Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes
Authors
Keywords
-
Journal
NATURE MEDICINE
Volume 19, Issue 9, Pages 1132-1140
Publisher
Springer Nature
Online
2013-08-19
DOI
10.1038/nm.3265
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Chronic Endocannabinoid System Stimulation Induces Muscle Macrophage and Lipid Accumulation in Type 2 Diabetic Mice Independently of Metabolic Endotoxaemia
- (2013) Lucie Geurts et al. PLoS One
- JD-5006 and JD-5037: Peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities
- (2012) Robert J. Chorvat et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production
- (2012) Arya E. Mehran et al. Cell Metabolism
- Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance
- (2012) Joseph Tam et al. Cell Metabolism
- Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome
- (2012) Christine M. Oslowski et al. Cell Metabolism
- IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
- (2012) Alana G. Lerner et al. Cell Metabolism
- Chronic activation of cannabinoid receptorsin vitrodoes not compromise mouse islet function
- (2012) Alonso Vilches-Flores et al. CLINICAL SCIENCE
- Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes
- (2012) Hye-Mi Lee et al. DIABETES
- Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight
- (2012) K. Rohrbach et al. DIABETES OBESITY & METABOLISM
- Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice
- (2012) Jie Liu et al. GASTROENTEROLOGY
- Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans
- (2012) Gijs H. Goossens et al. MOLECULAR IMMUNOLOGY
- The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
- (2012) Geun-Shik Lee et al. NATURE
- Beneficial Metabolic Effects of CB1R Anti-Sense Oligonucleotide Treatment in Diet-Induced Obese AKR/J Mice
- (2012) Yuting Tang et al. PLoS One
- Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids
- (2012) Dmitry Grapov et al. PLoS One
- JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
- (2012) M. S. Han et al. SCIENCE
- Cannabinoids Induce Pancreatic -Cell Death by Directly Inhibiting Insulin Receptor Activation
- (2012) W. Kim et al. Science Signaling
- Glucan particles for selective delivery of siRNA to phagocytic cells in mice
- (2011) Gregory J. Tesz et al. BIOCHEMICAL JOURNAL
- Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis
- (2011) J. D. O'Hare et al. DIABETES
- Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion
- (2011) M. A. Osundiji et al. DIABETES
- Hyperuricemia as a Mediator of the Proinflammatory Endocrine Imbalance in the Adipose Tissue in a Murine Model of the Metabolic Syndrome
- (2011) W. Baldwin et al. DIABETES
- Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic -Cells
- (2011) W. Kim et al. DIABETES
- Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage
- (2011) Yun-Hee Youm et al. ENDOCRINOLOGY
- Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice
- (2011) Alexandre Louvet et al. HEPATOLOGY
- Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: Evidence from cultured explants
- (2011) Tony Jourdan et al. HEPATOLOGY
- Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function
- (2011) Vivian C. Calegari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver
- (2011) B. Mukhopadhyay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Inflammasomes
- (2010) Kate Schroder et al. CELL
- The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
- (2010) Rinke Stienstra et al. Cell Metabolism
- Inhibitor of Fatty Acid Amide Hydrolase Normalizes Cardiovascular Function in Hypertension without Adverse Metabolic Effects
- (2010) Grzegorz Godlewski et al. CHEMISTRY & BIOLOGY
- CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice
- (2010) T. Jourdan et al. DIABETES
- Transcriptional Regulation of Cannabinoid Receptor-1 Expression in the Liver by Retinoic Acid Acting via Retinoic Acid Receptor-γ
- (2010) Bani Mukhopadhyay et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
- (2010) Joseph Tam et al. JOURNAL OF CLINICAL INVESTIGATION
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
- (2010) Seth L Masters et al. NATURE IMMUNOLOGY
- CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages
- (2009) K. H. Han et al. CARDIOVASCULAR RESEARCH
- From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
- (2009) R. A. DeFronzo DIABETES
- Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
- (2009) Myriam Aouadi et al. NATURE
- Thioredoxin-interacting protein links oxidative stress to inflammasome activation
- (2009) Rongbin Zhou et al. NATURE IMMUNOLOGY
- The future of endocannabinoid-oriented clinical research after CB1 antagonists
- (2009) Bernard Le Foll et al. PSYCHOPHARMACOLOGY
- The Acyclic CB1R Inverse Agonist Taranabant Mediates Weight Loss by Increasing Energy Expenditure and Decreasing Caloric Intake
- (2008) Carol Addy et al. Cell Metabolism
- SERENADE: The Study Evaluating Rimonabant Efficacy in Drug-Naive Diabetic Patients: Effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight, and lipid profile in drug-naive type 2 diabetes
- (2008) J. Rosenstock et al. DIABETES CARE
- Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle
- (2008) K. Eckardt et al. DIABETOLOGIA
- Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet
- (2008) Katarzyna M. Starowicz et al. Obesity
- Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
- (2008) C. Dostert et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started