Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond
Authors
Keywords
-
Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 18, Issue 10, Pages 770-796
Publisher
Springer Science and Business Media LLC
Online
2019-08-06
DOI
10.1038/s41573-019-0033-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study
- (2019) Robert J. Charnigo et al. CTS-Clinical and Translational Science
- Autosomal dominant polycystic kidney disease: Disrupted pathways and potential therapeutic interventions
- (2019) Talieh Malekshahabi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in patients with prodromal and mild Alzheimer’s disease
- (2019) Lutz Frölich et al. Alzheimers Research & Therapy
- Phosphodiesterases as therapeutic targets for respiratory diseases
- (2019) Haoxiao Zuo et al. PHARMACOLOGY & THERAPEUTICS
- Efficacy of Cilostazol Administration in Alzheimer’s Disease Patients with White Matter Lesions: A Positron-Emission Tomography Study
- (2019) Jun-Young Lee et al. Neurotherapeutics
- Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study
- (2019) Arjan Blokland et al. NEUROBIOLOGY OF AGING
- Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled
- (2019) Katy Pilarzyk et al. CURRENT BIOLOGY
- Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling
- (2018) Santosh V. Suryavanshi et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- A novel rhodopsin phosphodiesterase from Salpingoeca rosetta shows light-enhanced substrate affinity
- (2018) Yuehui Tian et al. BIOCHEMICAL JOURNAL
- Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition
- (2018) Yu Cai et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Estimation of clinical trial success rates and related parameters
- (2018) Chi Heem Wong et al. BIOSTATISTICS
- The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion
- (2018) Jiajia Chen et al. BRAIN RESEARCH BULLETIN
- Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance
- (2018) Anton Pekcec et al. BRITISH JOURNAL OF PHARMACOLOGY
- Milrinone Dosing and a Culture of Caution in Clinical Practice
- (2018) Luke Yong Zheng Chong et al. Cardiology in Review
- Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain
- (2018) Michy P. Kelly CELLULAR SIGNALLING
- Pharmacological Therapy of COPD: Reasons for Optimism
- (2018) Bartolome R. Celli CHEST
- Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition: A Translational Study in the Dog and Rabbit
- (2018) Toru Hashimoto et al. CIRCULATION
- Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer
- (2018) Rasmi R. Mishra et al. CLINICAL CANCER RESEARCH
- Transmembrane redox control and proteolysis of PdeC, a novel type of c‐di‐GMP phosphodiesterase
- (2018) Susanne Herbst et al. EMBO JOURNAL
- Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas
- (2018) Emilia Sbardella et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers
- (2018) Viktoria Moschetti et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Synthetic Adeno-Associated Viral Vector Efficiently Targets Mouse and Nonhuman Primate Retina In Vivo
- (2018) Livia S. Carvalho et al. HUMAN GENE THERAPY
- Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate
- (2018) Christopher J. Helal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nifedipine cream versus sildenafil cream for patients with secondary Raynaud phenomenon: A randomized, double-blind, controlled pilot study
- (2018) Ximena Wortsman et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment
- (2018) Naveen Kumar et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea
- (2018) Vincenzo Salpietro et al. MOVEMENT DISORDERS
- Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span
- (2018) Neema S. Patel et al. NEUROBIOLOGY OF AGING
- A negative allosteric modulator of PDE4D enhances learning after traumatic brain injury
- (2018) David J. Titus et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults
- (2018) M.A. Van Duinen et al. NEUROPHARMACOLOGY
- Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations
- (2018) P.R.A. Heckman et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Could chronic Vardenafil administration influence the cardiovascular risk in men with type 2 diabetes mellitus?
- (2018) Daniele Santi et al. PLoS One
- Evaluation of the Efficacy, Safety, and Tolerability of BI 409306, a Novel Phosphodiesterase 9 Inhibitor, in Cognitive Impairment in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial
- (2018) David Brown et al. SCHIZOPHRENIA BULLETIN
- Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge
- (2018) Fu-Chao Liu et al. JOURNAL OF NANOBIOTECHNOLOGY
- Cone Phosphodiesterase-6γ’ Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits
- (2018) Wen-Tao Deng et al. Frontiers in Molecular Neuroscience
- Neratinib augments the lethality of [regorafenib + sildenafil]
- (2018) Laurence Booth et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice
- (2018) Chong Zhang et al. NEUROPSYCHOPHARMACOLOGY
- PET Radioligands for imaging of the PDE10A in human: current status
- (2018) Giulia Boscutti et al. NEUROSCIENCE LETTERS
- Phosphodiesterase 7B/microRNA-200c relationship regulates triple-negative breast cancer cell growth
- (2018) Dan-Dan Zhang et al. ONCOGENE
- Association between phosphodiesterase type 5 inhibitors and prostate cancer: A systematic review
- (2018) Fouad Aoun et al. PROGRES EN UROLOGIE
- A phase 2, randomized, placebo-controlled study of the efficacy and safety of TAK-063 in subjects with an acute exacerbation of schizophrenia
- (2018) Thomas A. Macek et al. SCHIZOPHRENIA RESEARCH
- Targeting the paracrine hormone-dependent guanylate cyclase/cGMP/phosphodiesterases signaling pathway for colorectal cancer prevention
- (2018) N.S. Yarla et al. SEMINARS IN CANCER BIOLOGY
- Use of sildenafil citrate in cases of intrauterine growth restriction (IUGR); a prospective trial
- (2018) Mohammed Maged et al. Taiwanese Journal of Obstetrics & Gynecology
- It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods
- (2018) Bilal M. Qureshi et al. Open Biology
- Drug repurposing: progress, challenges and recommendations
- (2018) Sudeep Pushpakom et al. NATURE REVIEWS DRUG DISCOVERY
- An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients
- (2018) James Gilleen et al. PSYCHOPHARMACOLOGY
- Optogenetic Medicine: Synthetic Therapeutic Solutions Precision-Guided by Light
- (2018) Haifeng Ye et al. Cold Spring Harbor Perspectives in Medicine
- Targeting tumor cells based on Phosphodiesterase 3A expression
- (2017) Madiha Nazir et al. EXPERIMENTAL CELL RESEARCH
- MiR-541-5p regulates lung fibrosis by targeting cyclic nucleotide phosphodiesterase 1A
- (2017) Liqin Ren et al. EXPERIMENTAL LUNG RESEARCH
- A phase I, randomized, proof-of-clinical-mechanism study assessing the pharmacokinetics and pharmacodynamics of the oral PDE9A inhibitor BI 409306 in healthy male volunteers
- (2017) Katja Boland et al. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
- Sildenafil During PregnancyNovelty and Significance
- (2017) Nina D. Paauw et al. HYPERTENSION
- Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair
- (2017) Eric Knott et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A unique choanoflagellate enzyme rhodopsin exhibits light-dependent cyclic nucleotide phosphodiesterase activity
- (2017) Kazuho Yoshida et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Utero-placental perfusion Doppler indices in growth restricted fetuses: effect of sildenafil citrate
- (2017) Mohamed Adel El-Sayed et al. Journal of Maternal-Fetal & Neonatal Medicine
- Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties
- (2017) Brian Dyck et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
- (2017) Satoshi Mikami et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders
- (2017) Satoshi Mikami et al. JOURNAL OF MEDICINAL CHEMISTRY
- Neurotoxicity of cGMP in the vertebrate retina: from the initial research on rd mutant mice to zebrafish genetic approaches
- (2017) Maria Iribarne et al. JOURNAL OF NEUROGENETICS
- Modulation of signaling through GPCR-cAMP-PKA pathways by PDE4 depends on stimulus intensity: Possible implications for the pathogenesis of acrodysostosis without hormone resistance
- (2017) Emmanuelle Motte et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Patterns of age related changes for phosphodiesterase type-10A in comparison with dopamine D 2/3 receptors and sub-cortical volumes in the human basal ganglia: A PET study with 18 F-MNI-659 and 11 C-raclopride with correction for partial volume effect
- (2017) Patrik Fazio et al. NEUROIMAGE
- A phase 3 randomized placebo-controlled trial of tadalafil for Duchenne muscular dystrophy
- (2017) Ronald G. Victor et al. NEUROLOGY
- Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation
- (2017) Diana V. Avila et al. NEUROPHARMACOLOGY
- In vivo measurement of PDE10A enzyme occupancy by positron emission tomography (PET) following single oral dose administration of PF-02545920 in healthy male subjects
- (2017) Marielle Delnomdedieu et al. NEUROPHARMACOLOGY
- Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence
- (2017) Verena E Metz et al. NEUROPSYCHOPHARMACOLOGY
- Development of the Neuroimmune Modulator Ibudilast for the Treatment of Alcoholism: A Randomized, Placebo-Controlled, Human Laboratory Trial
- (2017) Lara A Ray et al. NEUROPSYCHOPHARMACOLOGY
- PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma
- (2017) J Delyon et al. ONCOGENE
- Ibudilast: a non-selective phosphodiesterase inhibitor in brain disorders
- (2017) Joanna Schwenkgrub et al. Postepy Higieny I Medycyny Doswiadczalnej
- Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial
- (2017) Pim R. A. Heckman et al. PSYCHOPHARMACOLOGY
- A Randomized Multiple Dose Pharmacokinetic Study of a Novel PDE10A Inhibitor TAK-063 in Subjects with Stable Schizophrenia and Japanese Subjects and Modeling of Exposure Relationships to Adverse Events
- (2017) Paul Goldsmith et al. Drugs in research & development
- STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials
- (2017) A. Pels et al. BMC Pregnancy and Childbirth
- Phosphodiesterase type 5 and cancers: progress and challenges
- (2017) Ines Barone et al. Oncotarget
- Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST)
- (2017) Pierre Vandenberghe et al. Oncotarget
- Vinpocetine Inhibits NF-κB-Dependent Inflammation in Acute Ischemic Stroke Patients
- (2017) Fang Zhang et al. Translational Stroke Research
- Effect of tadalafil administration on insulin secretion and insulin sensitivity in obese men
- (2017) Manuel González-Ortiz et al. ACTA CLINICA BELGICA
- Gene Therapy in a Large Animal Model of PDE6A-Retinitis Pigmentosa
- (2017) Freya M. Mowat et al. Frontiers in Neuroscience
- A pilot study of high-dose exisulind in men with biochemical relapse (BCR) of prostate cancer after definitive local therapy treated with intermittent androgen deprivation (IAD).
- (2017) Evan Y. Yu et al. JOURNAL OF CLINICAL ONCOLOGY
- Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)
- (2017) Mark E. Gurney et al. Scientific Reports
- STUDY DESIGN AND CHARACTERISTICS OF TWO PHASE II PROOF-OF-CONCEPT CLINICAL TRIALS OF THE PDE9 INHIBITOR BI 409306 IN EARLY ALZHEIMER'S DISEASE
- (2016) Glen Wunderlich et al. Alzheimers & Dementia
- Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement: a phase III, randomised, controlled trial (PALACE 3)
- (2016) Christopher J Edwards et al. ANNALS OF THE RHEUMATIC DISEASES
- Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
- (2016) Izzat T. Raheem et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Phosphodiesterase 4 inhibitors have wide-ranging activity in B-cell malignancies
- (2016) J. D. Cooney et al. BLOOD
- First-in-human study assessing safety, tolerability and pharmacokinetics of BI 409306, a selective phosphodiesterase 9A inhibitor, in healthy males
- (2016) Viktoria Moschetti et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5
- (2016) Graeme B. Bolger CELLULAR SIGNALLING
- Ibudilast attenuates subjective effects of methamphetamine in a placebo-controlled inpatient study
- (2016) Matthew J. Worley et al. DRUG AND ALCOHOL DEPENDENCE
- Role of Cyclic Nucleotide Phosphodiesterases During Meiotic Resumption From Diplotene Arrest in Mammalian Oocytes
- (2016) Anumegha Gupta et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- PDE5 Inhibition Ameliorates Visceral Adiposity Targeting the miR-22/SIRT1 Pathway: Evidence From the CECSID Trial
- (2016) Daniela Fiore et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Safety of Intravenous Methamphetamine Administration During Ibudilast Treatment
- (2016) Dustin Z. DeYoung et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Effect of a 4-Week Treatment with Cilostazol in Patients with Chronic Tinnitus: A Randomized, Prospective, Placebo-controlled, Double-blind, Pilot Study
- (2016) Hyun Woo Lim et al. Journal of International Advanced Otology
- Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases
- (2016) Peng Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory
- (2016) R. Havekes et al. JOURNAL OF NEUROSCIENCE
- Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis
- (2016) Diana V Avila et al. JOURNAL OF PATHOLOGY
- Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers
- (2016) Heather Wilson et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- PDE11A negatively regulates lithium responsivity
- (2016) G Pathak et al. MOLECULAR PSYCHIATRY
- Targeted Delivery of an Anti-inflammatory PDE4 Inhibitor to Immune Cells via an Antibody–drug Conjugate
- (2016) Shan Yu et al. MOLECULAR THERAPY
- CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa
- (2016) Wen-Hsuan Wu et al. MOLECULAR THERAPY
- Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012
- (2016) Susann Schröder et al. MOLECULES
- Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling
- (2016) Sanguk Yun et al. NATURE CELL BIOLOGY
- Change in PDE10 across early Huntington disease assessed by [18F]MNI-659 and PET imaging
- (2016) David S. Russell et al. NEUROLOGY
- Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models
- (2016) Vahri Beaumont et al. NEURON
- TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms
- (2016) Kazunori Suzuki et al. NEUROPSYCHOPHARMACOLOGY
- PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain
- (2016) Shweta Hegde et al. NEUROSCIENCE
- Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia
- (2016) Lígia Mendes Soares et al. NEUROSCIENCE
- Novel approaches to targeting PDE3 in cardiovascular disease
- (2016) Matthew Movsesian PHARMACOLOGY & THERAPEUTICS
- Structural and molecular bases of rod photoreceptor morphogenesis and disease
- (2016) Theodore G. Wensel et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats
- (2016) Gretchen L. Snyder et al. PSYCHOPHARMACOLOGY
- Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo
- (2016) Jose A. Morales-Garcia et al. STEM CELLS
- Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases
- (2016) René Böttcher et al. Oncotarget
- Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1
- (2016) Robbert Havekes et al. eLife
- Novel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder
- (2016) C M MacMullen et al. Translational Psychiatry
- The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases
- (2016) Verena Katharina Raker et al. Frontiers in Immunology
- Phosphodiesterase regulation of alcohol drinking in rodents
- (2015) Marian L. Logrip ALCOHOL
- cCMP causes caspase-dependent apoptosis in mouse lymphoma cell lines
- (2015) Sabine Wolter et al. BIOCHEMICAL PHARMACOLOGY
- Design and discovery of 2-(4-(1H-tetrazol-5-yl)-1H-pyrazol-1-yl)-4-(4-phenyl)thiazole derivatives as cardiotonic agents via inhibition of PDE3
- (2015) Li-Min Duan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Comparing the effectiveness and safety between triple antiplatelet therapy and dual antiplatelet therapy in type 2 diabetes mellitus patients after coronary stents implantation: a systematic review and meta-analysis of randomized controlled trials
- (2015) Pravesh Kumar Bundhun et al. BMC Cardiovascular Disorders
- Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson’s disease
- (2015) Flavia Niccolini et al. BRAIN
- Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression
- (2015) R Böttcher et al. BRITISH JOURNAL OF CANCER
- UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy
- (2015) Li Wang et al. CELLULAR SIGNALLING
- Toward a pragmatic migraine model for drug testing: 1. Cilostazol in healthy volunteers
- (2015) Emma Katrine Hansen et al. CEPHALALGIA
- Microdomain Switch of cGMP-Regulated Phosphodiesterases Leads to ANP-Induced Augmentation of -Adrenoceptor-Stimulated Contractility in Early Cardiac Hypertrophy
- (2015) R. K. Perera et al. CIRCULATION RESEARCH
- Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance
- (2015) Anna Zoccarato et al. CIRCULATION RESEARCH
- Tadalafil Augments Tumor Specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma
- (2015) J. A. Califano et al. CLINICAL CANCER RESEARCH
- Impact of BPRS interview length on ratings reliability in a schizophrenia trial
- (2015) Steven D. Targum et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes
- (2015) Elisabetta Mandosi et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- S-nitrosylation of PDE5 increases its ubiquitin–proteasomal degradation
- (2015) Yue Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Regulation of Sarcoplasmic Reticulum Ca2+ATPase 2 (SERCA2) Activity by Phosphodiesterase 3A (PDE3A) in Human Myocardium
- (2015) Faiyaz Ahmad et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6
- (2015) Zhixian Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum
- (2015) Corina Russwurm et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial
- (2015) Claudia E. Ramirez et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)
- (2015) Kim Papp et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Cilostazol and freedom from amputation after lower extremity revascularization
- (2015) J. David Neel et al. JOURNAL OF VASCULAR SURGERY
- Cilostazol blocks pregnancy in naturally cycling swine: An animal model
- (2015) Ahmed M. Taiyeb et al. LIFE SCIENCES
- Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease
- (2015) Dong I. Lee et al. NATURE
- Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
- (2015) Jerome Mertens et al. NATURE
- Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice
- (2015) Jose A. Morales-Garcia et al. NEUROBIOLOGY OF AGING
- Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in dopamine D2 neurons than in D1 neurons in the neostriatum
- (2015) Jonathan M. Wilson et al. NEUROPHARMACOLOGY
- Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition
- (2015) Alexander McGirr et al. NEUROPSYCHOPHARMACOLOGY
- The future of EPAC-targeted therapies: agonism versus antagonism
- (2015) Euan Parnell et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Short term monotherapy with GLP-1 receptor agonist liraglutide or PDE 4 inhibitor roflumilast is superior to metformin in weight loss in obese PCOS women: a pilot randomized study
- (2015) Mojca Jensterle et al. Journal of Ovarian Research
- Sildenafil does not improve cardiomyopathy in Duchenne/Becker muscular dystrophy
- (2014) Doris G. Leung et al. ANNALS OF NEUROLOGY
- Discovery of triazines as selective PDE4B versus PDE4D inhibitors
- (2014) Timothy J. Hagen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Phosphodiesterase 3 inhibitor cilostazol induces migraine-like attacks via cyclic AMP increase
- (2014) Song Guo et al. BRAIN
- The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells
- (2014) D J P Henderson et al. BRITISH JOURNAL OF CANCER
- Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis
- (2014) Tadashi Kaname et al. CELLULAR SIGNALLING
- Tadalafil Reduces Myeloid-Derived Suppressor Cells and Regulatory T Cells and Promotes Tumor Immunity in Patients with Head and Neck Squamous Cell Carcinoma
- (2014) D. T. Weed et al. CLINICAL CANCER RESEARCH
- Lack of Efficacy of an Inhibitor of PDE4 in Phase 1 and 2 Trials of Patients With Nonalcoholic Steatohepatitis
- (2014) Vlad Ratziu et al. Clinical Gastroenterology and Hepatology
- A Multicenter, Double-Blind, Placebo-Controlled Trial of the PDE9A Inhibitor, PF-04447943, in Alzheimer’s Disease
- (2014) Elias Schwam et al. Current Alzheimer Research
- Does Phosphodiesterase 11A (PDE11A) Hold Promise as a Future Therapeutic Target?
- (2014) Michy Kelly CURRENT PHARMACEUTICAL DESIGN
- The Roles of Phosphodiesterase 2 in the Central Nervous and Peripheral Systems
- (2014) Chong Zhang et al. CURRENT PHARMACEUTICAL DESIGN
- Improvement in in vitro fertilization outcome following in vivo synchronization of oocyte maturation in mice
- (2014) Ahmed M Taiyeb et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Phosphodiesterase 4 Inhibition as a Potential New Therapeutic Target in Obese Women With Polycystic Ovary Syndrome
- (2014) Mojca Jensterle et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway
- (2014) Rashika Joshi et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Advances in targeting cyclic nucleotide phosphodiesterases
- (2014) Donald H. Maurice et al. NATURE REVIEWS DRUG DISCOVERY
- PDE5 inhibition alleviates functional muscle ischemia in boys with Duchenne muscular dystrophy
- (2014) M. D. Nelson et al. NEUROLOGY
- The PDE4 Inhibitor HT-0712 Improves Hippocampus-Dependent Memory in Aged Mice
- (2014) Marco Peters et al. NEUROPSYCHOPHARMACOLOGY
- Improved Long-Term Memory via Enhancing cGMP-PKG Signaling Requires cAMP-PKA Signaling
- (2014) Eva Bollen et al. NEUROPSYCHOPHARMACOLOGY
- Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity
- (2014) N Li et al. ONCOGENE
- Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets
- (2014) F Ahmad et al. ORAL DISEASES
- Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase
- (2014) C. Gasser et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Phosphodiesterase 10 Positron Emission Tomography Tracer, [18F]MNI-659, as a Novel Biomarker for Early Huntington Disease
- (2014) David S. Russell et al. JAMA Neurology
- Targeted disruption of the heat shock protein 20-phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy
- (2014) Tamara P. Martin et al. FEBS Open Bio
- Decoding the SUMO signal
- (2013) Ronald T. Hay BIOCHEMICAL SOCIETY TRANSACTIONS
- Neuronal expression of soluble adenylyl cyclase in the mammalian brain
- (2013) Jonathan Chen et al. BRAIN RESEARCH
- Phosphodiesterase activity is regulated by CC2D1A that is implicated in non-syndromic intellectual disability
- (2013) Azza Al-Tawashi et al. Cell Communication and Signaling
- Select 3′,5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
- (2013) Michy P. Kelly et al. CELLULAR SIGNALLING
- Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease
- (2013) Louisa CY Lee et al. Future Medicinal Chemistry
- Effects of daily low-dose treatment with phosphodiesterase type 5 inhibitor on cognition, depression, somatization and erectile function in patients with erectile dysfunction: a double-blind, placebo-controlled study
- (2013) Y S Shim et al. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
- Interplay of Palmitoylation and Phosphorylation in the Trafficking and Localization of Phosphodiesterase 10A: Implications for the Treatment of Schizophrenia
- (2013) E. I. Charych et al. JOURNAL OF NEUROSCIENCE
- Cone Phosphodiesterase-6 ' Restores Rod Function and Confers Distinct Physiological Properties in the Rod Phosphodiesterase-6 -Deficient rd10 Mouse
- (2013) W.-T. Deng et al. JOURNAL OF NEUROSCIENCE
- The effects of the phosphodiesterase type 5 inhibitor vardenafil on cognitive performance in healthy adults: a behavioral- electroencephalography study
- (2013) OAH Reneerkens et al. JOURNAL OF PSYCHOPHARMACOLOGY
- PET imaging shows loss of striatal PDE10A in patients with Huntington disease
- (2013) R. Ahmad et al. NEUROLOGY
- Acute Effects of Sceletium tortuosum (Zembrin), a Dual 5-HT Reuptake and PDE4 Inhibitor, in the Human Amygdala and its Connection to the Hypothalamus
- (2013) David Terburg et al. NEUROPSYCHOPHARMACOLOGY
- Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D
- (2012) Zhaoxia Huo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice
- (2012) C. B. Almeida et al. BLOOD
- Randomized, double-blind, placebo-controlled trial of sulindac in individuals at risk for melanoma
- (2012) Clara Curiel-Lewandrowski et al. CANCER
- Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling
- (2012) Magali Berthouze-Duquesnes et al. CELLULAR SIGNALLING
- Chronic Inhibition of cGMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy
- (2012) Elisa Giannetta et al. CIRCULATION
- Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation
- (2012) Kim M. Brown et al. FEBS LETTERS
- Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay
- (2012) L.-C. L. Tsai et al. GENES BRAIN AND BEHAVIOR
- Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa
- (2012) K. J. Wert et al. HUMAN MOLECULAR GENETICS
- PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome
- (2012) Anna Terrin et al. JOURNAL OF CELL BIOLOGY
- Effect of the Phosphodiesterase 4 Inhibitor Roflumilast on Glucose Metabolism in Patients with Treatment-Naive, Newly Diagnosed Type 2 Diabetes Mellitus
- (2012) E. F. M. Wouters et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Application of External Review for Subject Selection in a Schizophrenia Trial
- (2012) Steven D. Targum et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds
- (2012) Miriam Redondo et al. JOURNAL OF MEDICINAL CHEMISTRY
- The PDE5 inhibitor vardenafil does not affect auditory sensory gating in rats and humans
- (2012) O. A. H. Reneerkens et al. PSYCHOPHARMACOLOGY
- Poster #212 RESULTS OF A PHASE 2A PROOF-OF-CONCEPT TRIAL WITH A PDE10A INHIBITOR IN THE TREATMENT OF ACUTE EXACERBATION OF SCHIZOPHRENIA
- (2012) Nicholas DeMartinis et al. SCHIZOPHRENIA RESEARCH
- Tadalafil Alleviates Muscle Ischemia in Patients with Becker Muscular Dystrophy
- (2012) E. A. Martin et al. Science Translational Medicine
- A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol
- (2012) Ma Xiao-Wei et al. Journal of Geriatric Cardiology
- Cilostazol: A Pilot Study on Safety and Clinical Efficacy in Neuropathies of Diabetes Mellitus Type 2 (ASCEND)
- (2011) Raymond L. Rosales et al. ANGIOLOGY
- Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart
- (2011) Clint L. Miller et al. BASIC RESEARCH IN CARDIOLOGY
- Discovery of new inhibitor for PDE3 by virtual screening
- (2011) Ki Young Kim et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Oncogenic BRAF Induces Melanoma Cell Invasion by Downregulating the cGMP-Specific Phosphodiesterase PDE5A
- (2011) Imanol Arozarena et al. CANCER CELL
- The cAMP-Dependent Protein Kinase Pathway as Therapeutic Target – Possibilities and Pitfalls
- (2011) Rune Kleppe et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease
- (2011) Albert Giralt et al. HUMAN MOLECULAR GENETICS
- Effects of repeated dosing with Udenafil (Zydena) on cognition, somatization and erection in patients with erectile dysfunction: a pilot study
- (2011) Y S Shim et al. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
- Activation of PDE10 and PDE11 Phosphodiesterases
- (2011) Ronald Jäger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats
- (2011) Ling-Xia Li et al. METABOLIC BRAIN DISEASE
- Selective phosphodiesterase inhibitors improve performance on the ED/ID cognitive task in rats
- (2011) Joshua S. Rodefer et al. NEUROPHARMACOLOGY
- Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
- (2011) Sharron H. Francis et al. PHYSIOLOGICAL REVIEWS
- Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK
- (2010) Xiang Li et al. BIOCHEMICAL JOURNAL
- Activation of PDE2 and PDE5 by specific GAF ligands: delayed activation of PDE5
- (2010) Ronald Jäger et al. BRITISH JOURNAL OF PHARMACOLOGY
- Drug Interactions With Phosphodiesterase-5 Inhibitors Used for the Treatment of Erectile Dysfunction or Pulmonary Hypertension
- (2010) Bryan G. Schwartz et al. CIRCULATION
- A Complex between FAK, RACK1, and PDE4D5 Controls Spreading Initiation and Cancer Cell Polarity
- (2010) Bryan Serrels et al. CURRENT BIOLOGY
- Cyclic Nucleotide Phosphodiesterases (PDE) and Peptide Motifs
- (2010) Therese Keravis et al. CURRENT PHARMACEUTICAL DESIGN
- Evolutionarily Conserved Role of Calcineurin in Phosphodegron-Dependent Degradation of Phosphodiesterase 4D
- (2010) H. Zhu et al. MOLECULAR AND CELLULAR BIOLOGY
- Compartmentalized Cyclic Adenosine 3′,5′-Monophosphate at the Plasma Membrane Clusters PDE3A and Cystic Fibrosis Transmembrane Conductance Regulator into Microdomains
- (2010) Himabindu Penmatsa et al. MOLECULAR BIOLOGY OF THE CELL
- Phosphatidic Acid Induces Ligand-independent Epidermal Growth Factor Receptor Endocytic Traffic through PDE4 Activation
- (2010) Andrés Norambuena et al. MOLECULAR BIOLOGY OF THE CELL
- The High-Affinity cAMP-Specific Phosphodiesterase 8B Controls Steroidogenesis in the Mouse Adrenal Gland
- (2010) L.-C. L. Tsai et al. MOLECULAR PHARMACOLOGY
- Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues
- (2010) Viktor Lakics et al. NEUROPHARMACOLOGY
- Sildenafil adjunctive therapy to risperidone in the treatment of the negative symptoms of schizophrenia: a double-blind randomized placebo-controlled trial
- (2010) Shahin Akhondzadeh et al. PSYCHOPHARMACOLOGY
- Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the β3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes
- (2009) Faiyaz Ahmad et al. BIOCHEMICAL JOURNAL
- Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells
- (2009) Hongli Dong et al. BIOCHEMICAL PHARMACOLOGY
- Design, synthesis and biological evaluation of 6-(benzyloxy)-4-methylquinolin-2(1H)-one derivatives as PDE3 inhibitors
- (2009) Mohsen Nikpour et al. BIOORGANIC & MEDICINAL CHEMISTRY
- The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release
- (2009) WK Ong et al. BRITISH JOURNAL OF PHARMACOLOGY
- Decreased Expression and Activity of cAMP Phosphodiesterases in Cardiac Hypertrophy and Its Impact on β-Adrenergic cAMP Signals
- (2009) Aniella Abi-Gerges et al. CIRCULATION RESEARCH
- Targeting cancer with phosphodiesterase inhibitors
- (2009) Rajkumar Savai et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Structural Requirements of the Photoreceptor Phosphodiesterase γ-Subunit for Inhibition of Rod PDE6 Holoenzyme and for Its Activation by Transducin
- (2009) Xiu-Jun Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mdm2 Directs the Ubiquitination of β-Arrestin-sequestered cAMP Phosphodiesterase-4D5
- (2009) Xiang Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia
- (2009) S. M. Grauer et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- A Phase II Study of Carboplatin, Etoposide, and Exisulind in Patients with Extensive Small Cell Lung Cancer: CALGB 30104
- (2009) Ramaswamy Govindan et al. Journal of Thoracic Oncology
- Cyclic nucleotide signaling in polycystic kidney disease
- (2009) Xiaofang Wang et al. KIDNEY INTERNATIONAL
- The 6-minute walk test as a new outcome measure in Duchenne muscular dystrophy
- (2009) Craig M. McDonald et al. MUSCLE & NERVE
- Sleep deprivation impairs cAMP signalling in the hippocampus
- (2009) Christopher G. Vecsey et al. NATURE
- Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
- (2009) Alex B Burgin et al. NATURE BIOTECHNOLOGY
- The type III secretion system of Pseudomonas aeruginosa: infection by injection
- (2009) Alan R. Hauser NATURE REVIEWS MICROBIOLOGY
- Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
- (2009) J. Pandit et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aiming Straight for the Heart: Prolyl Hydroxylases Set the BAR
- (2009) J. A. Garcia Science Signaling
- A Phase II Study of Estramustine, Docetaxel, and Exisulind in Patients with Hormone- Refractory Prostate Cancer: Results of Cancer and Leukemia Group B Trial 90004
- (2008) Nancy A. Dawson et al. Clinical Genitourinary Cancer
- Chronic G s Signaling in the Striatum Increases Anxiety-Related Behaviors Independent of Developmental Effects
- (2008) C. Favilla et al. JOURNAL OF NEUROSCIENCE
- Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia
- (2008) C. J. Schmidt et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Constitutive activation of the G-protein subunit G s within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression
- (2008) M. P. Kelly et al. LEARNING & MEMORY
- Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Gαs, a G-protein subunit genetically linked to schizophrenia
- (2008) M P Kelly et al. MOLECULAR PSYCHIATRY
- A placebo-controlled study of sildenafil effects on cognition in schizophrenia
- (2008) Donald C. Goff et al. PSYCHOPHARMACOLOGY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started