Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer

(2012) K. D. Proffitt et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Roles of N-glycosylation and lipidation in Wg secretion and signaling

(2012) Xiaofang Tang et al.   DEVELOPMENTAL BIOLOGY

A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities

(2012) Rani Najdi et al.   DIFFERENTIATION

WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis

(2012) Pei-Tzu Yang et al.   EMBO Molecular Medicine

Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling

(2012) Kyle D. Proffitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

PORCN Moonlights in a Wnt-Independent Pathway That Regulates Cancer Cell Proliferation

(2012) Tracy M. Covey et al.   PLoS One

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Drosophila S2 Cells Secrete Wingless on Exosome-Like Vesicles but the Wingless Gradient Forms Independently of Exosomes

(2012) Karen Beckett et al.   TRAFFIC

Wnt Proteins

(2012) K. Willert et al.   Cold Spring Harbor Perspectives in Biology

Porcupine-mediated lipidation is required for Wnt recognition by Wls

(2011) Patrick Herr et al.   DEVELOPMENTAL BIOLOGY

The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis

(2011) Iris Augustin et al.   EMBO Molecular Medicine

Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes

(2011) Xinxin Gao et al.   FEBS LETTERS

Differential Palmit(e)oylation of Wnt1 on C93 and S224 Residues Has Overlapping and Distinct Consequences

(2011) Lisa M. Galli et al.   PLoS One

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

The intracellular dynamic of protein palmitoylation

(2010) Christine Salaun et al.   JOURNAL OF CELL BIOLOGY

Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice

(2010) V. Fritz et al.   MOLECULAR CANCER THERAPEUTICS

The chemical toolbox for monitoring protein fatty acylation and prenylation

(2010) Rami N Hannoush et al.   Nature Chemical Biology

Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

(2010) Yan Gong et al.   PLoS One

Imaging the Lipidome: ω-Alkynyl Fatty Acids for Detection and Cellular Visualization of Lipid-Modified Proteins

(2009) Rami N. Hannoush et al.   ACS Chemical Biology

Lipid-modified morphogens: functions of fats

(2009) Josefa Steinhauer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

PORCNmutations in focal dermal hypoplasia: coping with lethality

(2009) Dorothea Bornholdt et al.   HUMAN MUTATION

Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry

(2009) Megan C. Yap et al.   JOURNAL OF LIPID RESEARCH

Inhibition of Wnt signaling by Dishevelled PDZ peptides

(2009) Yingnan Zhang et al.   Nature Chemical Biology

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology