2013) Antoinette Moran et al.   LANCET

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Regulation of iNOS Gene Transcription by IL-1β and IFN-γ Requires a Coactivator Exchange Mechanism

(2013) Susan J. Burke et al.   MOLECULAR ENDOCRINOLOGY

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

Quantifying biased agonism: understanding the links between affinity and efficacy

(2013) Sudarshan Rajagopal   NATURE REVIEWS DRUG DISCOVERY

The effects of NOD activation on adipocyte differentiation

(2013) Jaanki S. Purohit et al.   Obesity

The Kinetics of Plasmacytoid Dendritic Cell Accumulation in the Pancreas of the NOD Mouse during the Early Phases of Insulitis

(2013) Jojanneke M. C. Welzen-Coppens et al.   PLoS One

Immune mechanisms in type 1 diabetes

(2013) Maja Wållberg et al.   TRENDS IN IMMUNOLOGY

Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with Gi-protein pathway activation

(2012) Anne O. Watts et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection

(2012) Chung-Her Jenh et al.   BMC IMMUNOLOGY

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Acceleration of diabetes development in CXC chemokine receptor 3 (CXCR3)-deficient NOD mice

(2012) Y. Yamada et al.   DIABETOLOGIA

CXCR1/2 inhibition enhances pancreatic islet survival after transplantation

(2012) Antonio Citro et al.   JOURNAL OF CLINICAL INVESTIGATION

The Chemokine Receptors CXCR1 and CXCR2 Couple to Distinct G Protein-Coupled Receptor Kinases To Mediate and Regulate Leukocyte Functions

(2012) S. K. Raghuwanshi et al.   JOURNAL OF IMMUNOLOGY

Chemokine receptor CXCR2: Physiology regulator and neuroinflammation controller?

(2012) Mike Veenstra et al.   JOURNAL OF NEUROIMMUNOLOGY

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Immunologic profile of excessive body weight

(2011) Mansour Taghavi Azar Sharabiani et al.   BIOMARKERS

The central role of calcium in the effects of cytokines on beta-cell function: Implications for type 1 and type 2 diabetes

(2011) James W. Ramadan et al.   CELL CALCIUM

Advanced Glycation End Products Are Direct Modulators of  -Cell Function

(2011) M. T. Coughlan et al.   DIABETES

Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes

(2011) S. A. Sarkar et al.   DIABETES

Serum CXCL1 concentrations are elevated in type 1 diabetes mellitus, possibly reflecting activity of anti-islet autoimmune activity

(2011) Kazuma Takahashi et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes

(2011) J. M. Forbes et al.   DIABETOLOGIA

CXCR3 ligands: redundant, collaborative and antagonistic functions

(2011) Joanna R Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

Preliminary studies related to anti-interleukin-1β therapy in children with newly diagnosed type 1 diabetes

(2011) Kathryn M. Sumpter et al.   PEDIATRIC DIABETES

Conditional and specific inhibition of NF-κB in mouse pancreatic β cells prevents cytokine-induced deleterious effects and improves islet survival posttransplant

(2011) Jonathan S. Rink et al.   SURGERY

The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time

(2010) Antonios Chatzigeorgiou et al.   ANNALS OF MEDICINE

Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling

(2010) Stacey B. Dula et al.   CELL CALCIUM

CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis

(2010) LiPing Liu et al.   NATURE NEUROSCIENCE

Insulitis in Human Type 1 Diabetes

(2009) Toshiaki Hanafusa et al.   Annals of the New York Academy of Sciences

CXCL10 Impairs β Cell Function and Viability in Diabetes through TLR4 Signaling

(2009) Fabienne T. Schulthess et al.   Cell Metabolism

Islet-associated macrophages in type 2 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

Dynamic Regulation of CXCR1 and CXCR2 Homo- and Heterodimers

(2009) L. Martinez Munoz et al.   JOURNAL OF IMMUNOLOGY

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Emerging Genetic Architecture of Type 2 Diabetes

(2008) Alessandro Doria et al.   Cell Metabolism

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes

(2008) A. P. Martin et al.   DIABETES

Islet Inflammation in Type 2 Diabetes: From metabolic stress to therapy

(2008) M. Y. Donath et al.   DIABETES CARE

Insulitis in type 2 diabetes

(2008) M. Böni-Schnetzler et al.   DIABETES OBESITY & METABOLISM

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oral Presentations

(2008)   PEDIATRIC DIABETES

G Protein–Coupled Receptor Sorting to Endosomes and Lysosomes

(2007) Adriano Marchese et al.   Annual Review of Pharmacology and Toxicology

β-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction

(2007) K DeFea   BRITISH JOURNAL OF PHARMACOLOGY

Nod-like proteins in inflammation and disease

(2007) LAM Carneiro et al.   JOURNAL OF PATHOLOGY