Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers

RNF43 ubiquitinates and degrades phosphorylated E-cadherin by c-Src to facilitate epithelial-mesenchymal transition in lung adenocarcinoma

(2019) Yunfeng Zhang et al.   BMC CANCER

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

(2018) Rona Yaeger et al.   CANCER CELL

Impact of loss-of-function mutations at the RNF43 locus on colorectal cancer development and progression

(2018) Tsugio Eto et al.   JOURNAL OF PATHOLOGY

Microsatellite instability status determined by next-generation sequencing and compared with PD-L1 and tumor mutational burden in 11,348 patients

(2018) Ari Vanderwalde et al.   Cancer Medicine

Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells

(2018) Victoria Neumeyer et al.   CARCINOGENESIS

RNF43mutation frequently occurs withGNASmutation and mucin hypersecretion in intraductal papillary neoplasms of the bile duct

(2017) Jia-Huei Tsai et al.   HISTOPATHOLOGY

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation

(2016) Helen H N Yan et al.   GUT

Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma

(2016) Shigeki Sekine et al.   JOURNAL OF PATHOLOGY

Dysregulated Wnt signalling and recurrent mutations of the tumour suppressorRNF43in early gastric carcinogenesis

(2016) Byung-Hoon Min et al.   JOURNAL OF PATHOLOGY

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis

(2016) William J Gibson et al.   NATURE GENETICS

Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

(2016) Zachary Steinhart et al.   NATURE MEDICINE

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

(2016) Marios Giannakis et al.   Cell Reports

Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling

(2016) Wenhui Wang et al.   NEOPLASIA

Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer

(2016) Huai-Xiang Hao et al.   Cancers

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma

(2015) Lei Niu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling

(2015) Tadasuke Tsukiyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

(2015) Xiaomo Jiang et al.   MOLECULAR CELL

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

(2015) B Madan et al.   ONCOGENE

Porcupine inhibitor suppresses paracrine Wnt-driven growth ofRnf43;Znrf3-mutant neoplasia

(2015) Bon-Kyoung Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane

(2015) Anke Loregger et al.   Science Signaling

The nucleoprotein of influenza A virus induces p53 signaling and apoptosis via attenuation of host ubiquitin ligase RNF43

(2015) H Nailwal et al.   Cell Death & Disease

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors

(2015) Georgina L. Ryland et al.   Genome Medicine

Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways

(2015) Ho-Jin Lee et al.   eLife

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane

(2015) Anke Loregger et al.   Science Signaling

AXIN1 and AXIN2 variants in gastrointestinal cancers

(2014) Serina M. Mazzoni et al.   CANCER LETTERS

Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas

(2014) Hitomi Sakamoto et al.   MODERN PATHOLOGY

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

(2014) Kai Wang et al.   NATURE GENETICS

RNF43 is frequently mutated in colorectal and endometrial cancers

(2014) Marios Giannakis et al.   NATURE GENETICS

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

RSPO–LGR4 functions via IQGAP1 to potentiate Wnt signaling

(2014) Kendra S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

(2013) Yang Xie et al.   EMBO REPORTS

RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer

(2013) Yang Zou et al.   GENE

Whole-exome sequencing of pancreatic neoplasms with acinar differentiation

(2013) Yuchen Jiao et al.   JOURNAL OF PATHOLOGY

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

(2013) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin

(2013) Matthias Zebisch et al.   Nature Communications

RNF43is a tumour suppressor gene mutated in mucinous tumours of the ovary

(2012) Georgina L Ryland et al.   JOURNAL OF PATHOLOGY

Reversing Effect of Ring Finger Protein 43 Inhibition on Malignant Phenotypes of human Hepatocellular Carcinoma

(2012) C. Xing et al.   MOLECULAR CANCER THERAPEUTICS

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

(2011) Kai Wang et al.   NATURE GENETICS

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

(2011) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNF43 interacts with NEDL1 and regulates p53-mediated transcription

(2010) Keisuke Shinada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS