Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

The landscape of somatic mutation in normal colorectal epithelial cells

(2019) Henry Lee-Six et al.   NATURE

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

De Novo Generation of Somatic Stem Cells by YAP/TAZ

(2018) Tito Panciera et al.   Jove-Journal of Visualized Experiments

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

(2018) Francesca Zanconato et al.   NATURE MEDICINE

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

(2018) Sung-Hwan Moon et al.   CELL

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

(2018) Lei Chang et al.   NATURE

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

(2018) Akira Yokoyama et al.   NATURE

Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour

(2018) Giovanna Brusatin et al.   NATURE MATERIALS

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tissue Force Programs Cell Fate and Tumor Aggression

(2017) Jason J. Northey et al.   Cancer Discovery

ECM Mechano-Sensing Regulates Cytoskeleton Assembly and Receptor-Mediated Endocytosis of Nanoparticles

(2017) Valeria Panzetta et al.   ACS Biomaterials-Science & Engineering

ECM Mechano-Sensing Regulates Cytoskeleton Assembly and Receptor-Mediated Endocytosis of Nanoparticles

(2017) Valeria Panzetta et al.   ACS Biomaterials Science & Engineering

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ

(2016) Tito Panciera et al.   Cell Stem Cell

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

(2016) Ralph Gruber et al.   GASTROENTEROLOGY

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Quantification of regenerative potential in primary human mammary epithelial cells

(2015) J. R. Linnemann et al.   DEVELOPMENT

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity

(2015) Alexandra Van Keymeulen et al.   NATURE

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

(2014) Avnish Kapoor et al.   CELL

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

(2014) W. Zhang et al.   Science Signaling

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

Mechanical feedback between membrane tension and dynamics

(2012) Nils C. Gauthier et al.   TRENDS IN CELL BIOLOGY

Hyaluronic Acid Hydrogels for Biomedical Applications

(2011) Jason A. Burdick et al.   ADVANCED MATERIALS

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

(2011) Carmen Guerra et al.   CANCER CELL

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Early Requirement of Rac1 in a Mouse Model of Pancreatic Cancer

(2011) Irina Heid et al.   GASTROENTEROLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Negative control of Smad activity by ectodermin/Tif1  patterns the mammalian embryo

(2010) L. Morsut et al.   DEVELOPMENT

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL