Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

(2020) Youn-Sang Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Exosome‐mediated transfer of miR‐1260b promotes cell invasion through Wnt/β–catenin signaling pathway in lung adenocarcinoma

(2020) Yang Xia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Advances in molecular classification and precision oncology in hepatocellular carcinoma

(2020) Sandra Rebouissou et al.   JOURNAL OF HEPATOLOGY

CDDO-Me elicits anti-breast cancer activity by targeting LRP6 and FZD7 receptor complex

(2020) Liang Zhou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers

(2020) Shan Li et al.   ONCOGENE

Expression of Wnt pathway molecules is associated with disease outcome in metastatic high-grade serous carcinoma

(2020) Michal Chehover et al.   VIRCHOWS ARCHIV

LRP6 mediated signal transduction pathway triggered by tissue plasminogen activator acts through lipid rafts in neuroblastoma cells

(2020) Gloria Riitano et al.   Journal of Cell Communication and Signaling

Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway

(2020) Chenghuai Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and Wnt

(2020) Ahmed El-Sehemy et al.   JOURNAL OF CLINICAL INVESTIGATION

Fzd2 Contributes to Breast Cancer Cell Mesenchymal-Like Stemness and Drug Resistance

(2020) Ping Yin et al.   ONCOLOGY RESEARCH

Combination of Inositol Hexaphosphate and Inositol Inhibits Liver Metastasis of Colorectal Cancer in Mice Through the Wnt/β-Catenin Pathway

(2020) Xiaohan Liu et al.   OncoTargets and Therapy

Interleaflet Coupling of Lipid Nanodomains – Insights From in vitro Systems

(2020) Maria J. Sarmento et al.   Frontiers in Cell and Developmental Biology

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop

(2019) Megan J. Agajanian et al.   Cell Reports

Non-acylated Wnts Can Promote Signaling

(2019) Kelsey F. Speer et al.   Cell Reports

Aspirin ameliorates lung cancer by targeting the miR-98/WNT1 axis

(2019) Huizhu Gan et al.   Thoracic Cancer

Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma

(2019) Dimitra Kerdidani et al.   Nature Communications

Down-regulation of FZD3 receptor suppresses growth and metastasis of human melanoma independently of canonical WNT signaling

(2019) Chen Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

EIF 3E‐ RSPO 2 and PIEZO 1‐ RSPO 2 fusions in colorectal traditional serrated adenoma

(2019) Taiki Hashimoto et al.   HISTOPATHOLOGY

Frizzled 2-induced epithelial-mesenchymal transition correlates with vasculogenic mimicry, stemness, and Hippo signaling in hepatocellular carcinoma

(2019) Huohui Ou et al.   CANCER SCIENCE

Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response

(2019) Stefano Caruso et al.   GASTROENTEROLOGY

Overexpression of FZD7 is associated with poor survival in patients with colon cancer

(2019) Chengwei Ye et al.   PATHOLOGY RESEARCH AND PRACTICE

Long noncoding RNA DLX6-AS1 promotes tumorigenesis by modulating miR-497-5p/FZD4/ FZD6/Wnt/β-catenin pathway in pancreatic cancer

(2019) Jiyong Yang et al.   Cancer Management and Research

Lipids that directly regulate innate immune signal transduction

(2019) Katherine C Barnett et al.   Innate Immunity

The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation

(2019) M. Frenquelli et al.   LEUKEMIA

Hepatocellular carcinoma: Mechanisms of progression and immunotherapy

(2019) Yu Jiang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma

(2019) Marina Ruiz de Galarreta et al.   Cancer Discovery

Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal Cancer

(2019) Irantzu Gorroño-Etxebarria et al.   Cancers

A Review of the Role of Wnt in Cancer Immunomodulation

(2019) Whitney N. Goldsberry et al.   Cancers

WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling

(2019) Shaojie Jiang et al.   Cell Communication and Signaling

AGR3 promotes the stemness of colorectal cancer via modulating Wnt/β-catenin signalling

(2019) Jiangyang Chi et al.   CELLULAR SIGNALLING

A global view of hepatocellular carcinoma: trends, risk, prevention and management

(2019) Ju Dong Yang et al.   Nature Reviews Gastroenterology & Hepatology

CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin

(2019) Yaowu He et al.   ONCOGENE

PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers

(2019) Zheng Zhong et al.   ONCOGENE

miR-650 promotes non-small cell lung cancer cell proliferation and invasion by targeting ING4 through Wnt-1/β-catenin pathway

(2019) Xiangqin Tang et al.   Oncology Letters

Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration

(2019) Xiaobo Nie et al.   Frontiers in Pharmacology

Shaping membranes with disordered proteins

(2019) Mohammad A.A. Fakhree et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

WNT5B exerts oncogenic effects and is negatively regulated by miR-5587-3p in lung adenocarcinoma progression

(2019) Qun Zhang et al.   ONCOGENE

Membrane capacitance recordings resolve dynamics and complexity of receptor-mediated endocytosis in Wnt signalling

(2019) Vera Bandmann et al.   Scientific Reports

CAGE-miR-140-5p-Wnt1 Axis Regulates Autophagic Flux, Tumorigenic Potential of Mouse Colon Cancer Cells and Cellular Interactions Mediated by Exosomes

(2019) Minjeong Yeon et al.   Frontiers in Oncology

More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains

(2019) Yagmur Azbazdar et al.   Frontiers in Cell and Developmental Biology

Defining raft domains in the plasma membrane

(2019) Akihiro Kusumi et al.   TRAFFIC

From top to bottom: Cell polarity in Hedgehog and Wnt trafficking

(2018) Ana-Citlali Gradilla et al.   BMC BIOLOGY

A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients

(2018) Anne-Laure Giraudet et al.   BMC CANCER

Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?

(2018) RG Morgan et al.   BRITISH JOURNAL OF CANCER

Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents

(2018) Alfredo Erazo-Oliveras et al.   CANCER AND METASTASIS REVIEWS

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

(2018) Nithya Krishnamurthy et al.   CANCER TREATMENT REVIEWS

Aberrant Expression of miR-142-3p and its Target Gene HMGA1 and FZD7 in Breast Cancer and its Clinical Significance

(2018) Xiu-Peng Jia et al.   Clinical Laboratory

From instruction to output: Wnt/PCP signaling in development and cancer

(2018) Ashley Ceinwen Humphries et al.   CURRENT OPINION IN CELL BIOLOGY

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway

(2018) Kenyi Saito-Diaz et al.   DEVELOPMENTAL CELL

ERAD‐dependent control of the Wnt secretory factor Evi

(2018) Kathrin Glaeser et al.   EMBO JOURNAL

miRNA-185 serves as a prognostic factor and suppresses migration and invasion through Wnt1 in colon cancer

(2018) Wenjun Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Frizzled Receptors as Potential Therapeutic Targets in Human Cancers

(2018) Chui-Mian Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype

(2018) Tobias Sinnberg et al.   Molecular Cancer

Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/β-catenin Pathway

(2018) Hyeon Jeong Lee et al.   MOLECULAR CANCER RESEARCH

Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway

(2018) Jia‑Bing Tong et al.   Molecular Medicine Reports

Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate

(2018) Thomas C. von Erlach et al.   NATURE MATERIALS

Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells

(2018) Zhaolin Chen et al.   PHYTOMEDICINE

A molecular mechanism for Wnt ligand-specific signaling

(2018) Marie Eubelen et al.   SCIENCE

The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division

(2018) Ewa Stypulkowski et al.   Science Signaling

Downregulation of Frizzled-7 induces the apoptosis of hepatocellular carcinoma cells through inhibition of NF-κB

(2018) Yuyang Xue et al.   Oncology Letters

Wnt6 contributes tumorigenesis and development of colon cancer via its effects on cell proliferation, apoptosis, cell‑cycle and migration

(2018) Xiao‑Li Zheng et al.   Oncology Letters

Dramatic dysbalancing of the Wnt pathway in breast cancers

(2018) Alexey Koval et al.   Scientific Reports

Wnt/β-catenin regulates an ancient signaling network during zebrafish scale development

(2018) Andrew J Aman et al.   eLife

The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division

(2018) Ewa Stypulkowski et al.   Science Signaling

Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes

(2018) Shailesh R. Agarwal et al.   Frontiers in Pharmacology

Novel Regulatory Roles of Wnt1 in Infection-Associated Colorectal Cancer

(2018) Jianwei Wang et al.   NEOPLASIA

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A novel recombinant human Frizzled-7 protein exhibits anti-tumor activity against triple negative breast cancer via abating Wnt/β-catenin pathway

(2018) Wei Xie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structural and dynamic characterization of human Wnt2-Fzd7 complex using computational approaches

(2018) Hourieh Kalhor et al.   JOURNAL OF MOLECULAR MODELING

Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells

(2018) Ugo Testa et al.   Cancers

In vitro reconstitution of Wnt acylation reveals structural determinants of substrate recognition by the acyltransferase human Porcupine

(2018) Chul-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt lipidation: Roles in trafficking, modulation, and function

(2018) Vahid Hosseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

WNT6 is an effective marker for osteosarcoma diagnosis and prognosis

(2018) Kai Jiang et al.   MEDICINE

Actomyosin contractility modulates Wnt signaling through adherens junction stability

(2018) Eric T. Hall et al.   MOLECULAR BIOLOGY OF THE CELL

Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer

(2018) Nanpeng Li et al.   ONCOLOGY REPORTS

mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level

(2018) Hao Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR‑410 acts as an oncogene in colorectal cancer cells by targeting dickkopf‑related protein 1 via the Wnt/β‑catenin signaling pathway

(2018) Wei Wang et al.   Oncology Letters

The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt

(2018) Yan Huang et al.   eLife

Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells

(2017) Zhiqiang Wang et al.   EXPERIMENTAL CELL RESEARCH

Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments

(2017) Erdinc Sezgin et al.   FEBS Journal

Comprehensive characterization of RSPO fusions in colorectal traditional serrated adenomas

(2017) Shigeki Sekine et al.   HISTOPATHOLOGY

Molecular genetics and targeted therapy of WNT-related human diseases (Review)

(2017) Masuko Katoh et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding

(2017) Aaron H. Nile et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation study of DNA methylation of WNT6 gene with osteosarcoma in children

(2017) Li Li et al.   Oncology Letters

Effects of Wnt‑1 blockade in DEN‑induced hepatocellular adenomas of mice

(2017) Argyrios Sklavos et al.   Oncology Letters

Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus

(2017) Yusuke Mii et al.   Nature Communications

Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS

(2017) Nardos G. Tassew et al.   Cell Reports

Wnt Signaling in Ewing Sarcoma, Osteosarcoma, and Malignant Peripheral Nerve Sheath Tumors

(2017) Matthew G. Pridgeon et al.   Current Osteoporosis Reports

Garlic-derived compound S -allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway

(2017) Jia Xiao et al.   Acta Pharmaceutica Sinica B

miRNA-148a serves as a prognostic factor and suppresses migration and invasion through Wnt1 in non-small cell lung cancer

(2017) Yong Chen et al.   PLoS One

Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model

(2017) Giacomo Canesin et al.   PLoS One

miR-135b reverses chemoresistance of non-small cell lung cancer cells by downregulation of FZD1

(2016) Wenmei Su et al.   BIOMEDICINE & PHARMACOTHERAPY

Increased Wnt5a in squamous cell lung carcinoma inhibits endothelial cell motility

(2016) J. Rapp et al.   BMC CANCER

γ-Tocotrienol reversal of epithelial-to-mesenchymal transition in human breast cancer cells is associated with inhibition of canonical Wnt signalling

(2016) R. A. Ahmed et al.   CELL PROLIFERATION

Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation

(2016) Eva-Maria Brinkmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I study of DKN-01, an anti-DKK1 antibody, in combination with paclitaxel (pac) in patients (pts) with DKK1+ relapsed or refractory esophageal cancer (EC) or gastro-esophageal junction tumors (GEJ).

(2016) Johanna C. Bendell et al.   JOURNAL OF CLINICAL ONCOLOGY

Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6 ) in breast cancer

(2016) Gabriele Corda et al.   JOURNAL OF PATHOLOGY

Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled

(2016) Melissa V. Gammons et al.   MOLECULAR CELL

Fatty acylation of Wnt proteins

(2016) Aaron H Nile et al.   Nature Chemical Biology

Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

(2016) Zachary Steinhart et al.   NATURE MEDICINE

Novel Regulation of Wnt Signaling at the Proximal Membrane Level

(2016) Xiaomo Jiang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Long noncoding RNA AK126698 inhibits proliferation and migration of non-small cell lung cancer cells by targeting Frizzled-8 and suppressing Wnt/β-catenin signaling pathway

(2016) Xiao Fu et al.   OncoTargets and Therapy

Short hairpin RNA silencing of TGF-βRII and FZD-7 synergistically suppresses proliferation and metastasis of hepatocellular carcinoma cells

(2016) CONG CHEN et al.   Oncology Letters

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

(2016) Alexandra Avgustinova et al.   Nature Communications

Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a

(2016) Siwei Wang et al.   Oncotarget

Niclosamide sensitizes triple-negative breast cancer cells to ionizing radiation in association with the inhibition of Wnt/β-catenin signaling

(2016) Lina Yin et al.   Oncotarget

Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signaling

(2016) Yunli Tong et al.   Oncotarget

Motility and stem cell properties induced by the epithelial-mesenchymal transition require destabilization of lipid rafts

(2016) Michael J. Tisza et al.   Oncotarget

A novel non-canonical Wnt signature for prostate cancer aggressiveness

(2016) Elise Sandsmark et al.   Oncotarget

Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility

(2016) Richarda M. de Voer et al.   PLoS Genetics

Decreased Wnt5a Expression is a Poor Prognostic Factor in Triple-Negative Breast Cancer

(2016) ZhenBin Zhong et al.   MEDICAL SCIENCE MONITOR

Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells

(2015) N. Borcherding et al.   CANCER RESEARCH

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

(2015) Giovanni Ciriello et al.   CELL

CBX7 inhibits breast tumorigenicity through DKK-1-mediated suppression of the Wnt/β-catenin pathway

(2015) Hey-Yon Kim et al.   FASEB JOURNAL

Keeping Wnt Signalosome in Check by Vesicular Traffic

(2015) Qiang Feng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation

(2015) Jian Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular characteristics of recurrent triple-negative breast cancer

(2015) CHUNG-HSIN TSAI et al.   Molecular Medicine Reports

Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28

(2015) Phuong N. Le et al.   PHARMACOLOGY & THERAPEUTICS

Synovial Sarcoma: Recent Discoveries as a Roadmap to New Avenues for Therapy

(2015) Torsten O. Nielsen et al.   Cancer Discovery

Spatio-temporal Model of Endogenous ROS and Raft-Dependent WNT/Beta-Catenin Signaling Driving Cell Fate Commitment in Human Neural Progenitor Cells

(2015) Fiete Haack et al.   PLoS Computational Biology

Colorectal cancer

(2015) Ernst J. Kuipers et al.   Nature Reviews Disease Primers

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

(2015) Richard Ventura et al.   EBioMedicine

β-Catenin Is Required for the Tumorigenic Behavior of Triple-Negative Breast Cancer Cells

(2015) Jinhua Xu et al.   PLoS One

Adaptive Lipid Packing and Bioactivity in Membrane Domains

(2015) Erdinc Sezgin et al.   PLoS One

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype

(2015) Gyu-Beom Jang et al.   Scientific Reports

A Phase IB multicentre dose-determination study of BHQ880 in combination with anti-myeloma therapy and zoledronic acid in patients with relapsed or refractory multiple myeloma and prior skeletal-related events

(2014) Swaminathan P. Iyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer

(2014) Jian Shi et al.   CANCER CELL

Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells

(2014) Wenyan Lu et al.   CELLULAR SIGNALLING

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) rs10845498 Polymorphism Is Associated with a Decreased Risk of Non-Small Cell Lung Cancer

(2014) Dehou Deng et al.   International Journal of Medical Sciences

Tyrosine-based Signal Mediates LRP6 Receptor Endocytosis and Desensitization of Wnt/β-Catenin Pathway Signaling

(2014) Chia-Chen Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo analysis of formation and endocytosis of the Wnt/ -Catenin signaling complex in zebrafish embryos

(2014) A. I. H. Hagemann et al.   JOURNAL OF CELL SCIENCE

Salinomycin Suppresses LRP6 Expression and Inhibits Both Wnt/β-catenin and mTORC1 Signaling in Breast and Prostate Cancer Cells

(2014) Wenyan Lu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RNF43 is frequently mutated in colorectal and endometrial cancers

(2014) Marios Giannakis et al.   NATURE GENETICS

Wnt3a increases the metastatic potential of non-small cell lung cancer cells in vitro in part via its upregulation of Notch3

(2014) CHUNYAN LI et al.   ONCOLOGY REPORTS

Dynamic Association with Donor Cell Filopodia and Lipid-Modification Are Essential Features of Wnt8a during Patterning of the Zebrafish Neuroectoderm

(2014) Marta Luz et al.   PLoS One

Frizzled 7 Expression Is Positively Regulated by SIRT1 and β-Catenin in Breast Cancer Cells

(2014) Glenn E. Simmons et al.   PLoS One

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

Signalosome assembly by domains undergoing dynamic head-to-tail polymerization

(2014) Mariann Bienz   TRENDS IN BIOCHEMICAL SCIENCES

BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10

(2014) Chang Gong et al.   Nature Communications

Safety of Targeting ROR1 in Primates with Chimeric Antigen Receptor-Modified T Cells

(2014) C. Berger et al.   Cancer Immunology Research

Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells

(2013) T. A. Jan et al.   DEVELOPMENT

Lypd6 Enhances Wnt/β-Catenin Signaling by Promoting Lrp6 Phosphorylation in Raft Plasma Membrane Domains

(2013) Günes Özhan et al.   DEVELOPMENTAL CELL

Overexpression of Lgr5 correlates with resistance to 5-FU-based chemotherapy in colorectal cancer

(2013) Hung-Chih Hsu et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes

(2013) Ingyu Kim et al.   JOURNAL OF CELL BIOLOGY

A double-negative feedback loop between Wnt–β-catenin signaling and HNF4α regulates epithelial–mesenchymal transition in hepatocellular carcinoma

(2013) Meng Yang et al.   JOURNAL OF CELL SCIENCE

Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis

(2013) Sichuan Xi et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt Signaling Pathway in Non-Small Cell Lung Cancer

(2013) D. J. Stewart   JNCI-Journal of the National Cancer Institute

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Sphingolipid depletion impairs endocytic traffic and inhibits Wingless signaling

(2013) Julia Pepperl et al.   MECHANISMS OF DEVELOPMENT

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche

(2013) Andrea Flesken-Nikitin et al.   NATURE

Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine

(2013) Xinxin Gao et al.   Nature Chemical Biology

Wnt Pathway Activity in Breast Cancer Sub-Types and Stem-Like Cells

(2013) Rebecca Lamb et al.   PLoS One

Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/ -catenin-responsive neural stem cells

(2013) A. N. Bowman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland

(2012) Renée van Amerongen et al.   Cell Stem Cell

Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells

(2012) Wenyan Lu et al.   CELLULAR SIGNALLING

Roles of N-glycosylation and lipidation in Wg secretion and signaling

(2012) Xiaofang Tang et al.   DEVELOPMENTAL BIOLOGY

Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling

(2012) H. Sakane et al.   JOURNAL OF CELL SCIENCE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Upregulation of the Wnt Co-Receptor LRP6 Promotes Hepatocarcinogenesis and Enhances Cell Invasion

(2012) Edmund Kwok-Kwan Tung et al.   PLoS One

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis

(2012) Ming Geng   WORLD JOURNAL OF GASTROENTEROLOGY

Secreted and Transmembrane Wnt Inhibitors and Activators

(2012) C.-M. Cruciat et al.   Cold Spring Harbor Perspectives in Biology

Wnt Proteins

(2012) K. Willert et al.   Cold Spring Harbor Perspectives in Biology

Sub-resolution lipid domains exist in the plasma membrane and regulate protein diffusion and distribution

(2012) Dylan M. Owen et al.   Nature Communications

Lgr5+ve Stem/Progenitor Cells Contribute to Nephron Formation during Kidney Development

(2012) Nick Barker et al.   Cell Reports

Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling

(2011) Lenka Doubravska et al.   CELLULAR SIGNALLING

Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis

(2011) Bisei Ohkawara et al.   DEVELOPMENTAL CELL

Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium

(2011) Eugenia C. Pacheco-Pinedo et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt3 gene expression promotes tumor progression in non-small cell lung cancer

(2011) Nariyasu Nakashima et al.   LUNG CANCER

FZD7 has a critical role in cell proliferation in triple negative breast cancer

(2011) L Yang et al.   ONCOGENE

A Switch from Canonical to Noncanonical Wnt Signaling Mediates Drug Resistance in Colon Cancer Cells

(2011) Michael Bordonaro et al.   PLoS One

Differential Palmit(e)oylation of Wnt1 on C93 and S224 Residues Has Overlapping and Distinct Consequences

(2011) Lisa M. Galli et al.   PLoS One

Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome

(2010) Andrey I. Khramtsov et al.   AMERICAN JOURNAL OF PATHOLOGY

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

(2010) H. Sakane et al.   JOURNAL OF CELL SCIENCE

Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

(2010) Mary E. Irwin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

(2010) Felipe C Geyer et al.   MODERN PATHOLOGY

Noncanonical Wnt11 Inhibits Hepatocellular Carcinoma Cell Proliferation and Migration

(2010) T. Toyama et al.   MOLECULAR CANCER RESEARCH

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

(2010) C.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Palmitoylation regulates raft affinity for the majority of integral raft proteins

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