From top to bottom: Cell polarity in Hedgehog and Wnt trafficking

LGR5 receptor promotes cell–cell adhesion in stem cells and colon cancer cells via the IQGAP1–Rac1 pathway

(2017) Kendra S. Carmon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ca2+coordination controls sonic hedgehog structure and its Scube2-regulated release

(2017) Petra Jakobs et al.   JOURNAL OF CELL SCIENCE

Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation

(2017) Fergal O’Farrell et al.   NATURE CELL BIOLOGY

Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs

(2017) Elaine Y. C. Hsia et al.   Nature Communications

EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth

(2017) Chiswili Chabu et al.   Nature Communications

An apicobasal gradient of Rac activity determines protrusion form and position

(2017) Africa Couto et al.   Nature Communications

Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development

(2017) Hua He et al.   PLoS Genetics

Role of cytonemes in Wnt transport

(2016) Eliana Stanganello et al.   JOURNAL OF CELL SCIENCE

Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs

(2016) Yasuo Yamazaki et al.   NATURE CELL BIOLOGY

Mechanisms and functions of extracellular vesicle release in vivo—What we can learn from flies and worms

(2016) Katharina B. Beer et al.   Cell Adhesion & Migration

NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition

(2016) Babita Madan et al.   Oncotarget

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

(2016) Kai Jiang et al.   PLOS BIOLOGY

Communication between distant epithelial cells by filopodia-like protrusions during embryonic development

(2015) Sagar et al.   DEVELOPMENT

Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling

(2015) Gisela D’Angelo et al.   DEVELOPMENTAL CELL

Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions

(2015) J. C. Snyder et al.   JOURNAL OF CELL SCIENCE

Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion

(2015) Anup Parchure et al.   MOLECULAR BIOLOGY OF THE CELL

Notum deacylates Wnt proteins to suppress signalling activity

(2015) Satoshi Kakugawa et al.   NATURE

Filopodia-based Wnt transport during vertebrate tissue patterning

(2015) Eliana Stanganello et al.   Nature Communications

Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity

(2014) Sumit Kumar et al.   BMC BIOLOGY

Local Control of Intestinal Stem Cell Homeostasis by Enteroendocrine Cells in the Adult Drosophila Midgut

(2014) Alessandro Scopelliti et al.   CURRENT BIOLOGY

Cytonemes as specialized signaling filopodia

(2014) T. B. Kornberg et al.   DEVELOPMENT

The contrasting roles of primary cilia and cytonemes in Hh signaling

(2014) Thomas B. Kornberg   DEVELOPMENTAL BIOLOGY

Polarized Wnt Signaling Regulates Ectodermal Cell Fate in Xenopus

(2014) Ya-Lin Huang et al.   DEVELOPMENTAL CELL

WLS Retrograde Transport to the Endoplasmic Reticulum during Wnt Secretion

(2014) Jia Yu et al.   DEVELOPMENTAL CELL

In vivo analysis of formation and endocytosis of the Wnt/ -Catenin signaling complex in zebrafish embryos

(2014) A. I. H. Hagemann et al.   JOURNAL OF CELL SCIENCE

The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

(2014) Tamás Matusek et al.   NATURE

Dynamic Association with Donor Cell Filopodia and Lipid-Modification Are Essential Features of Wnt8a during Patterning of the Zebrafish Neuroectoderm

(2014) Marta Luz et al.   PLoS One

Cytoneme-Mediated Contact-Dependent Transport of the Drosophila Decapentaplegic Signaling Protein

(2014) S. Roy et al.   SCIENCE

Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle

(2014) Marcos Julián Cardozo et al.   Nature Communications

Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion

(2014) Ana-Citlali Gradilla et al.   Nature Communications

Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties

(2014) Neha Vyas et al.   Scientific Reports

Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning

(2013) H. Hamada et al.   DEVELOPMENT

Derlin2 Protein Facilitates HRD1-mediated Retro-translocation of Sonic Hedgehog at the Endoplasmic Reticulum

(2013) Chih-Hsiang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms

(2013) H. Yamamoto et al.   JOURNAL OF CELL SCIENCE

Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues

(2013) J. Steinhauer et al.   JOURNAL OF CELL SCIENCE

Patterning and growth control by membrane-tethered Wingless

(2013) Cyrille Alexandre et al.   NATURE

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

(2013) Timothy A. Sanders et al.   NATURE

Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia

(2013) Marcus Bischoff et al.   NATURE CELL BIOLOGY

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stearoyl CoA Desaturase Is Required to Produce Active, Lipid-Modified Wnt Proteins

(2013) Jessica Rios-Esteves et al.   Cell Reports

Secretion and Signaling Activities of Lipoprotein-Associated Hedgehog and Non-Sterol-Modified Hedgehog in Flies and Mammals

(2013) Wilhelm Palm et al.   PLOS BIOLOGY

Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling

(2012) K. L. Ayers et al.   DEVELOPMENT

Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif

(2012) Aphrodite Bilioni et al.   DEVELOPMENTAL BIOLOGY

Planar Polarized Protrusions Break the Symmetry of EGFR Signaling during Drosophila Bract Cell Fate Induction

(2012) Ying Peng et al.   DEVELOPMENTAL CELL

The Scribble–Dlg–Lgl polarity module in development and cancer: from flies to man

(2012) Imogen Elsum et al.   Essays in Biochemistry

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form

(2012) A. Creanga et al.   GENES & DEVELOPMENT

Mechanism of Evenness Interrupted (Evi)-Exosome Release at Synaptic Boutons

(2012) Kate Koles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Drosophila S2 Cells Secrete Wingless on Exosome-Like Vesicles but the Wingless Gradient Forms Independently of Exosomes

(2012) Karen Beckett et al.   TRAFFIC

Cytoneme-Mediated Delivery of Hedgehog Regulates the Expression of Bone Morphogenetic Proteins to Maintain Germline Stem Cells in Drosophila

(2012) Patricia Rojas-Ríos et al.   PLOS BIOLOGY

The Role of Glypicans in Wnt Inhibitory Factor-1 Activity and the Structural Basis of Wif1's Effects on Wnt and Hedgehog Signaling

(2012) Andrei Avanesov et al.   PLoS Genetics

Secreted Wnt “inhibitors” are not just inhibitors: Regulation of extracellular Wnt by secreted Frizzled-related proteins

(2011) Yusuke Mii et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Extracellular Movement of Signaling Molecules

(2011) Patrick Müller et al.   DEVELOPMENTAL CELL

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

(2011) Xin Chen et al.   JOURNAL OF CELL BIOLOGY

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

(2011) Martin Harterink et al.   NATURE CELL BIOLOGY

Cell Polarity and Migration: Emerging Role for the Endosomal Sorting Machinery

(2011) Viola Hélène Lobert et al.   PHYSIOLOGY

Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium

(2011) A. Callejo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specificity of Drosophila Cytonemes for Distinct Signaling Pathways

(2011) S. Roy et al.   SCIENCE

The Long-Range Activity of Hedgehog Is Regulated in the Apical Extracellular Space by the Glypican Dally and the Hydrolase Notum

(2010) Katie L. Ayers et al.   DEVELOPMENTAL CELL

Role of Lipid Metabolism in Smoothened Derepression in Hedgehog Signaling

(2010) Amir Yavari et al.   DEVELOPMENTAL CELL

Dynamic Filopodia Transmit Intermittent Delta-Notch Signaling to Drive Pattern Refinement during Lateral Inhibition

(2010) Michael Cohen et al.   DEVELOPMENTAL CELL

Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions

(2010) M. Georgiou et al.   JOURNAL OF CELL SCIENCE

Wnt Trafficking: New Insights into Wnt Maturation, Secretion and Spreading

(2010) Fillip Port et al.   TRAFFIC

Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans

(2009) Ming-Tzu Tsai et al.   BIOCHEMICAL JOURNAL

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

Evidence for a role of vertebrate Disp1 in long-range Shh signaling

(2009) L. A. Etheridge et al.   DEVELOPMENT

The Full-length Unprocessed Hedgehog Protein Is an Active Signaling Molecule

(2009) Robert Tokhunts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

(2009) Benjamin Bishop et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hhat Is a Palmitoylacyltransferase with Specificity forN-Palmitoylation of Sonic Hedgehog

(2008) John A. Buglino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wingless secretion promotes and requires retromer-dependent cycling of Wntless

(2008) Fillip Port et al.   NATURE CELL BIOLOGY

C. elegans AP-2 and Retromer Control Wnt Signaling by Regulating MIG-14/Wntless

(2007) Chun-Liang Pan et al.   DEVELOPMENTAL CELL