More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains

Non-acylated Wnts Can Promote Signaling

(2019) Kelsey F. Speer et al.   Cell Reports

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

(2018) Nithya Krishnamurthy et al.   CANCER TREATMENT REVIEWS

Frizzled Receptors as Potential Therapeutic Targets in Human Cancers

(2018) Chui-Mian Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular α-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G-protein signaling

(2018) Shaymaa Mohamed Mohamed Badawy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The imaging FCS diffusion law in the presence of multiple diffusive modes

(2018) Sapthaswaran Veerapathiran et al.   METHODS

Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes

(2018) Shailesh R. Agarwal et al.   Frontiers in Pharmacology

In vitro reconstitution of Wnt acylation reveals structural determinants of substrate recognition by the acyltransferase human Porcupine

(2018) Chul-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments

(2017) Erdinc Sezgin et al.   FEBS Journal

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding

(2017) Aaron H. Nile et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating the wnt signaling pathway with small molecules

(2017) Freddi Huan Tran et al.   PROTEIN SCIENCE

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Spatiotemporal mapping of diffusion dynamics and organization in plasma membranes

(2016) Nirmalya Bag et al.   Methods and Applications in Fluorescence

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled

(2015) Ho-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28

(2015) Phuong N. Le et al.   PHARMACOLOGY & THERAPEUTICS

The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway

(2015) Emine Guven-Maiorov et al.   Scientific Reports

The T cell receptor resides in ordered plasma membrane nanodomains that aggregate upon patching of the receptor

(2015) Jelena Dinic et al.   Scientific Reports

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Dynamic Association with Donor Cell Filopodia and Lipid-Modification Are Essential Features of Wnt8a during Patterning of the Zebrafish Neuroectoderm

(2014) Marta Luz et al.   PLoS One

Accuracy and Precision in Camera-Based Fluorescence Correlation Spectroscopy Measurements

(2013) Jagadish Sankaran et al.   ANALYTICAL CHEMISTRY

Lypd6 Enhances Wnt/β-Catenin Signaling by Promoting Lrp6 Phosphorylation in Raft Plasma Membrane Domains

(2013) Günes Özhan et al.   DEVELOPMENTAL CELL

Transforming Growth Factor-β1 (TGF-β1)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44 Co-localization in Lipid Rafts

(2013) Adam C. Midgley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine

(2013) Xinxin Gao et al.   Nature Chemical Biology

Genome-wide network analysis of Wnt signaling in three pediatric cancers

(2013) Ju Bao et al.   Scientific Reports

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Roles of N-glycosylation and lipidation in Wg secretion and signaling

(2012) Xiaofang Tang et al.   DEVELOPMENTAL BIOLOGY

In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains

(2012) Enrico Moro et al.   DEVELOPMENTAL BIOLOGY

Improved Parameters for the Martini Coarse-Grained Protein Force Field

(2012) Djurre H. de Jong et al.   Journal of Chemical Theory and Computation

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Targeting Wnt Pathways in Disease

(2012) Z. F. Zimmerman et al.   Cold Spring Harbor Perspectives in Biology

Wnt Proteins

(2012) K. Willert et al.   Cold Spring Harbor Perspectives in Biology

Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling

(2011) Lenka Doubravska et al.   CELLULAR SIGNALLING

Differential Palmit(e)oylation of Wnt1 on C93 and S224 Residues Has Overlapping and Distinct Consequences

(2011) Lisa M. Galli et al.   PLoS One

Regulation of Lrp6 phosphorylation

(2010) Christof Niehrs et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

(2010) H. Sakane et al.   JOURNAL OF CELL SCIENCE

g_wham—A Free Weighted Histogram Analysis Implementation Including Robust Error and Autocorrelation Estimates

(2010) Jochen S. Hub et al.   Journal of Chemical Theory and Computation

Single Plane Illumination Fluorescence Correlation Spectroscopy (SPIM-FCS) probes inhomogeneous three-dimensional environments

(2010) Thorsten Wohland et al.   OPTICS EXPRESS

Palmitoylation regulates raft affinity for the majority of integral raft proteins

(2010) I. Levental et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Proximal events in Wnt signal transduction

(2009) Stephane Angers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Wnt/β-catenin signaling: new (and old) players and new insights

(2008) He Huang et al.   CURRENT OPINION IN CELL BIOLOGY

Wnt3a and Dkk1 Regulate Distinct Internalization Pathways of LRP6 to Tune the Activation of β-Catenin Signaling

(2008) Hideki Yamamoto et al.   DEVELOPMENTAL CELL

In vivo role of lipid adducts on Wingless

(2008) X. Franch-Marro et al.   JOURNAL OF CELL SCIENCE

The MARTINI Coarse-Grained Force Field: Extension to Proteins

(2008) Luca Monticelli et al.   Journal of Chemical Theory and Computation