LRP6 mediated signal transduction pathway triggered by tissue plasminogen activator acts through lipid rafts in neuroblastoma cells

A multimolecular signaling complex including PrP C and LRP1 is strictly dependent on lipid rafts and is essential for the function of tissue plasminogen activator

(2019) Vincenzo Mattei et al.   JOURNAL OF NEUROCHEMISTRY

Neuroglobin overexpression plays a pivotal role in neuroprotection through mitochondrial raft-like microdomains in neuroblastoma SK-N-BE2 cells

(2018) Tina Garofalo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

“Lipid raft aging” in the human frontal cortex during nonpathological aging: gender influences and potential implications in Alzheimer's disease

(2018) Mario Díaz et al.   NEUROBIOLOGY OF AGING

C-terminal truncated HBx protein activates caveolin-1/LRP6/β-catenin/FRMD5 axis in promoting hepatocarcinogenesis

(2018) Xiaowen Mao et al.   CANCER LETTERS

LRP6 promotes invasion and metastasis of colorectal cancer through cytoskeleton dynamics

(2017) Qian Yao et al.   Oncotarget

Low-density lipoprotein receptor-related protein 6 is a novel coreceptor of protease-activated receptor-2 in the dynamics of cancer-associated β-catenin stabilization

(2017) Jeetendra Kumar Nag et al.   Oncotarget

The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains

(2016) Emilia Laudati et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response

(2016) Elisabetta Mantuano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling

(2016) Zhiqi Song et al.   Oncotarget

LRP receptor family member associated bone disease

(2015) N. Lara-Castillo et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Spatio-temporal Model of Endogenous ROS and Raft-Dependent WNT/Beta-Catenin Signaling Driving Cell Fate Commitment in Human Neural Progenitor Cells

(2015) Fiete Haack et al.   PLoS Computational Biology

Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice

(2014) Junyan Tao et al.   GASTROENTEROLOGY

β-Catenin-dependent pathway activation by both promiscuous “canonical” WNT3a–, and specific “noncanonical” WNT4– and WNT5a–FZD receptor combinations with strong differences in LRP5 and LRP6 dependency

(2013) Larisa Ring et al.   CELLULAR SIGNALLING

Lypd6 Enhances Wnt/β-Catenin Signaling by Promoting Lrp6 Phosphorylation in Raft Plasma Membrane Domains

(2013) Günes Özhan et al.   DEVELOPMENTAL CELL

tPA Regulates Neurite Outgrowth by Phosphorylation of LRP5/6 in Neural Progenitor Cells

(2013) Sung Hoon Lee et al.   MOLECULAR NEUROBIOLOGY

Ganglioside GD3 as a Raft Component in Cell Death Regulation

(2012) Maurizio Sorice et al.   Anti-Cancer Agents in Medicinal Chemistry

Both LRP5 and LRP6 Receptors Are Required to Respond to Physiological Wnt Ligands in Mammary Epithelial Cells and Fibroblasts

(2012) Shruti Goel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane raft disruption results in neuritic retraction prior to neuronal death in cortical neurons

(2012) Shawn N. Whitehead   BioScience Trends

LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

(2010) H. Sakane et al.   JOURNAL OF CELL SCIENCE

Wnt3a and Dkk1 Regulate Distinct Internalization Pathways of LRP6 to Tune the Activation of β-Catenin Signaling

(2008) Hideki Yamamoto et al.   DEVELOPMENTAL CELL