Wnt Signaling in Ewing Sarcoma, Osteosarcoma, and Malignant Peripheral Nerve Sheath Tumors

miR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis in osteosarcoma cells

(2016) Zhi Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-140-5p attenuates chemotherapeutic drug-induced cell death by regulating autophagy through inositol 1,4,5-trisphosphate kinase 2 (IP3k2) in human osteosarcoma cells

(2016) R. Wei et al.   BIOSCIENCE REPORTS

Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential

(2016) Piti Techavichit et al.   BMC CANCER

Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/β-catenin signaling

(2016) Sara R. Martins-Neves et al.   CANCER LETTERS

Activation of Wnt/ -Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States

(2016) E. A. Pedersen et al.   CANCER RESEARCH

Developing drugs that target the Wnt pathway: recent approaches in cancer and neurodegenerative diseases

(2016) Annalucia Serafino et al.   Expert Opinion on Drug Discovery

MicroRNA-224 promotes the sensitivity of osteosarcoma cells to cisplatin by targeting Rac1

(2016) Shuo Geng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

β-Catenin-Independent Roles of Wnt/LRP6 Signaling

(2016) Sergio P. Acebron et al.   TRENDS IN CELL BIOLOGY

Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

(2016) Tahereh Javaheri et al.   Cell Death & Disease

The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma

(2016) Kristina von Heyking et al.   Oncotarget

FOXM1 in sarcoma: role in cell cycle, pluripotency genes and stem cell pathways

(2016) Fergal C. Kelleher et al.   Oncotarget

The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma

(2016) Luisa Cironi et al.   Scientific Reports

A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers

(2016) Kamal Ahmed et al.   Cancers

Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials

(2016) Benjamin Lu et al.   Cancers

TCF/LEF Transcription Factors: An Update from the Internet Resources

(2016) Dusan Hrckulak et al.   Cancers

MicroRNA-21 Increases Proliferation and Cisplatin Sensitivity of Osteosarcoma-Derived Cells

(2016) Vanita Vanas et al.   PLoS One

Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt)

(2015) Yingzi Yang et al.   Annual Review of Cell and Developmental Biology

Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma

(2015) Emma K. Baker et al.   BONE

Notum Is Required for Neural and Head Induction via Wnt Deacylation, Oxidation, and Inactivation

(2015) Xinjun Zhang et al.   DEVELOPMENTAL CELL

Notum deacylates Wnt proteins to suppress signalling activity

(2015) Satoshi Kakugawa et al.   NATURE

NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma

(2015) S Zhao et al.   ONCOGENE

Synovial Sarcoma: Recent Discoveries as a Roadmap to New Avenues for Therapy

(2015) Torsten O. Nielsen et al.   Cancer Discovery

Aberrant activation of Wnt/β-catenin signaling drives proliferation of bone sarcoma cells

(2015) Changbao Chen et al.   Oncotarget

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades

(2015) James Andrew McCubrey et al.   Oncotarget

WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer

(2015) Annalucia Serafino et al.   Oncotarget

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

Ewing’s sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors

(2014) Miwa Tanaka et al.   JOURNAL OF CLINICAL INVESTIGATION

R-spondins: Novel matricellular regulators of the skeleton

(2014) M. Noelle Knight et al.   MATRIX BIOLOGY

The Genomic Landscape of Pediatric Ewing Sarcoma

(2014) B. D. Crompton et al.   Cancer Discovery

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

(2014) F. Tirode et al.   Cancer Discovery

The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation

(2014) Andrew S. Brohl et al.   PLoS Genetics

New insights into the regulation of Axin function in canonical Wnt signaling pathway

(2014) Xiaomin Song et al.   Protein & Cell

WNT signaling in bone development and homeostasis

(2014) Zhendong Zhong et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy

(2013) Yimin Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Activation of the WNT Signaling Pathway Is a Hallmark in Neurofibromatosis Type 1 Tumorigenesis

(2013) A. Luscan et al.   CLINICAL CANCER RESEARCH

Lipid modification in Wnt structure and function

(2013) Jiyuan Ke et al.   CURRENT OPINION IN LIPIDOLOGY

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis

(2013) Eric P Rahrmann et al.   NATURE GENETICS

SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma

(2013) M Trautmann et al.   ONCOGENE

miR-346 Regulates Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Targeting the Wnt/β-Catenin Pathway

(2013) Qing Wang et al.   PLoS One

Canonical Wnt/β-catenin Signaling Drives Human Schwann Cell Transformation, Progression, and Tumor Maintenance

(2013) Adrienne L. Watson et al.   Cancer Discovery

Targeting the Wnt Pathway in Synovial Sarcoma Models

(2013) W. Barham et al.   Cancer Discovery

LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/β-Catenin Signaling

(2013) Christopher A. Scannell et al.   Frontiers in Oncology

Wnt5a promotes ewing sarcoma cell migration through upregulating CXCR4 expression

(2012) Zhe Jin et al.   BMC CANCER

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation

(2012) Xinjun Zhang et al.   CELL

LRP5 and LRP6 in development and disease

(2012) Danese M. Joiner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

High-Frequency Canonical Wnt Activation in Multiple Sarcoma Subtypes Drives Proliferation through a TCF/β-Catenin Target Gene, CDC25A

(2011) Sapna Vijayakumar et al.   CANCER CELL

A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis

(2011) S. W. Leacock et al.   Disease Models & Mechanisms

Modeling Initiation of Ewing Sarcoma in Human Neural Crest Cells

(2011) Cornelia von Levetzow et al.   PLoS One

Birth incidence and prevalence of tumor-prone syndromes: Estimates from a UK family genetic register service

(2010) D.G. Evans et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The various roles of ubiquitin in Wnt pathway regulation

(2010) Daniele V. F. Tauriello et al.   CELL CYCLE

Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

(2010) Akiko Mukai et al.   EMBO JOURNAL

Receptor endocytosis: Frizzled joins the ubiquitin club

(2010) Ken M Cadigan   EMBO JOURNAL

New insights in sarcoma oncogenesis: a comprehensive analysis of a large series of 160 soft tissue sarcomas with complex genomics

(2010) Laure Gibault et al.   JOURNAL OF PATHOLOGY

The EWS/FLI1 oncogenic protein inhibits expression of the Wnt inhibitor DICKKOPF-1 gene and antagonizes β-catenin/TCF-mediated transcription

(2009) Diego Navarro et al.   CARCINOGENESIS

Noncanonical Wnt Signaling Orchestrates Early Developmental Events toward Hematopoietic Cell Fate from Human Embryonic Stem Cells

(2009) Kausalia Vijayaragavan et al.   Cell Stem Cell

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

(2009) Maya Kansara et al.   JOURNAL OF CLINICAL INVESTIGATION

A Molecular Function Map of Ewing's Sarcoma

(2009) Maximilian Kauer et al.   PLoS One

Current status of sporadic and neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors

(2009) Brigitte C. Widemann   Current Oncology Reports

Changes in Incidence and Survival of Ewing Sarcoma Patients Over the Past 3 Decades

(2008) Natia Esiashvili et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Wnt-3a and Dickkopf-1 Stimulate Neurite Outgrowth in Ewing Tumor Cells via a Frizzled3- and c-Jun N-Terminal Kinase-Dependent Mechanism

(2008) Y. Endo et al.   MOLECULAR AND CELLULAR BIOLOGY