The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?

cAMP signaling increases histone deacetylase 8 expression by inhibiting JNK-dependent degradation via autophagy and the proteasome system in H1299 lung cancer cells

(2016) Ji-Yeon Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Down-regulation of S100A9 inhibits osteosarcoma cell growth through inactivating MAPK and NF-κB signaling pathways

(2016) Si Cheng et al.   BMC CANCER

P2 receptors in cancer progression and metastatic spreading

(2016) Francesco Di Virgilio et al.   CURRENT OPINION IN PHARMACOLOGY

Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology

(2016) Rigney E. Turnham et al.   GENE

SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration

(2016) Paola Indovina et al.   JOURNAL OF CELLULAR PHYSIOLOGY

New Hopes in Cancer Battle - A Review of New Molecules and Treatment Strategies

(2016) Marika Turek et al.   Medicinal Chemistry

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

(2016) D. R. Pattabiraman et al.   SCIENCE

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

(2016) Muthu K Shanmugam et al.   SEMINARS IN CANCER BIOLOGY

The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)

(2016) Andrew M. Kidger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inhibition of breast cancer cell migration by activation of cAMP signaling

(2015) Hongli Dong et al.   BREAST CANCER RESEARCH AND TREATMENT

Activation of the Tumor Suppressor PP2A Emerges as a Potential Therapeutic Strategy for Treating Prostate Cancer

(2015) Ion Cristóbal et al.   Marine Drugs

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial

(2015) Hayley Loftus et al.   Nutrients

The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM

(2015) Virginie Follin-Arbelet et al.   Scientific Reports

Hyperphosphorylation of PP2A in colorectal cancer and the potential therapeutic value showed by its forskolin-induced dephosphorylation and activation

(2014) Ion Cristóbal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature

(2014) F. M. Millimouno et al.   Cancer Prevention Research

Adenylyl cyclases in the digestive system

(2014) Maria Eugenia Sabbatini et al.   CELLULAR SIGNALLING

Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation

(2014) Alexandra Amaro-Ortiz et al.   MOLECULES

cAMP signaling in subcellular compartments

(2014) Konstantinos Lefkimmiatis et al.   PHARMACOLOGY & THERAPEUTICS

cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: Effects of PKA and EPAC

(2013) Alex Burdyga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biological roles of cAMP: variations on a theme in the different kingdoms of life

(2013) Juana M. Gancedo   BIOLOGICAL REVIEWS

Death of multiple myeloma cells induced by cAMP-signaling involves downregulation of Mcl-1 via the JAK/STAT pathway

(2013) Virginie Follin-Arbelet et al.   CANCER LETTERS

Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells

(2013) Zhengfu Tai et al.   CELLULAR SIGNALLING

Editorial (Hot Topics: Naturally Occurring Molecules and Anticancer Combination Therapies in the Era of Personalized Medicine and Economic Crisis)

(2013) Silvio Naviglio et al.   CURRENT PHARMACEUTICAL DESIGN

Integrating leptin and cAMP signalling pathways in triple-negative breast cancer cells

(2013) Silvio Naviglio   Frontiers in Bioscience-Landmark

Forskolin Compared with Beclomethasone for Prevention of Asthma Attacks: A Single-Blind Clinical Trial

(2013) M Huerta et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Recent Advances in the Discovery of Small Molecules Targeting Exchange Proteins Directly Activated by cAMP (EPAC)

(2013) Haijun Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein phosphatase 2A: a target for anticancer therapy

(2013) Danilo Perrotti et al.   LANCET ONCOLOGY

β-Adrenergic system, a backstage manipulator regulating tumour progression and drug target in cancer therapy

(2013) Jing Tang et al.   SEMINARS IN CANCER BIOLOGY

Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics

(2013) Yanqiu Ou et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Forskolin: Upcoming antiglaucoma molecule

(2012) VD Wagh et al.   Journal of Postgraduate Medicine

The genetic/metabolic transformation concept of carcinogenesis

(2011) Leslie C. Costello et al.   CANCER AND METASTASIS REVIEWS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Coleus forskohlii extract induces hepatic cytochrome P450 enzymes in mice

(2011) Nantiga Virgona et al.   FOOD AND CHEMICAL TOXICOLOGY

Aging and photo-aging DNA repair phenotype of skin cells—Evidence toward an effect of chronic sun-exposure

(2011) Chloé Prunier et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Regulating Rap small G-proteins in time and space

(2011) Martijn Gloerich et al.   TRENDS IN CELL BIOLOGY

Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells

(2010) Silvio Naviglio et al.   CANCER BIOLOGY & THERAPY

Leptin potentiates antiproliferative action of cAMP elevation via protein kinase A down-regulation in breast cancer cells

(2010) Silvio Naviglio et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Intra-arterial colforsin daropate for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage

(2009) Satoshi Suzuki et al.   NEURORADIOLOGY

Natural compounds for cancer treatment and prevention

(2009) Stefania Nobili et al.   PHARMACOLOGICAL RESEARCH

Cyclic Nucleotide-regulated Cation Channels

(2008) Martin Biel   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation and Inhibition of Adenylyl Cyclase Isoforms by Forskolin Analogs

(2008) C. Pinto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS