The Hippo Signaling Pathway in Drug Resistance in Cancer

YAP1 is an independent prognostic marker in pancreatic cancer and associated with extracellular matrix remodeling

(2020) Qimin Zhou et al.   Journal of Translational Medicine

Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness

(2020) Sandra Muñoz-Galván et al.   Molecular Cancer

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

(2020) Tito Panciera et al.   NATURE MATERIALS

Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis

(2020) Daniela M. Santos et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Synergistic enhancement of efficacy of platinum drugs with verteporfin in ovarian cancer cells

(2020) Venkata Ramesh Dasari et al.   BMC CANCER

YAP1/TAZ drives ependymoma-like tumour formation in mice

(2020) Noreen Eder et al.   Nature Communications

Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer

(2020) Patricia García et al.   Cancers

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

(2020) Anwesha Dey et al.   NATURE REVIEWS DRUG DISCOVERY

TAZ-regulated expression of IL-8 is involved in chemoresistance of hepatocellular carcinoma cells

(2020) Hao Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Drug-drug interactions in breast cancer patients treated with CDK4/6 inhibitors

(2019) Stefano Fogli et al.   CANCER TREATMENT REVIEWS

Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

(2019) Weilong Yao et al.   Cancer Cell International

Phosphorylation of Merlin by Aurora A kinase appears necessary for mitotic progression

(2019) Vinay Mandati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of miR‑873 contributes to gemcitabine resistance in triple‑negative breast cancer via targeting ZEB1

(2019) Gangyue Wang et al.   Oncology Letters

The Hippo Signaling Pathway in Development and Disease

(2019) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond

(2019) George S. Baillie et al.   NATURE REVIEWS DRUG DISCOVERY

Reciprocal Crosstalk Between YAP1/Hippo Pathway and the p53 Family Proteins: Mechanisms and Outcomes in Cancer

(2019) Nitin Raj et al.   Frontiers in Cell and Developmental Biology

YAP1 Mediates Resistance to MEK1/2 Inhibition in Neuroblastomas with Hyperactivated RAS Signaling

(2019) Grace E. Coggins et al.   CANCER RESEARCH

Verteporfin- and sodium porfimer-mediated photodynamic therapy enhances pancreatic cancer cell death without activating stromal cells in the microenvironment

(2019) Jingjing Lu et al.   JOURNAL OF BIOMEDICAL OPTICS

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

RASSF6 Is Downregulated In Human Bladder Cancers And Regulates Doxorubicin Sensitivity And Mitochondrial Membrane Potential Via The Hippo Signaling Pathway

(2019) Shutao Tan et al.   OncoTargets and Therapy

Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma

(2019) Jacopo Gavini et al.   Cell Death & Disease

Verteporfin-Loaded Lipid Nanoparticles Improve Ovarian Cancer Photodynamic Therapy In Vitro and In Vivo

(2019) Michy et al.   Cancers

FDA- and EMA-Approved Tyrosine Kinase Inhibitors in Advanced EGFR-Mutated Non-Small Cell Lung Cancer: Safety, Tolerability, Plasma Concentration Monitoring, and Management

(2019) Isabelle Solassol et al.   Biomolecules

AJUBA increases the cisplatin resistance through hippo pathway in cervical cancer

(2018) Lihong Bi et al.   GENE

A global perspective on vasoactive agents in shock

(2018) Djillali Annane et al.   INTENSIVE CARE MEDICINE

Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway

(2018) Liang Dong et al.   International Journal of Medical Sciences

Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations

(2018) Matthew Dankner et al.   ONCOGENE

FDA Approval Summary: Dabrafenib and Trametinib for the Treatment of Metastatic Non‐Small Cell Lung Cancers HarboringBRAF V600EMutations

(2018) Lauretta Odogwu et al.   ONCOLOGIST

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism

(2018) Amin Ardestani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Verteporfin enhances the sensitivity of LOVO/TAX cells to taxol via YAP inhibition

(2018) Ganggang Shi et al.   Experimental and Therapeutic Medicine

miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2

(2018) Zeinab Mohamed et al.   Oncotarget

A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma

(2018) Jingya Sun et al.   Theranostics

Activation mechanisms of the Hippo kinase signaling cascade

(2018) Sung Jun Bae et al.   BIOSCIENCE REPORTS

Functional significance of Hippo/YAP signaling for drug resistance in colorectal cancer

(2018) Ruolan Song et al.   MOLECULAR CARCINOGENESIS

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

(2018) Francesca Zanconato et al.   NATURE MEDICINE

Inhibition of YAP reverses primary resistance to EGFR inhibitors in colorectal cancer cells

(2018) Bi‑Sheng Liu et al.   ONCOLOGY REPORTS

Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway

(2018) Zhiqiang Li et al.   CANCER CELL

Role of inhibitor of yes-associated protein 1 in triple-negative breast cancer with taxol-based chemoresistance

(2018) Ying Li et al.   CANCER SCIENCE

Statin use and mortality among ovarian cancer patients: A population-based cohort study

(2017) Freija Verdoodt et al.   INTERNATIONAL JOURNAL OF CANCER

Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2

(2017) M Orth et al.   ONCOGENE

Hippo pathway mediates resistance to cytotoxic drugs

(2017) Taranjit S. Gujral et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

(2017) Shi Jiao et al.   Nature Communications

YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC

(2017) Elena Ghiso et al.   NEOPLASIA

Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance

(2016) Jeong Eun Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway

(2016) Naihua Liu et al.   CANCER LETTERS

Overview of CDK9 as a target in cancer research

(2016) Fatima Morales et al.   CELL CYCLE

Verteporfin can Reverse the Paclitaxel Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression

(2016) Wang Pan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN HEART JOURNAL

The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?

(2016) Luigi Sapio et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MEK inhibitors as a novel therapy for neuroblastoma: Their in vitro effects and predicting their efficacy

(2016) Tomoko Tanaka et al.   JOURNAL OF PEDIATRIC SURGERY

Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma

(2016) Takaaki Higashi et al.   MEDICAL ONCOLOGY

Antitumor activity of dobutamine on human osteosarcoma cells

(2016) JUN YIN et al.   Oncology Letters

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

(2016) Waltraut Lehmann et al.   Nature Communications

YAP promotes erlotinib resistance in human non-small cell lung cancer cells

(2016) Ping-Chih Hsu et al.   Oncotarget

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Organ Size Control: Lessons from Drosophila

(2015) Iswar K. Hariharan   DEVELOPMENTAL CELL

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation

(2015) M. H. Kim et al.   EMBO JOURNAL

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

(2015) Chunbo He et al.   EMBO Molecular Medicine

Nuclear TAZ expression associates with the triple-negative phenotype in breast cancer

(2015) J. Diaz-Martin et al.   ENDOCRINE-RELATED CANCER

Oncoprotein YAP Regulates the Spindle Checkpoint Activation in a Mitotic Phosphorylation-dependent Manner through Up-regulation of BubR1

(2015) Shuping Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors

(2015) Chun-Han Lin et al.   MOLECULAR BIOLOGY OF THE CELL

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

(2015) Giorgio G. Galli et al.   MOLECULAR CELL

YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreatic cancer cells

(2015) YANLI YUAN et al.   Molecular Medicine Reports

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

(2015) Luping Lin et al.   NATURE GENETICS

Regulation of sensitivity of tumor cells to antitubulin drugs by Cdk1-TAZ signalling

(2015) Yulei Zhao et al.   Oncotarget

Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway

(2015) Meiyuan Chen et al.   Oncotarget

Verteporfin-based photodynamic therapy overcomes gemcitabine insensitivity in a panel of pancreatic cancer cell lines

(2015) Jonathan P. Celli et al.   LASERS IN SURGERY AND MEDICINE

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

(2014) Shi Jiao et al.   CANCER CELL

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

(2014) Wenjing Zhang et al.   CELL RESEARCH

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation

(2014) Katarzyna Brodowska et al.   EXPERIMENTAL EYE RESEARCH

The Hippo pathway in chemotherapeutic drug resistance

(2014) Yulei Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

Identification, Mechanism of Action, and Antitumor Activity of a Small Molecule Inhibitor of Hippo, TGF- , and Wnt Signaling Pathways

(2014) D. Basu et al.   MOLECULAR CANCER THERAPEUTICS

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

(2014) M Bartucci et al.   ONCOGENE

YAP1 is a potential biomarker for cetuximab resistance in head and neck cancer

(2014) Fredrik Jerhammar et al.   ORAL ONCOLOGY

Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles

(2014) L. M. Zasadil et al.   Science Translational Medicine

Inhibitory effects of dobutamine on human gastric adenocarcinoma

(2014) Hui-Xia Zheng   WORLD JOURNAL OF GASTROENTEROLOGY

Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53

(2013) Nan Bai et al.   CANCER BIOLOGY & THERAPY

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

(2013) Y. Touil et al.   CLINICAL CANCER RESEARCH

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin

(2012) Nuo Yang et al.   CELL CYCLE

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Exploration of a new drug that targets YAP

(2012) M. Fujii   JOURNAL OF BIOCHEMISTRY

KIBRA Regulates Aurora Kinase Activity and Is Required for Precise Chromosome Alignment During Mitosis

(2012) Lin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statin Use and Reduced Cancer-Related Mortality

(2012) Sune F. Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14

(2012) J-M Huang et al.   ONCOGENE

Overexpression of Yes-associated protein confers doxorubicin resistance in hepatocellullar carcinoma

(2012) XINYING HUO et al.   ONCOLOGY REPORTS

Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF

(2011) D. Lai et al.   CANCER RESEARCH

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription

(2011) Y. Bao et al.   JOURNAL OF BIOCHEMISTRY

KIBRA Protein Phosphorylation Is Regulated by Mitotic Kinase Aurora and Protein Phosphatase 1

(2011) Ling Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedgehog signal inhibitor forskolin suppresses cell proliferation and tumor growth of human rhabdomyosarcoma xenograft

(2011) Hiroaki Yamanaka et al.   JOURNAL OF PEDIATRIC SURGERY

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

(2011) Bin Zhao et al.   NATURE CELL BIOLOGY

Regulation of mitosis and taxane response by Daxx and Rassf1

(2011) S Giovinazzi et al.   ONCOGENE

Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway

(2011) S Visser-Grieve et al.   ONCOGENE

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

(2011) X Zhang et al.   ONCOGENE

Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma

(2011) M. R. Tanas et al.   Science Translational Medicine

Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivoin mice

(2010) Zhiwei Hu et al.   BMC CANCER

Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway

(2010) Meghna Das Thakur et al.   CURRENT BIOLOGY

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hippo signaling at a glance

(2010) Bin Zhao et al.   JOURNAL OF CELL SCIENCE

YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets

(2010) R Ehsanian et al.   ONCOGENE

Doxorubicin pathways

(2010) Caroline F. Thorn et al.   Pharmacogenetics and Genomics

Connective Tissue Growth Factor Confers Drug Resistance in Breast Cancer through Concomitant Up-regulation of Bcl-xL and cIAP1

(2009) M.-Y. Wang et al.   CANCER RESEARCH

Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms

(2009) Fangfang Ren et al.   DEVELOPMENTAL BIOLOGY

The FERM-Domain Protein Expanded Regulates Hippo Pathway Activity via Direct Interactions with the Transcriptional Activator Yorkie

(2009) Caroline Badouel et al.   DEVELOPMENTAL CELL

Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray

(2009) Stacy Visser et al.   GENE

In vivo analysis of Yorkie phosphorylation sites

(2009) H Oh et al.   ONCOGENE

Merlin Is a Potent Inhibitor of Glioma Growth

(2008) Y.-K. I. Lau et al.   CANCER RESEARCH

Down-regulation of Mammalian Sterile 20-Like Kinase 1 by Heat Shock Protein 70 Mediates Cisplatin Resistance in Prostate Cancer Cells

(2008) A. Ren et al.   CANCER RESEARCH

Microtubule dynamics as a target in oncology

(2008) April L. Risinger et al.   CANCER TREATMENT REVIEWS

Yes-associated protein (YAP) functions as a tumor suppressor in breast

(2008) M Yuan et al.   CELL DEATH AND DIFFERENTIATION

In vivo regulation of Yorkie phosphorylation and localization

(2008) H. Oh et al.   DEVELOPMENT

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

(2008) Shian Wu et al.   DEVELOPMENTAL CELL

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY