Macrophage Modification Strategies for Efficient Cell Therapy

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

Cellular backpacks for macrophage immunotherapy

(2020) C. Wyatt Shields et al.   Science Advances

M2 Macrophages as a Potential Target for Antiatherosclerosis Treatment

(2019) Ying Bi et al.   NEURAL PLASTICITY

p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis

(2019) Bo Li et al.   Aging-US

CXCR4 knockdown prevents inflammatory cytokine expression in macrophages by suppressing activation of MAPK and NF-κB signaling pathways

(2019) Xue Tian et al.   Cell and Bioscience

Ontogeny of Tumor-Associated Macrophages

(2019) Marie Laviron et al.   Frontiers in Immunology

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

Macrophage Polarization in Physiological and Pathological Pregnancy

(2019) Yongli Yao et al.   Frontiers in Immunology

Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide

(2019) Chanju Lee et al.   Journal for ImmunoTherapy of Cancer

Phenotypical and Functional Polymorphism of Liver Resident Macrophages

(2019) Andrey V. Elchaninov et al.   Cells

Tumor-Associated Macrophages (TAMs): A Critical Activator In Ovarian Cancer Metastasis

(2019) Meichen Yin et al.   OncoTargets and Therapy

Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

(2019) Tao Yu et al.   Nature Communications

Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

(2019) F. Zhang et al.   Nature Communications

miR-200c/PAI-2 promotes the progression of triple negative breast cancer via M1/M2 polarization induction of macrophage

(2019) Ziqi Meng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Distribution of M1 and M2 macrophages in tumor islets and stroma in relation to prognosis of non-small cell lung cancer

(2018) Jurgita Jackute et al.   BMC IMMUNOLOGY

MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα

(2018) Anant Jaiswal et al.   Cellular & Molecular Immunology

Fetal monocytes and the origins of tissue-resident macrophages

(2018) Guillaume Hoeffel et al.   CELLULAR IMMUNOLOGY

Delivering CRISPR: a review of the challenges and approaches

(2018) Christopher A. Lino et al.   DRUG DELIVERY

Role of Human Macrophage Polarization in Inflammation during Infectious Diseases

(2018) Chiraz Atri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages

(2018) Jared P. Taylor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HDAC inhibition helps post-MI healing by modulating macrophage polarization

(2018) Denise Kimbrough et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis

(2018) Fengna Chu et al.   JOURNAL OF NEUROIMMUNOLOGY

IL-34 Inhibits Acute Rejection of Rat Liver Transplantation by Inducing Kupffer Cell M2 Polarization

(2018) Zhengfei Zhao et al.   TRANSPLANTATION

Macrophages: The Road Less Traveled, Changing Anticancer Therapy

(2018) Jennifer L. Guerriero   TRENDS IN MOLECULAR MEDICINE

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

(2018) Degao Chen et al.   Nature Communications

M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis

(2018) Shoichi Fukui et al.   Frontiers in Immunology

Targeting Macrophages in Cancer: From Bench to Bedside

(2018) Ashleigh R. Poh et al.   Frontiers in Oncology

Paclitaxel reduces tumor growth by reprogramming tumor-associated macrophages to an M1- profile in a TLR4-dependent manner

(2018) Carlos W Wanderley et al.   CANCER RESEARCH

Silencing LAIR-1 in human THP-1 macrophage increases foam cell formation by modulating PPARγ and M2 polarization

(2018) Xin Yi et al.   CYTOKINE

Preparation of Induced Pluripotent Stem Cells Using Human Peripheral Blood Monocytes

(2018) Sumito Isogai et al.   Cellular Reprogramming

Transcriptional profiling identifies novel regulators of macrophage polarization

(2018) Kimberline Y. Gerrick et al.   PLoS One

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

(2018) Congfei Xu et al.   Nature Communications

Gene Regulatory Network Modeling of Macrophage Differentiation Corroborates the Continuum Hypothesis of Polarization States

(2018) Alessandro Palma et al.   Frontiers in Physiology

Imaging of Tumor-Associated Macrophages in a Transgenic Mouse Model of Orthotopic Ovarian Cancer

(2017) Huanhuan He et al.   MOLECULAR IMAGING AND BIOLOGY

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Functional Analysis of Dendritic Cells Generated from T-iPSCs from CD4+ T Cell Clones of Sjögren's Syndrome

(2017) Mana Iizuka-Koga et al.   Stem Cell Reports

Sestrin2 Suppresses Classically Activated Macrophages-Mediated Inflammatory Response in Myocardial Infarction through Inhibition of mTORC1 Signaling

(2017) Keping Yang et al.   Frontiers in Immunology

TALEN-mediated functional correction of human iPSC-derived macrophages in context of hereditary pulmonary alveolar proteinosis

(2017) Alexandra Kuhn et al.   Scientific Reports

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

(2016) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

Origins of Brain Tumor Macrophages

(2016) Michele De Palma   CANCER CELL

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

The development and maintenance of resident macrophages

(2016) Elisa Gomez Perdiguero et al.   NATURE IMMUNOLOGY

Genome-Edited Human Pluripotent Stem Cell–Derived Macrophages as a Model of Reverse Cholesterol Transport

(2015) Rajat M. Gupta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

M2 Polarization of Monocytes-Macrophages Is a Hallmark of Indian Post Kala-Azar Dermal Leishmaniasis

(2015) Debanjan Mukhopadhyay et al.   PLoS Neglected Tropical Diseases

Histone Deacetylase 9 Represses Cholesterol Efflux and Alternatively Activated Macrophages in Atherosclerosis Development

(2014) Qiang Cao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of NADPH Oxidase–Derived Superoxide Skews Macrophage Phenotypes to Delay Type 1 Diabetes

(2014) Lindsey E. Padgett et al.   DIABETES

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival

(2014) Emmanuel L. Gautier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

(2014) Laura Bonapace et al.   NATURE

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

(2014) M. Rosas et al.   SCIENCE

Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans

(2014) Leonie Beljaars et al.   Frontiers in Immunology

Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype

(2013) R.M. Boehler et al.   BIOTECHNOLOGY AND BIOENGINEERING

The nuclear receptor LXRα controls the functional specialization of splenic macrophages

(2013) Noelia A-Gonzalez et al.   NATURE IMMUNOLOGY

Experimental Pneumocystis lung infection promotes M2a alveolar macrophage-derived MMP12 production

(2012) Michael P. Nelson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages

(2012) Hui-Rong Jiang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systemic Analysis of PPAR  in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway Immunity

(2012) E. L. Gautier et al.   JOURNAL OF IMMUNOLOGY

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

(2012) Qiong-wen Zhang et al.   PLoS One

Microglia Function in Alzheimer’s Disease

(2012) Egle Solito et al.   Frontiers in Pharmacology

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Alternative activation of macrophages in human peritoneum: implications for peritoneal fibrosis

(2011) Teresa Bellón et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression

(2010) L. Sanchez-Martin et al.   BLOOD

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

(2010) Christian Steidl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fibrinogen drives dystrophic muscle fibrosis via a TGF /alternative macrophage activation pathway

(2008) B. Vidal et al.   GENES & DEVELOPMENT

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

(2008) Masako Kohyama et al.   NATURE