The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF

(2011) D. Lai et al.   CANCER RESEARCH

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie

(2011) M. Melissa Gilbert et al.   DEVELOPMENTAL CELL

Cooperative Regulation of Growth by Yorkie and Mad through bantam

(2011) Hyangyee Oh et al.   DEVELOPMENTAL CELL

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin

(2011) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAZ is a novel oncogene in non-small cell lung cancer

(2011) Z Zhou et al.   ONCOGENE

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

 -Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

(2011) M. R. Silvis et al.   Science Signaling

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

(2010) Tsutomu Oka et al.   BIOCHEMICAL JOURNAL

Organ size determination and the limits of regulation

(2010) Ben Z. Stanger   CELL CYCLE

Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell Proliferation

(2010) Binnaz Kucuk Staley et al.   CURRENT BIOLOGY

Modulation of Fat:Dachsous Binding by the Cadherin Domain Kinase Four-Jointed

(2010) Michael A. Simon et al.   CURRENT BIOLOGY

Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway

(2010) Meghna Das Thakur et al.   CURRENT BIOLOGY

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

(2010) Nicola A. Grzeschik et al.   CURRENT BIOLOGY

Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded

(2010) Brian S. Robinson et al.   CURRENT BIOLOGY

The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration

(2010) R. L. Shaw et al.   DEVELOPMENT

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

(2010) P. Karpowicz et al.   DEVELOPMENT

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster

(2010) Felix A. Grusche et al.   DEVELOPMENTAL BIOLOGY

Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors

(2010) Gongping Sun et al.   DEVELOPMENTAL BIOLOGY

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila

(2010) Roland Baumgartner et al.   DEVELOPMENTAL CELL

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

(2010) Jianzhong Yu et al.   DEVELOPMENTAL CELL

Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap

(2010) Ricardo M. Neto-Silva et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network

(2010) Alice Genevet et al.   DEVELOPMENTAL CELL

TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner

(2010) Eline Remue et al.   FEBS LETTERS

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

Structural basis of YAP recognition by TEAD4 in the Hippo pathway

(2010) L. Chen et al.   GENES & DEVELOPMENT

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

(2010) S. Benhamouche et al.   GENES & DEVELOPMENT

Structural insights into the YAP and TEAD complex

(2010) Z. Li et al.   GENES & DEVELOPMENT

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiomotin-like Proteins Associate with and Negatively Regulate YAP1

(2010) Wenqi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling

(2010) Paulo S. Ribeiro et al.   MOLECULAR CELL

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways

(2010) F. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

(2010) C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

(2010) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Feed-Forward Circuit Linking Wingless, Fat-Dachsous Signaling, and the Warts-Hippo Pathway to Drosophila Wing Growth

(2010) Myriam Zecca et al.   PLOS BIOLOGY

dMyc Functions Downstream of Yorkie to Promote the Supercompetitive Behavior of Hippo Pathway Mutant Cells

(2010) Marcello Ziosi et al.   PLoS Genetics

Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma

(2009) Michelle Z. Xu et al.   CANCER

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown

(2009) Richelle Sopko et al.   CURRENT BIOLOGY

Drosophila lowfat, a novel modulator of Fat signaling

(2009) Y. Mao et al.   DEVELOPMENT

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling

(2009) Hyangyee Oh et al.   DEVELOPMENTAL BIOLOGY

Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms

(2009) Fangfang Ren et al.   DEVELOPMENTAL BIOLOGY

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

(2009) Noriyuki Nishioka et al.   DEVELOPMENTAL CELL

The FERM-Domain Protein Expanded Regulates Hippo Pathway Activity via Direct Interactions with the Transcriptional Activator Yorkie

(2009) Caroline Badouel et al.   DEVELOPMENTAL CELL

Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc

(2009) H. W. Peng et al.   GENES & DEVELOPMENT

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

(2009) A. Fernandez-L et al.   GENES & DEVELOPMENT

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

(2009) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hippo pathway regulates apical-domain size independently of its growth-control function

(2009) A. Genevet et al.   JOURNAL OF CELL SCIENCE

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

(2009) Jianmin Zhang et al.   NATURE CELL BIOLOGY

Processing and phosphorylation of the Fat receptor

(2009) Y. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

(2009) K. Skouloudaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells

(2008) S. W. Chan et al.   CANCER RESEARCH

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

(2008) Lixing Zhan et al.   CELL

SCALLOPED Interacts with YORKIE, the Nuclear Effector of the Hippo Tumor-Suppressor Pathway in Drosophila

(2008) Youlian Goulev et al.   CURRENT BIOLOGY

MOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation

(2008) Maria Praskova et al.   CURRENT BIOLOGY

In vivo regulation of Yorkie phosphorylation and localization

(2008) H. Oh et al.   DEVELOPMENT

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

(2008) Shian Wu et al.   DEVELOPMENTAL CELL

The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control

(2008) Lei Zhang et al.   DEVELOPMENTAL CELL

Morphogen Control of Wing Growth through the Fat Signaling Pathway

(2008) Dragana Rogulja et al.   DEVELOPMENTAL CELL

A crucial role of WW45 in developing epithelial tissues in the mouse

(2008) Joo-Hyeon Lee et al.   EMBO JOURNAL

YAP regulates neural progenitor cell number via the TEA domain transcription factor

(2008) X. Cao et al.   GENES & DEVELOPMENT

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Expression of Yes-associated protein in common solid tumors

(2008) Angela A. Steinhardt et al.   HUMAN PATHOLOGY

Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-associated Protein (YAP)

(2008) Tsutomu Oka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

(2008) Eleonora Lapi et al.   MOLECULAR CELL

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation

(2008) M. Willecke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA